Jump to Main Content
- Williams, Thomas L.; Urbanc, Brigita; Marshall, Karen E.; Vadukul, Devkee M.; Jenkins, A. Toby A.; Serpell, Louise C.
- FEBS letters 2015 v.589 no.21 pp. 3228-3236
- Alzheimer disease; cell membranes; cytotoxicity; europium; fluorescence emission spectroscopy; gangliosides; peptides; receptors
- ... Soluble Amyloid-beta (Aβ) oligomers are a source of cytotoxicity in Alzheimer’s disease (AD). The toxicity of Aβ oligomers may arise from their ability to interact with and disrupt cellular membranes mediated by GM1 ganglioside receptors within these membranes. Therefore, inhibition of Aβ–membrane interactions could provide a means of preventing the toxicity associated with Aβ. Here, using Surface ...
- PubMed Central: