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You searched for: Journal name Food and chemical toxicology Remove constraint Journal name: Food and chemical toxicology Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term antioxidants Remove constraint Subject term: antioxidants Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Alleviative effect of resveratrol on polyvinyl chloride-induced reproductive toxicity in male Wistar rats

Author:
D. Archana; Ch. Supriya; B.P. Girish; B. Kishori; P. Sreenivasula Reddy
Source:
Food and chemical toxicology 2018 v.116 pp. 173-181
ISSN:
0278-6915
Subject:
adults; antioxidants; blood serum; body weight; enzyme activity; enzymes; epididymis; epithelium; laboratory animals; lipid peroxidation; males; oxidative stress; poly(vinyl chloride); protective effect; rats; reproductive toxicology; resveratrol; spermatogenesis; spermatozoa; steroidogenesis; testes; testosterone
Abstract:
... The present study was aimed to investigate the effect of PVC on reproductive competence in adult male Wistar rats. Further, the study also encompasses the protective effect of trans-resveratrol on PVC-induced reproductive toxicity in rats. Adult male rats weighing 210–240 g were administered with either PVC at two different doses 100 and 500 mg/kg body weight, orally, daily for 60 days or resverat ...
DOI:
10.1016/j.fct.2018.04.026

2. Ameliorative role of ferulic acid against diabetes associated oxidative stress induced spleen damage

Author:
Sumit Ghosh; Sayantani Chowdhury; Poulami Sarkar; Parames C. Sil
Source:
Food and chemical toxicology 2018 v.118 pp. 272-286
ISSN:
0278-6915
Subject:
DNA fragmentation; adverse effects; antioxidants; apoptosis; blood glucose; caspase-9; cytochrome c; cytokines; diabetic complications; ferulic acid; gene expression regulation; immune response; inflammation; insulin; laboratory animals; males; mitochondria; oxidative stress; pulp; rats; spleen; therapeutics; toxicology
Abstract:
... Spleen, a secondary lymphoid organ, is the site of initiation of most of the immune responses. The present study is centered on the ameliorative role of ferulic acid against diabetic complications in the spleen of male Wistar rats. Induction of diabetes by STZ (at a dose of 50 mg kg−1 body wt, i.p.) reduced the spleen size, plasma insulin level, enhanced the blood glucose level and disrupted the i ...
DOI:
10.1016/j.fct.2018.05.029

3. Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis

Author:
Yen-Nien Hsu; Huey-Wen Shyu; Tsui-Wen Hu; Jou-Pei Yeh; Ya-Wen Lin; Ling-Yi Lee; Yao-Tsung Yeh; Hong-Ying Dai; Daw-Shyong Perng; Shu-Hui Su; Yu-Hsuan Huang; Shu-Jem Su
Source:
Food and chemical toxicology 2018 v.112 pp. 194-204
ISSN:
0278-6915
Subject:
Trifolium pratense; acetylcysteine; antioxidants; apoptosis; biochanin A; caspase-3; caspase-9; cell growth; chemoprevention; cytochrome c; cytotoxicity; dose response; doxorubicin; glutathione; humans; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; osteosarcoma; phosphatidylserines; toxicology; vitamin E
Abstract:
... Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a ...
DOI:
10.1016/j.fct.2017.12.062

4. Antioxidant and pro-oxidant activities of carotenoids and their oxidation products

Author:
Daniela Ribeiro; Marisa Freitas; Artur M.S. Silva; Félix Carvalho; Eduarda Fernandes
Source:
Food and chemical toxicology 2018 v.120 pp. 681-699
ISSN:
0278-6915
Subject:
antioxidants; bioactive compounds; carbonyl compounds; carotenoids; diet; humans; lipids; nitrogen; oxidation; oxidative stress; oxygen; plant pigments; toxicology
Abstract:
... Carotenoids are lipid soluble plant pigments that make part of human daily diet. These compounds are able to react with diverse reactive species and originate a myriad of oxidation products that have similar or even more reactivity than their parent compounds. These products may be short-chain carbonyl compounds and, the commonly designated, apo-carotenoids. The effects fo these products in the hu ...
DOI:
10.1016/j.fct.2018.07.060

5. Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies

Author:
Iram Iqbal Hejazi; Rashmin Khanam; Syed Hassan Mehdi; Abdul Roouf Bhat; M.Moshahid Alam Rizvi; Sonu Chand Thakur; Fareeda Athar
Source:
Food and chemical toxicology 2018 v.115 pp. 244-259
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Curculigo orchioides; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; caspase-3; caspase-8; cell culture; chemical constituents of plants; cytotoxicity; ethyl acetate; free radicals; gas chromatography-mass spectrometry; human cell lines; humans; inhibitory concentration 50; mitochondria; neoplasm cells; neoplasms; oxidative stress; proteins
Abstract:
... Plant phytoconstituents have been a valuable source of clinically important anticancer agents. Antioxidant and anticancerous activity of plant Curculigo orchioides Gaertn were explored In vitro antioxidant activity, antioxidant enzyme activity of oxidatively stressed tissue, and cell culture studies on human cancer cell lines HepG2, HeLa and MCF-7 were carried out. Active plant fractions were subj ...
DOI:
10.1016/j.fct.2018.03.013

6. Antioxidative effect and phytochemical profile of natural products from the fruits of “babaçu” (Orbignia speciose) and “buriti” (Mauritia flexuosa)

Author:
Camila B. Nobre; Erlânio O. Sousa; Cícera J. Camilo; Jean F. Machado; João M.F.L. Silva; Jaime R. Filho; Henrique D.M. Coutinho; José G.M. Costa
Source:
Food and chemical toxicology 2018 v.121 pp. 423-429
ISSN:
0278-6915
Subject:
Attalea speciosa; Mauritia flexuosa; antioxidant activity; antioxidants; chelation; flavonoids; fruits; iron; margarine; new products; oxidative stress; phospholipids; tannins; thiobarbituric acid-reactive substances; trees; Brazil
Abstract:
... Orbignya speciosa and Mauritia flexuosa are two native palm tree species found in Brazil. Their fruits are rich in edible fixed oils, which are used for many purposes in industry, such as in the manufacture of soaps, surfactants and margarines. The aim of this work was to characterize the chemical profiles and antioxidant properties of the methanol extracts obtained from the fruits of O. speciosa ...
DOI:
10.1016/j.fct.2018.08.068

7. l- Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway

Author:
Mingcai Liang; Zhengxuan Wang; Hui Li; Liang Cai; Jianghao Pan; Hongjuan He; Qiong Wu; Yinzhao Tang; Jiapei Ma; Lin Yang
Source:
Food and chemical toxicology 2018 v.115 pp. 315-328
ISSN:
0278-6915
Subject:
antioxidant activity; antioxidants; arginine; body weight; catalase; essential amino acids; genes; glutathione; liver; males; messenger RNA; oral administration; oxidative stress; proteins; rats; superoxide dismutase; toxicology
Abstract:
... Arginine is a conditionally essential amino acid. To elucidate the influence of l-arginine on the activation of endogenous antioxidant defence, male Wistar rats were orally administered daily with l-arginine at different levels of 25, 50, 100 mg/100 g body weight. After 7 and 14 days feeding, the antioxidative capacities and glutathione (GSH) contents in the plasma and in the liver were uniformly ...
DOI:
10.1016/j.fct.2018.03.029

8. Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty

Author:
Gabriel Adan Araújo Leite; Thamiris Moreira Figueiredo; Marina Trevizan Guerra; Cibele dos Santos Borges; Fábio Henrique Fernandes; Janete Aparecida Anselmo-Franci; Wilma De Grava Kempinas
Source:
Food and chemical toxicology 2018 v.118 pp. 416-429
ISSN:
0278-6915
Subject:
DNA fragmentation; adolescence; adulthood; antioxidants; ascorbic acid; blood serum; childhood; children; cholesterol; epididymis; fathers; females; lipid composition; males; obesity; puberty; rats; reproduction; sodium chloride; spermatozoa; testes; toxicology
Abstract:
... Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 m ...
DOI:
10.1016/j.fct.2018.05.043

