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- Author:
- Isabel Borrás-Linares; Almudena Pérez-Sánchez; Jesús Lozano-Sánchez; Enrique Barrajón-Catalán; David Arráez-Román; Alejandro Cifuentes; Vicente Micol; Antonio Segura Carretero
- Source:
- Food and chemical toxicology 2015 v.80 pp. 215-222
- ISSN:
- 0278-6915
- Subject:
- active ingredients; antineoplastic activity; betulinic acid; bioactive compounds; chromatography; colorectal neoplasms; cytotoxicity; diterpenoids; fractionation; humans; models; neoplasm cells; phenolic compounds; rosemary; synergism; toxicology; viability
- Abstract:
- ... Rosemary extracts have exhibited potential cytostatic or cytotoxic effects in several cancer cell models but their bioactive compounds are yet to be discovered. In this work, the anticancer activity of a rosemary-leaf extract and its fractions were assayed to identify the phenolic compounds responsible for their antiproliferative/cytotoxic effects on a panel of human colon cancer cell lines. Biogu ...
- DOI:
- 10.1016/j.fct.2015.03.013
- https://doi.org/10.1016/j.fct.2015.03.013
- Author:
- F.B. Luciano; G. Meca; L. Manyes; J. Mañes
- Source:
- Food and chemical toxicology 2014 v.64 pp. 270-274
- ISSN:
- 0278-6915
- Subject:
- Fusarium; barley; benzyl isothiocyanate; bioactive compounds; corn; crops; dose response; flour; fumigants; liquid chromatography; metabolism; mycotoxins; pH; phosphates; rice; seeds; toxicology; wheat
- Abstract:
- ... Beauvericin (BEA) is a bioactive compound produced by the secondary metabolism of several Fusarium strains with a strong antibacterial, antifungal, and insecticidal activities.This study evaluated the reduction of BEA added at 25mg/kg in phosphate buffer saline (PBS) solutions at pH of 4, 7 and 10, or to different cereal products (kernels and flours) by the bioactive compounds phenyl isothiocyanat ...
- DOI:
- 10.1016/j.fct.2013.11.021
- https://doi.org/10.1016/j.fct.2013.11.021
- Author:
- Young Hee Choi; Seung Yon Han; You-Jin Kim; Young-Mi Kim; Young-Won Chin
- Source:
- Food and chemical toxicology 2014 v.66 pp. 140-146
- ISSN:
- 0278-6915
- Subject:
- absorption; animal models; binding proteins; bioactive compounds; blood proteins; disease models; lethal concentration 50; mangosteens; mice; pharmacokinetics; tissue distribution
- Abstract:
- ... The commercially available herbal products as the form of extract were usually mixtures containing various compounds. In spite of the purported efficacy in each active constituent, the coexisting constituents in the herbal extract might interfere with the efficacy and safety and affect the pharmacokinetic properties of active constituents. To compare for the pharmacokinetic properties of α-mangost ...
- DOI:
- 10.1016/j.fct.2014.01.028
- https://doi.org/10.1016/j.fct.2014.01.028
- Author:
- Yongqiu Cai; Hooi Ren Lim; Kuan Shiong Khoo; Hui-Suan Ng; Yanxue Cai; Jihui Wang; Andy Tak-Yee Chan; Pau Loke Show
- Source:
- Food and chemical toxicology 2021 v.158 pp. 112607
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; biomass; biorefining; dietary supplements; functional foods; human health; immunomodulation; metabolites; microalgae; nanocapsules; solubility; therapeutics; toxicology; value added
- Abstract:
- ... Microalgae metabolites include biologically active compounds with therapeutic effects such as anticancer, anti-inflammatory and immunomodulation effects. One of the most recent focuses is on utilizing microalgae lipid-based biologically active compounds in food applications. However, most microalgae biological active compounds in their natural forms have common drawbacks like low solubility, low p ...
- DOI:
- 10.1016/j.fct.2021.112607
- https://doi.org/10.1016/j.fct.2021.112607
- Author:
- Alfonso Varela-López; Maurizio Battino; María D. Navarro-Hortal; Francesca Giampieri; Tamara Y. Forbes-Hernández; José M. Romero-Márquez; Ricardo Collado; José L. Quiles
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acids; autophagy; bioactive compounds; bone marrow; brain; calcium; cardiotoxicity; cell lines; clinical trials; dietary minerals; doxorubicin; drug therapy; homeostasis; kidneys; liver; mechanism of action; neoplasm cells; neoplasms; nutrients; omega-3 fatty acids; protective effect; selenium; testes; toxicity; vitamin A; vitamin E
- Abstract:
- ... Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated f ...
- DOI:
- 10.1016/j.fct.2019.110834
- https://doi.org/10.1016/j.fct.2019.110834
- Author:
- Tianmu He; Jingxian Liu; Xiaoning Wang; Cancan Duan; Xiaofei Li; Jianyong Zhang
- Source:
- Food and chemical toxicology 2020 v.146 pp. 111845
- ISSN:
- 0278-6915
- Subject:
- Mylabris; antineoplastic activity; apoptosis; bioactive compounds; biomarkers; cantharidin; caspase-3; metabolomics; nephrotoxicity; phosphatidylcholines; phosphatidylethanolamines; protein synthesis; sphingolipids; therapeutics; toxicology
- Abstract:
- ... Cantharidin (CTD) is the major bioactive compound in Mylabris and has been shown to exhibit antitumor activity. However, its clinical application is relatively limited due to its potential toxic effects, especially nephrotoxicity. In this study, a UHPLC-QE/MS based metabolomics approach combined with network pharmacology was used to investigate the mechanism of CTD-induced nephrotoxicity in HK-2 c ...
- DOI:
- 10.1016/j.fct.2020.111845
- https://doi.org/10.1016/j.fct.2020.111845
- Author:
- José M. Alvarez-Suarez; Estefanía Carrillo-Perdomo; Angel Aller; Francesca Giampieri; Massimiliano Gasparrini; Lien González-Pérez; Pablo Beltrán-Ayala; Maurizio Battino
- Source:
- Food and chemical toxicology 2017 v.102 pp. 46-52
- ISSN:
- 0278-6915
- Subject:
- Prunus serotina; anthocyanins; anti-inflammatory activity; antioxidant activity; ascorbic acid; beta-carotene; bioactive compounds; cherries; cytotoxicity; free radical scavengers; fruits; human health; interleukin-1beta; lipopolysaccharides; macrophages; messenger RNA; nitrites; protective effect; secretion; toxicology; tumor necrosis factor-alpha; Ecuador
- Abstract:
- ... Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be ...
- DOI:
- 10.1016/j.fct.2017.01.024
- https://doi.org/10.1016/j.fct.2017.01.024
- Author:
- Lei Chen; Xiujun Lin; Xiaowei Xu; Lihao Wang; Hui Teng; Hui Cao
- Source:
- Food and chemical toxicology 2020 v.135 pp. 110953
- ISSN:
- 0278-6915
- Subject:
- Sonchus oleraceus; animal disease models; anti-inflammatory activity; bioactive compounds; blood glucose; diabetes; gastrointestinal system; glycemic effect; insulin; interleukin-6; liver; medicinal plants; metformin; polyphenols; rats; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Edible Sonchus oleraceus Linn is a medicinal plant with many bioactivities such as anti-diabetic activity and anti-inflammatory activity. However, the main bioactive components such as polyphenols in S. oleraceus Linn are poorly absorbed in gastrointestinal tract and rapidly metabolized. Thereby, a self-emulsifying delivery system containing S. oleraceus Linn extracts (SSEDDS) was introduced to ev ...
- DOI:
- 10.1016/j.fct.2019.110953
- https://doi.org/10.1016/j.fct.2019.110953
- Author:
- Mabel Guevara; Eduardo Tejera; Gabriel A. Iturralde; Tatiana Jaramillo-Vivanco; María G. Granda-Albuja; Silvana Granja-Albuja; Celestino Santos-Buelga; Ana M. González-Paramás; José M. Álvarez-Suarez
- Source:
- Food and chemical toxicology 2019 v.131 pp. 110594
- ISSN:
- 0278-6915
- Subject:
- anti-inflammatory activity; antioxidants; ascorbic acid; bioactive compounds; carotenoids; chlorogenic acid; cytokines; cytotoxicity; enzymes; glycosides; heat treatment; macrophages; polyphenols; protective effect; quercetin; toxicology; Ecuador
- Abstract:
- ... The phytochemical composition and the antioxidant and anti-inflammatory activities of a mixture of 23 plants, named Horchata, traditionally consumed in Ecuador, have been evaluated. The study was carried out using the hydroalcoholic extract (HHext) and infusion (IHext) of the horchata plant mixture. It was verified that thermal treatment affected the contents of vitamin C and carotenoids, but hard ...
- DOI:
- 10.1016/j.fct.2019.110594
- https://doi.org/10.1016/j.fct.2019.110594
- Author:
- Daniela Ribeiro; Marisa Freitas; Artur M.S. Silva; Félix Carvalho; Eduarda Fernandes
- Source:
- Food and chemical toxicology 2018 v.120 pp. 681-699
- ISSN:
- 0278-6915
- Subject:
- antioxidants; bioactive compounds; carbonyl compounds; carotenoids; diet; humans; lipids; nitrogen; oxidation; oxidative stress; oxygen; plant pigments; toxicology
- Abstract:
- ... Carotenoids are lipid soluble plant pigments that make part of human daily diet. These compounds are able to react with diverse reactive species and originate a myriad of oxidation products that have similar or even more reactivity than their parent compounds. These products may be short-chain carbonyl compounds and, the commonly designated, apo-carotenoids. The effects fo these products in the hu ...
- DOI:
- 10.1016/j.fct.2018.07.060
- https://doi.org/10.1016/j.fct.2018.07.060
11. Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway
- Author:
- Yosuke Tabei; Kazutoshi Murotomi; Aya Umeno; Masanori Horie; Yoshio Tsujino; Bumbu Masutani; Yasukazu Yoshida; Yoshihiro Nakajima
- Source:
- Food and chemical toxicology 2017 v.107 pp. 129-137
- ISSN:
- 0278-6915
- Subject:
- DNA damage; antioxidant activity; bioactive compounds; catalase; cell death; cytotoxicity; fibroblasts; gene expression regulation; genes; glutathione; heme oxygenase (biliverdin-producing); hepatocytes; hydrogen peroxide; mice; oxidation; oxidative stress; signal transduction; superoxide dismutase; toxicology
- Abstract:
- ... 5-Hydroxy-4-phenyl-butenolide (5H4PB) is a bioactive compound with antifungal and anti-obesity properties. Although it has recently been shown that 5H4PB activates peroxisome proliferator-activated receptor-gamma (PPARγ), the effect of 5H4PB on intracellular signaling pathways has not been clarified. In this study, we found that 5H4PB activated the nuclear factor erythroid 2-related factor 2 (Nrf2 ...
- DOI:
- 10.1016/j.fct.2017.06.039
- https://doi.org/10.1016/j.fct.2017.06.039
- Author:
- Martha Rocío Moreno-Jimenez; Fátima Trujillo-Esquivel; Marco A. Gallegos-Corona; Rosalia Reynoso-Camacho; Rubén Francisco González-Laredo; José Alberto Gallegos-Infante; Nuria Elizabeth Rocha-Guzmán; Minerva Ramos-Gomez
- Source:
- Food and chemical toxicology 2015 v.80 pp. 144-153
- ISSN:
- 0278-6915
- Subject:
- 1,2-dimethylhydrazine; Quercus; adenocarcinoma; anti-inflammatory activity; anticarcinogenic activity; antioxidants; bioactive compounds; body weight; carcinogenesis; chemoprevention; colon; interleukin-8; leaves; males; rats; toxicology; transcription factor NF-kappa B; Mexico
- Abstract:
- ... Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis ...
- DOI:
- 10.1016/j.fct.2015.03.011
- https://doi.org/10.1016/j.fct.2015.03.011
- Author:
- Fangfang Lang; Jinfeng Qu; Haiqin Yin; Lanyu Li; Yuanyuan Zhi; Yanping Liu; Zhenghui Fang; Enkui Hao
- Source:
- Food and chemical toxicology 2018 v.121 pp. 631-638
- ISSN:
- 0278-6915
- Subject:
- Angelica sinensis; animal ovaries; antioxidant activity; apoptosis; bioactive compounds; cell viability; dose response; epigenetics; flow cytometry; glutamate-cysteine ligase; humans; mitochondria; neoplasm cells; ovarian neoplasms; oxidative stress; quinones; small interfering RNA; toxicology; transferases; uridine diphosphate
- Abstract:
- ... Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress ...
