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- Kim, Byung Woo, et al. Show all 5 Authors
- Food and chemical toxicology 2014 v.68 pp. 38-43
- Vitis amurensis; acid treatment; betulinic acid; binding proteins; cyclic AMP; melanin; melanogenesis; mitogen-activated protein kinase; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase kinase; phosphatidylinositol 3-kinase; phosphorylation; signal transduction; therapeutics; toxicology; transcription factors
- ... Previously, betulinic acid was identified as one of the main compounds responsible for the anti-melanogenic effect in Vitis amurensis root. In this study, we investigated the precise mechanism underlying the anti-melanogenic activity of betulinic acid in B16F10 cells. Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyr ...