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You searched for: Journal name Food and chemical toxicology Remove constraint Journal name: Food and chemical toxicology Subject antioxidants Remove constraint Subject: antioxidants Subject term bioactive compounds Remove constraint Subject term: bioactive compounds
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1. Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents

Author:
Mohamad Fawzi Mahomoodally; Elwira Sieniawska; Kouadio Ibrahime Sinan; Marie Carene Nancy Picot-Allain; Serife Yerlikaya; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Ismail Senkardes; Kannan RR. Rengasamy; Gokhan Zengin
Source:
Food and chemical toxicology 2020 v.135 pp. 111052
ISSN:
0278-6915
Subject:
Rhododendron; alpha-glucosidase; antineoplastic agents; antioxidants; bioactive compounds; cell lines; cell viability; cholinesterase; cytotoxicity; enzyme inhibition; enzyme inhibitors; epigallocatechin; ethnobotany; ethyl acetate; growth retardation; inhibitory concentration 50; lung neoplasms; methanol; neoplasm cells; poisoning; secondary metabolites; structure-activity relationships; viability assays
Abstract:
... Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of ‘mad honey’ poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. l ...
DOI:
10.1016/j.fct.2019.111052

2. Anti-inflammatory effect of the medicinal herbal mixture infusion, Horchata, from southern Ecuador against LPS-induced cytotoxic damage in RAW 264.7 macrophages

Author:
Mabel Guevara; Eduardo Tejera; Gabriel A. Iturralde; Tatiana Jaramillo-Vivanco; María G. Granda-Albuja; Silvana Granja-Albuja; Celestino Santos-Buelga; Ana M. González-Paramás; José M. Álvarez-Suarez
Source:
Food and chemical toxicology 2019 v.131 pp. 110594
ISSN:
0278-6915
Subject:
anti-inflammatory activity; antioxidants; ascorbic acid; bioactive compounds; carotenoids; chlorogenic acid; cytokines; cytotoxicity; enzymes; glycosides; heat treatment; macrophages; polyphenols; protective effect; quercetin; toxicology; Ecuador
Abstract:
... The phytochemical composition and the antioxidant and anti-inflammatory activities of a mixture of 23 plants, named Horchata, traditionally consumed in Ecuador, have been evaluated. The study was carried out using the hydroalcoholic extract (HHext) and infusion (IHext) of the horchata plant mixture. It was verified that thermal treatment affected the contents of vitamin C and carotenoids, but hard ...
DOI:
10.1016/j.fct.2019.110594

3. Coffee, caffeine, chlorogenic acid, and the purinergic system

Author:
Naiara Stefanello; Roselia Maria Spanevello; Sabina Passamonti; Lisiane Porciúncula; Carla Denise Bonan; Ayodeji Augustine Olabiyi; João Batista Teixeira da Rocha; Charles Elias Assmann; Vera Maria Morsch; Maria Rosa Chitolina Schetinger
Source:
Food and chemical toxicology 2019 v.123 pp. 298-313
ISSN:
0278-6915
Subject:
adenosine; adenosine triphosphate; antioxidants; beverages; bioactive compounds; caffeine; central nervous system; chlorogenic acid; coffee beans; diterpenoids; enzyme activity; homeostasis; neurons; purinergic receptors; toxicology; trigonelline
Abstract:
... Coffee is a drink prepared from roasted coffee beans and is lauded for its aroma and flavour. It is the third most popular beverage in the world. This beverage is known by its stimulant effect associated with the presence of methylxanthines. Caffeine, a purine-like molecule (1,3,7 trymetylxantine), is the most important bioactive compound in coffee, among others such as chlorogenic acid (CGA), dit ...
DOI:
10.1016/j.fct.2018.10.005

4. Identification of moracin N in mulberry leaf and evaluation of antioxidant activity

Author:
Jiaming Tu; Dingding Shi; Lingrong Wen; Yueming Jiang; Yupeng Zhao; Jiali Yang; Huiling Liu; Guangrong Liu; Bao Yang
Source:
Food and chemical toxicology 2019 v.132 pp. 110730
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; anti-inflammatory activity; antioxidant activity; antioxidants; bioactive compounds; bioavailability; cell viability; diet; furans; inhibitory concentration 50; leaves; median effective concentration; moieties; mulberries; resveratrol; vegetables; viability assays
Abstract:
... Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified ...
DOI:
10.1016/j.fct.2019.110730