- DOI:
- 10.1016/j.fct.2018.09.041
- https://doi.org/10.1016/j.fct.2018.09.041
- Author:
- Rosa Palmeri; Lucia Parafati; Cristina Restuccia; Biagio Fallico
- Source:
- Food and chemical toxicology 2018 v.118 pp. 355-360
- ISSN:
- 0278-6915
- Subject:
- Opuntia; antioxidant activity; bacteria; beef; bioactive compounds; cold storage; color; dipping; food preservation; food spoilage; fruit extracts; fruits; microbial growth; polyphenols; shelf life; storage time; texture; toxicology
- Abstract:
- ... The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content.The extract was then applied by dippi ...
- DOI:
- 10.1016/j.fct.2018.05.044
- https://doi.org/10.1016/j.fct.2018.05.044
- Author:
- Francesca Giampieri; José L. Quiles; Francisco J. Orantes-Bermejo; Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Cristina Sánchez-González; Juan Llopis; Lorenzo Rivas-García; Sadia Afrin; Alfonso Varela-López; Danila Cianciosi; Patricia Reboredo-Rodriguez; Cristina Torres Fernández-Piñar; Ruben Calderón Iglesias; Roberto Ruiz; Silvia Aparicio; Jorge Crespo; Luis Dzul Lopez; Jianbo Xiao; Maurizio Battino
- Source:
- Food and chemical toxicology 2018 v.112 pp. 126-133
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; beeswax; bioactive compounds; byproducts; carbohydrates; cytotoxicity; dose response; flavonoids; hepatoma; human cell lines; human health; in vivo studies; liver; mitochondria; polyphenols; recycling; viability
- Abstract:
- ... During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 ...
- DOI:
- 10.1016/j.fct.2017.12.041
- https://doi.org/10.1016/j.fct.2017.12.041
16. Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases
- Author:
- Hong Xin; Xiao-Yi Qi; Jing-Jing Wu; Xin-Xin Wang; Yan Li; James Y. Hong; Wei He; Wei Xu; Guang-Bo Ge; Ling Yang
- Source:
- Food and chemical toxicology 2016 v.90 pp. 112-122
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; herbal medicines; humans; inhibitory concentration 50; licorice; life cycle assessment; liver microsomes; risk
- Abstract:
- ... Licochalcone A (LCA) is a major bioactive compound in Licorice, a widely used herbal medicine. In this study, the inhibitory effects of LCA against human UDP-glucuronosyltransferases (UGTs) and LCA associated herb-drug interactions were systematically investigated. Our results demonstrated that LCA displayed broad-spectrum inhibition against human UGTs. LCA exhibited strong inhibitory effects agai ...
- DOI:
- 10.1016/j.fct.2016.02.007
- https://doi.org/10.1016/j.fct.2016.02.007
- Author:
- Kannan RR. Rengasamy; Mohamad Fawzi Mahomoodally; Muhammad Zakariyyah Aumeeruddy; Gokhan Zengin; Jianbo Xiao; Doo Hwan Kim
- Source:
- Food and chemical toxicology 2020 v.135 pp. 111013
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; drugs; enzyme activity; enzymes; etiology; foods; macroalgae; mechanism of action; medicinal properties; metabolites; noninfectious diseases; toxicity
- Abstract:
- ... Seaweeds are among the significant currently exploited marine plant resources which are gaining full applications in culinary, cosmetic, pharmaceutical, and biotechnological processes. Much attention has been devoted to seaweeds based on their proven health benefits and is considered as a rich source of structurally different bioactive metabolites for the discovery of novel functional food-based p ...
- DOI:
- 10.1016/j.fct.2019.111013
- https://doi.org/10.1016/j.fct.2019.111013
- Author:
- Gokhan Zengin; Gizem Bulut; Adriano Mollica; Mehmet Zeki Haznedaroglu; Ahmet Dogan; Abdurrahman Aktumsek
- Source:
- Food and chemical toxicology 2017 v.107 pp. 597-608
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Achillea; Bupleurum; amylases; antioxidant activity; bioactive compounds; carboxylic ester hydrolases; chlorogenic acid; ethyl acetate; free radical scavengers; health promotion; high performance liquid chromatography; ingredients; methanol; quercetin; rutin; screening; sinapic acid; solvents; toxicology
- Abstract:
- ... This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities we ...
- DOI:
- 10.1016/j.fct.2017.03.037
- https://doi.org/10.1016/j.fct.2017.03.037
- Author:
- Ammad Ahmad Farooqi; Sumbul Khalid; Fatima Tahir; Uteuliev Yerzhan Sabitaliyevich; Ilhan Yaylim; Rukset Attar; Baojun Xu
- Source:
- Food and chemical toxicology 2018 v.119 pp. 98-105
- ISSN:
- 0278-6915
- Subject:
- Momordica charantia; anti-inflammatory activity; antineoplastic activity; bioactive compounds; carcinogenesis; cell cycle; cell lines; drugs; health promotion; mice; neoplasm cells; neoplasms; precision medicine; regulatory proteins; signal transduction; toxicology
- Abstract:
- ... Research over decades has progressively explored pharmacological actions of bitter gourd (Momordica charantia). Biologically and pharmacologically active molecules isolated from M. charantia have shown significant anti-cancer activity in cancer cell lines and xenografted mice. In this review spotlight was set on the bioactive compounds isolated from M. charantia that effectively inhibited cancer d ...
- DOI:
- 10.1016/j.fct.2018.05.024
- https://doi.org/10.1016/j.fct.2018.05.024
- Author:
- Dorota Wrześniok; Zuzanna Rzepka; Michalina Respondek; Artur Beberok; Jakub Rok; Karolina Szczepanik; Ewa Buszman
- Source:
- Food and chemical toxicology 2018 v.120 pp. 566-570
- ISSN:
- 0278-6915
- Subject:
- apoptosis; beverages; bioactive compounds; caffeine; cell lines; cell viability; chemoprevention; colorimetry; epidemiological studies; glutathione; homeostasis; humans; melanocytes; melanoma; public health; risk; thiols; toxicology
- Abstract:
- ... Coffee is one of the most popular beverages consumed worldwide and therefore even small effects of coffee bioactive compounds on cellular homeostasis could have a large impact on public health. Recent cohort health studies have shown an impressive inverse correlation between caffeinated coffee consumption and malignant melanoma risk. The aim of presented study was to examine the effect of caffeine ...
