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You searched for: Journal Food & function Remove constraint Journal: Food & function Publication Year 2021 Remove constraint Publication Year: 2021 Source 2021 v.12 no.7 Remove constraint Source: 2021 v.12 no.7
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1. A comprehensive assessment of the chemical composition, antioxidant, genoprotective and antigenotoxic activities of Lamiaceae species using different experimental models in vitro

Author:
Oalđe, Mariana; Kolarević, Stoimir; Živković, Jelena; Alimpić Aradski, Ana; Jovanović Marić, Jovana; Kračun Kolarević, Margareta; Đorđević, Jelena; Marin, Petar D.; Šavikin, Katarina; Vuković-Gačić, Branka; Duletić-Laušević, Sonja
Source:
Food & function 2021 v.12 no.7 pp. 3233-3245
ISSN:
2042-650X
Subject:
DNA repair; Escherichia coli; Glechoma hederacea; Hyssopus officinalis; Lavandula angustifolia; Leonurus cardiaca; Marrubium vulgare; Salmonella Typhimurium; Sideritis; antioxidant activity; assays; chemical composition; fibroblasts; genomics; humans; lungs; naringin; oxidative stress; plasmids; polyphenols; quercetin; reactive oxygen species; research
Abstract:
... This research was aimed to assess the potential of Glechoma hederacea, Hyssopus officinalis, Lavandula angustifolia, Leonurus cardiaca, Marrubium vulgare and Sideritis scardica (Lamiaceae) methanolic, ethanolic and aqueous extracts against the damaging effects of oxidative stress using different experimental models. The chemical characterization was done spectrophotometrically by quantifying total ...
DOI:
10.1039/d1fo00447f

2. Anti-fatigue effect of Lepidium meyenii Walp. (Maca) on preventing mitochondria-mediated muscle damage and oxidative stress in vivo and vitro

Author:
Zhu, Hongkang; Xu, Wenqian; Wang, Ning; Jiang, Wenhao; Cheng, Yuliang; Guo, Yahui; Yao, Weirong; Hu, Bin; Du, Peng; Qian, He
Source:
Food & function 2021 v.12 no.7 pp. 3132-3141
ISSN:
2042-650X
Subject:
Lepidium meyenii; athletic performance; biogenesis; blood; dietary supplements; energy metabolism; exercise; functional foods; lactic acid; metabolites; mice; mitochondria; muscles; oxidative stress; reactive oxygen species; skeletal muscle; urea nitrogen; viability
Abstract:
... Maca (Lepidium meyenii Walp.) has emerged as a popular functional plant food due to its various pharmacological properties, including anti-oxidation, anti-inflammation and anti-fatigue activity. In this study, we investigated the role of Maca aqueous extract (ME) on muscle during exercise-induced fatigue both in vivo and in vitro. As a result, ME significantly enhanced mouse leg grip-strength and ...
DOI:
10.1039/d1fo00383f

3. Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake

Author:
Yi, Zhenwei; Liu, Xiaofeng; Liang, Lihong; Wang, Guangqiang; Xiong, Zhiqiang; Zhang, Hui; Song, Xin; Ai, Lianzhong; Xia, Yongjun
Source:
Food & function 2021 v.12 no.7 pp. 2925-2937
ISSN:
2042-650X
Subject:
Lactobacillus; Taiwanofungus camphoratus; active ingredients; alcohol drinking; ascorbic acid; glutathione; inflammation; interleukin-17; interleukin-6; intestinal microorganisms; lipids; liver; metabolism; metabolome; metabolomics; microbiome; mycelium; oxidation; oxidative stress; protective effect; taurine
Abstract:
... This study aimed to investigate the protective effect of Antrodin A (AdA) from Antrodia camphorata (A. camphorata) mycelium on alcohol-induced gut microbiota and liver metabolomic disorders. In acute alcoholic liver injury mice, AdA ameliorated alcoholic exposure-induced hepatic lipid deposition (TC and TG), oxidative stress (MDA), inflammation (TNF-α, IL-1β, IL-6, IL-17 and IFN-γ), and liver dama ...
DOI:
10.1039/d0fo03345f

4. Bioactive compound from the Tibetan turnip (Brassica rapa L.) elicited anti-hypoxia effects in OGD/R-injured HT22 cells by activating the PI3K/AKT pathway