5. Utilization of Dianthus superbus L and its bioactive compounds for antioxidant, anti-influenza and toxicological effects

Author:
Doo Hwan Kim; Gyun Seok Park; Arti Shivraj Nile; Young Deuk Kwon; Gansukh Enkhtaivan; Shivraj Hariram Nile
Source:
Food and chemical toxicology 2019 v.125 pp. 313-321
ISSN:
0278-6915
Subject:
Dianthus superbus; antineoplastic activity; antioxidants; antiviral properties; bioactive compounds; butanol; cell lines; chemical analysis; computer simulation; cyclic peptides; dose response; enzyme inhibition; ethyl acetate; glucosides; influenza; inhibitory concentration 50; isorhamnetin; liquid chromatography; medicinal plants; membrane glycoproteins; neoplasm cells; neoplasms; quercetin; rutin; sialidase; tandem mass spectrometry; therapeutics; viruses; Asia
Abstract:
... Dianthus superbus (DS) is a traditional medicinal herb well known for its medicinal and therapeutic potential and widely distributed in various Asian countries. The ethyl acetate (EA), butanol (Bu) and distilled water (DW) extracts of DS assessed for extraction of bioactive compounds and their biological activities. The chemical analysis was done using LC-MS/MS and antioxidant, anticancer and anti ...
DOI:
10.1016/j.fct.2019.01.013

6. Antioxidant and pro-oxidant activities of carotenoids and their oxidation products

Author:
Daniela Ribeiro; Marisa Freitas; Artur M.S. Silva; Félix Carvalho; Eduarda Fernandes
Source:
Food and chemical toxicology 2018 v.120 pp. 681-699
ISSN:
0278-6915
Subject:
antioxidants; bioactive compounds; carbonyl compounds; carotenoids; diet; humans; lipids; nitrogen; oxidation; oxidative stress; oxygen; plant pigments; toxicology
Abstract:
... Carotenoids are lipid soluble plant pigments that make part of human daily diet. These compounds are able to react with diverse reactive species and originate a myriad of oxidation products that have similar or even more reactivity than their parent compounds. These products may be short-chain carbonyl compounds and, the commonly designated, apo-carotenoids. The effects fo these products in the hu ...
DOI:
10.1016/j.fct.2018.07.060

7. Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. (Asteraceae) and Veronica persica Poiret (Plantaginaceae)

Author:
Radu Claudiu Fierascu; Milen I. Georgiev; Irina Fierascu; Camelia Ungureanu; Sorin Marius Avramescu; Alina Ortan; Mihaela Ioana Georgescu; Anca Nicoleta Sutan; Anca Zanfirescu; Cristina Elena Dinu-Pirvu; Bruno Stefan Velescu; Valentina Anuta
Source:
Food and chemical toxicology 2018 v.111 pp. 44-52
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Arctium lappa; Aspergillus niger; Penicillium; Veronica persica; aerial parts; anti-inflammatory activity; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; chromosome aberrations; fungi; high performance liquid chromatography; inflammation; meristems; models; roots; toxicology
Abstract:
... The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the ...
DOI:
10.1016/j.fct.2017.11.008

8. Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Author:
Sengul Uysal; Asli Ugurlu; Gokhan Zengin; Mehmet Cengiz Baloglu; Yasemin Celik Altunoglu; Adriano Mollica; Luisa Custodio; Nuno R. Neng; José M.F. Nogueira; M. Fawzi Mahomoodally
Source:
Food and chemical toxicology 2018 v.111 pp. 525-536
ISSN:
0278-6915
Subject:
Bidens tripartita; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cell lines; cell viability; chlorogenic acid; computer simulation; cytotoxicity; enzyme inhibition; epicatechin; ethyl acetate; high performance liquid chromatography; hydrogen bonding; methanol; neoplasm cells; neoplasms; plasmids; toxicology; viability assays
Abstract:
... Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Perform ...
DOI:
10.1016/j.fct.2017.11.058

9. Subcritical water extraction of withanosides and withanolides from ashwagandha (Withania somnifera L) and their biological activities