9. Behavioral alterations in autism model induced by valproic acid and translational analysis of circulating microRNA

Author:
Mauro Mozael Hirsch; Iohanna Deckmann; Mellanie Fontes-Dutra; Guilherme Bauer-Negrini; Gustavo Della-Flora Nunes; Walquiria Nunes; Bruna Rabelo; Rudimar Riesgo; Rogerio Margis; Victorio Bambini-Junior; Carmem Gottfried
Source:
Food and chemical toxicology 2018 v.115 pp. 336-343
ISSN:
0278-6915
Subject:
antioxidants; autism; biomarkers; environmental factors; etiology; gene expression; maternal exposure; microRNA; models; non-coding RNA; patients; rats; resveratrol; risk; social behavior; toxicology; translation (genetics); valproic acid
Abstract:
... Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication and language, and restricted repertoire of activities and interests. The etiology of ASD remains unknown and no clinical markers for diagnosis were identified. Environmental factors, including prenatal exposure to valproic acid (VPA), may contribute to increased risk of developing ASD. MicroRNA (mi ...
DOI:
10.1016/j.fct.2018.02.061

10. Can nonalcoholic beer, silicon and hops reduce the brain damage and behavioral changes induced by aluminum nitrate in young male Wistar rats?

Author:
P. Merino; J.A. Santos-López; C.J. Mateos; I. Meseguer; A. Garcimartín; S. Bastida; F.J. Sánchez-Muniz; J. Benedí; M.J. González-Muñoz
Source:
Food and chemical toxicology 2018 v.118 pp. 784-794
ISSN:
0278-6915
Subject:
acetylcholinesterase; aluminum; antioxidant activity; antioxidants; beers; behavior change; brain; brain damage; enzyme activity; enzyme inhibition; gene expression; hops; laboratory animals; males; neurodegenerative diseases; nitrates; poisoning; rats; rearing; silicon; swimming; toxicology
Abstract:
... Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic beer (NABeer), silicon or hops, as well as their ef ...
DOI:
10.1016/j.fct.2018.06.004

11. Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis

Author:
Bojana Vasilijević; Jelena Knežević-Vukčević; Dragana Mitić-Ćulafić; Dejan Orčić; Marina Francišković; Tatjana Srdic-Rajic; Marina Jovanović; Biljana Nikolić
Source:
Food and chemical toxicology 2018 v.112 pp. 118-125
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Juniperus communis; adverse effects; antioxidants; apoptosis; cell cycle; chemical composition; cytotoxicity; doxorubicin; drug therapy; essential oils; fibroblasts; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; liquid chromatography; lung neoplasms; lungs; mutagens; neoplasm cells; quinic acid; rutin; synergism; tandem mass spectrometry; wastes
Abstract:
... Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibroblast (MRC-5) cells. GC-MS analysis identified 93.95% of total EO content and determined α-pinen as a dominant component (23.61%). LC-MS/MS analysis of ...
DOI:
10.1016/j.fct.2017.12.044

12. Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats

Author:
Sherif M. Shoieb; Ahmed Esmat; Amani E. Khalifa; Ashraf B. Abdel-Naim
Source:
Food and chemical toxicology 2018 v.111 pp. 650-659
ISSN:
0278-6915
Subject:
antioxidants; apoptosis; bees; caspase-3; catalase; chrysin; enzyme activity; gene expression; glutathione; hyperplasia; insulin-like growth factor I; insulin-like growth factor I receptor; lipid peroxidation; men; messenger RNA; oxidative stress; plant estrogens; plant extracts; proliferating cell nuclear antigen; propolis; protective effect; protein synthesis; rats; superoxide dismutase; testosterone; toxicology; transcription factor NF-kappa B
Abstract:
... Benign prostate hyperplasia (BPH) is a common age-related health problem affecting almost 3 out of 4 men in their sixties. Chrysin is a dietary phytoestrogen found naturally in bee propolis and various plant extracts. It possesses antioxidant, anti-inflammatory and anti-proliferative properties. The current study was conducted to explore the role chrysin plays in protection against testosterone-in ...
DOI:
10.1016/j.fct.2017.12.017

13. Colonic metabolites from flavanols stimulate nitric oxide production in human endothelial cells and protect against oxidative stress-induced toxicity and endothelial dysfunction