- DOI:
- 10.1016/j.fct.2018.07.049
- https://doi.org/10.1016/j.fct.2018.07.049
- Author:
- Graziela Bragueto Escher; Jânio Sousa Santos; Neiva Deliberali Rosso; Mariza Boscacci Marques; Luciana Azevedo; Mariana Araújo Vieira do Carmo; Heitor Daguer; Luciano Molognoni; Leonardo do Prado-Silva; Anderson S. Sant'Ana; Marcia Cristina da Silva; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.118 pp. 439-453
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Centaurea cyanus; anthocyanins; antihypertensive effect; antioxidant activity; bioactive compounds; cell death; cell lines; corolla; coumarin; cytotoxicity; ferulic acid; functional properties; inhibitory concentration 50; isoquercitrin; lipid peroxidation; p-coumaric acid; pH; plant extracts; reactive oxygen species; statistical analysis; temperature
- Abstract:
- ... This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, ...
- DOI:
- 10.1016/j.fct.2018.05.046
- https://doi.org/10.1016/j.fct.2018.05.046
- Author:
- Naiara Stefanello; Roselia Maria Spanevello; Sabina Passamonti; Lisiane Porciúncula; Carla Denise Bonan; Ayodeji Augustine Olabiyi; João Batista Teixeira da Rocha; Charles Elias Assmann; Vera Maria Morsch; Maria Rosa Chitolina Schetinger
- Source:
- Food and chemical toxicology 2019 v.123 pp. 298-313
- ISSN:
- 0278-6915
- Subject:
- adenosine; adenosine triphosphate; antioxidants; beverages; bioactive compounds; caffeine; central nervous system; chlorogenic acid; coffee beans; diterpenoids; enzyme activity; homeostasis; neurons; purinergic receptors; toxicology; trigonelline
- Abstract:
- ... Coffee is a drink prepared from roasted coffee beans and is lauded for its aroma and flavour. It is the third most popular beverage in the world. This beverage is known by its stimulant effect associated with the presence of methylxanthines. Caffeine, a purine-like molecule (1,3,7 trymetylxantine), is the most important bioactive compound in coffee, among others such as chlorogenic acid (CGA), dit ...
- DOI:
- 10.1016/j.fct.2018.10.005
- https://doi.org/10.1016/j.fct.2018.10.005
- Author:
- Gokhan Zengin; Ramazan Ceylan; Jelena Katanić; Adriano Mollica; Abdurrahman Aktumsek; Tatjana Boroja; Sanja Matić; Vladimir Mihailović; Snežana Stanić; Zaahira Aumeeruddy-Elalfi; Mustafa Abdullah Yilmaz; Mohamad Fawzi Mahomoodally
- Source:
- Food and chemical toxicology 2017 v.107 pp. 540-553
- ISSN:
- 0278-6915
- Subject:
- DNA damage; Drosophila melanogaster; acetylcholinesterase; alpha-amylase; alpha-glucosidase; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; diabetes; functional foods; hesperidin; liquid chromatography; malic acid; metabolites; mutagens; phytopharmaceuticals; protocatechuic acid; rosmarinic acid; rutin; tandem mass spectrometry; toxicology
- Abstract:
- ... Methanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Willd.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potenti ...
- DOI:
- 10.1016/j.fct.2017.04.004
- https://doi.org/10.1016/j.fct.2017.04.004
- Author:
- Dariusz Jedrejek; Bernadetta Lis; Agata Rolnik; Anna Stochmal; Beata Olas
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- chemical constituents of plants; coumaric acids; cytotoxicity; anticoagulant activity; blood platelets; sesquiterpenoid lactones; free radical scavengers; amino acids; inositols; bioactive compounds; anticoagulants; mass spectrometry; blood plasma; Taraxacum officinale; antioxidant activity; oxidation; liquid chromatography; roots; protective effect
- Abstract:
- ... Although the majority of potentially bioactive components of dandelion root have been described, revealing the presence of hydroxycinnamic acids (HCAs) and sesquiterpene lactones (SLs), new compounds are still being discovered, an example of which are the recently characterized 4-hydroxyphenylacetate inositol esters (PIEs). In this work, the dandelion root was separated into five preparations (A-E ...
- DOI:
- 10.1016/j.fct.2019.02.017
- https://doi.org/10.1016/j.fct.2019.02.017
- Author:
- Blanca Escudero-López; Genoveva Berná; Ángeles Ortega; Griselda Herrero-Martín; Isabel Cerrillo; Franz Martín; María-Soledad Fernández-Pachón
- Source:
- Food and chemical toxicology 2015 v.78 pp. 78-85
- ISSN:
- 0278-6915
- Subject:
- C-reactive protein; alcoholic fermentation; alcohols; antioxidant activity; beverages; bilirubin; bioactive compounds; biomarkers; cardiovascular diseases; enzyme activity; fruits; glutathione; humans; interleukin-6; lipid composition; low density lipoprotein; mice; orange juice; pasteurization; risk factors; synergism; toxicology; uric acid
- Abstract:
- ... The consumption of fruits prevents the risk of cardiovascular diseases. Alcoholic fermentation has been carried out in fruits resulting in products which provide high concentration of bioactive compounds and variable alcohol content. The aim of this study was to assess the potential beneficial effect of an orange beverage obtained by alcoholic fermentation and pasteurization of orange juice on car ...
- DOI:
- 10.1016/j.fct.2015.02.006
- https://doi.org/10.1016/j.fct.2015.02.006
- Author:
- Giuseppe Chichiriccò; Claudio Ferrante; Luigi Menghini; Lucia Recinella; Sheila Leone; Annalisa Chiavaroli; Luigi Brunetti; Simonetta Di Simone; Maurizio Ronci; Pierpaolo Piccone; Barbara Lanza; Stefania Cesa; Annamaria Poma; Giulia Vecchiotti; Giustino Orlando
- Source:
- Food and chemical toxicology 2019 v.126 pp. 7-14
- ISSN:
- 0278-6915
- Subject:
- Artemia; Crocus sativus; anthers; antioxidant activity; bioactive compounds; byproducts; cell lines; cell movement; chemical constituents of plants; cytotoxicity; fatty acid composition; lipopolysaccharides; long chain fatty acids; malondialdehyde; mutagens; nitrites; protective effect; rats; reactive oxygen species; saffron; tissue repair; toxicology
- Abstract:
- ... Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isol ...
