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You searched for: Journal name Food and chemical toxicology Remove constraint Journal name: Food and chemical toxicology Subject antioxidants Remove constraint Subject: antioxidants
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1. Acute and subchronic 90-days toxicity assessment of propyl-propane-thiosulfinate (PTS) in rats

Author:
Antonio Cascajosa-Lira; Silvia Pichardo; Alberto Baños; Enrique Guillamón; Verónica Molina-Hernández; Rosario Moyano; Ángeles Jos; Ana M Cameán
Source:
Food and chemical toxicology 2022 v.161 pp. 112827
ISSN:
0278-6915
Subject:
Allium; adverse effects; antioxidants; body weight; calcium; females; food consumption; food industry; gastrointestinal system; histopathology; musculoskeletal system; rats
Abstract:
... The organosulfur compounds (OSC) extracted from Allium spp. exhibit antibacterial, antifungal, and antioxidant properties. The agri-food industry is taking advantage of these properties by using them as natural feed and food additives. In the present work, an acute and a subchronic 90-days toxicity studies have been conducted for the first time to assess the safety of the OSC propyl-propane-thiosu ...
DOI:
10.1016/j.fct.2022.112827

2. Ameliorative effect of Lactobacillus plantarum Lp2 against cyclophosphamide-induced liver injury in mice

Author:
Nan Zhang; Yuan Tian; Yu Wang; Yuling Fan; Yue Zhang; Xinyue Xing; Bo Nan; Zhiyi Ai; Xia Li; Yuhua Wang
Source:
Food and chemical toxicology 2022 v.169 pp. 113433
ISSN:
0278-6915
Subject:
Lactobacillus plantarum; antioxidant activity; antioxidants; apoptosis; culture media; cyclophosphamide; fermentation; liver; models; oxidative stress; toxicology
Abstract:
... Cyclophosphamide (CTX) is a widely used anticancer drug that can cause liver injury, but there is no effective treatment available at present. The antioxidant properties of Lactobacillus plantarum Lp2 in vitro and its effect on CTX-induced liver injury in mice were investigated thoroughly. The order of antioxidant capacity of the fermentate of Lp2 was as followed: fermented supernatant > cell-free ...
DOI:
10.1016/j.fct.2022.113433

3. Caffeic acid phenethyl ester protects against doxorubicin-induced cardiotoxicity and increases chemotherapeutic efficacy by regulating the unfolded protein response

Author:
Ying Zhang; Dezhi Kong; Han Han; YongJun Cao; HongXuan Zhu; Guozhen Cui
Source:
Food and chemical toxicology 2022 v.159 pp. 112770
ISSN:
0278-6915
Subject:
antioxidants; breast neoplasms; caffeic acid; cancer therapy; cardiotoxicity; cytotoxicity; doxorubicin; drug therapy; endoplasmic reticulum; honey bees; humans; ingredients; mice; propolis; protective effect; toxicology; unfolded protein response
Abstract:
... Doxorubicin (Dox) is an efficient drug used in breast cancer chemotherapy. However, the clinical application of Dox in cancer treatment is limited due to its cardiotoxicity. Caffeic acid phenethyl ester (CAPE) is a critical bioactive ingredient of honeybee propolis that possesses various beneficial pharmacological properties, such as antioxidant and anticancer activities. Here, we aimed to investi ...
DOI:
10.1016/j.fct.2021.112770

4. Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway

Author:
Yingjie Wang; Fangju Liu; Mengru Liu; Xin Zhou; Min Wang; Kexin Cao; Sanjun Jin; Anshan Shan; Xingjun Feng
Source:
Food and chemical toxicology 2022 v.161 pp. 112823
ISSN:
0278-6915
Subject:
Aspergillus; aflatoxin B1; antioxidants; blood serum; caspase-1; curcumin; glutathione transferase; hepatotoxicity; humans; inflammasomes; interleukin-18; liver; liver function; medicinal properties; oxidative stress; polyphenols; pyroptosis; secondary metabolites; toxicology; turmeric; weight loss
Abstract:
... Aflatoxins are produced as secondary metabolites by the toxigenic Aspergillus fungi. Among the aflatoxins, aflatoxin B1 (AFB1) is a common contaminant of global concern in human and animal food products. Prolonged exposure to AFB1 may provoke hepatocyte pyroptosis and oxidative stress, which leads to liver damage. Dietary polyphenols could protect the liver from a wide range of toxins. Curcumin, a ...
DOI:
10.1016/j.fct.2022.112823

5. Effect of solvent type on ultrasound-assisted extraction of antioxidant compounds from Ficaria kochii: Optimization by response surface methodology

Author:
Seyed-Ahmad Shahidi
Source:
Food and chemical toxicology 2022 v.163 pp. 112981
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ficaria; antioxidant activity; antioxidants; food storage; gallic acid; methanol; quercetin; raw materials; response surface methodology; solvents; temperature; toxicology; ultrasonic treatment
Abstract:
... The optimization of extraction conditions to recover antioxidant rich extract from plant of Ficaria Kochii with an ultrasound-assisted system was achieved by response surface methodology. The rotatable central composite design (RCCD) was used to optimize extraction parameters in terms of total phenolic and total flavonoid content and antioxidant activity. The optimum conditions for extraction by m ...
DOI:
10.1016/j.fct.2022.112981

6. Efficient green photocatalyst of silver-based palladium nanoparticles for methyle orange photodegradation, investigation of lipid peroxidation inhibition, antimicrobial, and antioxidant activity

Author:
Fatemeh Karimi; Negin Rezaei-savadkouhi; Mustafa Uçar; Aysenur Aygun; Rima Nour Elhouda Tiri; Ismet Meydan; Elaheh Aghapour; Hamdullah Seckin; Derya Berikten; Tugba Gur; Fatih Sen
Source:
Food and chemical toxicology 2022 v.169 pp. 113406
ISSN:
0278-6915
Subject:
Bacillus subtilis; Candida albicans; Enterococcus faecalis; Escherichia coli; Hibiscus sabdariffa; Pseudomonas aeruginosa; antimicrobial properties; antioxidant activity; antioxidants; dyes; ethanol; flavonoids; gallic acid; irradiation; lipid peroxidation; methyl orange; nanoparticles; palladium; photocatalysts; photolysis; solar radiation; toxicology
Abstract:
... Nanotechnology is an interdisciplinary study that has been developing worldwide in recent years and has a serious impact on human life. The fact that the nanoparticles of plant origin are clean, non-toxic, and biocompatible has enabled new fields of study. The Hibiscus sabdariffa (H. sabdariffa) plant has been attracted by scientists because of its impact on health and many other areas. The lipid ...
DOI:
10.1016/j.fct.2022.113406

