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You searched for: Journal name Food and chemical toxicology Remove constraint Journal name: Food and chemical toxicology Subject term antioxidants Remove constraint Subject term: antioxidants Subject term antioxidant activity Remove constraint Subject term: antioxidant activity Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. (-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats

Author:
Medola, J.F.; Cintra, V.P.; Silva, E.P.P. e; Royo, V. de A.; Silva, R. da; Saraiva, J.; Albuquerque, S.; Bastos, J.K.; Silva, M.L.A. e; Tavares, D.C.
Source:
Food and chemical toxicology 2007 v.45 no.4 pp. 638-642
ISSN:
0278-6915
Subject:
Piper cubeba; reticulocytes; seed extracts; DNA damage; seeds; antimutagenic activity; hydrogen peroxide; essential oils; chromosome aberrations; lignans; DNA repair; animal models; genotoxicity; antioxidant activity; drying; rats
DOI:
10.1016/j.fct.2006.10.012
PubMed:
17141387

2. Acetylcholinesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp. caucasicus var. caucasicus, Echinacea purpurea and E. pallida

Author:
Orhan, I.; Şenol, F.S.; Gülpinar, A.R.; Kartal, M.; Şekeroglu, N.; Deveci, M.; Kan, Y.; Şener, B.
Source:
Food and chemical toxicology 2009 v.47 no.6 pp. 1304-1310
ISSN:
0278-6915
Subject:
spectrophotometers; acetylcholinesterase; Thymus (Lamiaceae); Echinacea pallida; plant extracts; flowers; essential oils; free radical scavengers; enzyme inhibitors; indigenous species; Echinacea purpurea; antioxidant activity; enzyme inhibition; leaves; Turkey (country)
DOI:
10.1016/j.fct.2009.03.004
PubMed:
19285534

3. Activation of pCREB/Nrf-2 signaling mediates re-positioning of liraglutide as hepato-protective for methotrexate -induced liver injury (MILI)

Author:
Aya I. Abdelaziz; Eman M. Mantawy; Amany M. Gad; Hala M. Fawzy; Samar S. Azab
Source:
Food and chemical toxicology 2019 v.132 pp. 110719
ISSN:
0278-6915
Subject:
agonists; antioxidant activity; antioxidants; apoptosis; autoimmune diseases; caspase-3; cyclic AMP; glucagon-like peptide 1; hepatocytes; hepatotoxicity; inflammation; interleukin-6; liver; methotrexate; neoplasms; oxidative stress; protective effect; rats; toxicology; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Methotrexate (MTX) is commonly used to treat several types of cancer and autoimmune diseases. However, there is increasing concern over its organs toxicities particularly liver toxicity. Liraglutide, a glucagon like peptide-1 agonist, possesses antioxidant and anti-inflammatory features. This study aimed to explore the potential protective effect of liraglutide pre-treatment in ameliorating MTX-in ...
DOI:
10.1016/j.fct.2019.110719

4. Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation

Author:
Cirico, T.L.; Omaye, S.T.
Source:
Food and chemical toxicology 2006 v.44 no.4 pp. 510-516
ISSN:
0278-6915
Subject:
vegetables; blood lipids; copper; lipid peroxidation; low density lipoprotein; antioxidants; hesperidin; antioxidant activity; oxidation; synergism; catechin; ferulic acid; quercetin; thiobarbituric acid-reactive substances
DOI:
10.1016/j.fct.2005.08.025
PubMed:
16216401