- DOI:
- 10.1016/j.fct.2019.01.040
- https://doi.org/10.1016/j.fct.2019.01.040
- Author:
- Renata Giacomeli; Flavia Elizabete Guerra Teixeira; Felipe Barbosa Carvalho; Camila Oliveira Pacheco; Alcides José Martins Parisotto; Ana Claudia Funguetto Ribeiro; Marcelo Gomes de Gomes; Sandra Elisa Haas
- Source:
- Food and chemical toxicology 2020 v.144 pp. 111625
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; blood; body weight changes; curcumin; dietary supplements; fetal development; fetus; food intake; histopathology; liver; nanocapsules; organogenesis; placenta; polymers; pregnancy; toxicity; toxicology
- Abstract:
- ... This study was designed to examine fetal and maternal toxicity of curcumin (CURC) loaded lipid-core nanocapsules (LNC) prepared with poly(ϵ-caprolactone) as a polymer, administered during the organogenesis period. Free CURC and CURC loaded-LNC (C-LNC) (2 mg/kg), blank LNC (B-LNC) and saline (CONTROL) were administered per oral route from the 7° to 13° gestational day (GD). Dams were evaluated dail ...
- DOI:
- 10.1016/j.fct.2020.111625
- https://doi.org/10.1016/j.fct.2020.111625
- Author:
- Andrei Mocan; Alina Diuzheva; Simone Carradori; Vasil Andruch; Chiara Massafra; Cadmiel Moldovan; Cristian Sisea; Jacobus P. Petzer; Anél Petzer; Susi Zara; Guya Diletta Marconi; Gokhan Zengin; Gianina Crișan; Marcello Locatelli
- Source:
- Food and chemical toxicology 2018 v.119 pp. 189-198
- ISSN:
- 0278-6915
- Subject:
- Prunus domestica; alpha-glucosidase; bioactive compounds; cultivars; cytotoxicity; enzyme inhibition; fibroblasts; food industry; humans; leaves; liquid-phase microextraction; microwave treatment; phenolic compounds; quantitative analysis; toxicology
- Abstract:
- ... In the present work, fourteen cultivars of Prunus domestica were analyzed to investigate their phenolic pattern with the purpose of using the leaves as potential resources of bioactive compounds in the pharmaceutical and food industry. Microwave-assisted extraction (MAE), dispersive liquid–liquid microextraction and sugaring-out liquid–liquid extraction techniques were optimized in order to obtain ...
- DOI:
- 10.1016/j.fct.2018.04.045
- https://doi.org/10.1016/j.fct.2018.04.045
- Author:
- Abishek B. Santhakumar; Maurizio Battino; José M. Alvarez-Suarez
- Source:
- Food and chemical toxicology 2018 v.113 pp. 49-65
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; atherosclerosis; bioactive compounds; bioavailability; cardioprotective effect; chronic diseases; clinical trials; epidemiological studies; fruits; hemostasis; lipid metabolism; longevity; polyphenols; toxicology; vegetables
- Abstract:
- ... Epidemiological studies have demonstrated that nutritional habits, like those based on high consumption of fruits and vegetables, have been associated with a longer life expectancy and a significant decrease in the incidence and prevalence of several chronic diseases with inflammatory basis, such as cardiovascular diseases (CVD). This beneficial activity has been related to the content of several ...
- DOI:
- 10.1016/j.fct.2018.01.022
- https://doi.org/10.1016/j.fct.2018.01.022
- Author:
- Subramaniya Bharathi Raja; Vijayabharathi Rajendiran; Nirmal Kumar Kasinathan; Amrithalakshmi P; Sivaramakrishnan Venkatabalasubramanian; Malliga Raman Murali; Halagowder Devaraj; Sivasithamparam Niranjali Devaraj
- Source:
- Food and chemical toxicology 2017 v.106 pp. 92-106
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidants; apoptosis; bioactive compounds; caspase-3; cell viability; cyclins; cytochrome c; cytotoxicity; gene overexpression; genes; humans; inhibitory concentration 50; intestinal mucosa; neoplasm cells; neoplasms; peroxidase; quercetin
- Abstract:
- ... Quercetin is a bioactive compound with anti-inflammatory, antioxidant and anticancer properties. This study exemplifies the differential cytotoxic activity of Quercetin on two human colonic cancer cell lines, HT29 and HCT15. IC50 of Quercetin for HT29 and HCT15 cells were 42.5 μM and 77.4 μM, respectively. Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt ...
- DOI:
- 10.1016/j.fct.2017.05.006
- https://doi.org/10.1016/j.fct.2017.05.006
- Author:
- Beata Olas; Magdalena Bryś
- Source:
- Food and chemical toxicology 2019 v.127 pp. 31-41
- ISSN:
- 0278-6915
- Subject:
- bioactive compounds; blood platelets; caffeine; cyclic AMP; disease control; endothelial cells; energy drinks; enzymes; fibrinolysis; models; monitoring; platelet activation; reactive oxygen species; risk; thrombosis
- Abstract:
- ... Hemostasis is a process which encompasses the clotting, fibrinolysis, blood platelet activation and endothelial cell function. Certain dietary components may modulate some elements of hemostasis, particularly blood platelet function, and modify the progression of cardiovascular diseases. The aim of this review paper is to provide an overview of current knowledge of the role of coffee, energy drink ...
- DOI:
- 10.1016/j.fct.2019.02.039
- https://doi.org/10.1016/j.fct.2019.02.039
- Author:
- Jicheng Chen; Jingjing Tian; Huifang Ge; Ruihai Liu; Jianbo Xiao
- Source:
- Food and chemical toxicology 2017 v.109 pp. 930-940
- ISSN:
- 0278-6915
- Subject:
- human cell lines; protein synthesis; dose response; liver; catalase; vinegars; reactive oxygen species; superoxide dismutase; lipid composition; cholesterol; gene expression; toxicology; bioactive compounds; hypolipidemia; lipemic effect; antioxidant activity; ABC transporters; peroxisome proliferator-activated receptors
- Abstract:
- ... Tetramethylpyrazine is a bioactive compound found in Chinese black vinegar. This work is to investigate the potential effects of tetramethylpyrazine on intracellular cholesterol modulation in HepG2 cells. The results demonstrated that tetramethylpyrazine can induce intracellular cholesterol efflux. Tetramethylpyrazine may also improve endothelial function through its antioxidant effects by inhibit ...
