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Food and chemical toxicology
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bioactive compounds
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- Author:
- Alfonso Varela-López; Maurizio Battino; María D. Navarro-Hortal; Francesca Giampieri; Tamara Y. Forbes-Hernández; José M. Romero-Márquez; Ricardo Collado; José L. Quiles
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acids; autophagy; bioactive compounds; bone marrow; brain; calcium; cardiotoxicity; cell lines; clinical trials; dietary minerals; doxorubicin; drug therapy; homeostasis; kidneys; liver; mechanism of action; neoplasm cells; neoplasms; nutrients; omega-3 fatty acids; protective effect; selenium; testes; toxicity; vitamin A; vitamin E
- Abstract:
- ... Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated f ...
- DOI:
- 10.1016/j.fct.2019.110834
- https://doi.org/10.1016/j.fct.2019.110834
- Author:
- José M. Alvarez-Suarez; Estefanía Carrillo-Perdomo; Angel Aller; Francesca Giampieri; Massimiliano Gasparrini; Lien González-Pérez; Pablo Beltrán-Ayala; Maurizio Battino
- Source:
- Food and chemical toxicology 2017 v.102 pp. 46-52
- ISSN:
- 0278-6915
- Subject:
- Prunus serotina; anthocyanins; anti-inflammatory activity; antioxidant activity; ascorbic acid; beta-carotene; bioactive compounds; cherries; cytotoxicity; free radical scavengers; fruits; human health; interleukin-1beta; lipopolysaccharides; macrophages; messenger RNA; nitrites; protective effect; secretion; toxicology; tumor necrosis factor-alpha; Ecuador
- Abstract:
- ... Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be ...
- DOI:
- 10.1016/j.fct.2017.01.024
- https://doi.org/10.1016/j.fct.2017.01.024
3. Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway
- Author:
- Yosuke Tabei; Kazutoshi Murotomi; Aya Umeno; Masanori Horie; Yoshio Tsujino; Bumbu Masutani; Yasukazu Yoshida; Yoshihiro Nakajima
- Source:
- Food and chemical toxicology 2017 v.107 pp. 129-137
- ISSN:
- 0278-6915
- Subject:
- DNA damage; antioxidant activity; bioactive compounds; catalase; cell death; cytotoxicity; fibroblasts; gene expression regulation; genes; glutathione; heme oxygenase (biliverdin-producing); hepatocytes; hydrogen peroxide; mice; oxidation; oxidative stress; signal transduction; superoxide dismutase; toxicology
- Abstract:
- ... 5-Hydroxy-4-phenyl-butenolide (5H4PB) is a bioactive compound with antifungal and anti-obesity properties. Although it has recently been shown that 5H4PB activates peroxisome proliferator-activated receptor-gamma (PPARγ), the effect of 5H4PB on intracellular signaling pathways has not been clarified. In this study, we found that 5H4PB activated the nuclear factor erythroid 2-related factor 2 (Nrf2 ...
- DOI:
- 10.1016/j.fct.2017.06.039
- https://doi.org/10.1016/j.fct.2017.06.039
- Author:
- Fangfang Lang; Jinfeng Qu; Haiqin Yin; Lanyu Li; Yuanyuan Zhi; Yanping Liu; Zhenghui Fang; Enkui Hao
- Source:
- Food and chemical toxicology 2018 v.121 pp. 631-638
- ISSN:
- 0278-6915
- Subject:
- Angelica sinensis; animal ovaries; antioxidant activity; apoptosis; bioactive compounds; cell viability; dose response; epigenetics; flow cytometry; glutamate-cysteine ligase; humans; mitochondria; neoplasm cells; ovarian neoplasms; oxidative stress; quinones; small interfering RNA; toxicology; transferases; uridine diphosphate
- Abstract:
- ... Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress ...
- DOI:
- 10.1016/j.fct.2018.09.041
- https://doi.org/10.1016/j.fct.2018.09.041
- Author:
- Rosa Palmeri; Lucia Parafati; Cristina Restuccia; Biagio Fallico
- Source:
- Food and chemical toxicology 2018 v.118 pp. 355-360
- ISSN:
- 0278-6915
- Subject:
- Opuntia; antioxidant activity; bacteria; beef; bioactive compounds; cold storage; color; dipping; food preservation; food spoilage; fruit extracts; fruits; microbial growth; polyphenols; shelf life; storage time; texture; toxicology
- Abstract:
- ... The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content.The extract was then applied by dippi ...
- DOI:
- 10.1016/j.fct.2018.05.044
- https://doi.org/10.1016/j.fct.2018.05.044
- Author:
- Francesca Giampieri; José L. Quiles; Francisco J. Orantes-Bermejo; Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Cristina Sánchez-González; Juan Llopis; Lorenzo Rivas-García; Sadia Afrin; Alfonso Varela-López; Danila Cianciosi; Patricia Reboredo-Rodriguez; Cristina Torres Fernández-Piñar; Ruben Calderón Iglesias; Roberto Ruiz; Silvia Aparicio; Jorge Crespo; Luis Dzul Lopez; Jianbo Xiao; Maurizio Battino
- Source:
- Food and chemical toxicology 2018 v.112 pp. 126-133
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; beeswax; bioactive compounds; byproducts; carbohydrates; cytotoxicity; dose response; flavonoids; hepatoma; human cell lines; human health; in vivo studies; liver; mitochondria; polyphenols; recycling; viability
- Abstract:
- ... During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 ...
- DOI:
- 10.1016/j.fct.2017.12.041
- https://doi.org/10.1016/j.fct.2017.12.041
- Author:
- Gokhan Zengin; Gizem Bulut; Adriano Mollica; Mehmet Zeki Haznedaroglu; Ahmet Dogan; Abdurrahman Aktumsek
- Source:
- Food and chemical toxicology 2017 v.107 pp. 597-608
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Achillea; Bupleurum; amylases; antioxidant activity; bioactive compounds; carboxylic ester hydrolases; chlorogenic acid; ethyl acetate; free radical scavengers; health promotion; high performance liquid chromatography; ingredients; methanol; quercetin; rutin; screening; sinapic acid; solvents; toxicology
- Abstract:
- ... This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities we ...
- DOI:
- 10.1016/j.fct.2017.03.037
- https://doi.org/10.1016/j.fct.2017.03.037
- Author:
- Graziela Bragueto Escher; Jânio Sousa Santos; Neiva Deliberali Rosso; Mariza Boscacci Marques; Luciana Azevedo; Mariana Araújo Vieira do Carmo; Heitor Daguer; Luciano Molognoni; Leonardo do Prado-Silva; Anderson S. Sant'Ana; Marcia Cristina da Silva; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.118 pp. 439-453
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Centaurea cyanus; anthocyanins; antihypertensive effect; antioxidant activity; bioactive compounds; cell death; cell lines; corolla; coumarin; cytotoxicity; ferulic acid; functional properties; inhibitory concentration 50; isoquercitrin; lipid peroxidation; p-coumaric acid; pH; plant extracts; reactive oxygen species; statistical analysis; temperature
- Abstract:
- ... This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, ...
- DOI:
- 10.1016/j.fct.2018.05.046
- https://doi.org/10.1016/j.fct.2018.05.046
- Author:
- Gokhan Zengin; Ramazan Ceylan; Jelena Katanić; Adriano Mollica; Abdurrahman Aktumsek; Tatjana Boroja; Sanja Matić; Vladimir Mihailović; Snežana Stanić; Zaahira Aumeeruddy-Elalfi; Mustafa Abdullah Yilmaz; Mohamad Fawzi Mahomoodally
- Source:
- Food and chemical toxicology 2017 v.107 pp. 540-553
- ISSN:
- 0278-6915
- Subject:
- DNA damage; Drosophila melanogaster; acetylcholinesterase; alpha-amylase; alpha-glucosidase; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; diabetes; functional foods; hesperidin; liquid chromatography; malic acid; metabolites; mutagens; phytopharmaceuticals; protocatechuic acid; rosmarinic acid; rutin; tandem mass spectrometry; toxicology
- Abstract:
- ... Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potenti ...
- DOI:
- 10.1016/j.fct.2017.04.004
- https://doi.org/10.1016/j.fct.2017.04.004
- Author:
- Dariusz Jedrejek; Bernadetta Lis; Agata Rolnik; Anna Stochmal; Beata Olas
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- chemical constituents of plants; coumaric acids; cytotoxicity; anticoagulant activity; blood platelets; sesquiterpenoid lactones; free radical scavengers; amino acids; inositols; bioactive compounds; anticoagulants; mass spectrometry; blood plasma; Taraxacum officinale; antioxidant activity; oxidation; liquid chromatography; roots; protective effect
- Abstract:
- ... Although the majority of potentially bioactive components of dandelion root have been described, revealing the presence of hydroxycinnamic acids (HCAs) and sesquiterpene lactones (SLs), new compounds are still being discovered, an example of which are the recently characterized 4-hydroxyphenylacetate inositol esters (PIEs). In this work, the dandelion root was separated into five preparations (A-E ...