7. Facile synthesis of Cu NPs@Fe3O4-lignosulfonate: Study of catalytic and antibacterial/antioxidant activities

Author:
Zahra Nezafat; Mohammad Mahdi Karimkhani; Mahmoud Nasrollahzadeh; Shahrzad Javanshir; Abdollah Jamshidi; Yasin Orooji; Ho Won Jang; Mohammadreza Shokouhimehr
Source:
Food and chemical toxicology 2022 v.168 pp. 113310
ISSN:
0278-6915
Subject:
Fourier transform infrared spectroscopy; X-radiation; X-ray diffraction; antioxidants; catalysts; catalytic activity; copper nanoparticles; energy-dispersive X-ray analysis; human health; lignosulfonates; magnetism; methylene blue; p-nitrophenol; pollution; remediation; sodium borohydride; toxicology; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... Environmental pollution is one of the important concerns for human health. There are different types of pollutants and techniques to eliminate them from the environment. We hereby report an efficient method for the remediation of environmental contaminants through the catalytic reduction of the selected pollutants. A green method has been developed for the immobilization of copper nanoparticles on ...
DOI:
10.1016/j.fct.2022.113310

8. High speed homogenization assisted encapsulation of synergistic essential oils formulation: Characterization, in vitro release study, safety profile, and efficacy towards mitigation of aflatoxin B1 induced deterioration in rice samples

Author:
Somenath Das; Anand Kumar Chaudhari; Vipin Kumar Singh; Bijendra Kumar Singh; Nawal Kishore Dubey
Source:
Food and chemical toxicology 2022 v.169 pp. 113443
ISSN:
0278-6915
Subject:
Cupressus sempervirens; Juniperus communis; Oryza sativa; Pinus roxburghii; aflatoxin B1; antioxidants; biodegradation; biosynthesis; chitosan; encapsulation; ergosterol; fatty acids; fungal growth; growth retardation; homogenization; lipid peroxidation; mammals; nanocomposites; rice; secretion; shelf life; staple foods; stored grain; toxicity; toxicology
Abstract:
... Application of essential oils to mitigate aflatoxin B₁ (AFB₁) contamination in food is a current research hotspot; however, their direct incorporation may cause toxic effects, and changes in food organoleptic properties. This work aimed to synthesize novel synergistic formulation of Pinus roxburghii, Juniperus communis, and Cupressus sempervirens essential oils by mixture design assay (PJC) and en ...
DOI:
10.1016/j.fct.2022.113443

9. Kaempferol prevents the activation of complement C3 protein and the generation of reactive A1 astrocytes that mediate rat brain degeneration induced by 3-nitropropionic acid

Author:
Carmen Lopez-Sanchez; Joana Poejo; Virginio Garcia-Lopez; Jairo Salazar; Virginio Garcia-Martinez; Carlos Gutierrez-Merino
Source:
Food and chemical toxicology 2022 v.164 pp. 113017
ISSN:
0278-6915
Subject:
3-nitropropionic acid; adults; amyloid; animal models; antioxidants; astrocytes; complement; hippocampus; human nutrition; kaempferol; neurodegenerative diseases; proteolysis; rats; secretion; toxicology
Abstract:
... Kaempferol is a natural antioxidant present in vegetables and fruits used in human nutrition. In previous work, we showed that intraperitoneal (i.p.) kaempferol administration strongly protects against striatum neurodegeneration induced by i.p. injections of 3-nitropropionic acid (NPA), an animal model of Huntington's disease. Recently, we have shown that reactive A1 astrocytes generation is an ea ...
DOI:
10.1016/j.fct.2022.113017

10. Mono-n-butyl phthalate regulates nuclear factor erythroid 2–related factor 2 and nuclear factor kappa B pathway in an ovalbumin-induced asthma mouse model

Author:
Quang Luu Quoc; Tra Cao Thi Bich; Seo-Hee Kim; Min Sook Ryu; Hae-Sim Park; Yoo Seob Shin
Source:
Food and chemical toxicology 2022 v.166 pp. 113171
ISSN:
0278-6915
Subject:
CD4-positive T-lymphocytes; antioxidants; asthma; cell proliferation; chronic exposure; cytokines; eosinophils; epithelium; humans; mice; phthalates; risk; toxicology; transcription factor NF-kappa B; urine; vitamin E
Abstract:
... Recent studies have emphasized the role of endocrine-disrupting chemicals in asthma development, especially in eosinophilic asthma. However, the exact mechanism was unknown. Among all the endocrine-disrupting chemicals, mono-n-butyl phthalate (MnBP) was a chemical that was most frequently detected in human urine. Our study was performed with the aim of investigating the harmful effects of MnBP on ...
DOI:
10.1016/j.fct.2022.113171

11. Morus macroura Miq. Fruit extract protects against acetic acid-induced ulcerative colitis in rats: Novel mechanistic insights on its impact on miRNA-223 and on the TNFα/NFκB/NLRP3 inflammatory axis

Author:
Rania M. Salama; Samar F. Darwish; Ismail El Shaffei; Noura F. Elmongy; Nouran M. Fahmy; Manal S. Afifi; Ghada A. Abdel-Latif
Source:
Food and chemical toxicology 2022 v.165 pp. 113146
ISSN:
0278-6915
Subject:
Morus (Moraceae); acetic acid; animal models; anti-inflammatory activity; antioxidants; caspase-1; fruit extracts; fruits; high performance liquid chromatography; inflammasomes; interleukin-18; mass spectrometry; mulberries; oxidative stress; pathogenesis; phytochemicals; protective effect; toxicology; tumor necrosis factor-alpha; ulcerative colitis
Abstract:
... Nod-like receptor pyrin domain-1 containing 3 (NLRP3) inflammasome/tumor necrosis factor alpha (TNFα)/nuclear factor kappa B (NFκB) inflammatory pathway is known to be involved in the pathogenesis of ulcerative colitis (UC). Inversely, miRNA-223 can exert counter-regulatory effect on NLRP3 expression. The mulberry tree (Morus macroura) fruit is attaining increased importance for its antioxidant an ...
DOI:
10.1016/j.fct.2022.113146

12. Omarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation

Author:
Haidy E. Michel; Mariam M. Tadros; Moataz S. Hendy; Shereen Mowaka; Bassam M. Ayoub
Source:
Food and chemical toxicology 2022 v.164 pp. 113015
ISSN:
0278-6915
Subject:
Parkinson disease; antioxidants; apoptosis; blood-brain barrier; caspase-12; decline; endoplasmic reticulum; endoplasmic reticulum stress; heme oxygenase (biliverdin-producing); histology; hypoglycemic agents; immunomodulation; lipid peroxidation; neuroprotective effect; oxidative stress; toxicology
Abstract:
... The current study aimed to explore the potential neuroprotective effect of omarigliptin (OG), an antidiabetic drug that crosses the blood-brain barrier (BBB), in a Parkinson's disease (PD) rotenone-based rat-model. Results showed that OG attenuated motor impairment, histological aberrations, α-synuclein accumulation, and rescued the dopaminergic neurons in rotenone-administered rats. Furthermore, ...
DOI:
10.1016/j.fct.2022.113015

13. Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo

Author:
Hui Chen; Lixing Cao; Kai Han; Han Zhang; Jinling Cui; Xuan Ma; Shuang Zhao; Chong Zhao; Shutao Yin; Lihong Fan; Hongbo Hu
Source:
Food and chemical toxicology 2022 v.166 pp. 113255
ISSN:
0278-6915
Subject:
acute kidney injury; antioxidants; antiporters; biosynthesis; cystine; ferroptosis; glutamic acid; glutathione; mice; nephrotoxicity; oxidative stress; patulin; toxicology; tripeptides
Abstract:
... Patulin (PAT) is a common food-borne mycotoxin with diverse toxic effects including nephrotoxicity. The induction of oxidative stress is suggested to be a key mechanism contributed to toxicities of PAT. Reduced glutathione (GSH), a sulfhydryl-containing tripeptide, is a key reason for PAT-mediated oxidative stress. Cystine/glutamate antiporter (system xc⁻)-mediated cystine uptake plays a critical ...
DOI:
10.1016/j.fct.2022.113255

14. Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine

Author:
Shuwei Wang; Qi Han; Zhaolan Wei; Yunyi Wang; Jing Xie; Mingqing Chen
Source:
Food and chemical toxicology 2022 v.162 pp. 112904
ISSN:
0278-6915
Subject:
acetylcholine; antioxidants; glutathione; hippocampus; memory; microplastics; nerve tissue; neurotoxicity; neurotransmitters; oxidative stress; pollution; polystyrenes; toxicology; vitamin E
Abstract:
... Microplastics pollution has become a growing environmental concern, but its potential neurotoxic effects remain unknown. In this study, we determined the effects of exposure to polystyrene microplastics (micro-PS) on learning and memory, and explored the underlying mechanisms. Kunming mice were orally exposed to 0.01, 0.1, 1 mg/d micro-PS or saline for four weeks. Employing the Morris water maze t ...
DOI:
10.1016/j.fct.2022.112904

15. Progress on the detoxification of aflatoxin B1 using natural anti-oxidants

Author:
Xiaoxuan Wang; Tiancheng Wang; Eugenie Nepovimova; Miao Long; Wenda Wu; Kamil Kuca
Source:
Food and chemical toxicology 2022 v.169 pp. 113417
ISSN:
0278-6915
Subject:
Aspergillus; aflatoxin B1; antioxidants; biotransformation; carcinogenicity; cytotoxicity; immunotoxicity; mutagens; oxidative stress; secondary metabolites; teratogenicity; toxicology
Abstract:
... Aflatoxins are toxic secondary metabolites produced by Aspergillus fungi. The most toxic among them is Aflatoxin B1 (AFB1) which is known to have genotoxic, immunotoxic, teratogenic, carcinogenic, and mutagenic toxic effects (amongst others). The mechanisms responsible for its toxicity include the induction of oxidative stress, cytotoxicity, and DNAdamage. Studies have found that natural anti-oxid ...
DOI:
10.1016/j.fct.2022.113417

16. Purple tea (Camellia sinensis var. assamica) leaves as a potential functional ingredient: From extraction of phenolic compounds to cell-based antioxidant/biological activities

Author:
Cristiane de Moura; Tufy Kabbas Junior; Fernanda Rafaelly de O. Pedreira; Luciana Azevedo; Marianna M. Furtado; Anderson S. Sant'Ana; Marcelo Franchin; Vinicius Rafael Gonzaga; Yuqing Cui; Mingchun Wen; Liang Zhang; Romaiana P. Pereira; Daniel Granato
Source:
Food and chemical toxicology 2022 v.159 pp. 112668
ISSN:
0278-6915
Subject:
Camellia sinensis var. assamica; Listeria monocytogenes; Staphylococcus aureus; Staphylococcus epidermidis; alpha-amylase; antimicrobial properties; antioxidant activity; antioxidants; chemokine CXCL2; citric acid; cytotoxicity; ethanol; freeze drying; green tea; ingredients; interleukin-6; macrophages; pH; toxicology
Abstract:
... A statistical optimization study was used to maximize the extraction of bioactive compounds and antioxidant activity from green tea derived from purple leaves of Camellia sinensis var. assamica. Simultaneous optimization was applied, and a combination of 60 °C, 15 min, and a mass-solvent ratio of 1 g of dehydrated purple leaves to 62.3 mL of an ethanol/citric acid solution, were determined as the ...
DOI:
10.1016/j.fct.2021.112668

17. T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications

Author:
Chongshan Dai; Subhajit Das Gupta; Zhanhui Wang; Haiyang Jiang; Tony Velkov; Jianzhong Shen
Source:
Food and chemical toxicology 2022 v.167 pp. 113262
ISSN:
0278-6915
Subject:
T-2 toxin; antioxidants; ascorbic acid; autophagy; cardiomyocytes; cardiotoxicity; catalase; death; endoplasmic reticulum; fibrosis; hemorrhage; methylprednisolone; mitochondria; necrosis; permeability; peroxisome proliferator-activated receptor gamma; rapamycin; selenium; therapeutics; toxicity; toxicology
Abstract:
... T-2 toxin is one of the most toxic and common trichothecene mycotoxins, and can cause various cardiovascular diseases. In this review, we summarized the current knowledge-base and challenges as it relates to T-2 toxin related cardiotoxicity. The molecular mechanisms and potential treatment approaches were also discussed. Pathologically, T-2 toxin-induced cardiac toxicity is characterized by cell i ...
DOI:
10.1016/j.fct.2022.113262

18. A caffeic acid electrochemical sensor amplified with GNR/CoFe2O4@NiO and 1-Ethyl-3-methylimidazolium acetate; a new perspective for food analysis

Author:
Reza Mostafazadeh; Ali Ghaffarinejad; Fariba Tajabadi
Source:
Food and chemical toxicology 2022 v.167 pp. 113312
ISSN:
0278-6915
Subject:
acetates; antioxidants; caffeic acid; carbon; carbon electrodes; detection limit; food analysis; liquids; sensors (equipment); toxicology
Abstract:
... Determining Caffeic acid is important as an antioxidant compound in food. In this study, caffeic acid (CA) was measured using a carbon paste electrode modified with GNR/CoFe₂O₄@NiO and 1-Ethyl-3-methylimidazolium acetate (EMIM Ac) as ion liquid. A simple sensor showed a higher current than a bare carbon paste; thus, it can be said that the modified electrode has a higher sensitivity for detecting ...
DOI:
10.1016/j.fct.2022.113312

19. The hypolipidemic, anti-inflammatory and antioxidant effect of Kavolì® aqueous extract, a mixture of Brassica oleracea leaves, in a rat model of NAFLD