- DOI:
- 10.1016/j.fct.2016.12.017
- https://doi.org/10.1016/j.fct.2016.12.017
- Author:
- Tianmu He; Qiyi Wang; Jingwen Ao; Kuan Chen; Xiaofei Li; Jianyong Zhang; Cancan Duan
- Source:
- Food and chemical toxicology 2022 v.163 pp. 112986
- ISSN:
- 0278-6915
- Subject:
- Mylabris; Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; bioactive compounds; cantharidin; caspase-3; cytotoxicity; endoplasmic reticulum; endoplasmic reticulum stress; nephrotoxicity; renal function; toxicology
- Abstract:
- ... Mylabris, as a natural product of traditional Chinese medicine (TCM), exhibiting typical antitumor activity, and cantharidin (CTD) is the major bioactive component. However, drug-induced nephrotoxicity (DIN) extremely limited its clinical application. In this study, we proved that activation of the endoplasmic reticulum (ER) stress-dependent PERK/CHOP pathway exerts a toxic role in rats and HK-2 c ...
- DOI:
- 10.1016/j.fct.2022.112986
- https://doi.org/10.1016/j.fct.2022.112986
- Author:
- Huifang Ge; Yazhen Chen; Jicheng Chen; Jingjing Tian; Xiaofeng Liang; Lei Chen
- Source:
- Food and chemical toxicology 2018 v.119 pp. 417-424
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ligusticum sinense; Oriental traditional medicine; antioxidant activity; bioactive compounds; cardiovascular diseases; digestion; dose response; ethanol; ferulic acid; free radical scavengers; hydroxyl radicals; intestines; liquids; oxidative stress; polyphenols; pyrazines; rhizomes; toxicology
- Abstract:
- ... The Rhizome of Ligusticum chuanxiong Hort, a traditional Chinese medicine, is widely used to treat cardiovascular diseases and attenuate oxidative stress. The main bioactive compounds including tetramethylpyrazine (TMP), polyphenols, ferulic acid have been reported to be responsible for these effects. This study was to evaluate the influence of Ligusticum chuanxiong extraction (LCE) in mimic gastr ...
- DOI:
- 10.1016/j.fct.2017.12.035
- https://doi.org/10.1016/j.fct.2017.12.035
- Author:
- E.J. Llorent-Martínez; P. Ortega-Barrales; G. Zengin; A. Mocan; M.J. Simirgiotis; R. Ceylan; S. Uysal; A. Aktumsek
- Source:
- Food and chemical toxicology 2017 v.107 pp. 609-619
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Lathyrus cicera; acetylcholinesterase; aerial parts; agricultural land; alpha-amylase; alpha-glucosidase; antioxidant activity; antioxidants; bioactive compounds; cholinesterase; enzyme inhibition; flavonoids; food industry; functional foods; high performance liquid chromatography; ionization; mass spectrometry; phytopharmaceuticals; screening; toxicology
- Abstract:
- ... The genus Lathyrus has great importance in terms of food and agricultural areas. In this study, the in vitro antioxidant activity (phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC and metal chelating) and enzyme inhibitory activity evaluation (acetylcholinesterase, butyrylcholinesterase, α-amylase and α-glucosidase) of L. cicera and L. digitatus were investigated, as well as their phytochemical profile ...
- DOI:
- 10.1016/j.fct.2017.03.002
- https://doi.org/10.1016/j.fct.2017.03.002
- Author:
- Aziza A. El-Nekeety; Asmaa S. Salman; Amal S. Hathout; Bassem A. Sabry; Sekena H. Abdel-Aziem; Nabila S. Hassan; Mosaad A. Abdel-Wahhab
- Source:
- Food and chemical toxicology 2017 v.105 pp. 241-255
- ISSN:
- 0278-6915
- Subject:
- Actinomyces; DNA fragmentation; aflatoxin B1; antioxidant genes; bioactive compounds; blood; bone marrow; cytotoxicity; drugs; females; food additives; genotoxicity; histology; liver; liver function; oxidative stress; rats; toxicology
- Abstract:
- ... This study aimed to determine the bioactive compounds of actinomyces (ACT) isolated from the Egyptian environment (D-EGY) and to evaluate their protective activity against AFB1 in female Sprague-Dawley rats. Six groups of animals were treated orally for 3 weeks included: C, the control group, T1, AFB1-treated group (80 μg/kg b.w), T2 and T3, the groups received ACT extract at low (25 mg/kg b.w) or ...
- DOI:
- 10.1016/j.fct.2017.04.024
- https://doi.org/10.1016/j.fct.2017.04.024
- Author:
- María Figueiredo-González; Patrícia Valentão; David M. Pereira; Paula B. Andrade
- Source:
- Food and chemical toxicology 2017 v.109 pp. 386-392
- ISSN:
- 0278-6915
- Subject:
- African Americans; Solanum lycopersicum var. lycopersicum; acetone; adenocarcinoma; alkaloids; antineoplastic activity; antioxidant activity; bioactive compounds; byproducts; cell viability; cultivars; cytotoxicity; human health; humans; inhibitory concentration 50; leaf extracts; leaves; nitric oxide; superoxide anion; tomatoes
- Abstract:
- ... This study focused the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of tomato plant cultivars (Caramba, Valentine, Negro, Abuela, and Anairis). AE, HME and AcE extracts of all cultivars reduced cell viability, IC50 values ranging from 9 ± 2 to 55 ± 11, from 103 ± 25 t ...
- DOI:
- 10.1016/j.fct.2017.09.018
- https://doi.org/10.1016/j.fct.2017.09.018
- Author:
- Wen-Juan Li; Lu Li; Weng-Ya Zhen; Le-Feng Wang; Meng Pan; Jia-Qian Lv; Fan Wang; Yu-Fei Yao; Shao-Ping Nie; Ming-Yong Xie
- Source:
- Food and chemical toxicology 2017 v.99 pp. 199-208
- ISSN:
- 0278-6915
- Subject:
- Ganoderma; T-lymphocytes; antioxidant activity; apoptosis; bioactive compounds; body weight; catalase; cell viability; cyclophosphamide; glutathione peroxidase; immunosuppression; interleukin-2; lipid peroxidation; mice; polysaccharides; reactive oxygen species; spleen; superoxide dismutase; thymus gland; toxicology; tumor necrosis factor-alpha
- Abstract:
- ... Ganoderma atrum polysaccharide (PSG-1) is a bioactive compound with antioxidant and immunomodulatory activities. The aim of this study was to determine the effect of PSG-1 on reactive oxygen species (ROS) generation and apoptosis in spleen and thymus of cyclophosphamide (CTX)-induced immunosuppressed mice. The results showed that PSG-1 protected mice against CTX-mediated immunosuppression, as evid ...