- DOI:
- 10.1016/j.fct.2019.02.017
- https://doi.org/10.1016/j.fct.2019.02.017
- Author:
- Blanca Escudero-López; Genoveva Berná; Ángeles Ortega; Griselda Herrero-Martín; Isabel Cerrillo; Franz Martín; María-Soledad Fernández-Pachón
- Source:
- Food and chemical toxicology 2015 v.78 pp. 78-85
- ISSN:
- 0278-6915
- Subject:
- C-reactive protein; alcoholic fermentation; alcohols; antioxidant activity; beverages; bilirubin; bioactive compounds; biomarkers; cardiovascular diseases; enzyme activity; fruits; glutathione; humans; interleukin-6; lipid composition; low density lipoprotein; mice; orange juice; pasteurization; risk factors; synergism; toxicology; uric acid
- Abstract:
- ... The consumption of fruits prevents the risk of cardiovascular diseases. Alcoholic fermentation has been carried out in fruits resulting in products which provide high concentration of bioactive compounds and variable alcohol content. The aim of this study was to assess the potential beneficial effect of an orange beverage obtained by alcoholic fermentation and pasteurization of orange juice on car ...
- DOI:
- 10.1016/j.fct.2015.02.006
- https://doi.org/10.1016/j.fct.2015.02.006
- Author:
- Giuseppe Chichiriccò; Claudio Ferrante; Luigi Menghini; Lucia Recinella; Sheila Leone; Annalisa Chiavaroli; Luigi Brunetti; Simonetta Di Simone; Maurizio Ronci; Pierpaolo Piccone; Barbara Lanza; Stefania Cesa; Annamaria Poma; Giulia Vecchiotti; Giustino Orlando
- Source:
- Food and chemical toxicology 2019 v.126 pp. 7-14
- ISSN:
- 0278-6915
- Subject:
- Artemia; Crocus sativus; anthers; antioxidant activity; bioactive compounds; byproducts; cell lines; cell movement; chemical constituents of plants; cytotoxicity; fatty acid composition; lipopolysaccharides; long chain fatty acids; malondialdehyde; mutagens; nitrites; protective effect; rats; reactive oxygen species; saffron; tissue repair; toxicology
- Abstract:
- ... Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isol ...
- DOI:
- 10.1016/j.fct.2019.01.040
- https://doi.org/10.1016/j.fct.2019.01.040
- Author:
- Abishek B. Santhakumar; Maurizio Battino; José M. Alvarez-Suarez
- Source:
- Food and chemical toxicology 2018 v.113 pp. 49-65
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; atherosclerosis; bioactive compounds; bioavailability; cardioprotective effect; chronic diseases; clinical trials; epidemiological studies; fruits; hemostasis; lipid metabolism; longevity; polyphenols; toxicology; vegetables
- Abstract:
- ... Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several ...
- DOI:
- 10.1016/j.fct.2018.01.022
- https://doi.org/10.1016/j.fct.2018.01.022
- Author:
- Jicheng Chen; Jingjing Tian; Huifang Ge; Ruihai Liu; Jianbo Xiao
- Source:
- Food and chemical toxicology 2017 v.109 pp. 930-940
- ISSN:
- 0278-6915
- Subject:
- human cell lines; protein synthesis; dose response; liver; catalase; vinegars; reactive oxygen species; superoxide dismutase; lipid composition; cholesterol; gene expression; toxicology; bioactive compounds; hypolipidemia; lipemic effect; antioxidant activity; ABC transporters; peroxisome proliferator-activated receptors
- Abstract:
- ... Tetramethylpyrazine is a bioactive compound found in Chinese black vinegar. This work is to investigate the potential effects of tetramethylpyrazine on intracellular cholesterol modulation in HepG2 cells. The results demonstrated that tetramethylpyrazine can induce intracellular cholesterol efflux. Tetramethylpyrazine may also improve endothelial function through its antioxidant effects by inhibit ...