Author:
Andrea Vornoli; Francesco Vizzarri; Clara Maria Della Croce; Teresa Grande; Marisa Palazzo; Július Árvay; Laura Pucci; Morena Gabriele; Marco Matteucci; Moreno Paolini; Vincenzo Longo; Luisa Pozzo
Source:
Food and chemical toxicology 2022 v.167 pp. 113261
ISSN:
0278-6915
Subject:
Brassica oleracea; animal models; antioxidant activity; antioxidants; biomarkers; brain; cardiovascular diseases; fatty liver; feces; high fat diet; hypercholesterolemia; inflammation; lipid content; liver; metabolites; oxidative stress; polyphenols; streptozotocin; toxicology; transaminases
Abstract:
... Herein we characterized the bioactive metabolites of the aqueous extract of Kavolì®, a commercial product composed of a mixture of Brassica oleracea leaves, and assessed its potential ameliorating effects in a rat model of non-alcoholic fatty liver disease (NAFLD). Kavolì® extract showed high levels of bioactive compounds and strong in vitro antioxidant activities. Chlorogenic and neochlorogenic a ...
DOI:
10.1016/j.fct.2022.113261

20. Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent

Author:
Yun Zhou; Yijun Yu; He Lv; Hao Zhang; Tianzi Liang; Guoer Zhou; Liping Huang; Yizhou Tian; Wenqing Liang
Source:
Food and chemical toxicology 2022 v.168 pp. 113385
ISSN:
0278-6915
Subject:
angiogenesis; antineoplastic activity; antioxidants; apigenin; apoptosis; autophagy; bioavailability; cancer therapy; cell cycle; mechanism of action; medicine; metastasis; nanotechnology; neoplasms; solubility; toxicology
Abstract:
... Apigenin (APG) is a flavonoid presence in beverages, vegetables, and fruits containing anti-diabetic, anti-oxidant, and anti-viral activities, as well as cancer management properties. There is growing evidence that APG presented extensive anti-cancer effects in several cancer types by modulating various cellular processes, including angiogenesis, apoptosis, metastasis, autophagy, cell cycle, and i ...
DOI:
10.1016/j.fct.2022.113385

21. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide

Author:
María-Aránzazu Martínez; Irma Ares; Marta Martínez; Bernardo Lopez-Torres; Jorge-Enrique Maximiliano; Jose-Luis Rodríguez; María-Rosa Martínez-Larrañaga; Arturo Anadón; Cesar Peteiro; Susana Rubiño; María Hortos
Source:
Food and chemical toxicology 2021 v.156 pp. 112460
ISSN:
0278-6915
Subject:
Phaeophyceae; antioxidant activity; antioxidants; apoptosis; cell viability; dietary supplements; genes; inflammation; interleukin-6; mitogen-activated protein kinase; oxidative stress; toxicology; Baltic Sea; Mauritania; Mediterranean Sea
Abstract:
... Gongolaria baccata (S.G. Gmelin) is marine brown seaweed mainly found on the coasts of the Baltic Sea south to the Mediterranean Sea, Canary Islands, Mauritania and Western Sahara. Herein, we report the cell viability and protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by tre ...
DOI:
10.1016/j.fct.2021.112460

22. Chemical composition, antioxidant, and anti-diabetic activities of ethyl acetate fraction of Stachys riederi var. japonica (Miq.) in streptozotocin-induced type 2 diabetic mice

Author:
Kandasamy Saravanakumar; SeonJu Park; Arokia Vijaya Anand Mariadoss; Anbazhagan Sathiyaseelan; Vishnu Priya Veeraraghavan; SeongJung Kim; Myeong-Hyeon Wang
Source:
Food and chemical toxicology 2021 v.155 pp. 112374
ISSN:
0278-6915
Subject:
Stachys; acarbose; alpha-amylase; antioxidants; blood glucose; body weight; caffeic acid; catalytic activity; chemical composition; cholesterol; creatinine; cytotoxicity; ethyl acetate; gene expression; glucose; glycemic effect; insulin; noninsulin-dependent diabetes mellitus; oleanolic acid; rosmarinic acid; solvents; ursolic acid
Abstract:
... This work analysed the chemical composition, antioxidant, and enzyme inhibitory activities of solvent extract (SJ-ME) and fractions (SJ-HF, SJ-EAF, and SJ-MF) of the Stachys riederi var. japonica (Miq.) (SJ). Furthermore, the effect of SJ-EAF in STZ induced type 2 diabetic mice was examined. Among the samples, SJ-EAF exhibited a lower IC₅₀ concentration of 64.2 ± 0.48 μg/mL for DPPH and 82.6 ± 0.0 ...
DOI:
10.1016/j.fct.2021.112374

23. Comparative analysis of metabolic variations, antioxidant potential and cytotoxic effects in different parts of Chelidonium majus L

Author:
Shivraj Hariram Nile; Hui Wang; Arti Nile; Xianmin Lin; Huilin Dong; Baskar Venkidasamy; Elwira Sieniawska; Gansukh Enkhtaivan; Guoyin Kai
Source:
Food and chemical toxicology 2021 v.156 pp. 112483
ISSN:
0278-6915
Subject:
Chelidonium majus; antioxidant activity; antioxidants; chromatography; cytotoxicity; dose response; flavonoids; flower extracts; flowers; humans; leaves; root extracts; spectroscopy; toxicology
Abstract:
... Metabolic variations, antioxidant potential and cytotoxic effects were investigated in the different plant parts like the leaf, stem, flower, pod, and root of C. majus L. using spectroscopic and chromatographic methods. Total phenolics and flavonoids were studied in the different parts of C. majus L., leaf showed higher flavonoid content (137.43 mg/g), while the pod showed the highest phenolic (23 ...
DOI:
10.1016/j.fct.2021.112483

24. Comprehensive chemical characterization and biological evaluation of two Acacia species: A. nilotica and A. ataxacantha

Author:
Dimitrina Zheleva-Dimitrova; Kouadio Ibrahime Sinan; Ouattara Katinan Etienne; Gunes Ak; Jugreet B. Sharmeen; Gokhan Dervisoglu; Fethi Ahmet Ozdemir; Mohamad Fawzi Mahomoodally; Gokhan Zengin
Source:
Food and chemical toxicology 2021 v.156 pp. 112446
ISSN:
0278-6915
Subject:
Acacia; acetylcholinesterase; anti-infective agents; antioxidants; bark; biological assessment; cytotoxicity; dietary supplements; flavonoids; humans; leaves; maceration; toxicology; ultrasonic treatment
Abstract:
... The genus Acacia (Family Leguminosae) is composed of several medicinal plants used for treating miscellaneous diseases. Amid the important members of this genus, A. nilotica and A. ataxacantha are widely employed for their tremendous healing properties. Hence, this present work aimed to determine the total phenolic and flavonoid contents and investigate the antioxidant, antiproliferative, anti-enz ...
DOI:
10.1016/j.fct.2021.112446

25. Comprehensive evaluation of two Astragalus species (A. campylosema and A. hirsutus) based on biological, toxicological properties and chemical profiling

