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You searched for: Journal Fitoterapia Remove constraint Journal: Fitoterapia Publication Year 2017 Remove constraint Publication Year: 2017 Source 2017 v.118 Remove constraint Source: 2017 v.118
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1. Anti-inflammatory pentacyclic triterpenes from the stems of Euonymus carnosus

Author:
Zhou, Jian; Wei, Xiao-hua; Chen, Fang-you; Li, Chuang-jun; Yang, Jing-zhi; Ma, Jie; Bao, Xiu-qi; Zhang, Dan; Zhang, Dong-ming
Source:
Fitoterapia 2017 v.118 pp. 21-26
ISSN:
0367-326X
Subject:
Euonymus; inhibitory concentration 50; neuroglia; nitric oxide; nuclear magnetic resonance spectroscopy; spectral analysis; stems; triterpenoids
Abstract:
... Three new lupane-type triterpenoids (1–3), three new oleane-type triterpenoids (4–6), as well as two known compounds (7–8) were isolated from Euonymus carnosus. The structures of the compounds were elucidated on the basis of spectroscopic data analyses, including UV, IR, MS, and NMR experiments. The inhibitory on LPS-induced NO production in microglia BV2 cells of compounds 1–8 were also evaluated ...
DOI:
10.1016/j.fitote.2017.01.015

2. Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood

Author:
Huo, Hui-Xia; Gu, Yu-Fan; Sun, Hui; Zhang, Yun-Feng; Liu, Wen-Jing; Zhu, Zhi-Xiang; Shi, She-Po; Song, Yue-Lin; Jin, Hong-Wei; Zhao, Yun-Fang; Tu, Peng-Fei; Li, Jun
Source:
Fitoterapia 2017 v.118 pp. 49-55
ISSN:
0367-326X
Subject:
circular dichroism spectroscopy; inhibitory concentration 50; nitric oxide; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Five new 2-(2-phenylethyl)chromone derivatives (1–5), along with eleven known compounds (6–16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2–4 were determined by electronic circular dichroism (ECD) calculat ...
DOI:
10.1016/j.fitote.2017.02.009

3. Aristolochic acid derivatives from the rhizome of Arisolochia championii

Author:
Wang, Xin; Shi, Guo-Ru; Liu, Yan-Fei; Li, Li; Chen, Ruo-Yun; Yu, De-Quan
Source:
Fitoterapia 2017 v.118 pp. 63-68
ISSN:
0367-326X
Subject:
Aristolochia; cytotoxicity; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; rhizomes; spectral analysis
Abstract:
... Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5–14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for t ...
DOI:
10.1016/j.fitote.2017.01.006

4. Biotransfomation of cyperenoic acid by Cunninghamella elegans AS 3.2028 and the potent anti-angiogenic activities of its metabolites

Author:
Chen, Yu; Tian, Jin-Long; Wu, Jing-Shuai; Sun, Tie-Min; Zhou, Li-Na; Song, Shao-Jiang; You, Song
Source:
Fitoterapia 2017 v.118 pp. 32-37
ISSN:
0367-326X
Subject:
Croton; Cunninghamella elegans; biotransformation; cytotoxicity; enzyme-linked immunosorbent assay; metabolites; neoplasms; sesquiterpenoids; therapeutics; vascular endothelial growth factors
Abstract:
... Cyperenoic acid (1) is one of the major sesquiterpenes isolated from Croton crassifolius, which exhibited potent anti-angiogenic activity. Traditional structural modification of 1 is difficult to perform by chemical technology due to the remarkable stability of the patchoulane skeleton. In order to overcome chemical synthesis difficulties and obtain structurally diverse derivations, microbial tran ...
DOI:
10.1016/j.fitote.2017.02.004

5. Chenopodium bonus-henricus L. – A source of hepatoprotective flavonoids

Author:
Kokanova-Nedialkova, Zlatina; Nedialkov, Paraskev; Kondeva-Burdina, Magdalena; Simeonova, Rumyana; Tzankova, Virginia; Aluani, Denitsa
Source:
Fitoterapia 2017 v.118 pp. 13-20
ISSN:
0367-326X
Subject:
Chenopodium; aerial parts; antioxidant activity; cell viability; cytotoxicity; glycosides; hepatocytes; hepatotoxicity; human cell lines; lipids; methanol; models; nuclear magnetic resonance spectroscopy; rats; silymarin
Abstract:
... Three new flavonoid glycosides (7–9) named patuletin-3-O-(5″′-О-Е-feruloyl)-β-d-apiofuranosyl(1→2)[β-d-glucopyranosyl (1→6)]-β-d-glucopyranoside (7), spinacetin-3-O-(5″′-О-Е-feruloyl)-β-d-apiofuranosyl (1→2)[β-d-glucopyranosyl(1→6)]-β-d-glucopyranoside (8) and 6-methoxykaempferol-3-O-(5″′-О-Е-feruloyl)-β-d-apiofuranosyl(1→2)[β-d-glucopyranosyl (1→6)]-β-d-glucopyranoside (9) together with six known ...
DOI:
10.1016/j.fitote.2017.02.001

