Jump to Main Content
- Kim, Jong H.; Campbell, Bruce C.; Mahoney, Noreen; Chan, Kathleen L.; Molyneux, Russell J.; May, Gregory S.
- FEMS microbiology letters 2007 v.270 no.2 pp. 284
- pyrroles; antifungal agents; fungicides; synergism; benzoic acid; mitogen-activated protein kinase; signal transduction; glutathione; homeostasis; antioxidant activity; oxidative stress; Aspergillus fumigatus; animal pathogenic fungi; plant pathogenic fungi; Aspergillus flavus; Aspergillus parasiticus; Aspergillus niger; Aspergillus oryzae; Aspergillus nidulellus
- ... The activity of fludioxonil, a phenylpyrrole fungicide, is elevated by coapplication of the aspirin/salicylic acid metabolite, 2,5-dihydroxybenzoic acid (2,5-DHBA). Fludioxonil activity is potentiated through a mitogen-activated protein kinase (MAPK) pathway that regulates osmotic/oxidative stress-responses. 2,5-DHBA disrupts cellular GSH (reduced glutathione)/GSSG (oxidized glutathione) homeostas ...