- DOI:
- 10.1016/j.fct.2016.11.033
- https://doi.org/10.1016/j.fct.2016.11.033
- Author:
- Milda Pukalskienė; Gražina Slapšytė; Veronika Dedonytė; Juozas Rimantas Lazutka; Jūratė Mierauskienė; Petras Rimantas Venskutonis
- Source:
- Food and chemical toxicology 2018 v.113 pp. 303-313
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Agrimonia; Ames test; DNA; DNA damage; Filipendula; Salmonella; antioxidant activity; antioxidants; bioactive compounds; comet assay; flavonoids; functional foods; genotoxicity; herbs; humans; lymphocytes; mass spectrometry; micronucleus tests; mutagens; mutation; phenolic acids; phenylpropanoids; plant extracts; traditional medicine; ultra-performance liquid chromatography
- Abstract:
- ... The species of Agrimonia and Filipendula have been traditionally used in folk medicine as anti-inflammatory herbs. This study extends the knowledge on bioactivities of F. palmata, A. eupatoria, A. procera, F. ulmaria and F. vulgaris by comprehensive characterization of their methanolic extracts. Antioxidant properties of extracts were evaluated by DPPH• (2,2-diphenyl-1-picrylhydrazyl), ABTS•+ 2,2′ ...
- DOI:
- 10.1016/j.fct.2017.12.031
- https://doi.org/10.1016/j.fct.2017.12.031
- Author:
- André M. Marques; Catharina E. Fingolo; Maria Auxiliadora C. Kaplan
- Source:
- Food and chemical toxicology 2017 v.109 pp. 1111-1117
- ISSN:
- 0278-6915
- Subject:
- Piper; bioactive compounds; countercurrent chromatography; essential oils; gas chromatography-mass spectrometry; hydrophobicity; inflorescences; leaves; linalool; nerolidol; toxicology; Brazil
- Abstract:
- ... High Speed Countercurrent Chromatography (HSCCC) technique was used for the preparative isolation of the major leishmanicidal compounds from the essential oils of Piper claussenianum species in Brazil. The essential oils from inflorescences of P. claussenianum were analyzed by GC-FID and GC-MS. The enantiomeric ratio of the major constituents of the P. claussenianum essential oils were determined ...
- DOI:
- 10.1016/j.fct.2017.04.026
- https://doi.org/10.1016/j.fct.2017.04.026
- Author:
- S.A. Petropoulos; A. Karkanis; N. Martins; I.C.F.R. Ferreira
- Source:
- Food and chemical toxicology 2018 v.114 pp. 155-169
- ISSN:
- 0278-6915
- Subject:
- basins; bioactive compounds; biosynthesis; climate change; halophytes; herbs; indigenous species; pharmaceutical industry; salinity; secondary metabolites; toxicology; traditional medicine
- Abstract:
- ... Wild native species are usually grown under severe and stressful conditions, while a special category includes halophytic species that are tolerant to high salinity levels. Native halophytes are valuable sources of bioactive molecules whose content is higher in saline than normal conditions, since the adaptation to salinity mechanisms involve apart from changes in physiological functions the biosy ...
- DOI:
- 10.1016/j.fct.2018.02.031
- https://doi.org/10.1016/j.fct.2018.02.031
- Author:
- Selvaraj Miltonprabu; Michał Tomczyk; Krystyna Skalicka-Woźniak; Luca Rastrelli; Maria Daglia; Seyed Fazel Nabavi; Seyed Moayed Alavian; Seyed Mohammad Nabavi
- Source:
- Food and chemical toxicology 2017 v.108 pp. 365-374
- ISSN:
- 0278-6915
- Subject:
- European Union; alcohol drinking; apples; bioactive compounds; bioavailability; biosynthesis; citrus fruits; hepatitis A; hepatitis B; hepatitis C; hepatoprotective effect; herbal medicines; liver; onions; people; pepper; quercetin; red wines; small fruits; tea; tomatoes; toxicology; traditional medicine; viruses; United States
- Abstract:
- ... Liver diseases caused by viral hepatitis infections have a negative impact on global health. Approximately 30 million people in the USA and 29 million people in the European Union suffer from chronic liver disease. There are many kinds of diseases of the liver, caused by viruses, such as hepatitis A, hepatitis B and hepatitis C, or by certain drugs and poisons including excessive alcohol consumpti ...
- DOI:
- 10.1016/j.fct.2016.08.034
- https://doi.org/10.1016/j.fct.2016.08.034
- Author:
- Laércio Galvão Maciel; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Heitor Daguer; Luciano Molognoni; Mereci Mendes de Almeida; Daniel Granato; Neiva Deliberali Rosso
- Source:
- Food and chemical toxicology 2018 v.113 pp. 187-197
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Hibiscus sabdariffa; antioxidant activity; ascorbic acid; bioactive compounds; calyx; cell lines; color; cytotoxicity; electrospray ionization mass spectrometry; inhibitory concentration 50; lethal concentration 50; liquid chromatography; myrtillin; neoplasm cells; pH; temperature
- Abstract:
- ... Hibiscus sabdariffa calyx is a rich source of anthocyanins and other bioactive compounds but no study reported the effects of experimental conditions on the extraction of these chemical compounds. Therefore, the effects of time and extraction temperature on the bioactive compounds and antioxidant activity of Hibiscus sabdariffa calyx were evaluated. In addition, the effects of copigmentation and p ...
- DOI:
- 10.1016/j.fct.2018.01.053
- https://doi.org/10.1016/j.fct.2018.01.053
- Author:
- Vanessa Vieira; Carla Pereira; Rui M.V. Abreu; Ricardo C. Calhelha; Maria José Alves; João A.P. Coutinho; Olga Ferreira; Lillian Barros; Isabel C.F.R. Ferreira
- Source:
- Food and chemical toxicology 2020 v.137 pp. 111189
- ISSN:
- 0278-6915
- Subject:
- Gram-positive bacteria; Juglans regia; anti-inflammatory activity; antibacterial properties; antioxidant activity; bioactive compounds; cell culture; cell lines; chemical constituents of plants; coumaric acids; crop production; cytotoxicity; flavonols; hemolysis; hulls; naphthalene; neoplasms; nitric oxide; thiobarbituric acid-reactive substances; walnuts; wastes
- Abstract:
- ... Juglans regia L. (walnut) green husks are an important fraction of waste resulting from the walnut production, thus representing an interesting natural matrix to explore as a source of bioactive compounds. In this work, the hydroethanolic extract of walnut green husks was studied considering the phytochemical composition and the biological activity using different cell model assays, most of them e ...