Author:
İnci Kurt-Celep; Gokhan Zengin; Kouadio Ibrahime Sinan; Gunes Ak; Fevzi Elbasan; Evren Yıldıztugay; Filippo Maggi; Giovanni Caprioli; Simone Angeloni; Jugreet B. Sharmeen; Mohamad Fawzi Mahomoodally
Source:
Food and chemical toxicology 2021 v.154 pp. 112330
ISSN:
0278-6915
Subject:
Astragalus; amylases; antioxidant activity; antioxidants; carbohydrates; cytotoxicity; flowers; genotoxicity; leaf extracts; polyphenols; rutin; therapeutics; toxicology
Abstract:
... Astragalus L. (Fabaceae) is an important genus with numerous species having various traditional medicinal uses making them of interest for scientific investigations to ascertain their therapeutic benefits. In the present study, the quantitative polyphenolic profiles of methanolic extracts from different parts (leaves, flowers, and roots) of two endemic Astragalus species growing in Turkey, i.e. A. ...
DOI:
10.1016/j.fct.2021.112330

26. Fritillaria thunbergii Miq. (Zhe Beimu): A review on its traditional uses, phytochemical profile and pharmacological properties

Author:
Shivraj Hariram Nile; Jiajia Su; Die Wu; Leran Wang; Jiangning Hu; Elwira Sieniawska; Guoyin Kai
Source:
Food and chemical toxicology 2021 v.153 pp. 112289
ISSN:
0278-6915
Subject:
Fritillaria thunbergii; analgesics; antioxidants; blood; bronchitis; chemical constituents of plants; cough; diarrhea; diterpenoids; drug development; hypertension; inflammation; lignans; neuroprotective effect; nucleosides; rheology; sterols; therapeutics; toxicology; traditional medicine; China
Abstract:
... Fritillaria thunbergii Miq. (Zhe beimu) ranked as oldest known homeopathic traditional folk medicine in China. The bulbs are medicinally important curing cough, inflammation, gastric ulcers, hypertension, diarrhea, and bronchitis. The aim of this review is to enlighten the deeper knowledge about F. thunbergii giving a comprehensive overview on its traditional uses, phytochemistry and pharmacology ...
DOI:
10.1016/j.fct.2021.112289

27. Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme

Author:
Garima Sharma; Eun-Joo Shin; Naveen Sharma; Seung-Yeol Nah; Huynh Nhu Mai; Bao Trong Nguyen; Ji Hoon Jeong; Xin Gen Lei; Hyoung-Chun Kim
Source:
Food and chemical toxicology 2021 v.148 pp. 111945
ISSN:
0278-6915
Subject:
Alzheimer disease; Parkinson disease; antioxidants; bipolar disorder; drugs; genes; glutathione; glutathione peroxidase; ischemia; poisoning; schizophrenia; therapeutics; toxicology
Abstract:
... Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinson's disease, Alzheimer's disease, cerebral ischemia, and convulsive disorders). In addition, we summarized the recent findings indicating tha ...
DOI:
10.1016/j.fct.2020.111945

28. Health beneficial and pharmacological properties of p-cymene

Author:
Abdelaali Balahbib; Nasreddine El Omari; Naoufal EL. Hachlafi; Fatima Lakhdar; Naoual El Menyiy; Najoua Salhi; Hanae Naceiri Mrabti; Saad Bakrim; Gokhan Zengin; Abdelhakim Bouyahya
Source:
Food and chemical toxicology 2021 v.153 pp. 112259
ISSN:
0278-6915
Subject:
Artemisia; Origanum; Protium; analgesics; antioxidants; antiparasitic agents; apoptosis; cell cycle checkpoints; grapefruits; health services; humans; monoterpenoids; orange juice; p-cymene; tangerines; toxicology; vasodilator agents
Abstract:
... p-cymene also known as p-cymol or p-isopropyltoluene is an alkyl-substituted aromatic compound naturally occurring in essential oils (EOs) of various aromatic plants, including the genus of Artemisia, Protium, Origanum, and Thymus. It is related to the family of terpenes, especially monocyclic monoterpenes. p-cymene is also present in several food-based plants such as carrots, orange juice, grapef ...
DOI:
10.1016/j.fct.2021.112259

29. Lack of potential carcinogenicity for steviol glycosides - Systematic evaluation and integration of mechanistic data into the totality of evidence

Author:
G.A. Chappell; M.M. Heintz; S.J. Borghoff; C.L. Doepker; D.S. Wikoff
Source:
Food and chemical toxicology 2021 v.150 pp. 112045
ISSN:
0278-6915
Subject:
Stevia rebaudiana; antioxidants; carcinogenicity; cell death; cell proliferation; genotoxicity; glycosides; humans; inflammation; leaves; metabolites; mutagens; neoplasms; oxidative stress; rodents; steviol; sweetness; toxicology
Abstract:
... Steviol glycosides are present in the leaves of the Stevia rebaudiana plant, have a sweet taste, and have been used as a sweetener for centuries. To build on previous authoritative safety assessments of steviol glycosides, a systematic assessment of mechanistic data related to key characteristics of carcinogens (KCCs) was conducted. Over 900 KCC-relevant endpoints from peer-reviewed literature and ...
DOI:
10.1016/j.fct.2021.112045

30. Lycopene alleviates di(2-ethylhexyl) phthalate-induced splenic injury by activating P62-Keap1-NRF2 signaling

Author:
Xue-Yan Dai; Shi-Yong Zhu; Jian Chen; Mu-Zi Li; Yi Zhao; Milton Talukder; Jin-Long Li
Source:
Food and chemical toxicology 2022 v.168 pp. 113324
ISSN:
0278-6915
Subject:
antioxidants; corn oil; histopathology; inflammation; lycopene; mitochondria; phthalates; pollutants; spleen; therapeutics; toxicology
Abstract:
... Di(2-ethylhexyl) phthalate (DEHP) is an omnipresent environmental pollutant. It has been determined that DEHP is involved in multiple health disorders. Lycopene (Lyc) is a natural carotenoid pigment, with anti-inflammatory and antioxidant properties. However, it is not clear whether Lyc can protect the spleen from DEHP-induced oxidative damage. A total of 140 mice were randomly divided into seven ...
DOI:
10.1016/j.fct.2022.113324

31. Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways

Author:
Petar D. Petrov; Polina Soluyanova; Sonia Sánchez-Campos; José V. Castell; Ramiro Jover
Source:
Food and chemical toxicology 2021 v.158 pp. 112664
ISSN:
0278-6915
Subject:
amoxicillin; antioxidants; bile acids; blood serum; clavulanic acid; cytotoxicity; hepatocytes; hepatotoxicity; humans; intrahepatic cholestasis; liver; oxidative stress; sulforaphane; toxicology
Abstract:
... Treatment of β-lactamase positive bacterial infections with a combination of amoxicillin (AMOX) and clavulanic acid (CLAV) causes idiosyncratic drug-induced liver injury (iDILI) in a relevant number of patients, often with features of intrahepatic cholestasis. This study aims to determine serum bile acid (BA) levels in amoxicillin/clavulanate (A+C)-iDILI patients and to investigate the mechanism o ...
DOI:
10.1016/j.fct.2021.112664