Author:
Shivraj Hariram Nile; Arti Nile; Enkhtaivan Gansukh; Venkidasamy Baskar; Guoyin Kai
Source:
Food and chemical toxicology 2019 v.132 pp. 110659
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Withania somnifera; antioxidant activity; antioxidants; bioactive compounds; cell viability; cytotoxicity; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; maceration; medicinal properties; microwave treatment; solid phase extraction; temperature; therapeutics; uterine cervical neoplasms
Abstract:
... Subcritical water extraction (SWE) applied to analyses the bioactives from ashwagandha (W. somnifera) at varying temperature (100–200 °C) and extraction time (10–30 min). The effect of temperature and time has been investigated in terms of extraction yield (EY), total phenolic content (TPC), cytotoxicity, antioxidant, and enzyme inhibitory activities. The withanosides and withanolides responsible ...
DOI:
10.1016/j.fct.2019.110659

10. UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation

Author:
Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
Source:
Food and chemical toxicology 2018 v.115 pp. 414-424
ISSN:
0278-6915
Subject:
foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
Abstract:
... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
DOI:
10.1016/j.fct.2018.01.054

11. Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources. Part I: Cystoseira barbata (Stackhouse) C. Agardh

Author:
Adriana Trifan; Alexandru Vasincu; Simon Vlad Luca; Christiana Neophytou; Evelyn Wolfram; Sebastian E.W. Opitz; Daciana Sava; Laura Bucur; Bogdan I. Cioroiu; Anca Miron; Ana Clara Aprotosoaie; Oana Cioanca; Monica Hancianu; Alexandra Jitareanu; Andreas I. Constantinou
Source:
Food and chemical toxicology 2019 v.134 pp. -
ISSN:
0278-6915
Subject:
Cystoseira; DNA; DNA fragmentation; acetone; antioxidant activity; antioxidants; apoptosis; bioactive compounds; coasts; colon; cytotoxicity; dietary supplements; drugs; epithelium; human cell lines; macroalgae; methanol; neoplasm cells; neoplasms; Black Sea; Romania
Abstract:
... The Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coast of Romania. The 70% acetone, methanol and water ...
DOI:
10.1016/j.fct.2019.110820

12. Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea

Author:
Gokhan Zengin; Ramazan Ceylan; Jelena Katanić; Adriano Mollica; Abdurrahman Aktumsek; Tatjana Boroja; Sanja Matić; Vladimir Mihailović; Snežana Stanić; Zaahira Aumeeruddy-Elalfi; Mustafa Abdullah Yilmaz; Mohamad Fawzi Mahomoodally
Source:
Food and chemical toxicology 2017 v.107 pp. 540-553
ISSN:
0278-6915
Subject:
DNA damage; Drosophila melanogaster; acetylcholinesterase; alpha-amylase; alpha-glucosidase; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; diabetes; functional foods; hesperidin; liquid chromatography; malic acid; metabolites; mutagens; phytopharmaceuticals; protocatechuic acid; rosmarinic acid; rutin; tandem mass spectrometry; toxicology
Abstract:
... Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potenti ...
DOI:
10.1016/j.fct.2017.04.004

13. Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus: Potential sources of bioactive compounds for the food industry

Author:
E.J. Llorent-Martínez; P. Ortega-Barrales; G. Zengin; A. Mocan; M.J. Simirgiotis; R. Ceylan; S. Uysal; A. Aktumsek
Source:
Food and chemical toxicology 2017 v.107 pp. 609-619
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lathyrus cicera; acetylcholinesterase; aerial parts; agricultural land; alpha-amylase; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; enzyme inhibition; flavonoids; food industry; functional foods; high performance liquid chromatography; ionization; mass spectrometry; phytopharmaceuticals; screening; toxicology
Abstract:
... The genus Lathyrus has great importance in terms of food and agricultural areas. In this study, the in vitro antioxidant activity (phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC and metal chelating) and enzyme inhibitory activity evaluation (acetylcholinesterase, butyrylcholinesterase, α-amylase and α-glucosidase) of L. cicera and L. digitatus were investigated, as well as their phytochemical profile ...
DOI:
10.1016/j.fct.2017.03.002

14. Genotoxicity and antioxidant activity of five Agrimonia and Filipendula species plant extracts evaluated by comet and micronucleus assays in human lymphocytes and Ames Salmonella/microsome test