- DOI:
- 10.1016/j.fct.2016.12.017
- https://doi.org/10.1016/j.fct.2016.12.017
- Author:
- Huifang Ge; Yazhen Chen; Jicheng Chen; Jingjing Tian; Xiaofeng Liang; Lei Chen
- Source:
- Food and chemical toxicology 2018 v.119 pp. 417-424
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ligusticum sinense; Oriental traditional medicine; antioxidant activity; bioactive compounds; cardiovascular diseases; digestion; dose response; ethanol; ferulic acid; free radical scavengers; hydroxyl radicals; intestines; liquids; oxidative stress; polyphenols; pyrazines; rhizomes; toxicology
- Abstract:
- ... The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastr ...
- DOI:
- 10.1016/j.fct.2017.12.035
- https://doi.org/10.1016/j.fct.2017.12.035
- Author:
- E.J. Llorent-Martínez; P. Ortega-Barrales; G. Zengin; A. Mocan; M.J. Simirgiotis; R. Ceylan; S. Uysal; A. Aktumsek
- Source:
- Food and chemical toxicology 2017 v.107 pp. 609-619
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Lathyrus cicera; acetylcholinesterase; aerial parts; agricultural land; alpha-amylase; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; enzyme inhibition; flavonoids; food industry; functional foods; high performance liquid chromatography; ionization; mass spectrometry; phytopharmaceuticals; screening; toxicology
- Abstract:
- ... The genus Lathyrus has great importance in terms of food and agricultural areas. In this study, the in vitro antioxidant activity (phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC and metal chelating) and enzyme inhibitory activity evaluation (acetylcholinesterase, butyrylcholinesterase, α-amylase and α-glucosidase) of L. cicera and L. digitatus were investigated, as well as their phytochemical profile ...
- DOI:
- 10.1016/j.fct.2017.03.002
- https://doi.org/10.1016/j.fct.2017.03.002
- Author:
- María Figueiredo-González; Patrícia Valentão; David M. Pereira; Paula B. Andrade
- Source:
- Food and chemical toxicology 2017 v.109 pp. 386-392
- ISSN:
- 0278-6915
- Subject:
- African Americans; Solanum lycopersicum var. lycopersicum; acetone; adenocarcinoma; alkaloids; antineoplastic activity; antioxidant activity; bioactive compounds; byproducts; cell viability; cultivars; cytotoxicity; human health; humans; inhibitory concentration 50; leaf extracts; leaves; nitric oxide; superoxide anion; tomatoes
- Abstract:
- ... This study focused the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of tomato plant cultivars (Caramba, Valentine, Negro, Abuela, and Anairis). AE, HME and AcE extracts of all cultivars reduced cell viability, IC50 values ranging from 9 ± 2 to 55 ± 11, from 103 ± 25 t ...
- DOI:
- 10.1016/j.fct.2017.09.018
- https://doi.org/10.1016/j.fct.2017.09.018
- Author:
- Wen-Juan Li; Lu Li; Weng-Ya Zhen; Le-Feng Wang; Meng Pan; Jia-Qian Lv; Fan Wang; Yu-Fei Yao; Shao-Ping Nie; Ming-Yong Xie
- Source:
- Food and chemical toxicology 2017 v.99 pp. 199-208
- ISSN:
- 0278-6915
- Subject:
- Ganoderma; T-lymphocytes; antioxidant activity; apoptosis; bioactive compounds; body weight; catalase; cell viability; cyclophosphamide; glutathione peroxidase; immunosuppression; interleukin-2; lipid peroxidation; mice; polysaccharides; reactive oxygen species; spleen; superoxide dismutase; thymus gland; toxicology; tumor necrosis factor-alpha
- Abstract:
- ... Ganoderma atrum polysaccharide (PSG-1) is a bioactive compound with antioxidant and immunomodulatory activities. The aim of this study was to determine the effect of PSG-1 on reactive oxygen species (ROS) generation and apoptosis in spleen and thymus of cyclophosphamide (CTX)-induced immunosuppressed mice. The results showed that PSG-1 protected mice against CTX-mediated immunosuppression, as evid ...