Author:
Hua, Hanyi; Zhu, Hongkang; Liu, Chang; Zhang, Wenyi; Li, Jiayi; Hu, Bin; Guo, Yahui; Cheng, Yuliang; Pi, Fuwei; Xie, Yunfei; Yao, Weirong; Qian, He
Source:
Food & function 2021 v.12 no.7 pp. 2901-2913
ISSN:
2042-650X
Subject:
Brassica rapa; Western blotting; age; anti-inflammatory activity; bioactive compounds; caspase-3; death; functional foods; glucose; ischemia; neuroprotective effect; oxidative stress; oxygen; phosphatidylinositol 3-kinase; pretreatment; prevalence; stroke; turnips; China
Abstract:
... Cerebral stroke, a common clinical problem, is the predominant cause of disability and death worldwide. Its prevalence increases and infarctions exacerbate with age. A Tibetan plant, Brassica rapa L., possesses multiple medicinal effects, such as anti-altitude sickness, anti-hyperlipidemia and anti-fatigue, as mentioned in the noted ancient Tibet pharmacopeia “The Four Medical Tantras”. Our prelim ...
DOI:
10.1039/d0fo03190a

5. Biosafety evaluation of Nannochloropsis oculata and Schizochytrium sp. oils as novel human milk fat substitutes

Author:
Qiu, Changyang; He, Yongjin; Huang, Zicheng; Qiu, Weisang; Huang, Jian; Wang, Mingzi; Chen, Bilian
Source:
Food & function 2021 v.12 no.7 pp. 2972-2984
ISSN:
2042-650X
Subject:
Nannochloropsis; Schizochytrium; behavior; biosafety; body weight; cell viability; chemistry; corn oil; cytotoxicity; diet study techniques; feedstocks; food consumption; hematology; human milk fat; infant formulas; microalgae; necropsy; rats
Abstract:
... The biosafety assessment of novel human milk fat substitutes (HMFs) from microalgae oils of Nannochloropsis oculata and Schizochytrium sp. was evaluated by testing the cytotoxic activity using IEC-6 cells, and by conducting a sub-chronic 28-day dietary study using Sprague–Dawley (SD) suckling rats in this study. The results of the cytotoxic activity of IEC-6 cells treated with HMFs showed no appar ...
DOI:
10.1039/d0fo03000g

6. Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging

Author:
Tao, Li; Zhang, Wei; Zhang, Yaxin; Zhang, Mei; Zhang, Yueying; Niu, Xing; Zhao, Qing; Liu, Zhenxing; Li, Yuyin; Diao, Aipo
Source:
Food & function 2021 v.12 no.7 pp. 2914-2924
ISSN:
2042-650X
Subject:
animals; caffeine; cell senescence; decline; histology; length; liver; spleen; tea; telomerase; telomeres
Abstract:
... Telomere shortening is one of the main causes of cellular senescence. Caffeine is a natural stimulant most commonly found in coffee and tea. In this study, caffeine was found to promote the expression of telomerase reverse transcriptase (TERT) at both mRNA and protein levels, and consequently extended the telomere length and prevented cellular senescence. Knockdown of TERT eliminated the effect of ...
DOI:
10.1039/d0fo03246h

7. Cardioprotective action of chia (Salvia hispanica L.) in ovariectomized rats fed a high fat diet

Author:
Mishima, Marcella Duarte Villas; Ladeira, Luiz Carlos Maia; da Silva, Bárbara Pereira; Toledo, Renata Celi Lopes; de Oliveira, Thomás Valente; Costa, Neuza Maria Brunoro; Martino, Hércia Stampini Duarte
Source:
Food & function 2021 v.12 no.7 pp. 3069-3082
ISSN:
2042-650X
Subject:
Salvia hispanica; adenosinetriphosphatase; adiposity; antioxidant activity; biometry; cardiovascular diseases; catalase; estrogens; females; heart; high fat diet; hypertrophy; lipid content; mineral content; nitric oxide; ovariectomy; oxidative stress; risk; superoxide dismutase; weight gain
Abstract:
... The reduction in estrogen levels is associated with the increased risk factors for cardiovascular disease development. The present study aimed to evaluate the effect of chia consumption in a standard diet (SD) or high fat diet (HFD) on ovariectomized (OVX) and non-ovariectomized (SHAM) rats, in relation to biometric measurements, oxidative stress, mineral content and ATPase enzymes in the heart. T ...
DOI:
10.1039/d0fo03206a

8. Coconut oil supplementation during development reduces brain excitability in adult rats nourished and overnourished in lactation

