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- Diaz-San Segundo, Fayna, et al. Show all 5 Authors
- FEMS immunology and medical microbiology 2008 v.53 no.1 pp. 8
- foot-and-mouth disease; immune response; gene expression regulation; transcription (genetics); apoptosis; dendritic cells; antigen presentation; major histocompatibility complex; Foot-and-mouth disease virus; viral proteins; proteinases
- ... Foot-and-mouth disease virus (FMDV) causes an economically devastating disease of cloven-hoofed animals. In this review, we discuss the mechanisms FMDV has evolved to counteract the host innate and adaptive immune responses and the role of viral proteins in this process. The viral leader proteinase, Lpro, limits the host innate response by inhibiting the induction of interferon beta (IFNβ) mRNA an ...