- DOI:
- 10.1016/j.fct.2016.11.033
- https://doi.org/10.1016/j.fct.2016.11.033
- Author:
- Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
- Source:
- Food and chemical toxicology 2018 v.113 pp. 303-313
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
- Abstract:
- ... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
- DOI:
- 10.1016/j.fct.2017.12.031
- https://doi.org/10.1016/j.fct.2017.12.031
- Author:
- Laércio Galvão Maciel; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Heitor Daguer; Luciano Molognoni; Mereci Mendes de Almeida; Daniel Granato; Neiva Deliberali Rosso
- Source:
- Food and chemical toxicology 2018 v.113 pp. 187-197
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Hibiscus sabdariffa; antioxidant activity; ascorbic acid; bioactive compounds; calyx; cell lines; color; cytotoxicity; electrospray ionization mass spectrometry; inhibitory concentration 50; lethal concentration 50; liquid chromatography; myrtillin; neoplasm cells; pH; temperature
- Abstract:
- ... Hibiscus sabdariffa calyx is a rich source of anthocyanins and other bioactive compounds but no study reported the effects of experimental conditions on the extraction of these chemical compounds. Therefore, the effects of time and extraction temperature on the bioactive compounds and antioxidant activity of Hibiscus sabdariffa calyx were evaluated. In addition, the effects of copigmentation and p ...
- DOI:
- 10.1016/j.fct.2018.01.053
- https://doi.org/10.1016/j.fct.2018.01.053
- Author:
- Vanessa Vieira; Carla Pereira; Rui M.V. Abreu; Ricardo C. Calhelha; Maria José Alves; João A.P. Coutinho; Olga Ferreira; Lillian Barros; Isabel C.F.R. Ferreira
- Source:
- Food and chemical toxicology 2020 v.137 pp. 111189
- ISSN:
- 0278-6915
- Subject:
- Gram-positive bacteria; Juglans regia; anti-inflammatory activity; antibacterial properties; antioxidant activity; bioactive compounds; cell culture; cell lines; chemical constituents of plants; coumaric acids; crop production; cytotoxicity; flavonols; hemolysis; hulls; naphthalene; neoplasms; nitric oxide; thiobarbituric acid-reactive substances; walnuts; wastes
- Abstract:
- ... Juglans regia L. (walnut) green husks are an important fraction of waste resulting from the walnut production, thus representing an interesting natural matrix to explore as a source of bioactive compounds. In this work, the hydroethanolic extract of walnut green husks was studied considering the phytochemical composition and the biological activity using different cell model assays, most of them e ...
- DOI:
- 10.1016/j.fct.2020.111189
- https://doi.org/10.1016/j.fct.2020.111189
- Author:
- Jiaming Tu; Dingding Shi; Lingrong Wen; Yueming Jiang; Yupeng Zhao; Jiali Yang; Huiling Liu; Guangrong Liu; Bao Yang
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110730
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; anti-inflammatory activity; antioxidant activity; antioxidants; bioactive compounds; bioavailability; cell viability; diet; furans; inhibitory concentration 50; leaves; median effective concentration; moieties; mulberries; resveratrol; vegetables; viability assays
- Abstract:
- ... Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified ...
- DOI:
- 10.1016/j.fct.2019.110730
- https://doi.org/10.1016/j.fct.2019.110730
- Author:
- Azzurra Stefanucci; Gokhan Zengin; Marcello Locatelli; Giorgia Macedonio; Chin-Kun Wang; Ettore Novellino; M.Fawzi Mahomoodally; Adriano Mollica
- Source:
- Food and chemical toxicology 2018 v.118 pp. 181-189
- ISSN:
- 0278-6915
- Subject:
- Capparis spinosa; acetylcholinesterase; active ingredients; antioxidant activity; bioactive compounds; buds; cholinesterase; chromatography; enzyme inhibition; essential oils; fatty acids; free radical scavengers; medicinal plants; phenolic compounds; provenance; rutin; toxicology; Italy; Morocco; Turkey (country)
- Abstract:
- ... Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of differen ...
