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- Author:
- Gao, Qin; Wang, Hong-Ju; Wang, Xiao-Mei; Kang, Pin-Fang; Yu, Ying; Ye, Hong-Wei; Zhou, Huan; Li, Zheng-Hong
- Source:
- Food and chemical toxicology 2013 v.56 pp. 419-424
- ISSN:
- 0278-6915
- Subject:
- blood glucose; diabetes; ethanol; fasting; glycosylation; hemoglobin; messenger RNA; rats; superoxide dismutase; toxicology
- Abstract:
- ... This study assessed changes in myocardial ALDH2 expression in the diabetic rat, in particular the diabetic rat pretreated with ALDH2 activator ethanol (EtOH). The rats were divided into six groups: control, EtOH control, diabetic rat at 4th week (DM4W), 8th week (DM8W), 12th week (DM12W) and EtOH+DM8W groups. Compared with control group, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA ...
- DOI:
- 10.1016/j.fct.2013.02.057
-
https://dx.doi.org/10.1016/j.fct.2013.02.057
- Author:
- Bhattacharyya, Sudip; Pal, Pabitra Bikash; Sil, Parames C.
- Source:
- Food and chemical toxicology 2013 v.56 pp. 119-130
- ISSN:
- 0278-6915
- Subject:
- mitochondrial membrane; reactive oxygen species; lipid peroxidation; phosphorylation; mitogen-activated protein kinase; protective effect; glutathione; cell viability; Phyllanthus niruri; iron; toxicology; mitochondria; apoptosis; IKappaB kinase; transcription factor NF-kappa B; caspases; cytotoxicity; mice; ferrous sulfate; antioxidant activity; hepatocytes; free radical scavengers; membrane potential
- Abstract:
- ... It has been reported that the herb, Phyllanthus niruri, possess antioxidant, anti-infection, anti-asthmatic, anti-diuretic, anti-soresis and many more beneficial activities. The goal of our present study was to evaluate the protective role of a 35kD protein (PNP) isolated from this herb against iron-induced cytotoxicity in murine hepatocytes. Exposure of hepatocytes to iron (FeSO4) caused elevatio ...
- DOI:
- 10.1016/j.fct.2013.02.013
-
https://dx.doi.org/10.1016/j.fct.2013.02.013
- Author:
- Xu, Shi-Ping; Mao, Xue-Ying; Cheng, Xue; Chen, Bin
- Source:
- Food and chemical toxicology 2013 v.56 pp. 1-7
- ISSN:
- 0278-6915
- Subject:
- adipose tissue; antioxidants; casein; cholesterol; droplet size; fatty liver; fatty-acid synthase; glutathione peroxidase; glycerol-3-phosphate dehydrogenase; high fat diet; hydrofluorocarbons; ingredients; interleukin-6; leptin; liver; malondialdehyde; obesity; rats; secretion; superoxide dismutase; tissue weight; toxicology; triacylglycerols; tumor necrosis factor-alpha
- Abstract:
- ... The effect of casein glycomacropeptide (GMP) as a specific regulating mediator in obese rats induced by high-fat (HF) diet was investigated. Male obese Sprague-Dawley (SD) rats induced by high-fat diet for 8weeks period were fed high-fat, high-fat with GMP of 100mg/kg BW (HFLG), 200mg/kg BW (HFMG) and 400mg/kg BW (HFHG) for 6weeks. Compared with the high-fat control (HFC) group GMP supplementation ...
- DOI:
- 10.1016/j.fct.2013.01.027
-
https://dx.doi.org/10.1016/j.fct.2013.01.027
- Author:
- Wu, Yongning; Zhang, Yu
- Source:
- Food and chemical toxicology 2013 v.56 pp. 325-335
- ISSN:
- 0278-6915
- Subject:
- World Health Organization; high performance liquid chromatography; capillary electrophoresis; urinary tract; ingestion; acceptable daily intake; analytical chemistry; risk assessment; enzyme-linked immunosorbent assay; toxicology; melamine; metabolic studies; infant formulas; tissues; humans; cohort studies; kidney diseases; dairy products; histopathology; infants; tandem mass spectrometry; gas chromatography; nephrotoxicity
- Abstract:
- ... This review summarizes the most recent scientific literature and regulations regarding analytical chemistry, toxicology, epidemiology, exposure, and risk assessment of melamine in infant formula. For analyses, enzyme-linked immunosorbent assay, high-performance liquid chromatography, capillary electrophoresis, gas chromatography coupled with mass spectrometry and liquid chromatography coupled with ...