6. C21 steroidal glycosides and oligosaccharides from the root bark of Periploca sepium

Author:
Gu, Xin-Yue; Wu, Zhou-Wei; Wang, Lun; Li, Fu; Chen, Bin; Yu, Kai; Wang, Ming-Kui
Source:
Fitoterapia 2017 v.118 pp. 6-12
ISSN:
0367-326X
Subject:
anticarcinogenic activity; bark; chemical structure; cytotoxicity; glycosides; human cell lines; humans; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; oligosaccharides; roots; spectral analysis
Abstract:
... Four new C21 steroidal glycosides (1–4), named perisepiumosides FI (1–4) together with six known steroidal glycosides (5–10) and four oligosaccharides (11–14), were isolated from the root bark of Periploca sepium. Their structures were characterized on the basis of 1D and 2D–NMR spectroscopic data as well as HR-ESI-MS analysis. The evaluation of inhibition activity against human A-549 and HepG2 ce ...
DOI:
10.1016/j.fitote.2017.02.005

7. Dual high-resolution inhibition profiling and HPLC-HRMS-SPE-NMR analysis for identification of α-glucosidase and radical scavenging inhibitors in Solanum americanum Mill.

Author:
Silva, Eder L.; Almeida-Lafetá, Rita C.; Borges, Ricardo M.; Staerk, Dan
Source:
Fitoterapia 2017 v.118 pp. 42-48
ISSN:
0367-326X
Subject:
4-hydroxybenzoic acid; Solanum americanum; alkaloids; alpha-glucosidase; antioxidant activity; ethyl acetate; medicinal plants; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; Guatemala
Abstract:
... Solanum americanum is one of the most prominent species used to treat type 2 diabetes in Guatemala. In our ongoing efforts to find antidiabetic and antioxidative compounds from natural sources, an ethyl acetate extract of this medicinal herb was investigated using dual high-resolution α-glucosidase/radical scavenging inhibition profiling. The high-resolution biochromatograms obtained by this techn ...
DOI:
10.1016/j.fitote.2017.02.002

8. Evaluation of antibacterial potential and toxicity of plant volatile compounds using new broth microdilution volatilization method and modified MTT assay

Author:
Houdkova, Marketa; Rondevaldova, Johana; Doskocil, Ivo; Kokoska, Ladislav
Source:
Fitoterapia 2017 v.118 pp. 56-62
ISSN:
0367-326X
Subject:
8-hydroxyquinoline; Haemophilus influenzae; Staphylococcus aureus; Streptococcus pneumoniae; antibacterial properties; antibiotics; carvacrol; cytotoxicity; ethylene-vinyl acetate; eugenol; fibroblasts; inhibitory concentration 50; labor; minimum inhibitory concentration; screening; tetrazolium; thymol; vapors; volatile compounds; volatilization
Abstract:
... With aim to develop effective proof-of-concept approach which can be used in a development of new preparations for the inhalation therapy, we designed a new screening method for simple and rapid simultaneous determination of antibacterial potential of plant volatiles in the liquid and the vapour phase at different concentrations. In addition, EVA (ethylene vinyl acetate) capmat™ as vapour barrier ...
DOI:
10.1016/j.fitote.2017.02.008

9. Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae)

Author:
Ortiz, Sergio; Dali-Yahia, Kamel; Vasquez-Ocmin, Pedro; Grougnet, Raphaël; Grellier, Philippe; Michel, Sylvie; Maciuk, Alexandre; Boutefnouchet, Sabrina
Source:
Fitoterapia 2017 v.118 pp. 1-5
ISSN:
0367-326X
Subject:
Asteraceae; Plasmodium falciparum; antimalarials; hemoglobin; mass spectrometry; metabolites
Abstract:
... A heme-binding assay based on mass spectrometry was performed on P. monodiana Maire (Asteraceae) extracts to identify metabolites able to form adducts with heminic part of haemoglobin, as potential antimalarial drugs. Main adducts were characterized and their stability was measured. Isolation of main constituents of P. monodiana Maire lead to identification of the two methoxyflavones 3′-O-methyleu ...
DOI:
10.1016/j.fitote.2017.01.012