- DOI:
- 10.1016/j.fct.2018.05.003
- https://doi.org/10.1016/j.fct.2018.05.003
- Author:
- Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.120 pp. 479-490
- ISSN:
- 0278-6915
- Subject:
- lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
- Abstract:
- ... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
- DOI:
- 10.1016/j.fct.2018.07.043
- https://doi.org/10.1016/j.fct.2018.07.043
- Author:
- Maria João Rodrigues; Katkam N. Gangadhar; Gokhan Zengin; Adriano Mollica; João Varela; Luísa Barreira; Luísa Custódio
- Source:
- Food and chemical toxicology 2017 v.107 pp. 590-596
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Juncus acutus; antioxidant activity; bioactive compounds; chemical elements; cholinesterase; cognition; food additives; food industry; free radicals; functional foods; high performance liquid chromatography; leaves; methylene chloride; molecular models; neuroglia; neurons; neuroprotective effect; roots; sedatives; sleep disorders; toxicology
- Abstract:
- ... Several Juncus species are traditionally used as sedative and to treat health problems like insomnia. This work was based on the hypothesis that Juncus acutus, J. maritimus and J. inflexus may have molecules with bioactivities relevant for the improvement of cognitive functions and thus with potential use as food additives and/or nutraceuticals. Therefore leaves and roots extracts of those species ...
- DOI:
- 10.1016/j.fct.2017.04.006
- https://doi.org/10.1016/j.fct.2017.04.006
- Author:
- Radu Claudiu Fierascu; Milen I. Georgiev; Irina Fierascu; Camelia Ungureanu; Sorin Marius Avramescu; Alina Ortan; Mihaela Ioana Georgescu; Anca Nicoleta Sutan; Anca Zanfirescu; Cristina Elena Dinu-Pirvu; Bruno Stefan Velescu; Valentina Anuta
- Source:
- Food and chemical toxicology 2018 v.111 pp. 44-52
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Arctium lappa; Aspergillus niger; Penicillium; Veronica persica; aerial parts; anti-inflammatory activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; chromosome aberrations; fungi; high performance liquid chromatography; inflammation; meristems; models; roots; toxicology
- Abstract:
- ... The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the ...
- DOI:
- 10.1016/j.fct.2017.11.008
- https://doi.org/10.1016/j.fct.2017.11.008
- Author:
- Gokhan Zengin; Claudio Ferrante; Ismail Senkardes; Reneta Gevrenova; Dimitrina Zheleva-Dimitrova; Luigi Menghini; Giustino Orlando; Lucia Recinella; Annalisa Chiavaroli; Sheila Leone; Luigi Brunetti; Carene Marie Nancy Picot-Allain; Kannan RR. Rengasamy; Mohamad Fawzi Mahomoodally
- Source:
- Food and chemical toxicology 2019 v.127 pp. 237-250
- ISSN:
- 0278-6915
- Subject:
- Rubus sanctus; alpha-amylase; alpha-glucosidase; antioxidant activity; bioactive compounds; bioassays; cholinesterase; colitis; colorectal neoplasms; cosmetics; coumaric acids; data collection; drugs; ethyl acetate; flavonoids; functional foods; humans; hydroxybenzoic acids; leaves; methanol; models; neoplasm cells; protective effect; tissue repair; triterpenoid saponins
- Abstract:
- ... In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ...
- DOI:
- 10.1016/j.fct.2019.03.041
- https://doi.org/10.1016/j.fct.2019.03.041
- Author:
- Valérian Bunel; Marie-Hélène Antoine; Caroline Stévigny; Joëlle Nortier; Pierre Duez
- Source:
- Food and chemical toxicology 2016 v.87 pp. 77-87
- ISSN:
- 0278-6915
- Subject:
- Aristolochia; Magnolia officinalis; acids; antioxidant activity; apoptosis; autophagy; bioactive compounds; cell viability; cytotoxicity; dialysis; fibrosis; flow cytometry; honokiol; interphase; kidney diseases; magnolol; microscopy; necrosis; nephrotoxicity; oxidative stress; patients; toxicology
- Abstract:
- ... Aristolochic acids (AA) are nephrotoxic agents found in Aristolochia species whose consumption leads to the onset of a progressive tubulointerstitial fibrosis. This AA-nephropathy was first reported during the Belgian outbreak of the 1990's in which more than a hundred patients consumed slimming pills containing an Aristolochia species and Magnolia officinalis. The patients developed an end-stage ...