Author:
Alves, Danielle Viana de Souza; Sousa, Mariana Séfora Bezerra; Tavares, Maryane Gabriela Borba; Batista-de-Oliveira Hornsby, Manuella; Amancio-dos-Santos, Angela
Source:
Food & function 2021 v.12 no.7 pp. 3096-3103
ISSN:
2042-650X
Subject:
adults; brain; coconut oil; electrophysiology; environmental enrichment; information; lactation; lipid peroxidation; nutritional status; overnutrition; rats; therapeutics; velocity
Abstract:
... Introduction: Coconut oil has been considered as a therapeutic alternative in several pathologies, but there is limited information regarding its effects on brain functioning. Objective: This study analyzed whether early virgin coconut oil (VCO) supplementation interferes with electrical activity of the adult rat brain and its lipid peroxidation. Moreover, it investigated whether the putative effe ...
DOI:
10.1039/d1fo00086a

9. Development of β-carotene loaded oil-in-water emulsions using mixed biopolymer–particle–surfactant interfaces

Author:
Wei, Yang; Zhou, Dan; Yang, Shufang; Dai, Lei; Zhang, Liang; Mao, Like; Gao, Yanxiang; Mackie, Alan
Source:
Food & function 2021 v.12 no.7 pp. 3246-3265
ISSN:
2042-650X
Subject:
alginates; bioavailability; biopolymers; cosmetics; digestion; digestive tract; droplet size; drugs; emulsions; encapsulation; gastrointestinal system; lipolysis; microstructure; propylene glycol; rhamnolipids; zein
Abstract:
... In this study, β-carotene loaded oil-in-water emulsions were stabilized by complex interfaces composed of propylene glycol alginate (PGA), rhamnolipids (Rha), and zein colloidal particles (ZCPs). The influence of mixed biopolymer–surfactant, biopolymer–particle, surfactant–particle and biopolymer–surfactant–particle interfaces on the performance of the emulsions was investigated. The stability, mi ...
DOI:
10.1039/d0fo02975k

10. Differential protection by anthocyanin-rich bilberry extract and resveratrol against lipid micelle-induced oxidative stress and monolayer permeability in Caco-2 intestinal epithelial cells

Author:
Ershad, Maryam; Shigenaga, Mark K.; Bandy, Brian
Source:
Food & function 2021 v.12 no.7 pp. 2950-2961
ISSN:
2042-650X
Subject:
Western diets; anthocyanins; bilberries; bile; carcinogenesis; cell viability; cytotoxicity; dietary fat; electrical resistance; epithelial cells; epithelium; human cell lines; inflammation; intestines; lipids; micelles; mitochondria; models; oxidative stress; permeability; polyphenols; reactive oxygen species; resveratrol
Abstract:
... Excess dietary fat, and associated bile acids, can impair intestinal barrier integrity, produce intestinal or systemic inflammation and promote tumorigenesis. Dietary polyphenols in foods such as berries display antioxidant and other protective effects in many biological systems, but little is known about their protective effects on intestinal epithelial cells exposed to dietary fat. In a Caco-2 c ...
DOI:
10.1039/d0fo02377a

11. Effect of fermentation with single and co-culture of lactic acid bacteria on okara: evaluation of bioactive compounds and volatile profiles

Author:
Hadj Saadoun, Jasmine; Calani, Luca; Cirlini, Martina; Bernini, Valentina; Neviani, Erasmo; Del Rio, Daniele; Galaverna, Gianni; Lazzi, Camilla
Source:
Food & function 2021 v.12 no.7 pp. 3033-3043
ISSN:
2042-650X
Subject:
Lactobacillus acidophilus; Pediococcus acidilactici; appearance (quality); biotransformation; byproducts; coculture; food industry; glucosides; isoflavones; lactic acid; odors; off flavors; okara; polyphenols; solid state fermentation; soybeans; soymilk; tofu
Abstract:
... Okara is the main soybean by-product resulting from the processing of soy milk and tofu. Despite being a product with a lot of potential and rich in many bioactive compounds such as polyphenols, it presents an unpleasant, rancid aroma. For this reason its use in the food industry is limited. In this study, we have reported the integral use of okara in a solid state fermentation process, conducted ...
DOI:
10.1039/d0fo02916e

12. Effect of konjac glucomannan on metabolites in the stomach, small intestine and large intestine of constipated mice and prediction of the KEGG pathway

