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- Chang, Jung-Su, et al. Show all 6 Authors
- Food & function 2019 v.10 no.7 pp. 4113-4123
- Western blotting; adults; animal disease models; apoptosis; biogenesis; biosynthesis; diet; germ cells; hepcidin; iron; iron overload; laboratory animals; lipid content; males; men; mitochondria; obesity; proteins; rats; staining; testes; testosterone; therapeutics
- ... This study was motivated by clinical observations that dysmetabolic iron overload syndrome (DIOS) and an androgen deficiency are common features observed in obese adult men; however, the molecular mechanism underlying the effects of DIOS on androgen deficiency remains to be elucidated. We established a DIOS animal model by feeding Sprague-Dawley rats an iron/fat-enriched diet (50% fat plus 0.25, 1 ...
- Chang, Jung-Su, et al. Show all 7 Authors
- Food & function 2016 v.7 no.1 pp. 194-201
- Western blotting; adverse effects; anemia; animal disease models; at-risk population; citrates; diabetes; diet; dose response; glucose; hepcidin; humans; hyperinsulinemia; insulin; insulin receptor substrate proteins; iron; iron absorption; islets of Langerhans; males; nicotinamide; patients; rats; signal transduction; streptozotocin; stress response
- ... Diabetic patients are at high risk of developing anemia; however, pharmacological doses of iron supplementation may vary greatly depending on diabetes-related complications. The aim of this study was to investigate the dose-dependent effect of iron on glucose disposal with a special focus on endoplasmic reticular (ER) stress, iron metabolism, and insulin signalling pathways. Diabetes was induced i ...