- DOI:
- 10.1016/j.fct.2015.11.020
- https://doi.org/10.1016/j.fct.2015.11.020
- Author:
- Sotiria Makri; Ioannis Kafantaris; Dimitrios Stagos; Theodora Chamokeridou; Konstantinos Petrotos; Konstantinos Gerasopoulos; Anastasios Mpesios; Nikolaos Goutzourelas; Stylianos Kokkas; Panagiotis Goulas; Dimitrios Komiotis; Dimitrios Kouretas
- Source:
- Food and chemical toxicology 2017 v.102 pp. 24-31
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; bioactive compounds; blood; byproducts; catalase; chickens; experimental diets; feeds; glutathione; grape pomace; hydrogen peroxide; pollution; thiobarbituric acid-reactive substances; tissues; toxicity; toxicology; wastes; wine industry
- Abstract:
- ... Currently, there is a great interest in the production of animal feed with antioxidant activity. The aim of this study was to examine the potential antioxidant effects of a feed supplemented with grape pomace (GP), a winery by-product with high environmental load, in chickens. Broilers of 15 days post birth were separated into two groups fed either with standard diet or with diet supplemented with ...
- DOI:
- 10.1016/j.fct.2017.01.019
- https://doi.org/10.1016/j.fct.2017.01.019
- Author:
- Sengul Uysal; Asli Ugurlu; Gokhan Zengin; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Adriano Mollica; Luisa Custodio; Nuno R. Neng; José M.F. Nogueira; M. Fawzi Mahomoodally
- Source:
- Food and chemical toxicology 2018 v.111 pp. 525-536
- ISSN:
- 0278-6915
- Subject:
- Bidens tripartita; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cell lines; cell viability; chlorogenic acid; computer simulation; cytotoxicity; enzyme inhibition; epicatechin; ethyl acetate; high performance liquid chromatography; hydrogen bonding; methanol; neoplasm cells; neoplasms; plasmids; toxicology; viability assays
- Abstract:
- ... Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Perform ...
- DOI:
- 10.1016/j.fct.2017.11.058
- https://doi.org/10.1016/j.fct.2017.11.058
- Author:
- Ana F. Vinha; Sérgio V.P. Barreira; Anabela S.G. Costa; Rita C. Alves; M. Beatriz P.P. Oliveira
- Source:
- Food and chemical toxicology 2014 v.67 pp. 139-144
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; ascorbic acid; bioactive compounds; cultivars; flavonoids; fruits; lycopene; organic foods; organic production; phenolic compounds; phytopharmaceuticals; pulp; seeds; sensory evaluation; sensory properties; tomatoes; toxicology
- Abstract:
- ... The effect of organic and conventional agricultural systems on the physicochemical parameters, bioactive compounds content, and sensorial attributes of tomatoes (“Redondo” cultivar) was studied. The influence on phytochemicals distribution among peel, pulp and seeds was also accessed. Organic tomatoes were richer in lycopene (+20%), vitamin C (+30%), total phenolics (+24%) and flavonoids (+21%) an ...
- DOI:
- 10.1016/j.fct.2014.02.018
- https://doi.org/10.1016/j.fct.2014.02.018
- Author:
- Lei Chen; Kang Li; Qian Liu; José L. Quiles; Rosanna Filosa; Mohammad Amjad Kamal; Fang Wang; Guoyin Kai; Xiaobo Zou; Hui Teng; Jianbo Xiao
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; bioactive compounds; cyanidin; fruit extracts; human cell lines; hydrogen peroxide; metabolic detoxification; oxidative stress; protective effect; protein synthesis; proteins; raspberries; signal transduction
- Abstract:
- ... The aim of the present study was to explore the protective effects of raspberry and its bioactive compound cyanidin 3-O-glucoside against H2O2-induced oxidative stress in HepG2 cells. We established a model of oxidative stress in HepG2 cells induced by H2O2 and examined the protein expression of Keap1/Nrf2. The antioxidant activity of raspberry extract was carried out measuring the level of reacti ...
- DOI:
- 10.1016/j.fct.2019.110781
- https://doi.org/10.1016/j.fct.2019.110781
- Author:
- Beata Olas
- Source:
- Food and chemical toxicology 2016 v.97 pp. 199-204
- ISSN:
- 0278-6915
- Subject:
- Hippophae rhamnoides; antioxidant activity; antiviral properties; bioactive compounds; blood platelets; blood pressure; cardioprotective effect; cardiovascular diseases; cholesterol; fatty acids; flavonoids; fruits; leaves; oils; phenolic compounds; phytosterols; platelet aggregation; toxicology; vitamins
- Abstract:
- ... Hippophae rhamnoides (sea buckthorn) offers many health benefits. It has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. In addition, sea buckthorn has antibacterial ...