10. New phenylpropanoid and 6H-dibenzo[b,d]pyran-6-one derivatives from the stems of Dasymaschalon rostratum

Author:
Yu, Zhang-Xin; Niu, Zhi-Gang; Li, Xiao-Bao; Zheng, Cai-Juan; Song, Xin-Ming; Chen, Guang-Ying; Song, Xiao-Ping; Han, Chang-Ri; Wu, Shu-Xian
Source:
Fitoterapia 2017 v.118 pp. 27-31
ISSN:
0367-326X
Subject:
Human immunodeficiency virus 1; X-ray diffraction; antiviral properties; cinnamic acid; cyclohexenes; median effective concentration; spectroscopy; stems
Abstract:
... Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5–11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated d ...
DOI:
10.1016/j.fitote.2017.02.003

11. Nortriterpenoids from the stems and leaves of Schisandra viridis

Author:
Liu, Ye; Tian, Tian; Yu, Heng-Yi; Zhou, Ming; Ruan, Han-Li
Source:
Fitoterapia 2017 v.118 pp. 38-41
ISSN:
0367-326X
Subject:
Schisandra; antineoplastic activity; chemical structure; cytotoxicity; leaves; neoplasms; nuclear magnetic resonance spectroscopy; stems
Abstract:
... An extensive phytochemical study on the stems and leaves of Schisandra viridis A. C. Smith led to the isolation of two novel highly oxygenated schinortriterpenoids, pre-schisanartanin P (1) and wuweizidilactone Q (2), together with four known ones (3–6). Their structures with absolute configurations were established on the basis of comprehensive spectroscopic methods, including HRESIMS, 1D and 2D ...
DOI:
10.1016/j.fitote.2017.02.006

12. Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum

Author:
Gao, Fei; Yao, Yuan-Cheng; Cai, Sheng-Bao; Zhao, Tian-Rui; Yang, Xiao-Yan; Fan, Jian; Li, Xiao-Nian; Cao, Jian-Xin; Cheng, Gui-Guang
Source:
Fitoterapia 2017 v.118 pp. 107-111
ISSN:
0367-326X
Subject:
chemical structure; concanavalin A; dexamethasone; glycosides; immunosuppression; leaves; mice; nuclear magnetic resonance spectroscopy; spectral analysis; splenocytes
Abstract:
... Phytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C21 pregnane glycosides, epigynosides, E–G (1–3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported data. The immunological activiti ...
DOI:
10.1016/j.fitote.2017.02.011

13. Sesquiterpenoids from the cultured mycelia of Ganoderma capense

Author:
Tan, Zhen; Zhao, Jinlian; Liu, Jimei; Zhang, Min; Chen, Ridao; Xie, Kebo; Dai, Jungui
Source:
Fitoterapia 2017 v.118 pp. 73-79
ISSN:
0367-326X
Subject:
Ganoderma; anticarcinogenic activity; chemical structure; circular dichroism spectroscopy; cytotoxicity; humans; inhibitory concentration 50; mycelium; neoplasms; sesquiterpenoids; spectral analysis
Abstract:
... Eleven new sesquiterpenoids, including eight cadinane-type sesquiterpenoids, Ganodermanol A–H (1–8), and three eudesmane-type sesquiterpenoids, Ganodermanol I–K (9–11), together with three known compounds (12–14), were isolated from the cultured mycelia of Ganoderma capense. Their structures and absolute configurations were identified through combined extensive spectroscopic analysis, circular dic ...
DOI:
10.1016/j.fitote.2017.02.007

14. Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

Author:
Trinh, Binh T.D.; Quach, Tam T.T.; Bui, Dung N.; Staerk, Dan; Nguyen, Lien-Hoa D.; Jäger, Anna K.
Source:
Fitoterapia 2017 v.118 pp. 126-131
ISSN:
0367-326X
Subject:
Garcinia; active ingredients; alpha-glucosidase; branches; ethyl acetate; glycemic effect; inhibitory concentration 50; mass spectrometry; nuclear magnetic resonance spectroscopy; spectral analysis; xanthones
Abstract:
... Three new xanthones, oblongixanthone F–H (1–3), along with eight known xanthones (4–11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition ass ...
DOI:
10.1016/j.fitote.2017.03.003