- DOI:
- 10.1016/j.fct.2013.02.044
-
https://dx.doi.org/10.1016/j.fct.2013.02.044
- Author:
- Matsumoto, Mariko; Yamaguchi, Makiko; Yoshida, Yuka; Senuma, Mika; Takashima, Hiromasa; Kawamura, Tomoko; Kato, Hina; Takahashi, Mika; Hirata-Koizumi, Mutsuko; Ono, Atsushi; Yokoyama, Kazuhito; Hirose, Akihiko
- Source:
- Food and chemical toxicology 2013 v.56 pp. 290-296
- ISSN:
- 0278-6915
- Subject:
- adverse effects; antioxidants; developmental toxicity; dystocia; females; gestation period; hypothermia; labor; pregnancy; pups; rats; toxicity testing
- Abstract:
- ... A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N′-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28days at 0, 100, 300, or 1000mg/kg bw/day or for a total of 42–46days at 0, 8, 50, or 300mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicit ...
- DOI:
- 10.1016/j.fct.2013.02.029
-
https://dx.doi.org/10.1016/j.fct.2013.02.029
- Author:
- Guo, Chao; Xu, Lingyuan; He, Qiaoling; Liang, Tao; Duan, Xiaoqun; Li, Rong
- Source:
- Food and chemical toxicology 2013 v.56 pp. 436-442
- ISSN:
- 0278-6915
- Subject:
- Pueraria montana var. lobata; active ingredients; alanine transaminase; albumins; aspartate transaminase; blood serum; chronic diseases; collagen; enzyme activity; extracellular matrix; fibrosis; gelatinase A; hepatocytes; hydroxyproline; liver; metabolism; protective effect; rats; therapeutics; toxicity; toxicology
- Abstract:
- ... Hepatic fibrosis (HF) is a chronic disease, which primarily leads to liver unregulated metabolism. In this study, we aimed to investigate the therapeutic effects of puerarin (PR), an active ingredient from kudzu root, on CCl4-induced HF rats. PR effectively ameliorated the liver metabolic function, resulting in reduced serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotr ...
- DOI:
- 10.1016/j.fct.2013.02.051
-
https://dx.doi.org/10.1016/j.fct.2013.02.051
- Author:
- Miguel, Maria G.; Faleiro, Leonor; Antunes, Maria D.; Aazza, Smail; Duarte, Joana; Silvério, Ana R.
- Source:
- Food and chemical toxicology 2013 v.56 pp. 136-144
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; antioxidants; antiviral properties; bacteriophages; beekeepers; pathogenicity; phenol; pigments; respiratory system; toxicology; Portugal
- Abstract:
- ... “Água-mel” is a honey-based product produced in Portugal for ancient times. Several attributes have been reported to “água-mel” particularly in the alleviation of simple symptoms of upper respiratory tract. Samples of “água-mel” from diverse beekeepers from different regions of Portugal were studied in what concerns antimicrobial, antioxidant and antiviral properties. The amounts of phenol and bro ...
- DOI:
- 10.1016/j.fct.2013.02.007
-
https://dx.doi.org/10.1016/j.fct.2013.02.007
- Author:
- Juan-García, Ana; Manyes, Lara; Ruiz, María-José; Font, Guillermina
- Source:
- Food and chemical toxicology 2013 v.56 pp. 40-59
- ISSN:
- 0278-6915
- Subject:
- Alternaria; Aspergillus; Fusarium; Penicillium; air; apoptosis; cell cycle; cell growth; crops; deoxynivalenol; flow cytometry; food chain; fungi; mammals; membrane potential; mitochondrial membrane; rapid methods; secondary metabolites; toxicity; toxicology; viability; zearalenone
- Abstract:
- ... This review gives an overview of flow cytometry applications to toxicological studies of several physiological target sites of mycotoxins on different mammalian cell lines. Mycotoxins are secondary metabolites of fungi that may be present in food, feed, air and water. The increasing presence of mycotoxins in crops, their wide distribution in the food chain, and their potential for toxicity demonst ...