- DOI:
- 10.1016/j.fct.2016.09.008
- https://doi.org/10.1016/j.fct.2016.09.008
- Author:
- Catarina Guerreiro Pereira; Luísa Barreira; Nuno da Rosa Neng; José Manuel Florêncio Nogueira; Cátia Marques; Tamára F. Santos; João Varela; Luísa Custódio
- Source:
- Food and chemical toxicology 2017 v.107 pp. 581-589
- ISSN:
- 0278-6915
- Subject:
- epicatechin; hydroxybenzaldehyde; herbal tea; Crithmum maritimum; mammals; chlorogenic acid; beverages; stems; health promotion; toxicology; halophytes; sodium; mineral content; leaves; calcium; bioactive compounds; minerals; toxicity; antioxidant activity; ferulic acid; pyrocatechol; food industry; flowers; magnesium; Aspalathus linearis; essential oil crops
- Abstract:
- ... Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linear ...
- DOI:
- 10.1016/j.fct.2017.04.018
- https://doi.org/10.1016/j.fct.2017.04.018
- Author:
- Francesca Giampieri; Jose M. Alvarez-Suarez; Massimiliano Gasparrini; Tamara Y. Forbes- Hernandez; Sadia Afrin; Stefano Bompadre; Corrado Rubini; Antonio Zizzi; Paola Astolfi; Celestino Santos-Buelga; Ana M. González-Paramás; Josè L. Quiles; Bruno Mezzetti; Maurizio Battino
- Source:
- Food and chemical toxicology 2016 v.94 pp. 128-137
- ISSN:
- 0278-6915
- Subject:
- DNA; antioxidant activity; antioxidants; bioactive compounds; biomarkers; diet; doxorubicin; drug therapy; enzyme activity; fruits; histopathology; liver; mitochondria; oxidative stress; protective effect; rats; strawberries; toxicity; toxicology; vegetables
- Abstract:
- ... Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health a ...
- DOI:
- 10.1016/j.fct.2016.06.003
- https://doi.org/10.1016/j.fct.2016.06.003
- Author:
- Shivraj Hariram Nile; Arti Nile; Enkhtaivan Gansukh; Venkidasamy Baskar; Guoyin Kai
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110659
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Withania somnifera; antioxidant activity; antioxidants; bioactive compounds; cell viability; cytotoxicity; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; maceration; medicinal properties; microwave treatment; solid phase extraction; temperature; therapeutics; uterine cervical neoplasms
- Abstract:
- ... Subcritical water extraction (SWE) applied to analyses the bioactives from ashwagandha (W. somnifera) at varying temperature (100–200 °C) and extraction time (10–30 min). The effect of temperature and time has been investigated in terms of extraction yield (EY), total phenolic content (TPC), cytotoxicity, antioxidant, and enzyme inhibitory activities. The withanosides and withanolides responsible ...
- DOI:
- 10.1016/j.fct.2019.110659
- https://doi.org/10.1016/j.fct.2019.110659
- Author:
- Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
- Source:
- Food and chemical toxicology 2018 v.115 pp. 414-424
- ISSN:
- 0278-6915
- Subject:
- foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
- Abstract:
- ... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
- DOI:
- 10.1016/j.fct.2018.01.054
- https://doi.org/10.1016/j.fct.2018.01.054
- Author:
- Adriana Trifan; Alexandru Vasincu; Simon Vlad Luca; Christiana Neophytou; Evelyn Wolfram; Sebastian E.W. Opitz; Daciana Sava; Laura Bucur; Bogdan I. Cioroiu; Anca Miron; Ana Clara Aprotosoaie; Oana Cioanca; Monica Hancianu; Alexandra Jitareanu; Andreas I. Constantinou
- Source:
- Food and chemical toxicology 2019 v.134 pp. -
- ISSN:
- 0278-6915
- Subject:
- Cystoseira; DNA; DNA fragmentation; acetone; antioxidant activity; antioxidants; apoptosis; bioactive compounds; coasts; colon; cytotoxicity; dietary supplements; drugs; epithelium; human cell lines; macroalgae; methanol; neoplasm cells; neoplasms; Black Sea; Romania
- Abstract:
- ... The Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coast of Romania. The 70% acetone, methanol and water ...
- DOI:
- 10.1016/j.fct.2019.110820
- https://doi.org/10.1016/j.fct.2019.110820