Author:
Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
Source:
Food and chemical toxicology 2018 v.113 pp. 303-313
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
Abstract:
... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
DOI:
10.1016/j.fct.2017.12.031

15. In vitro antioxidant and antihypertensive compounds from camu-camu (Myrciaria dubia McVaugh, Myrtaceae) seed coat: A multivariate structure-activity study

Author:
Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
Source:
Food and chemical toxicology 2018 v.120 pp. 479-490
ISSN:
0278-6915
Subject:
lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
Abstract:
... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
DOI:
10.1016/j.fct.2018.07.043

16. The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

Author:
Oludemi Taofiq; Sandrina A. Heleno; Ricardo C. Calhelha; Maria José Alves; Lillian Barros; Ana M. González-Paramás; Maria F. Barreiro; Isabel C.F.R. Ferreira
Source:
Food and chemical toxicology 2017 v.108 pp. 139-147
ISSN:
0278-6915
Subject:
Ganoderma lucidum; antioxidants; bioactive compounds; color; cosmetics; cytotoxicity; ganoderic acid; ingredients; nutritive value; pH; phenolic acids; polysaccharides; toxicology; triterpene acids
Abstract:
... Ganoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further characterized in terms of phenolic acids, polysaccharides and triterpenoids. Finally, the obtained extracts were tested as cosmeceutical ingredients. G.  ...
DOI:
10.1016/j.fct.2017.07.051

17. Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression

Author:
Subramaniya Bharathi Raja; Vijayabharathi Rajendiran; Nirmal Kumar Kasinathan; Amrithalakshmi P; Sivaramakrishnan Venkatabalasubramanian; Malliga Raman Murali; Halagowder Devaraj; Sivasithamparam Niranjali Devaraj
Source:
Food and chemical toxicology 2017 v.106 pp. 92-106
ISSN:
0278-6915
Subject:
antineoplastic activity; antioxidants; apoptosis; bioactive compounds; caspase-3; cell viability; cyclins; cytochrome c; cytotoxicity; gene overexpression; genes; humans; inhibitory concentration 50; intestinal mucosa; neoplasm cells; neoplasms; peroxidase; quercetin
Abstract:
... Quercetin is a bioactive compound with anti-inflammatory, antioxidant and anticancer properties. This study exemplifies the differential cytotoxic activity of Quercetin on two human colonic cancer cell lines, HT29 and HCT15. IC50 of Quercetin for HT29 and HCT15 cells were 42.5 μM and 77.4 μM, respectively. Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt ...
DOI:
10.1016/j.fct.2017.05.006

18. Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress

Author:
Francesca Giampieri; Jose M. Alvarez-Suarez; Massimiliano Gasparrini; Tamara Y. Forbes- Hernandez; Sadia Afrin; Stefano Bompadre; Corrado Rubini; Antonio Zizzi; Paola Astolfi; Celestino Santos-Buelga; Ana M. González-Paramás; Josè L. Quiles; Bruno Mezzetti; Maurizio Battino
Source:
Food and chemical toxicology 2016 v.94 pp. 128-137
ISSN:
0278-6915
Subject:
DNA; antioxidant activity; antioxidants; bioactive compounds; biomarkers; diet; doxorubicin; drug therapy; enzyme activity; fruits; histopathology; liver; mitochondria; oxidative stress; protective effect; rats; strawberries; toxicity; toxicology; vegetables
Abstract:
... Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health a ...
DOI:
10.1016/j.fct.2016.06.003

19. Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

Author:
Martha Rocío Moreno-Jimenez; Fátima Trujillo-Esquivel; Marco A. Gallegos-Corona; Rosalia Reynoso-Camacho; Rubén Francisco González-Laredo; José Alberto Gallegos-Infante; Nuria Elizabeth Rocha-Guzmán; Minerva Ramos-Gomez
Source:
Food and chemical toxicology 2015 v.80 pp. 144-153
ISSN:
0278-6915
Subject:
1,2-dimethylhydrazine; Quercus; adenocarcinoma; anti-inflammatory activity; anticarcinogenic activity; antioxidants; bioactive compounds; body weight; carcinogenesis; chemoprevention; colon; interleukin-8; leaves; males; rats; toxicology; transcription factor NF-kappa B; Mexico
Abstract:
... Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis ...
DOI:
10.1016/j.fct.2015.03.011