- DOI:
- 10.1016/j.fct.2013.02.005
-
https://dx.doi.org/10.1016/j.fct.2013.02.005
- Author:
- Zeng, Qiang; Wei, Chenxi; Wu, Yang; Li, Ke; Ding, Shumao; Yuan, Junlin; Yang, Xu; Chen, Mingqing
- Source:
- Food and chemical toxicology 2013 v.56 pp. 18-27
- ISSN:
- 0278-6915
- Subject:
- dibutyl phthalate; enzyme-linked immunosorbent assay; fluorescent antibody technique; food intake; hair follicles; kidneys; liver; monoclonal antibodies; rats; stomach; sweat glands; testes; toxicology
- Abstract:
- ... Dibutyl phthalate (DBP) is mainly taken up by the general population from food intake. To estimate intake of phthalates, determining distribution and accumulation of DBP in biological materials was a critical need. In this work, we set up two novel approaches with a monoclonal antibody specific to DBP to determine the distribution and accumulation of DBP in vivo. The contents of DBP in liver, kidn ...
- DOI:
- 10.1016/j.fct.2013.01.045
-
https://dx.doi.org/10.1016/j.fct.2013.01.045
- Author:
- Wang, Meirong; Zhang, Jinjin; Song, Xiaodong; Liu, Wenbo; Zhang, Lixia; Wang, Xiuwen; Lv, Changjun
- Source:
- Food and chemical toxicology 2013 v.56 pp. 450-458
- ISSN:
- 0278-6915
- Subject:
- actin; apoptosis; astaxanthin; blood-brain barrier; brain; collagen; fibrosis; hydroxyproline; muscles; physiological transport; toxicology; vimentin
- Abstract:
- ... Astaxanthin, a member of the carotenoid family, is the only known ketocarotenoid transported into the brain by transcytosis through the blood–brain barrier. However, whether astaxanthin has antifibrotic functions is unknown. In this study, we investigated the effects of astaxanthin on transforming growth factor β1-mediated and bleomycin-induced pulmonary fibrosis in vitro and in vivo. The results ...
- DOI:
- 10.1016/j.fct.2013.03.004
-
https://dx.doi.org/10.1016/j.fct.2013.03.004
- Author:
- Valentová, Kateřina; Vidlář, Aleš; Zatloukalová, Martina; Stuchlík, Milan; Vacek, Jan; Šimánek, Vilím; Ulrichová, Jitka
- Source:
- Food and chemical toxicology 2013 v.56 pp. 178-183
- ISSN:
- 0278-6915
- Subject:
- adverse effects; antioxidant activity; antioxidants; arginine; beverages; biosafety; blood proteins; blood serum; catalase; cross-over studies; erythrocytes; gamma-glutamyltransferase; glutathione; glutathione peroxidase; glutathione transferase; glutathione-disulfide reductase; humans; malondialdehyde; men; oxidation; silymarin; superoxide dismutase; toxicology; urine; volunteers
- Abstract:
- ... The study objective was to investigate the potential of a beverage containing silymarin and l-arginine to alter basic physiological and urodynamic parameters in 22 normal healthy men aged 38–59years. The volunteers drank 500ml/day beverage without silymarin and l-arginine for 10days followed, after a 7-day washout period, by the beverage with 400mg silymarin and 295mg l-arginine for 10days. Blood ...
- DOI:
- 10.1016/j.fct.2013.02.023
-
https://dx.doi.org/10.1016/j.fct.2013.02.023
- Author:
- Anwar, Javed; Spanevello, Roselia Maria; Pimentel, Victor Camera; Gutierres, Jessié; Thomé, Gustavo; Cardoso, Andreia; Zanini, Daniela; Martins, Caroline; Palma, Heloisa Einloft; Bagatini, Margarete Dulce; Baldissarelli, Jucimara; Schmatz, Roberta; Leal, Cláudio Alberto Martins; Costa, Pauline da; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina
- Source:
- Food and chemical toxicology 2013 v.56 pp. 459-466
- ISSN:
- 0278-6915
- Subject:
- acid treatment; adenine; adenosine deaminase; adenosine diphosphate; adenosine triphosphate; adults; caffeic acid; hydrolysis; lymphocytes; nucleosides; oils; platelet aggregation; rats; tissues; toxicology
- Abstract:
- ... This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III ...
- DOI:
- 10.1016/j.fct.2013.02.030
-
https://dx.doi.org/10.1016/j.fct.2013.02.030
- Author:
- Zarros, Apostolos; Kalopita, Konstantina; Tsakiris, Stylianos; Baillie, George S.