32. Protective effect of olive leaves phenolic compounds against neurodegenerative disorders: Promising alternative for Alzheimer and Parkinson diseases modulation

Author:
Fatma Hadrich; Mohamed Chamkha; Sami Sayadi
Source:
Food and chemical toxicology 2022 v.159 pp. 112752
ISSN:
0278-6915
Subject:
Olea europaea; antioxidants; apigenin; dietary supplements; luteolin; olives; toxicology
Abstract:
... The main objective of this work was to review literature on compounds extracted from olive tree leaves, such as simple phenols (hydroxytyrosol) and flavonoids (Apigenin, apigenin-7-O-glucoside, luteolin.) and their diverse pharmacological activities as antioxidant, antimicrobial, anti-viral, anti-obesity, anti-inflammatory and neuroprotective properties. In addition, the study discussed the key me ...
DOI:
10.1016/j.fct.2021.112752

33. Protective effects of rivaroxaban against cisplatin-induced testicular damage in rats: Impact on oxidative stress, coagulation, and p–NF–κB/VCAM-1 signaling

Author:
Sara I. Shafiey; Ali A. Abo-Saif; Amira M. Abo-Youssef; Wafaa R. Mohamed
Source:
Food and chemical toxicology 2022 v.169 pp. 113419
ISSN:
0278-6915
Subject:
17-beta-hydroxysteroid dehydrogenase; Western blotting; antioxidants; blood serum; cell adhesion; cisplatin; coagulation; gene expression; histopathology; immunohistochemistry; inflammation; necrosis; neoplasms; oxidative stress; pathogenesis; spermatozoa; steroidogenesis; steroidogenic acute regulatory protein; testes; testosterone; toxicology; vascular cell adhesion molecules
Abstract:
... Coagulation is a main pathway in various diseases pathogenesis including testicular damage. This study evaluated rivaroxaban (RVX) protective effects in testicular impairment by cisplatin (CP). Rats were randomly allocated into five groups: Control, RVX (7 mg/kg/day), CP (10 mg/kg), RVX 5 mg + CP and RVX 7 mg + CP. Serum testosterone and testicular ALT, AST, and ALP were assessed. Testicular oxida ...
DOI:
10.1016/j.fct.2022.113419

34. Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis

Author:
Li Chen; Jingjing Liu; Guibin Mei; Huimin Chen; Shufen Peng; Ying Zhao; Ping Yao; Yuhan Tang
Source:
Food and chemical toxicology 2021 v.154 pp. 112314
ISSN:
0278-6915
Subject:
animals; antioxidants; bile acids; bioinformatics; databases; fatty acid metabolism; fatty liver; gene expression; hepatitis; hepatoprotective effect; intestinal microorganisms; polyphenols; quercetin; toxicology
Abstract:
... Quercetin, a polyphenol widely present in the plant kingdom, has received great interest due to pleiotropic effects. As evidenced by animal and cellular studies, quercetin exerts hepatoprotection against non-alcoholic fatty liver disease (NAFLD), particularly in hepatic steatosis and hepatitis. Mechanically, various hypotheses of such protective effects have been actively proposed, including impro ...
DOI:
10.1016/j.fct.2021.112314

35. Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

Author:
Samy E. Elshaer; Gamal M. Hamad; Elsayed E. Hafez; Hoda H. Baghdadi; Fatma M. El-Demerdash; Jesus Simal-Gandara
Source:
Food and chemical toxicology 2022 v.166 pp. 113225
ISSN:
0278-6915
Subject:
Saussurea costus; adults; antioxidant activity; antioxidants; biomarkers; decapitation; ethanol; flavonoids; food additives; food industry; histopathology; kidneys; lipid composition; liver; males; meat; methanol; oral administration; rats; renal function; sensory evaluation; sodium nitrite; toxicity; toxicology
Abstract:
... The goal of this study was to investigate the effects of three different extracts of Saussurea costus roots (ethanol, methanol, and water) as a food additive in alleviating the harmful effect of sodium nitrite in rat meals. Thirty-five adult male rats were divided into five groups as follows: control, sodium nitrite (NaNO₂; 75 mg/kg BW, single oral dose), S. costus 70% ethanol, 70% methanol, and a ...
DOI:
10.1016/j.fct.2022.113225

36. Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway

Author:
Junlin Ge; Rili Hao; Xue Rong; Q. Ping Dou; Xintong Tan; Guannan Li; Feng Li; Dapeng Li
Source:
Food and chemical toxicology 2022 v.159 pp. 112733
ISSN:
0278-6915
Subject:
alanine transaminase; alkaline phosphatase; antioxidants; apoptosis; aspartate transaminase; blood serum; body weight; creatinine; inflammation; linseed; liver; males; mitogen-activated protein kinase; nephrotoxicity; oxidative stress; toxicology; urea nitrogen
Abstract:
... Benzo[a]pyrene (BaP) can cause hepatorenal toxicity. Secoisolariciresinol diglucoside (SDG), a polyphenolic compound present in flaxseed, has shown a variety of biological activities including antioxidant, anti-inflammatory, anti-apoptotic effects. This study aimed to investigate the protective effects and working mechanisms of SDG against BaP-induced hepatorenal injury. Forty male mice were admin ...
DOI:
10.1016/j.fct.2021.112733

37. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects

Author:
Arti Nile; Shivraj Hariram Nile; Carlos L. Cespedes-Acuña; Jae-Wook Oh
Source:
Food and chemical toxicology 2021 v.154 pp. 112327
ISSN:
0278-6915
Subject:
B-cell lymphoma; agonists; antineoplastic activity; antioxidants; apoptosis; cell growth; cyclin-dependent kinase; death; ethanol; genes; methanol; onions; quercetin; reversed-phase high performance liquid chromatography; solvents; toxicology; wastes
Abstract:
... Red onion skin waste (ROSW) was analyzed for extraction of naturally occurring 4′-O-glucoside of quercetin, spiraeoside (SPI) with promising biological activities. Reversed-phase high-performance liquid chromatography was used to determine the SPI content in three different solvent extracts of ROSW: water (12.2 mg/g), methanol (27.6 mg/g), and ethanol (32.5 mg/g). The ethanol extract and SPI showe ...
DOI:
10.1016/j.fct.2021.112327

38. Strategies to reduce sodium levels in European seabass sausages

Author:
Anabel Estévez; Carolina Camacho; Tatiana Correia; Vera Barbosa; António Marques; Helena Lourenço; Carmo Serrano; Margarida Sapata; Maria Paula Duarte; Carla Pires; Amparo Gonçalves; Maria Leonor Nunes; Helena Oliveira
Source:
Food and chemical toxicology 2021 v.153 pp. 112262
ISSN:
0278-6915
Subject:
Dicentrarchus labrax; antioxidants; hardness; ingestion; oleoresins; processed seafood; protective effect; saltiness; sodium; sodium chloride; texture; toxicology
Abstract:
... Considering the increasing demand towards “ready-to-cook” processed seafood products, recognised as being potential contributors to high sodium (Na) intake by consumers, this study aimed to assess the effect of sodium chloride (NaCl) reduction on physicochemical, microbiological and sensory properties of European seabass (Dicentrarchus labrax) sausages stored in chilling conditions during 5 weeks. ...
DOI:
10.1016/j.fct.2021.112262