Author:
Zhang, Qi; Zhong, Dian; Ren, Yuan-Yuan; Meng, Zi-kuan; Pegg, Ronald B.; Zhong, Geng
Source:
Food & function 2021 v.12 no.7 pp. 3044-3056
ISSN:
2042-650X
Subject:
arachidonic acid; biosynthesis; blood serum; body weight; constipation; deoxycholic acid; digestive tract; histamine; konjac mannan; large intestine; linoleic acid; metabolomics; occurrence; peptides; phenylalanine; prediction; secondary metabolites; small intestine; stomach; sulfates; thiamin; tryptophan; tyrosine; water content
Abstract:
... The occurrence of constipation involves the whole gastrointestinal tract. Konjac glucomannan (KGM) has been clinically proven to alleviate constipation, but its mechanism has not been fully understood. The present study aimed to investigate the excretion-promoting effect of KGM on constipated mice and the underlying molecular mechanism. In this study, the UHPLC-QE orbitrap/MS method was used to de ...
DOI:
10.1039/d0fo02682d

13. Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion

Author:
Heerup, Christine; Ebbesen, Morten Frendø; Geng, Xiaolu; Madsen, Sofie Falkenløve; Berthelsen, Ragna; Müllertz, Anette
Source:
Food & function 2021 v.12 no.7 pp. 2938-2949
ISSN:
2042-650X
Subject:
digestion; emulsions; humans; infant formulas; intestines; lipid metabolism; models; pancreatin; phosphatidylcholines; swine; triacylglycerol lipase
Abstract:
... The aim of the study was to implement a gastric digestion step using recombinant human gastric lipase (rHGL) in an in vitro pediatric gastro-intestinal digestion model to achieve a physiologically relevant gastric contribution to total gastro-intestinal lipid digestion. A commercial infant formula (NAN Comfort stage 1 (NAN1)) with 3.4% lipid and an in-lab prepared oil-in-water emulsion, emulsified ...
DOI:
10.1039/d0fo02976a

14. Exploring the interactions between Lactobacillus rhamnosus GG and whey protein isolate for preservation of the viability of bacteria through spray drying

Author:
Lu, Wenjie; Fu, Nan; Woo, Meng Wai; Chen, Xiao Dong
Source:
Food & function 2021 v.12 no.7 pp. 2995-3008
ISSN:
2042-650X
Subject:
Lactobacillus rhamnosus; adsorption; biochemical pathways; cell membranes; cell viability; heat tolerance; heat treatment; kinetics; lactic acid; skim milk; spray drying; surface roughness; trehalose; whey protein isolate
Abstract:
... Protective agents used in spray drying protect the activity of lactic acid bacteria (LAB) by stabilizing the subcellular structures, constituting a protective layer at the cellular surface, or having mild drying kinetics. The effects of a reputed protectant, whey protein isolate (WPI), on Lactobacillus rhamnosus GG (LGG) were examined by exposing the cells to WPI solution to induce protein adsorpt ...
DOI:
10.1039/d0fo02906h

15. Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites

Author:
Yan, Xiumei; Yan, Jingbin; Xiang, Qiangwei; Wang, Fanyan; Dai, Huan; Huang, Kaiyu; Fang, Lingjuan; Yao, Hao; Wang, Lingya; Zhang, Weixi
Source:
Food & function 2021 v.12 no.7 pp. 3191-3205
ISSN:
2042-650X
Subject:
CD4-positive T-lymphocytes; Verrucomicrobiae; aryl hydrocarbon receptors; blood serum; correlation; feces; food allergies; food intake; fructooligosaccharides; inflammation; interleukin-10; interleukin-17; intestinal microorganisms; intestines; kynurenine; liquid chromatography; metabolites; mice; models; ovalbumin; protective effect; research; serotonin; tandem mass spectrometry; tryptophan
Abstract:
... Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA). Furthermore, the protective mechanism of FOS against FA is unclear. In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS. Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse mod ...
DOI:
10.1039/d0fo03371e

16. Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition

Author:
Bai, Xue; Fu, Rongzhan; Duan, Zhiguang; Liu, Yannan; Zhu, Chenhui; Fan, Daidi
Source:
Food & function 2021 v.12 no.7 pp. 2874-2885
ISSN:
2042-650X
Subject:
Panax notoginseng; absorption barrier; bile; bioactive compounds; ginsenosides; inflammation; intestinal microorganisms; intestines; models; phenotype
Abstract:
... Ginsenoside Rh4, as a bioactive component obtained from Panax notoginseng, has excellent pharmacological properties. However, its role in regulating gut microbiota and intestinal inflammation is still poorly understood. Thus, the aim of this study is to investigate the effect of Rh4 on gut microbiota, especially antibiotic-induced microbiota perturbation, and the underlying mechanisms. C57BL/6 mic ...
DOI:
10.1039/d1fo00242b

17. Goat and cow milk differ in altering microbiota composition and fermentation products in rats with gut dysbiosis induced by amoxicillin