5. Alleviative effects of s-allyl cysteine and s-ethyl cysteine on MCD diet-induced hepatotoxicity in mice

Author:
Lin, Chun-Che; Yin, Mei-Chin; Liu, Wen-hu
Source:
Food and chemical toxicology 2008 v.46 no.11 pp. 3401-3406
ISSN:
0278-6915
Subject:
choline; nutrition-genotype interaction; protein deficiencies; metalloproteinases; acetyl coenzyme A; dietary exposure; glutathione; malondialdehyde; cysteine; hepatoprotective effect; NADP-glucose-6-phosphate dehydrogenase; superoxide dismutase; garlic; triacylglycerols; mice; tumor necrosis factor-alpha; allyl sulfur compounds; antioxidant activity; free radicals; interleukin-6; cholesterol; free radical scavengers; glutathione peroxidase; animal models; methionine; fatty-acid synthase; hepatotoxicity
DOI:
10.1016/j.fct.2008.08.010
PubMed:
18786595

6. Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects

Author:
Xin Wang; Yang Yu; Lin Ji; Xin Liang; Tao Zhang; Chun-Xu Hai
Source:
Food and chemical toxicology 2011 v.49 no.11 pp. 2750-2757
ISSN:
0278-6915
Subject:
anti-inflammatory activity; lipoic acid; myocardial ischemia; oxidative stress; reactive oxygen species; inflammation; creatine kinase; toxicology; rats; antioxidant activity; apoptosis; protective effect
Abstract:
... Myocardial ischemia/reperfusion (MI/R) is a major cause for the events of cardiovascular disease. Oxidative stress plays a critical role in the development of ischemia/reperfusion (IR) injury. As a potent antioxidant, alpha-lipoic acid (LA) has been shown to provide a benefit for the inhibition of IR injury and inhibit reactive oxygen species (ROS) generation during MI/R in rats. However, the mech ...
DOI:
10.1016/j.fct.2011.07.065

7. Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice

Author:
Diana Rocio Herrera-Aco; Omar Noel Medina-Campos; José Pedraza-Chaverri; Edda Sciutto-Conde; Gabriela Rosas-Salgado; Gladis Fragoso-González
Source:
Food and chemical toxicology 2019 v.124 pp. 300-315
ISSN:
0278-6915
Subject:
xanthone; lipid peroxidation; oral administration; immunoglobulin G; glutathione; dendritic cells; lymphocytes; toxicology; apoptosis; NAD(P)H oxidase (H2O2-forming); blood serum; histology; mice; enzyme activity; antioxidant activity; histopathology; adverse effects; autoantibodies; antioxidants; rheumatoid arthritis; interleukin-6; new drugs
Abstract:
... Rheumatoid arthritis (RA) is an autoimmune disease that causes physical disability in people worldwide. Despite progress made in RA treatment in the past decade, new drugs with high efficacy but few long-term adverse effects are still needed.This study focused on evaluating the therapeutic potential of α-mangostin on established collagen-induced arthritis (CIA) in DBA/1J mice. Arthritic DBA/1J mic ...
DOI:
10.1016/j.fct.2018.12.018

8. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs

Author:
El-Demerdash, Fatma M.; Yousef, Mokhtar I.; Radwan, Fatma M.E.
Source:
Food and chemical toxicology 2009 v.47 no.1 pp. 249-254
ISSN:
0278-6915
Subject:
lipid peroxidation; essential oils; plant extracts; lungs; oxidative stress; sodium arsenite; tissue repair; glutathione transferase; brain; antinutritional factors; testes; turmeric; superoxide dismutase; sulfhydryl groups; rats; curcumin; antioxidant activity; antioxidants; thiobarbituric acid-reactive substances; catalase; animal models; nephrotoxicity; hepatotoxicity
DOI:
10.1016/j.fct.2008.11.013
PubMed:
19049818

9. Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice

Author:
Mahsa Zarei; T. Shivanandappa
Source:
Food and chemical toxicology 2013 v.57 pp. 179-184
ISSN:
0278-6915
Subject:
aspartate transaminase; drug therapy; reactive oxygen species; lipid peroxidation; genes; roots; oxidative stress; glutathione; alanine transaminase; glutathione transferase; alanine; toxicology; lactate dehydrogenase; gene expression regulation; blood serum; superoxide dismutase; mice; antioxidant activity; liver; glutathione-disulfide reductase; catalase; glutathione peroxidase; cyclophosphamide; alkaline phosphatase; hepatotoxicity
Abstract:
... Hepatoprotective potential of the aqueous extract of the roots of Decalepis hamiltonii (DHA) against cyclophosphamide (CP)-induced oxidative stress has been investigated in mice. Administration of CP (25mg/kg b.w., i.p) for 10days induced hepatic damage as indicated by the serum marker enzymes aspartate and alanine transaminases (AST, ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH ...
DOI:
10.1016/j.fct.2013.03.028

10. Ameliorative effect of Cyclocarya paliurus polysaccharides against carbon tetrachloride induced oxidative stress in liver and kidney of mice

Author:
Ting Wu; Mingyue Shen; Shihua Liu; Qiang Yu; Yi Chen; Jianhua Xie
Source:
Food and chemical toxicology 2020 v.135 pp. 111014
ISSN:
0278-6915
Subject:
Cyclocarya paliurus; adverse effects; alanine transaminase; animal models; antioxidant activity; antioxidants; aspartate transaminase; blood serum; body weight changes; carbon tetrachloride; glutathione peroxidase; histopathology; kidneys; liver; medicine; mice; oxidative stress; polysaccharides; superoxide dismutase; therapeutics
Abstract:
... Chemical liver and kidney injury have become a serious concern to human. Side effects occur when they are treated with medicine. The present study evaluated the preventive effect of Cyclocarya paliurus polysaccharides (CP) on hepatic and renal injury in carbon tetrachloride (CCl₄) induced mice. The results showed that CP treatment could effectively prevent H₂O₂-induced oxidative damage of NCTC-146 ...
DOI:
10.1016/j.fct.2019.111014

11. Analysis of urinary andrographolides and antioxidant status after oral administration of Andrographis paniculata leaf extract in rats

Author:
Akowuah, G.A.; Zhari, I.; Mariam, A.
Source:
Food and chemical toxicology 2008 v.46 no.12 pp. 3616-3620
ISSN:
0278-6915
Subject:
urine; Andrographis paniculata; malondialdehyde; chemical constituents of plants; medicinal plants; plant extracts; free radical scavengers; leaves; animal models; indigenous species; reversed-phase high performance liquid chromatography; rats; antioxidant activity; oral administration; Oriental traditional medicine; Asia
DOI:
10.1016/j.fct.2008.09.008
PubMed:
18824206

12. Anti-apoptotic activity of hydroxytyrosol and hydroxytyrosyl laurate

Author:
Sabrina Burattini; Sara Salucci; Valentina Baldassarri; Augusto Accorsi; Elena Piatti; Andres Madrona; Josè L. Espartero; Manila Candiracci; Giovanni Zappia; Elisabetta Falcieri
Source:
Food and chemical toxicology 2013 v.55 pp. 248-256
ISSN:
0278-6915
Subject:
neoplasm cells; metabolites; myoblasts; cell viability; hydrogen peroxide; toxicology; transmission electron microscopy; apoptosis; human diseases; humans; muscles; olive oil; wastewater; models; mice; antioxidant activity; olives; cardiovascular system; anti-infective properties; cell cycle; researchers
Abstract:
... Hydroxytyrosol (HyT) is a polyphenol primarily released in olive mill wastewater and in olive oil. In animal and cell model studies, HyT and its metabolites have strong antioxidant and antimicrobial activities, as well as beneficial effects on the cardiovascular system and in several human diseases. Differently, many researchers reported that HyT down-regulates tumor cell viability and cell cycle ...
DOI:
10.1016/j.fct.2012.12.049

13. Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model

Author:
Guan-Jhong Huang; Chun-Hsu Pan; Fon-Chang Liu; Tian-Shung Wu; Chieh-Hsi Wu
Source:
Food and chemical toxicology 2012 v.50 no.5 pp. 1485-1493
ISSN:
0278-6915
Subject:
Antrodia; anti-inflammatory activity; antioxidant activity; antioxidants; carrageenan; cell growth; edema; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; malondialdehyde; models; neutrophils; nitric oxide; prostaglandin synthase; proteins; tissues; toxicology; tumor necrosis factor-alpha
Abstract:
... The purpose of this study was to examine anti-inflammatory effect of ethanolic extract of Antrodia salmonea (EAS) in the lipopolysaccharide (LPS)-stimulated RAW246.7 macrophages and the carrageenan (Carr)-induced edema paw model, and to clarify its possible molecular mechanisms. Inhibitory effects of EAS were examined on cells proliferation, nitric oxide (NO) production, expression of inducible ni ...
DOI:
10.1016/j.fct.2012.01.041

14. Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models

Author:
Ramzi A.A. Mothana
Source:
Food and chemical toxicology 2011 v.49 no.10 pp. 2594-2599
ISSN:
0278-6915
Subject:
Boswellia elongata; Jatropha; acetic acid; anti-inflammatory activity; antioxidant activity; antioxidants; cotton; edema; granuloma; mice; models; rats; toxicology
Abstract:
... In the present study, the two endemic Soqotraen plants Boswellia elongata and Jatropha unicostata were investigated for their anti-inflammatory, antinociceptive and antioxidant potential. To assess the anti-inflammatory and antinociceptive activities, two concentrations of each extract (200 and 400mg/kg, p.o.) were tested in carrageenan-induced rat paw edema, cotton pellet granuloma in rats, aceti ...
DOI:
10.1016/j.fct.2011.06.079

15. Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

Author:
So Hyung Hong; Ki Tae Suk; Sang Hyeon Choi; Jung Wook Lee; Ho Taik Sung; Chang Hoon Kim; Eun Ji Kim; Myoung Jo Kim; Sang Hak Han; Moon Young Kim; Soon Koo Baik; Dong Joon Kim; Gyoung-Ja Lee; Sang-kyu Lee; Seung Ha Park; Ohk Hyun Ryu
Source:
Food and chemical toxicology 2013 v.55 pp. 586-591
ISSN:
0278-6915
Subject:
Panax ginseng; Toxicodendron vernicifluum; antioxidant activity; antioxidants; blood serum; diet; fatty liver; high density lipoprotein cholesterol; inflammation; liver; liver function; neutrophils; rats; toxicology; triacylglycerols; ursodeoxycholic acid; Korean Peninsula
Abstract:
... Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10months; after this period. The OLETF rats were divided into the following four group ...
DOI:
10.1016/j.fct.2013.01.022

16. Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on d-Galactosamine induced hepatitis in rats

Author:
Sathivel, Arumugam; Raghavendran, Hanumantha Rao Balaji; Srinivasan, Periasamy; Devaki, Thiruvengadam
Source:
Food and chemical toxicology 2008 v.46 no.10 pp. 3262-3267
ISSN:
0278-6915
Subject:
Ulva; edible seaweed; crude fiber; structure-activity relationships; antioxidants; antioxidant activity; hypolipidemia; cholesteremic effect; rats; animal disease models; hepatitis; oxidative stress; galactosamine; hepatotoxicity; polysaccharides; cholesterol metabolism; low density lipoprotein; high density lipoprotein; phospholipids; free fatty acids; very low density lipoprotein; lipid peroxidation; glutathione; histopathology; tissue repair
DOI:
10.1016/j.fct.2008.07.016

17. Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.) leaf tea in diet-induced obese mice