- Source:
- Food and chemical toxicology 2013 v.56 pp. 406-410
- ISSN:
- 0278-6915
- Subject:
- acetylcholinesterase; adults; anesthesia; biomarkers; brain; cadmium; long term effects; neurotoxicity; rodents; toxicology
- Abstract:
- ... Gonçalves et al. (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents’ brain regions. Their study can be regarded as a significant contribution to the field, as there is paucity of information on the AChE activity in brain regions following exposure to Cd. Howe ...
- DOI:
- 10.1016/j.fct.2013.02.048
-
https://dx.doi.org/10.1016/j.fct.2013.02.048
- Author:
- Afoulous, Samia; Ferhout, Hicham; Raoelison, Emmanuel Guy; Valentin, Alexis; Moukarzel, Béatrice; Couderc, François; Bouajila, Jalloul
- Source:
- Food and chemical toxicology 2013 v.56 pp. 352-362
- ISSN:
- 0278-6915
- Subject:
- sesquiterpenoids; anti-inflammatory activity; essential oils; medicinal plants; neoplasm cells; mass spectrometry; toxicology; leaves; traditional medicine; humans; cytotoxicity; antioxidant activity; antioxidants; Plasmodium falciparum; chemical composition; gas chromatography; antimalarials; breast neoplasms; anticarcinogenic activity; Madagascar
- Abstract:
- ... The essential oil from Cedrelopsis grevei leaves, an aromatic and medicinal plant from Madagascar, is widely used in folk medicine. Essential oil was characterized by GC–MS and quantified by GC–FID. Sixty-four components were identified. The major constituents were: (E)-β-farnesene (27.61%), δ-cadinene (14.48%), α-copaene (7.65%) and β-elemene (6.96%). The essential oil contained a complex mixture ...
- DOI:
- 10.1016/j.fct.2013.02.008
-
https://dx.doi.org/10.1016/j.fct.2013.02.008
- Author:
- Tomczynska, Malgorzata; Malinowska, Joanna; Morel, Agnieszka; Hamed, Arafa I.; Oleszek, Wieslaw; Stochmal, Anna; Olas, Beata
- Source:
- Food and chemical toxicology 2013 v.56 pp. 266-271
- ISSN:
- 0278-6915
- Subject:
- Pterocarpus; Tribulus; aerial parts; bioactive properties; blood platelets; collagen; models; platelet activation; secretion; toxicology
- Abstract:
- ... The phenolic fraction and the crude extract from Tribulus pterocarpus have different biological activity, including antiplatelet–antiadhesive properties. Since it is demonstrated that hyperhomocysteinemia may act as stimulator of blood platelet activation (platelet adhesion, aggregation, and secretion), but various antiplatelet compounds are able to reduce hyperactivation of blood platelets induce ...
- DOI:
- 10.1016/j.fct.2013.01.025
-
https://dx.doi.org/10.1016/j.fct.2013.01.025
- Author:
- Hernández-Moreno, David; Soffers, Ans E.M.F.; Wiratno,; Falke, Hein E.; Rietjens, Ivonne M.C.M.; Murk, Albertinka J.
- Source:
- Food and chemical toxicology 2013 v.56 pp. 483-490
- ISSN:
- 0278-6915
- Subject:
- Acorus calamus; acceptable daily intake; active ingredients; black pepper; botanical pesticides; carcinogenicity; cloves; crop production; eugenol; farmers; genotoxicity; margin of safety; plant protection; pyrethrins; risk factors; rotenone; small fruits; toxicology
- Abstract:
- ... This study presents a consumer and farmer safety evaluation on the use of four botanical pesticides in pepper berry crop protection. The pesticides evaluated include preparations from clove, tuba root, sweet flag and pyrethrum. Their safety evaluation was based on their active ingredients being eugenol, rotenone, β-asarone and pyrethrins, respectively.Botanical pesticides from Acorus calamus are o ...