Author:
David Álvarez-Cilleros; Sonia Ramos; Luis Goya; María Ángeles Martín
Source:
Food and chemical toxicology 2018 v.115 pp. 88-97
ISSN:
0278-6915
Subject:
AMP-activated protein kinase; antioxidants; bioavailability; cell death; endothelial cells; endothelial nitric oxide synthase; flavanols; humans; intestinal microorganisms; metabolites; nitric oxide; non-specific serine/threonine protein kinase; oxidative stress; phosphorylation; risk; signal transduction; toxicity; toxicology
Abstract:
... Oxidative stress is involved in endothelial dysfunction, the key player in the development of vascular events. Flavanols, the major antioxidants in cocoa have been related to vascular protection and lower cardiovascular risk. However, the bioavailability of cocoa flavanols is very low and their bioactivity in vivo seems to be greatly mediated by the derived phenolic metabolites formed by intestina ...
DOI:
10.1016/j.fct.2018.03.006

14. Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice

Author:
Songtao Fan; Xiaojun Huang; Sunan Wang; Chang Li; Zhihong Zhang; Mingyong Xie; Shaoping Nie
Source:
Food and chemical toxicology 2018 v.119 pp. 66-72
ISSN:
0278-6915
Subject:
Ganoderma; Ophiocordyceps sinensis; Toll-like receptor 9; alanine transaminase; alkaline phosphatase; antioxidants; apoptosis; aspartate transaminase; cyclophosphamide; cytokines; fungi; glutathione; glutathione peroxidase; hepatotoxicity; inducible nitric oxide synthase; inflammation; liver; mice; mitochondria; oxidants; peroxisome proliferator-activated receptor alpha; polysaccharides; prostaglandin synthase; protective effect; toxicology
Abstract:
... This study investigated the possible protective effect of combined fungal polysaccharides (CFP), consisting of Cordyceps sinensis polysaccharides (CSP) and Ganoderma atrum polysaccharides (PSG) with well-defined structural characteristics, against cyclophosphamide (CTX)-induced hepatotoxicity in mice. Our results indicated CFP effectively prevented the liver injury by decreasing toxicity markers ( ...
DOI:
10.1016/j.fct.2018.05.027

15. Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Author:
Aleksandra Cvetanović; Gökhan Zengin; Zoran Zeković; Jaroslava Švarc-Gajić; Slavica Ražić; Ana Damjanović; Pavle Mašković; Milan Mitić
Source:
Food and chemical toxicology 2018 v.121 pp. 458-466
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Aronia melanocarpa; antimicrobial properties; antioxidant activity; antioxidants; cell lines; chemical composition; cholinesterase; cytotoxicity; diodes; elastase; enzyme inhibition; flavonoids; high performance liquid chromatography; in vitro studies; leaves; lipid peroxidation; small fruits; stems; temperature
Abstract:
... Preparation of functional products as well as natural-based products requires non-toxic but effective extraction techniques. In this study, subcritical water extraction was used for the extraction of different aronia parts in order to explore their potential. Stems, leaves and berries of Aronia melanocarpa were extracted under the following conditions: temperature 130 °C; pressure 35 bar; time 20  ...
DOI:
10.1016/j.fct.2018.09.045

16. Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

Author:
Cheryl A. Hobbs; Mihoko Koyanagi; Carol Swartz; Jeffrey Davis; Sawako Kasamoto; Robert Maronpot; Leslie Recio; Shim-mo Hayashi
Source:
Food and chemical toxicology 2018 v.113 pp. 218-227
ISSN:
0278-6915
Subject:
GRAS substances; antioxidants; beverages; bioavailability; chromosome aberrations; comet assay; dietary supplements; food safety; genotoxicity; glucose; human health; isoquercitrin; mice; moieties; mutagens; mutation; quercetin; rats; solubility; tissues; Japan
Abstract:
... Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce alpha-glycosyl iso ...
DOI:
10.1016/j.fct.2017.12.059

17. Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

Author:
Fang Li; Fangfang Lang; Yidan Wang; Chunxiao Zhai; Chuanbei Zhang; Liping Zhang; Enkui Hao
Source:
Food and chemical toxicology 2018 v.120 pp. 104-111
ISSN:
0278-6915
Subject:
anthocyanins; anti-inflammatory activity; antioxidants; cardiac output; caspase-3; cell death; chemokine CCL2; creatine kinase; cyanidin; endotoxins; food chain; glutathione; homeostasis; inflammation; interleukin-1beta; lactate dehydrogenase; ligands; lipopolysaccharides; mitochondria; models; myosin light chains; oxidation; oxidative stress; sepsis (infection); therapeutics; toxicity; toxicology; troponin I; tumor necrosis factor-alpha
Abstract:
... Cyanidin, an anthocyanin pigment, demonstrates anti-oxidant and anti-inflammatory properties. Here, we examined the mechanistic role of cyanidin in endotoxin induced myocardial injury in inflammation and oxidative stress. In lipopolysaccharide (LPS) induced myocardial injury model, cyanidin ameliorated cardiac injury (Lactate dehydrogenase or LDH, Creatine Kinase or CK, cardiac troponin I or cTnI ...
DOI:
10.1016/j.fct.2018.05.053

18. Cytogenetic tests reveal no toxicity in lymphocytes of rabbit (Oryctolagus cuniculus, 2n=44) feed in presence of verbascoside and/or lycopene

Author:
Angela Perucatti; Viviana Genualdo; Alfredo Pauciullo; Ciro Iorio; Domenico Incarnato; Cristina Rossetti; Francesco Vizzarri; Marisa Palazzo; Donato Casamassima; Leopoldo Iannuzzi; Alessandra Iannuzzi
Source:
Food and chemical toxicology 2018 v.114 pp. 311-315
ISSN:
0278-6915
Subject:
Oryctolagus cuniculus; antioxidants; cell culture; chromosome aberrations; chromosomes; crossing over; cytotoxicity; diet; glycosides; humans; lycopene; lymphocytes; mutagens; rabbits; toxicology; verbascoside
Abstract:
... Phenylpropanoid glycosides (PPG), like other phenolic compounds, are a powerful antioxidants and the Verbascoside (VB) is one of the most active of them. A previous study, by using in vitro exposure of blood human lymphocytes to Verbascoside, reported a significant increasings of chromosome fragility compared to control. In the present study, four homogeneous groups of rabbits were used to test in ...
DOI:
10.1016/j.fct.2018.02.053

19. Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury

Author:
Taehyun Roh; Umasankar De; Seong Kwang Lim; Min Kook Kim; Seul Min Choi; Duck Soo Lim; Sungpil Yoon; Sam Kacew; Hyung Sik Kim; Byung-Mu Lee
Source:
Food and chemical toxicology 2018 v.114 pp. 11-22
ISSN:
0278-6915
Subject:
acetaminophen; alanine transaminase; antioxidant activity; antioxidants; apoptosis; aspartate transaminase; betaine; caspase-3; cell viability; cytochrome c; glutathione; hepatoprotective effect; hepatotoxicity; human cell lines; lipid peroxidation; methionine; oxidative stress; protein content; pyridoxine; toxicology
Abstract:
... The detoxifying effect of pyridoxine against acetaminophen (APAP)-induced hepatotoxicity was investigated. HepG2 cells were co-treated with APAP and pyridoxine to compare with betaine or methionine for 24 h. LDH, ALT and AST activities were measured to determine direct cells damage in vitro and in vivo. Lipid peroxidation, antioxidant enzymes activity, and glutathione level were measured. Cytochro ...
DOI:
10.1016/j.fct.2018.02.017

20. Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid

Author:
Boopathi Sowndhar Rajan; Senthamizharasi Manivasagam; Suresh Dhanusu; Navvi Chandrasekar; Kalaiselvi Krishna; Lakshmi Priya Kalaiarasu; Aadhil Ashwaq Babu; Elangovan Vellaichamy
Source:
Food and chemical toxicology 2018 v.114 pp. 237-245
ISSN:
0278-6915
Subject:
advanced glycation end products; albino; antioxidants; blood serum; chemokines; curcumin; diet; enzyme-linked immunosorbent assay; gallic acid; inflammation; interleukin-1alpha; mice; protective effect; toxicology
Abstract:
... The present study was aimed to investigate the effect of diet derived AGEs (dAGEs) on the circulatory levels of pro-inflammatory cytokines, chemokines and to evaluate the protective efficacy of natural anti-oxidants curcumin (CU) and gallic acid (GA) respectively against the dAGEs-induced systemic inflammation in experimental Swiss albino mice. The experimental mice were fed with dAGEs in the pres ...
DOI:
10.1016/j.fct.2018.02.016