Author:
Hae-In Lee; Mi-Su Kim; Kyung-Mi Lee; Seok-Kyu Park; Kwon-Il Seo; Hye-Jin Kim; Myung-Joo Kim; Myung-Sook Choi; Mi-Kyung Lee
Source:
Food and chemical toxicology 2011 v.49 no.9 pp. 2370-2376
ISSN:
0278-6915
Subject:
leptin; obesity; beta oxidation; dose response; alanine transaminase; toxicology; leaves; animal disease models; peroxides; tea; visceral fat; NADP-glucose-6-phosphate dehydrogenase; superoxide dismutase; triacylglycerols; mice; antioxidant activity; excretion; weight gain; erythrocytes; cholesterol; glutathione peroxidase; Hippophae rhamnoides
Abstract:
... The potential health benefits of tea have long been studied. This study examined the role of powdered sea buckthorn leaf tea (SLT) in high-fat diet-induced obese mice. The mice were fed two different doses of SLT (1% and 5%, wt/wt) for six weeks. SLT suppressed body weight gain in a dose-dependent manner and significantly reduced visceral fat, plasma levels of leptin, triglyceride and total choles ...
DOI:
10.1016/j.fct.2011.06.049

18. Antidiabetic activity of Diospyros peregrina fruit: Effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetes

Author:
Dewanjee, Saikat; Das, Anup K.; Sahu, Ranabir; Gangopadhyay, Moumita
Source:
Food and chemical toxicology 2009 v.47 no.10 pp. 2679-2685
ISSN:
0278-6915
Subject:
polyphenols; hyperlipidemia; lipid peroxidation; noninsulin-dependent diabetes mellitus; oxidative stress; glutathione; insulin resistance; pathogenesis; hyperglycemia; metabolic syndrome; nutritional intervention; phytochemicals; superoxide dismutase; glycemic effect; hypoglycemia; Diospyros; kidneys; antioxidant activity; hydroperoxides; thiobarbituric acid-reactive substances; glycemic control; liver; catalase; fruit extracts; streptozotocin
DOI:
10.1016/j.fct.2009.07.038
PubMed:
19660513

19. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Author:
Bagri, Priyanka; Ali, Mohd.; Aeri, Vidhu; Bhowmik, Malay; Sultana, Shahnaz
Source:
Food and chemical toxicology 2009 v.47 no.1 pp. 50-54
ISSN:
0278-6915
Subject:
pancreas; Punica granatum; lipid peroxidation; plant extracts; dietary supplements; fruit trees; cholesteremic effect; oxidative stress; glutathione; glutathione transferase; animal disease models; blood lipids; phytochemicals; superoxide dismutase; glycemic effect; blood glucose; rats; antioxidant activity; thiobarbituric acid-reactive substances; supercritical fluid extraction; glucose tolerance; glycemic control; high density lipoprotein; pomegranates; glutathione-disulfide reductase; very low density lipoprotein; flowers; streptozotocin; free radical scavengers; low density lipoprotein; glutathione peroxidase
DOI:
10.1016/j.fct.2008.09.058
PubMed:
18950673

20. Antigenotoxic effect of acute, subacute and chronic treatments with Amazonian camu–camu (Myrciaria dubia) juice on mice blood cells

Author:
Francisco Carlos da Silva; Andrelisse Arruda; Alexandre Ledel; Cíntia Dauth; Nathalia Faria Romão; Rafaele Nazário Viana; Alexandre de Barros Falcão Ferraz; Jaqueline Nascimento Picada; Patrícia Pereira
Source:
Food and chemical toxicology 2012 v.50 no.7 pp. 2275-2281
ISSN:
0278-6915
Subject:
nutrient content; juices; humans; hydrogen peroxide; Myrciaria dubia; mice; toxicology; blood cells; indigenous species; flavonoids; genotoxicity; antioxidant activity; metabolites; ascorbic acid; Amazonia
Abstract:
... Myrciaria dubia, a plant native to the Amazon region, stands out as a fruit rich in vitamin C and other metabolites with nutritional potential. We evaluated the antioxidant, genotoxic and antigenotoxic potential of M. dubia juice on blood cells of mice after acute, subacute and chronic treatments. Flavonoids and vitamin C present in the fruit of M. dubia were quantified. In vitro antioxidant activ ...
DOI:
10.1016/j.fct.2012.04.021