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- Grubman, Marvin J.; Moraes, Mauro Pires; Diaz-San Segundo, Fayna; Pena, Lindomar; de los Santos, Teresa
- FEMS immunology and medical microbiology 2008 v.53 no.1 pp. 8
- foot-and-mouth disease; immune response; gene expression regulation; transcription (genetics); apoptosis; dendritic cells; antigen presentation; major histocompatibility complex; Foot-and-mouth disease virus; viral proteins; proteinases
- ... Foot-and-mouth disease virus (FMDV) causes an economically devastating disease of cloven-hoofed animals. In this review, we discuss the mechanisms FMDV has evolved to counteract the host innate and adaptive immune responses and the role of viral proteins in this process. The viral leader proteinase, Lpro, limits the host innate response by inhibiting the induction of interferon beta (IFNβ) mRNA an ...
- Chang, Jason; Pang, Ervinna; He, Haiqi; Kwang, Jimmy
- FEMS immunology and medical microbiology 2008 v.53 no.1 pp. 26
- Salmonella enteritidis; adenosine triphosphate; adults; antibodies; antibody formation; biosynthesis; cell invasion; cell membranes; chicks; diarrhea; food pathogens; gene expression regulation; genes; hens; humans; immunoglobulin G; lethal dose 50; lipopolysaccharides; liver; macrophages; microbial growth; mutants; nitrogen; oxygen; paratyphoid; pathogen survival; reactive oxygen species; spleen; transposons; virulence
- ... Salmonella Enteritidis is a major food-borne pathogen that causes nontyphoidal diarrhoea in humans. Infection of adult egg-laying hens usually results in symptomless carriage but in young chicks it may cause paratyphoid disease. It is not known whether S. Enteritidis requires genes additional to known virulence genes for systemic infection of young chickens. A transposon insertion library was crea ...