39. Study of enzymatic activity in human neuroblastoma cells SH-SY5Y exposed to zearalenone's derivates and beauvericin

Author:
Fojan Agahi; Ana Juan-García; Guillermina Font; Cristina Juan
Source:
Food and chemical toxicology 2021 v.152 pp. 112227
ISSN:
0278-6915
Subject:
Fusarium; antioxidants; catalase; cell lines; cytotoxicity; enzyme activity; glutathione peroxidase; glutathione transferase; humans; neurotoxicity; oxidative stress; superoxide dismutase; toxicology; zearalenone
Abstract:
... Beauvericin (BEA), α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL), are produced by several Fusarium species that contaminate cereal grains. These mycotoxins can cause cytotoxicity and neurotoxicity in various cell lines and they are also capable of produce oxidative stress at molecular level. However, mammalian cells are equipped with a protective endogenous antioxidant system formed by no-enzymati ...
DOI:
10.1016/j.fct.2021.112227

40. Tanacetum vulgare L. (Tansy) as an effective bioresource with promising pharmacological effects from natural arsenal

Author:
Gunes Ak; Reneta Gevrenova; Kouadio Ibrahime Sinan; Gokhan Zengin; Dimitrina Zheleva; Mohamad Fawzi Mahomoodally; Ismail Senkardes; Luigi Brunetti; Sheila Leone; Simonetta Cristina Di Simone; Lucia Recinella; Annalisa Chiavaroli; Luigi Menghini; Giustino Orlando; Claudio Ferrante
Source:
Food and chemical toxicology 2021 v.153 pp. 112268
ISSN:
0278-6915
Subject:
Tanacetum vulgare; amylases; antioxidants; biocompatibility; bioinformatics; cell lines; cholinesterase; cosmetics; cytotoxicity; dietary supplements; enzyme inhibition; flavonoids; gene expression; health promotion; hexane; multivariate analysis; norepinephrine; raw materials; terpenoids; toxicology; traditional medicine; viability
Abstract:
... The Tanacetum genus is a big treasure with the presence of biologically-active compounds and members of this genus are widely used for the treatment of several diseases in traditional medicine system. Considering this fact, we aimed to analyze the extracts from Tanacetum vulgare L. in case of chemical profiles and biological effects. Chemical characterization was performed by using UHPLC-HRMS tech ...
DOI:
10.1016/j.fct.2021.112268

41. Ultrasensitive electrochemical sensor for detection of rutin antioxidant by layered Ti3Al0.5Cu0.5C2 MAX phase

Author:
Ahmet Şenocak; Vildan Sanko; Süreyya Oğuz Tümay; Yasin Orooji; Erhan Demirbas; Yeojoon Yoon; Alireza Khataee
Source:
Food and chemical toxicology 2022 v.164 pp. 113016
ISSN:
0278-6915
Subject:
X-ray diffraction; X-ray photoelectron spectroscopy; agricultural land; antioxidants; detection limit; electrical conductivity; electrochemistry; glassy carbon electrode; heat tolerance; high performance liquid chromatography; reflectance spectroscopy; rutin; sensors (equipment); thermogravimetry; toxicology; transmission electron microscopy; voltammetry
Abstract:
... MAX phases have attracted great attention due to unique features such as thermal and electrical conductivity, easy fabrication, heat resistant, and lightweight. In this study, an easy and green method was employed to successfully develop a Ti₃Al₀.₅Cu₀.₅C₂ MAX phase structure, and a Ti₃Al₀.₅Cu₀.₅C₂ based glassy carbon electrode (GCE) was applied for the electrochemical determination of rutin antiox ...
DOI:
10.1016/j.fct.2022.113016

42. A review on nanomaterial-based electrochemical sensors for determination of vanillin in food samples

Author:
Omid Moradi
Source:
Food and chemical toxicology 2022 v.168 pp. 113391
ISSN:
0278-6915
Subject:
antidepressants; antioxidants; carbon nanofibers; carbon nanotubes; carbon nitride; catalytic activity; chocolate; cost effectiveness; custards; electrochemistry; food safety; graphene; human health; nanocomposites; nanoparticles; odors; oxidation; puddings; toxicology; vanillin
Abstract:
... Vanillin is an organic compound that not only acts as a flavoring and fragrance enhancer in some foods, but also can have antioxidant, anti-inflammatory, anti-cancer and anti-depressant effects. Nevertheless, its excessive use can be associated with side effects on human health. Consequently, there is a need to achieve a rapid vanillin determination approach to enhance food safety. The diversity a ...
DOI:
10.1016/j.fct.2022.113391

43. 6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice

Author:
Ebenezer O. Farombi; Babajide O. Ajayi; Isaac A. Adedara
Source:
Food and chemical toxicology 2020 v.142 pp. 111483
ISSN:
0278-6915
Subject:
angiogenesis; angiopoietin-1; antioxidants; apoptosis; carcinogenesis; chemoprevention; colon; colorectal neoplasms; corn oil; cyclins; dextran; ginger; sodium; sulfates; toxicology; wnt proteins
Abstract:
... Colorectal cancer (CRC) has been linked to dietary consumption of benzo[a]pyrene (B[a]P). 6-Gingerol (6-G), a component of ginger has been reported to possess anti-inflammatory and antioxidant activities, but little is known regarding the mechanism of 6-G in CRC chemoprevention. We therefore investigated the effect of 6-G on B[a]P. and dextran sulphate sodium (DSS) induced CRC in mice. Mice in Gro ...
DOI:
10.1016/j.fct.2020.111483

44. Amelioration of butylated hydroxytoluene against inorganic mercury induced cytotoxicity and mitochondrial apoptosis in PC12 cells via antioxidant effects

Author:
Kaniz Fatima Binte Hossain; Toshiyuki Hosokawa; Takeshi Saito; Masaaki Kurasaki
Source:
Food and chemical toxicology 2020 v.146 pp. 111819
ISSN:
0278-6915
Subject:
DNA fragmentation; antioxidants; apoptosis; butylated hydroxytoluene; caspase-3; cell viability; cytotoxicity; food additives; glutathione; humans; mercury; mitochondria; mitogen-activated protein kinase; oxidative stress; therapeutics; toxicology
Abstract:
... Mercury (Hg) is a toxic metal, well-known for its dangerous health effects on human. Butylated hydroxytoluene (BHT) is a phenolic component generally consumed as a food additive as an antioxidant. However, BHT induced antioxidant properties against heavy metals-influenced toxicity are little studied. We hypothesized that BHT has a regulatory effect on Hg-induced cytotoxicity. The objective of this ...
DOI:
10.1016/j.fct.2020.111819

45. Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss

Author:
Fabiola Paciello; Antonella Di Pino; Rolando Rolesi; Diana Troiani; Gaetano Paludetti; Claudio Grassi; Anna Rita Fetoni
Source:
Food and chemical toxicology 2020 v.143 pp. 111555
ISSN:
0278-6915
Subject:
antioxidants; brain stem; caffeic acid; cell death; fluorescent antibody technique; models; noise pollution; oxidative stress; polyphenols; therapeutics; toxicology
Abstract:
... The imbalance of cellular redox status, in conjunction with the activation of inflammatory processes, have been considered common predominant mechanisms of noise-induced hearing loss. The identification of novel natural products as potential therapeuticstargeting oxidative stress and inflammatory pathways is an emerging field. Here, we focused on the polyphenol caffeic acid (CA), the major represe ...
DOI:
10.1016/j.fct.2020.111555

46. Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications

Author:
Seyede Nazanin Zarneshan; Sajad Fakhri; Mohammad Hosein Farzaei; Haroon Khan; Luciano Saso
Source:
Food and chemical toxicology 2020 v.145 pp. 111714
ISSN:
0278-6915
Subject:
antioxidants; apoptosis; astaxanthin; diabetes mellitus; liver failure; oxidative stress; pathogenesis; phosphatidylinositol 3-kinase; therapeutics; toxicology
Abstract:
... The complex pathophysiological mechanisms behind destructive chronic conditions, including cancer, neurodegenerative diseases, diabetes mellitus, cardiovascular diseases, and hepatic failure urge the need for finding related pivotal dysregulated signaling mediators, as well as multi-target therapeutic agents. In the current study, critical roles of phosphoinositide 3-kinase (PI3K)/protein kinase B ...
DOI:
10.1016/j.fct.2020.111714

47. Attenuation of arsenic induced high fat diet exacerbated oxidative stress mediated hepatic and cardiac injuries in male Wistar rats by piperine involved antioxidative mechanisms

Author:
Tiyasa Dey; Auroma Ghosh; Sanatan Mishra; Palash Kumar Pal; Aindrila Chattopadhyay; Sanjib K. Pattari; Debasish Bandyopadhyay
Source:
Food and chemical toxicology 2020 v.142 pp. 111477
ISSN:
0278-6915
Subject:
DNA damage; antioxidant activity; antioxidants; arsenic; biomarkers; cytokines; electron transport chain; free radicals; heart; high fat diet; histopathology; lipid metabolism; liver; males; membrane potential; mitochondrial DNA; mitochondrial membrane; oral administration; oxidative stress; rats; toxicology
Abstract:
... The current study explored the efficacy of piperine in attenuating arsenic induced high fat diet aggravated oxidative stress mediated injury in hepatic and cardiac tissues of male Wistar rats. Oral administration of piperine significantly (p < 0.05) reduced the levels of organ specific and oxidative stress biomarkers in arsenic and high fat diet treated rat hepatic and cardiac tissues in a dose de ...
DOI:
10.1016/j.fct.2020.111477

48. Beneficial effects of Ajuga chamaepitys (L.) Schreber subsp. chia (Schreber) and its iridoids on the colitis model: Histopathological and biochemical evidence

Author:
Esra Küpeli Akkol; Mert Ilhan; Büşra Karpuz; Hakkı Taştan; Eduardo Sobarzo-Sánchez; Haroon Khan
Source:
Food and chemical toxicology 2020 v.144 pp. 111589
ISSN:
0278-6915
Subject:
Ajuga; Salvia hispanica; antioxidants; butanol; caspase-3; chromatography; diarrhea; ethyl acetate; hexane; histopathology; interleukin-6; iridoids; methanol; methylene chloride; models; myeloperoxidase; rats; therapeutics; toxicology; traditional medicine; ulcerative colitis
Abstract:
... In Turkish folk medicine, aerial parts of Ajuga chamaepitys (L.) Schreber subsp. chia (Schreber) are used for the treatment of diarrhea. The crude methanolic extract of aerial parts of A. chamaepitys subsp. chia was sequentially fractionated into five subextracts; n-hexane, dichloromethane, ethyl acetate, n-butanol and aqueous extracts. Effects of the methanol extract, subextracts and fractions we ...
DOI:
10.1016/j.fct.2020.111589

49. Bergamot essential oil attenuate aluminum-induced anxiety-like behavior through antioxidation, anti-inflammatory and GABA regulation in rats

Author:
Yonghua Cui; Yi Che; Hongxin Wang
Source:
Food and chemical toxicology 2020 v.145 pp. 111766
ISSN:
0278-6915
Subject:
aluminum; aluminum chloride; antioxidants; anxiety; catalase; elevated plus-maze test; essential oils; frontal lobe; glutathione peroxidase; hippocampus; humans; interleukin-1beta; interleukin-6; malondialdehyde; neurotoxicity; oxidative stress; plant extracts; raw fruit; superoxide dismutase; toxicology; tumor necrosis factor-alpha
Abstract:
... A large number of studies showed that aluminum (Al) has potential neurotoxicity to human and animal bodies. Al-treated animals showed anxiety-like behavior, oxidative stress, neuroinflammation and γ-aminobutyric acid (GABA) changes. Bergamot essential oil (BEO) is a kind of well-known plant extract from the fresh fruit of bergamot. Previous studies suggested that BEO improved mood and relieved sym ...
DOI:
10.1016/j.fct.2020.111766

50. Betulinic acid modulates urethane-induced genotoxicity and mutagenicity in mice and Drosophila melanogaster

Author:
Victor Constante Oliveira; Maria Paula Carvalho Naves; Cássio Resende de Morais; Sarah Alves Rodrigues Constante; Priscila Capelari Orsolin; Bianca Silva Alves; Francisco Rinaldi Neto; Lucas Henrique Domingos da Silva; Lucas Teixeira Souza de Oliveira; Natália Helen Ferreira; Tábata Rodrigues Esperandim; Wilson Roberto Cunha; Denise Crispim Tavares; Mário Antônio Spanó
Source:
Food and chemical toxicology 2020 v.138 pp. 111228
ISSN:
0278-6915
Subject:
Drosophila melanogaster; alanine transaminase; antioxidants; apoptosis; aspartate transaminase; betulinic acid; bone marrow cells; creatinine; crossing; cytotoxicity; genotoxicity; hepatotoxicity; liver; mice; micronucleus tests; mutagenicity; mutagens; mutants; nephrotoxicity; somatic cells; somatic mutation; urea; urethane
Abstract:
... Betulinic acid (BA) is a pentacyclic triterpenoid found in several plant species. Urethane (URE) is a known promutagen. Here, we examine the genotoxicity and mutagenicity of BA alone or in combination with URE using the bone marrow micronucleus assay in mice bone marrow cells and the Somatic Mutation and Recombination Test in Drosophila melanogaster. Findings revealed that BA alone was not genotox ...
DOI:
10.1016/j.fct.2020.111228