Author:
Butts, Christine A.; Paturi, Gunaranjan; Hedderley, Duncan I.; Martell, Sheridan; Dinnan, Hannah; Stoklosinski, Halina; Carpenter, Elizabeth A.
Source:
Food & function 2021 v.12 no.7 pp. 3104-3119
ISSN:
2042-650X
Subject:
Bifidobacterium; Clostridium perfringens; Lactobacillus; amoxicillin; animal models; cecum; colon; cows; dysbiosis; feces; fermentation; gentamicin; goat milk; goats; intestinal microorganisms; length; metronidazole; milk; oral administration; rats
Abstract:
... Antibiotics are effective treatments for bacterial infections, however, their oral administration can have unintended consequences and may alter the gut microbiota composition. In this study, we examined the influence of antibiotics on the induction of gut dysbiosis and then evaluated the potential of cow and goat milk to restore the microbiota composition and metabolism in newly weaned rats. In t ...
DOI:
10.1039/d0fo02950e

18. Immunomodulatory effect of Noni fruit and its isolates: insights into cell-mediated immune response and inhibition of LPS-induced THP-1 macrophage inflammation

Author:
Ezzat, Marwa I.; Hassan, Mariam; Abdelhalim, Mai A.; EL-Desoky, Ahmed M.; Mohamed, Shanaz O.; Ezzat, Shahira M.
Source:
Food & function 2021 v.12 no.7 pp. 3170-3179
ISSN:
2042-650X
Subject:
Morinda citrifolia; cell-mediated immunity; cytotoxicity; dietary supplements; edema; ethanol; fractionation; gallic acid; hesperidin; immunomodulators; immunosuppression; inflammation; lipopolysaccharides; macrophage activation; macrophages; medicinal plants; methanol; methylene chloride; naringin; quercetin; viability assays; water; India; South East Asia
Abstract:
... Morinda citrifolia L. is a plant of the family Rubiaceae and is known as Indian mulberry or Noni in India. It is a perennial herb native to Southeast Asia and has been used over the years as a food supplement and medicinal plant. Noni fruits are reported to possess anticancer, fungicidal, antiviral and antiarthritic effects. The objective of our study is the screening of the immunomodulatory activ ...
DOI:
10.1039/d0fo03402a

19. Impact of encapsulating a probiotic (Pediococcus pentosaceus Li05) within gastro-responsive microgels on Clostridium difficile infections

Author:
Xie, Jiaojiao; Yao, Mingfei; Lu, Yanmeng; Yu, Mengjia; Han, Shengyi; McClements, David J.; Xiao, Hang; Li, Lanjuan
Source:
Food & function 2021 v.12 no.7 pp. 3180-3190
ISSN:
2042-650X
Subject:
Clostridium difficile; Pediococcus pentosaceus; antibiotics; bioactive properties; biopolymers; cytokines; diarrhea; encapsulation; gastrointestinal system; histology; infection; intestinal microorganisms; mice; microgels; models; oral administration; probiotics; spleen; storage; storage time; survival rate; viability; weight
Abstract:
... Antibiotic treatment is often followed by Clostridium difficile infection (CDI), which causes severe diarrhea and other health issues. Oral administration of Pediococcus pentosaceus Li05 (Li05) has been shown to have great potential in preventing CDI. However, the viability of Li05 is greatly reduced during storage and passage through the gastrointestinal (GI) tract, which limits its biological ac ...
DOI:
10.1039/d0fo03235b

20. Intestinal microbiota fingerprint in subjects with irritable bowel syndrome responders to a low FODMAP diet

Author:
Valdez-Palomares, Fernanda; Nambo-Venegas, Rafael; Uribe-García, Jacqueline; Mendoza-Vargas, Alfredo; Granados-Portillo, Omar; Meraz-Cruz, Noemí; Palacios-González, Berenice
Source:
Food & function 2021 v.12 no.7 pp. 3206-3218
ISSN:
2042-650X
Subject:
Bifidobacterium; Butyrivibrio; FODMAP diet; Prevotella; Ruminococcus; Veillonella; accuracy; biomarkers; discriminant analysis; gastrointestinal system; genes; intestinal microorganisms; irritable bowel syndrome; models; oligosaccharides; pain; polyols
Abstract:
... Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and altered bowel habit. IBS patients report that FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet induce or exacerbate their symptoms. It has been reported that low-FODMAP diet (LFD) improves the symptoms in 50%–80% of IBS patients. We aimed to identify I ...
DOI:
10.1039/d0fo03162c