- DOI:
- 10.1016/j.fct.2020.111189
- https://doi.org/10.1016/j.fct.2020.111189
- Author:
- Jiaming Tu; Dingding Shi; Lingrong Wen; Yueming Jiang; Yupeng Zhao; Jiali Yang; Huiling Liu; Guangrong Liu; Bao Yang
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110730
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; anti-inflammatory activity; antioxidant activity; antioxidants; bioactive compounds; bioavailability; cell viability; diet; furans; inhibitory concentration 50; leaves; median effective concentration; moieties; mulberries; resveratrol; vegetables; viability assays
- Abstract:
- ... Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified ...
- DOI:
- 10.1016/j.fct.2019.110730
- https://doi.org/10.1016/j.fct.2019.110730
- Author:
- Aziz A. Fallah; Elham Sarmast; Parichehr Fatehi; Tina Jafari
- Source:
- Food and chemical toxicology 2020 v.135 pp. 110922
- ISSN:
- 0278-6915
- Subject:
- C-reactive protein; adhesion; adiponectin; anthocyanins; bioactive compounds; inflammation; intercellular adhesion molecule-1; interleukin-1beta; interleukin-6; meta-analysis; randomized clinical trials; systematic review; tumor necrosis factor-alpha; vascular cell adhesion molecules
- Abstract:
- ... Anthocyanins are natural bioactive compounds that have several health benefits. This systematic review and meta-analysis assessed the impact of dietary anthocyanins on markers of systemic and vascular inflammation. Meta-analysis of 32 randomised controlled trials indicated that dietary anthocyanins significantly decreased levels of C-reactive protein (CRP; −0.33 mg/l, 95% CI: −0.55 to −0.11, P = 0 ...
- DOI:
- 10.1016/j.fct.2019.110922
- https://doi.org/10.1016/j.fct.2019.110922
- Author:
- Azzurra Stefanucci; Gokhan Zengin; Marcello Locatelli; Giorgia Macedonio; Chin-Kun Wang; Ettore Novellino; M.Fawzi Mahomoodally; Adriano Mollica
- Source:
- Food and chemical toxicology 2018 v.118 pp. 181-189
- ISSN:
- 0278-6915
- Subject:
- Capparis spinosa; acetylcholinesterase; active ingredients; antioxidant activity; bioactive compounds; buds; cholinesterase; chromatography; enzyme inhibition; essential oils; fatty acids; free radical scavengers; medicinal plants; phenolic compounds; provenance; rutin; toxicology; Italy; Morocco; Turkey (country)
- Abstract:
- ... Capparis spinosa L. (caper), is a traditionally used medicinal plant and widely studied for its biological properties. We aimed for the first time to compare the biological and phenolic fingerprints of C. spinosa buds, collected from Morocco, Turkey, and Italy. Phenolic compounds, fatty acids, and essential oils were profiled by chromatographic techniques. Enzymes inhibitory activities of differen ...
- DOI:
- 10.1016/j.fct.2018.05.003
- https://doi.org/10.1016/j.fct.2018.05.003
- Author:
- Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Mariana Vieira do Carmo; Luciana Azevedo; Marcia Cristina da Silva; Predrag Putnik; Daniel Granato
- Source:
- Food and chemical toxicology 2018 v.120 pp. 479-490
- ISSN:
- 0278-6915
- Subject:
- lipid peroxidation; 2,2-diphenyl-1-picrylhydrazyl; high performance liquid chromatography; flavonoids; brain; antihypertensive effect; toxicology; peptidyl-dipeptidase A; principal component analysis; bioassays; egg yolk; bioactive compounds; rats; resveratrol; antioxidant activity; ethanol; antioxidants; phenolic acids; laboratory animals; Myrciaria dubia; nutritive value; functional properties; seed coat; pulp
- Abstract:
- ... Camu-camu (Myrciaria dubia) pulp, seeds, and skin are widely known because of their nutritional properties. However, the seed coat has never been studied as a source of bioactive compounds. Herein, we characterized the phenolic composition, the antioxidant activity, and inhibition of angiotensin-converting enzyme (ACE) of three different extracts (water, propanone, and ethanol) from this residue a ...
- DOI:
- 10.1016/j.fct.2018.07.043
- https://doi.org/10.1016/j.fct.2018.07.043
- Author:
- L. Manyes; F.B. Luciano; J. Mañes; G. Meca
- Source:
- Food and chemical toxicology 2015 v.83 pp. 293-299
- ISSN:
- 0278-6915
- Subject:
- Aspergillus parasiticus; Penicillium expansum; acceptable daily intake; aflatoxins; allyl isothiocyanate; animal models; anti-infective agents; antifungal properties; average daily intake; bioactive compounds; cell culture; epidemiological studies; food intake; fungi; glucosinolates; humans; metabolites; neoplasms; patulin; risk reduction; spoilage; toxicology; vegetables
- Abstract:
- ... Isothiocyanates (ITCs) are natural compounds derived from cruciferous vegetables produced by enzymatic conversion of metabolites called glucosinolates. They are potentially useful antimicrobial compounds for food applications have been shown to be promising agents against cancer in human cell culture, animal models, and in epidemiological studies. In this study, the antifungal activity of the ally ...
- DOI:
- 10.1016/j.fct.2015.06.011
- https://doi.org/10.1016/j.fct.2015.06.011
- Author:
- Maria João Rodrigues; Katkam N. Gangadhar; Gokhan Zengin; Adriano Mollica; João Varela; Luísa Barreira; Luísa Custódio
- Source:
- Food and chemical toxicology 2017 v.107 pp. 590-596
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Juncus acutus; antioxidant activity; bioactive compounds; chemical elements; cholinesterase; cognition; food additives; food industry; free radicals; functional foods; high performance liquid chromatography; leaves; methylene chloride; molecular models; neuroglia; neurons; neuroprotective effect; roots; sedatives; sleep disorders; toxicology
- Abstract:
- ... Several Juncus species are traditionally used as sedative and to treat health problems like insomnia. This work was based on the hypothesis that Juncus acutus, J. maritimus and J. inflexus may have molecules with bioactivities relevant for the improvement of cognitive functions and thus with potential use as food additives and/or nutraceuticals. Therefore leaves and roots extracts of those species ...
- DOI:
- 10.1016/j.fct.2017.04.006
- https://doi.org/10.1016/j.fct.2017.04.006