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- Chang, Jer-Wei, et al. Show all 9 Authors
- Food and chemical toxicology 2017 v.108 pp. 276-288
- acetylcysteine; alpha-linolenic acid; apoptosis; arachidonic acid; breast neoplasms; cell proliferation; cytochrome c; docosahexaenoic acid; eicosapentaenoic acid; gamma-linolenic acid; gene expression; growth inhibitors; linoleic acid; messenger RNA; mitochondria; neoplasm cells; omega-3 fatty acids; phosphatidylinositol 3-kinase; phosphorylation; protein synthesis; reactive oxygen species; signal transduction; toxicology
- ... Oxidative stress-induced growth inhibitor 1 (OSGIN1), a tumor suppressor, inhibits cell proliferation and induces cell death. N-6 and n-3 PUFAs protect against breast cancer, but the molecular mechanisms of this effect are not clear. We investigated the effect of n-6 and n-3 PUFAs on OSGIN1 expression and whether OSGIN1 is involved in PUFA-induced apoptosis in breast cancer cells. We used 100 μM o ...