- DOI:
- 10.1016/j.fct.2013.01.033
-
https://dx.doi.org/10.1016/j.fct.2013.01.033
- Author:
- Nho, Kyoung Jin; Chun, Jin Mi; Kim, Ho Kyoung
- Source:
- Food and chemical toxicology 2013 v.56 pp. 8-17
- ISSN:
- 0278-6915
- Subject:
- NAD ADP-ribosyltransferase; acetylcysteine; adenocarcinoma; apoptosis; caspases; cell cycle; cell viability; humans; medicinal plants; proteins; reactive oxygen species; toxicology
- Abstract:
- ... Corosolic acid (CRA), a triterpenoid from medicinal herbs, has been shown to induce apoptosis in several cell lines, with the exception of A549 cells. In this report, we investigated the apoptotic effect and mechanism of CRA in A549 cells. The present study shows that CRA significantly inhibits cell viability in a concentration- and time-dependent manner. Exposure to CRA induces sub-G1 cell cycle ...
- DOI:
- 10.1016/j.fct.2013.02.002
-
https://dx.doi.org/10.1016/j.fct.2013.02.002
- Author:
- Adejumo, Oloyede; Atanda, Olusegun; Raiola, Assunta; Somorin, Yinka; Bandyopadhyay, Ranajit; Ritieni, Alberto
- Source:
- Food and chemical toxicology 2013 v.56 pp. 171-177
- ISSN:
- 0278-6915
- Subject:
- European Union; aflatoxin B1; aflatoxin M1; breast milk; dietary exposure; foods; lactation; metabolites; milk; mothers; risk; socioeconomic status; toxicology; Nigeria
- Abstract:
- ... Aflatoxin M1 (AF M1), a hydroxylated metabolite of AF B1, is an important toxin that can contaminate the milk of lactating mothers. A correlation study was conducted to determine the relationship between AF M1 content of breast milk, dietary exposure to AF B1 and socioeconomic status of lactating mothers in the three Senatorial districts of Ogun State, Nigeria. Equal amounts of breast milk (20ml) ...
- DOI:
- 10.1016/j.fct.2013.02.027
-
https://dx.doi.org/10.1016/j.fct.2013.02.027
- Author:
- Choi, Jae Ho; Jin, Sun Woo; Park, Bong Hwan; Kim, Hyung Gyun; Khanal, Tilak; Han, Hwa Jeong; Hwang, Yong Pil; Choi, Jun Min; Chung, Young Chul; Hwang, Sang Kyu; Jeong, Tae Cheon; Jeong, Hye Gwang
- Source:
- Food and chemical toxicology 2013 v.56 pp. 195-203
- ISSN:
- 0278-6915
- Subject:
- CD4-positive T-lymphocytes; Panax; antioxidants; atopic dermatitis; bioactive properties; blood serum; chemokines; dermis; ears; gene expression; ginsenosides; histopathology; immunoglobulin E; interferon-gamma; interleukin-13; interleukin-4; interleukin-5; keratinocytes; messenger RNA; mice; skin lesions; therapeutics; toxicology; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Ginseng contains many bioactive constituents, including various ginsenosides that are believed to have anti-allergic, anti-oxidant, and immunostimulatory activities; however, its effects on atopic dermatitis (AD) remain unclear. In the current study, we hypothesized that cultivated ginseng (CG) would inhibit 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice by regulating ...
- DOI:
- 10.1016/j.fct.2013.02.037
-
https://dx.doi.org/10.1016/j.fct.2013.02.037
- Author:
- Kalaiselvi, Palaniswamy; Rajashree, Krishnaswamy; Bharathi Priya, Lohanathan; Padma, Viswanadha Vijaya
- Source:
- Food and chemical toxicology 2013 v.56 pp. 110-118
- ISSN:
- 0278-6915
- Subject:
- Fusarium; anti-inflammatory activity; apoptosis; caspase-3; cell viability; cytotoxicity; deoxynivalenol; dose response; epigallocatechin; green tea; inflammation; oxidative stress; pretreatment; prostaglandin synthase; toxicology; transcription factor NF-kappa B
- Abstract:
- ... Deoxynivalenol (DON) is a mycotoxin produced by Fusarium sp., and is known to elicit pro-inflammatory responses in the cell. The cells exposed to DON undergo apoptosis as a mechanism to shut down the inflammation. In this study, we tested the cytoprotective effect of the green tea polyphenol epigallocatechin 3-gallate (EGCG) on DON-induced toxicity in HT-29 cells. EGCG prevented DON-induced cytoto ...
- DOI:
- 10.1016/j.fct.2013.01.042
-
https://dx.doi.org/10.1016/j.fct.2013.01.042