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You searched for: Journal name Food and chemical toxicology Remove constraint Journal name: Food and chemical toxicology Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term antioxidant activity Remove constraint Subject term: antioxidant activity Subject term bioactive compounds Remove constraint Subject term: bioactive compounds
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1. Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2

Author:
Fangfang Lang; Jinfeng Qu; Haiqin Yin; Lanyu Li; Yuanyuan Zhi; Yanping Liu; Zhenghui Fang; Enkui Hao
Source:
Food and chemical toxicology 2018 v.121 pp. 631-638
ISSN:
0278-6915
Subject:
Angelica sinensis; animal ovaries; antioxidant activity; apoptosis; bioactive compounds; cell viability; dose response; epigenetics; flow cytometry; glutamate-cysteine ligase; humans; mitochondria; neoplasm cells; ovarian neoplasms; oxidative stress; quinones; small interfering RNA; toxicology; transferases; uridine diphosphate
Abstract:
... Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress ...
DOI:
10.1016/j.fct.2018.09.041

2. Application of prickly pear fruit extract to improve domestic shelf life, quality and microbial safety of sliced beef

Author:
Rosa Palmeri; Lucia Parafati; Cristina Restuccia; Biagio Fallico
Source:
Food and chemical toxicology 2018 v.118 pp. 355-360
ISSN:
0278-6915
Subject:
Opuntia; antioxidant activity; bacteria; beef; bioactive compounds; cold storage; color; dipping; food preservation; food spoilage; fruit extracts; fruits; microbial growth; polyphenols; shelf life; storage time; texture; toxicology
Abstract:
... The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content.The extract was then applied by dippi ...
DOI:
10.1016/j.fct.2018.05.044

3. Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?

Author:
Francesca Giampieri; José L. Quiles; Francisco J. Orantes-Bermejo; Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Cristina Sánchez-González; Juan Llopis; Lorenzo Rivas-García; Sadia Afrin; Alfonso Varela-López; Danila Cianciosi; Patricia Reboredo-Rodriguez; Cristina Torres Fernández-Piñar; Ruben Calderón Iglesias; Roberto Ruiz; Silvia Aparicio; Jorge Crespo; Luis Dzul Lopez; Jianbo Xiao; Maurizio Battino
Source:
Food and chemical toxicology 2018 v.112 pp. 126-133
ISSN:
0278-6915
Subject:
antineoplastic activity; antioxidant activity; beeswax; bioactive compounds; byproducts; carbohydrates; cytotoxicity; dose response; flavonoids; hepatoma; human cell lines; human health; in vivo studies; liver; mitochondria; polyphenols; recycling; viability
Abstract:
... During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 ...
DOI:
10.1016/j.fct.2017.12.041

4. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract

Author:
Graziela Bragueto Escher; Jânio Sousa Santos; Neiva Deliberali Rosso; Mariza Boscacci Marques; Luciana Azevedo; Mariana Araújo Vieira do Carmo; Heitor Daguer; Luciano Molognoni; Leonardo do Prado-Silva; Anderson S. Sant'Ana; Marcia Cristina da Silva; Daniel Granato
Source:
Food and chemical toxicology 2018 v.118 pp. 439-453
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Centaurea cyanus; anthocyanins; antihypertensive effect; antioxidant activity; bioactive compounds; cell death; cell lines; corolla; coumarin; cytotoxicity; ferulic acid; functional properties; inhibitory concentration 50; isoquercitrin; lipid peroxidation; p-coumaric acid; pH; plant extracts; reactive oxygen species; statistical analysis; temperature
Abstract:
... This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, ...
DOI:
10.1016/j.fct.2018.05.046

5. Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

Author:
Abishek B. Santhakumar; Maurizio Battino; José M. Alvarez-Suarez
Source:
Food and chemical toxicology 2018 v.113 pp. 49-65
ISSN:
0278-6915
Subject:
antioxidant activity; atherosclerosis; bioactive compounds; bioavailability; cardioprotective effect; chronic diseases; clinical trials; epidemiological studies; fruits; hemostasis; lipid metabolism; longevity; polyphenols; toxicology; vegetables
Abstract:
... Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several ...
DOI:
10.1016/j.fct.2018.01.022

6. Evaluation of antioxidant activities of ethanol extract from Ligusticum subjected to in-vitro gastrointestinal digestion

Author:
Huifang Ge; Yazhen Chen; Jicheng Chen; Jingjing Tian; Xiaofeng Liang; Lei Chen
Source:
Food and chemical toxicology 2018 v.119 pp. 417-424
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ligusticum sinense; Oriental traditional medicine; antioxidant activity; bioactive compounds; cardiovascular diseases; digestion; dose response; ethanol; ferulic acid; free radical scavengers; hydroxyl radicals; intestines; liquids; oxidative stress; polyphenols; pyrazines; rhizomes; toxicology
Abstract:
... The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastr ...
DOI:
10.1016/j.fct.2017.12.035

7. Genotoxicity and antioxidant activity of five Agrimonia and Filipendula species plant extracts evaluated by comet and micronucleus assays in human lymphocytes and Ames Salmonella/microsome test

Author:
Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
Source:
Food and chemical toxicology 2018 v.113 pp. 303-313
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
Abstract:
... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
DOI:
10.1016/j.fct.2017.12.031

8. Hibiscus sabdariffa anthocyanins-rich extract: Chemical stability, in vitro antioxidant and antiproliferative activities

Author:
Laércio Galvão Maciel; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Heitor Daguer; Luciano Molognoni; Mereci Mendes de Almeida; Daniel Granato; Neiva Deliberali Rosso
Source:
Food and chemical toxicology 2018 v.113 pp. 187-197
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Hibiscus sabdariffa; antioxidant activity; ascorbic acid; bioactive compounds; calyx; cell lines; color; cytotoxicity; electrospray ionization mass spectrometry; inhibitory concentration 50; lethal concentration 50; liquid chromatography; myrtillin; neoplasm cells; pH; temperature
Abstract:
... Hibiscus sabdariffa calyx is a rich source of anthocyanins and other bioactive compounds but no study reported the effects of experimental conditions on the extraction of these chemical compounds. Therefore, the effects of time and extraction temperature on the bioactive compounds and antioxidant activity of Hibiscus sabdariffa calyx were evaluated. In addition, the effects of copigmentation and p ...
DOI:
10.1016/j.fct.2018.01.053

9. Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.)

Author:
Azzurra Stefanucci; Gokhan Zengin; Marcello Locatelli; Giorgia Macedonio; Chin-Kun Wang; Ettore Novellino; M.Fawzi Mahomoodally; Adriano Mollica
Source:
Food and chemical toxicology 2018 v.118 pp. 181-189
ISSN:
0278-6915
Subject:
Capparis spinosa; acetylcholinesterase; active ingredients; antioxidant activity; bioactive compounds; buds; cholinesterase; chromatography; enzyme inhibition; essential oils; fatty acids; free radical scavengers; medicinal plants; phenolic compounds; provenance; rutin; toxicology; Italy; Morocco; Turkey (country)
Abstract:
... Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of differen ...
DOI:
10.1016/j.fct.2018.05.003

10. In vitro antioxidant and antihypertensive compounds from camu-camu (Myrciaria dubia McVaugh, Myrtaceae) seed coat: A multivariate structure-activity study

Author:
Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
Source:
Food and chemical toxicology 2018 v.120 pp. 479-490
ISSN:
0278-6915
Subject:
lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
Abstract:
... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
DOI:
10.1016/j.fct.2018.07.043

11. Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. (Asteraceae) and Veronica persica Poiret (Plantaginaceae)

Author:
Radu Claudiu Fierascu; Milen I. Georgiev; Irina Fierascu; Camelia Ungureanu; Sorin Marius Avramescu; Alina Ortan; Mihaela Ioana Georgescu; Anca Nicoleta Sutan; Anca Zanfirescu; Cristina Elena Dinu-Pirvu; Bruno Stefan Velescu; Valentina Anuta
Source:
Food and chemical toxicology 2018 v.111 pp. 44-52
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Arctium lappa; Aspergillus niger; Penicillium; Veronica persica; aerial parts; anti-inflammatory activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; chromosome aberrations; fungi; high performance liquid chromatography; inflammation; meristems; models; roots; toxicology
Abstract:
... The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the ...
DOI:
10.1016/j.fct.2017.11.008

12. Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Author:
Sengul Uysal; Asli Ugurlu; Gokhan Zengin; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Adriano Mollica; Luisa Custodio; Nuno R. Neng; José M.F. Nogueira; M. Fawzi Mahomoodally
Source:
Food and chemical toxicology 2018 v.111 pp. 525-536
ISSN:
0278-6915
Subject:
Bidens tripartita; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cell lines; cell viability; chlorogenic acid; computer simulation; cytotoxicity; enzyme inhibition; epicatechin; ethyl acetate; high performance liquid chromatography; hydrogen bonding; methanol; neoplasm cells; neoplasms; plasmids; toxicology; viability assays
Abstract:
... Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Perform ...
DOI:
10.1016/j.fct.2017.11.058

13. UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation

Author:
Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
Source:
Food and chemical toxicology 2018 v.115 pp. 414-424
ISSN:
0278-6915
Subject:
foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
Abstract:
... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
DOI:
10.1016/j.fct.2018.01.054