Jump to Main Content
- Karve, Tejaswita M.; Li, Xin; Saha, Tapas
- Functional & integrative genomics 2012 v.12 no.1 pp. 63-79
- DNA replication; breast neoplasms; carcinogenesis; cell cycle; etiology; gene expression; gene therapy; genes; heterozygosity; mutation; ovarian development; ovarian neoplasms; patients; signal transduction; transforming growth factor beta 1; tumor necrosis factor-alpha
- ... The link between loss or defect in functional BRCA1 and predisposition for development of ovarian and breast cancer is well established. Germ-line mutations in BRCA1 are responsible for both hereditary breast and ovarian cancer, which is around 5–10% for all breast and 10–15% of all ovarian cancer cases. However, majority of cases of ovarian cancer are sporadic in nature. The inactivation of cellu ...