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You searched for: Journal name Gene Remove constraint Journal name: Gene Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.809 Remove constraint Source: 2022 v.809
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1. The AGTPBP1 gene in neurobiology

Author:
Robert Lalonde; Catherine Strazielle
Source:
Gene 2022 v.809 pp. 146001
ISSN:
0378-1119
Subject:
cerebellum; cognition; genes; glutamic acid; humans; mutants; neurophysiology; olfactory bulb
Abstract:
... The function of the Agtpbp1 gene has mainly been delineated by studying Agtpbp1ᵖᶜᵈ (pcd) mutant mice, characterized by losses in cerebellar Purkinje and granule cells along with degeneration of retinal photoreceptors, mitral cells of the olfactory bulb, thalamic neurons, and alpha-motoneurons. As a result of cerebellar degeneration, cerebellar GABA and glutamate concentrations in Agtpbp1ᵖᶜᵈ mutant ...
DOI:
10.1016/j.gene.2021.146001

2. Candidate sex-associated gene identification in Trachinotus ovatus (Carangidae) using an integrated SLAF-seq and bulked segregant analysis approach

Author:
Pingping He; Pinyuan Wei; Yuan Ma; Shenhua Hu; Jiuxiang Yao; Xiaozhen Jiang; Youhou Xu; Peng Zhu; Mingli Wei; Weiming Jiang; Jinxia Peng
Source:
Gene 2022 v.809 pp. 146026
ISSN:
0378-1119
Subject:
DNA; Trachinotus ovatus; chromosomes; genes; single nucleotide polymorphism
Abstract:
... It is difficult to distinguish the sexes of Trachinotus ovatus based on appearance, and little data about sex-determining genes are available for this species. Here, we generated 200 F2 individuals using the parents R404 and R403. DNA samples were collected from 50 individuals of each sex and aggregated into sex-specific DNA pools. Specific-locus amplified fragment sequencing was integrated with b ...
DOI:
10.1016/j.gene.2021.146026

3. Characterization of the voltage-dependent anion channel (VDAC) gene family in wheat (Triticum aestivum L.) and its potential mechanism in response to drought and salinity stresses

Author:
Ming Yu; Yang Yu; Tianqi Song; Yunrui Zhang; Fan Wei; Jie Cheng; Bo Zhang; Xiaoke Zhang
Source:
Gene 2022 v.809 pp. 146031
ISSN:
0378-1119
Subject:
Arabidopsis thaliana; TATA box; Triticum aestivum; drought; genes; mitochondrial membrane; phylogeny; plant growth; salinity; salt stress; salt tolerance; sequence alignment; superoxide anion; superoxide dismutase; water stress; wheat
Abstract:
... Voltage-dependent anion channels (VDACs) are major transport proteins localized in the outer membrane of mitochondria and play critical roles in regulating plant growth and responding to stress. In this study, a total of 26 VDAC genes in common wheat (Triticum aestivum L.) were identified. TaVDACs that contained β-barrel structures were classified into three groups with phylogenetic and sequence a ...
DOI:
10.1016/j.gene.2021.146031

4. Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle

Author:
Peng Yang; Cuicui Cai; Mengxiao Niu; Xian Liu; Hongli Wang; Huifeng Liang; Baowei Cheng; Zijing Zhang; Fuying Chen; Jianliang Xie; Zengfang Qi; Guojie Yang; Qiaoting Shi; Eryao Wang; Chuzhao Lei; Hong Chen; Baorui Ru; Yongzhen Huang
Source:
Gene 2022 v.809 pp. 146014
ISSN:
0378-1119
Subject:
animal growth; beef cattle; blood; chest; computer software; copy number variation; diabetes; gene expression; genes; genetic markers; genetic polymorphism; glycerophospholipids; growth performance; heart; hydrolysis; lysophospholipids; market competition; meat quality; phospholipase A2; phospholipases
Abstract:
... As a member of genetic polymorphism, copy number variation has been a commonly used method in the world for investigating effect of genetic polymorphism on gene expression. Effect of genetic polymorphism made on livestock development has been more and more important in beef cattle molecular breeding. The characteristics of Chinese cattle are excellent meat quality, tolerant to rough feeding, good ...
DOI:
10.1016/j.gene.2021.146014

5. Electrospun silk nanofibers promoted the in vitro expansion potential of CD 133+ cells derived from umbilical cord blood

Author:
Mohammad Reza Mahdavi; Seyed Ehsan Enderami
Source:
Gene 2022 v.809 pp. 146005
ISSN:
0378-1119
Subject:
blood; flow cytometry; genes; magnetism; medicine; nanofibers; quantitative polymerase chain reaction; silk; somatic cells; stem cells; tissue culture; toxicity testing; umbilical cord; viability
Abstract:
... Stem cells from umbilical cord blood (UCB) are able to proliferate and differentiate into various somatic cell types. Thereby, they are considered as one of the attractive stem cell sources in tissue engineering and regenerative medicine. However, the limited number of hematopoietic CD 133⁺ stem cells in UCB restricted the clinical application of such stem cells. This study was aimed to expand CD ...
DOI:
10.1016/j.gene.2021.146005

6. Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor

Author:
David Sybers; Amber Joka Bernauw; Diala El Masri; Hassan Ramadan Maklad; Daniel Charlier; Marjan De Mey; Indra Bervoets; Eveline Peeters
Source:
Gene 2022 v.809 pp. 146010
ISSN:
0378-1119
Subject:
DNA; Escherichia coli; Sulfolobus; acyl coenzyme A; fluorescence; gene expression; genes; hybrids; ligands; phylogeny; promoter regions; synthetic biology; transcription (genetics); transcription factors
Abstract:
... Synthetic biology requires well-characterized biological parts that can be combined into functional modules. One type of biological parts are transcriptional regulators and their cognate operator elements, which enable to either generate an input-specific response or are used as actuator modules. A range of regulators has already been characterized and used for orthogonal gene expression engineeri ...
DOI:
10.1016/j.gene.2021.146010

7. GABRB2, a key player in neuropsychiatric disorders and beyond

Author:
Manel Barki; Hong Xue
Source:
Gene 2022 v.809 pp. 146021
ISSN:
0378-1119
Subject:
Chinese people; Internet; amino acid sequences; antipsychotics; autism; bipolar disorder; brain; chromosomes; electrophysiology; epigenetics; epilepsy; genes; humans; messenger RNA; neurogenesis; neuroplasticity; schizophrenia; substance abuse; synaptogenesis; therapeutics
Abstract:
... The GABA receptors represent the main inhibitory system in the central nervous system that ensure synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and learning. GABAA receptors are pentameric in structure and belong to the Cys-loop superfamily. The GABRB2 gene, located on chromosome 5q34, encodes the β₂ subunit that combines with the α and γ subunits to form the major subtyp ...
DOI:
10.1016/j.gene.2021.146021

8. Genetic characterization evaluation of a novel multiple system containing 57 deletion/insertion polymorphic loci with short amplicons in Hunan Han population and its intercontinental populations analyses

Author:
Yating Fang; Congying Zhao; Xiaoye Jin; Qiong Lan; Jiangwei Lan; Tong Xie; Bofeng Zhu
Source:
Gene 2022 v.809 pp. 146006
ISSN:
0378-1119
Subject:
DNA; capillary electrophoresis; forensic sciences; gene frequency; genes; genetic markers; paternity; China
Abstract:
... Deletion/insertion polymorphism (DIP) is a promising genetic marker of DNA length polymorphism. However, there are relatively few studies on the exploration of DIP genetic polymorphisms and investigation of population genetic data at present, which limits its application in forensic identification. In this study, the genetic polymorphisms of 57 autosomal DIPs and forensic application evaluations o ...
DOI:
10.1016/j.gene.2021.146006

9. Genome-wide characterization of gap junction (connexins and pannexins) genes in turbot (Scophthalmus maximus L.): evolution and immune response following Vibrio anguillarum infection

Author:
Xin Cai; Chengbin Gao; Min Cao; Baofeng Su; Xiaoli Liu; Beibei Wang; Chao Li
Source:
Gene 2022 v.809 pp. 146032
ISSN:
0378-1119
Subject:
Cynoglossus semilaevis; Larimichthys crocea; Paralichthys olivaceus; Scophthalmus maximus; Vibrio anguillarum; bacterial infections; connexins; cytoplasm; gap junctions; genes; immune response; innexins; pannexins; phylogeny; turbot
Abstract:
... Gap junction (GJ), a special intercellular junction between different cell types, directly connects the cytoplasm of adjacent cells, allows various molecules, ions and electrical impulses to pass through the intercellular regulatory gate, and plays vital roles in response to bacterial infection. Up to date, the information about the GJ in turbot (Scophthalmus maximus L.) is still limited. In curre ...
DOI:
10.1016/j.gene.2021.146032

10. Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study

Author:
Chahra Chbili; Neila Fathallah; Chayma Laadhari; Bouraoui Ouni; Saad Saguem; Maha Ben Fredj; Ahmed Abdelghani; Helmi Ben Saad; Chaker Ben Salem
Source:
Gene 2022 v.809 pp. 146019
ISSN:
0378-1119
Subject:
adenosine; alleles; case-control studies; drug therapy; genetic polymorphism; genotyping; glutathione transferase; guanine; hepatotoxicity; homozygosity; liver; mutants; polymerase chain reaction; risk; tuberculosis
Abstract:
... GST non-functional genotypes can lead to the accumulation of toxic intermediates, resulting in liver damage and increasing susceptibility to ATDH.To investigate the impact of GST Mu (GSTM1), GST Theta (GSTT1) null genotypes, and GST Pi (GSTP1; adenosine (A) > guanine (G), rs1695) variant allele on the development of ATDH in Tunisian patients treated with anti-tuberculosis therapy.This was a case-c ...
DOI:
10.1016/j.gene.2021.146019

11. Homeostatic regulation of flavonoid and lignin biosynthesis in phenylpropanoid pathway of transgenic tobacco

Author:
Jiewei Shi; Xu Yan; Tingting Sun; Yuxiao Shen; Qi Shi; Wenen Wang; Manzhu Bao; Hong Luo; Fuzhao Nian; Guogui Ning
Source:
Gene 2022 v.809 pp. 146017
ISSN:
0378-1119
Subject:
Arabidopsis; Rosa rugosa; anthocyanidins; anthocyanins; biosynthesis; flavonols; genes; lignin; oxidoreductases; phenotype; plant growth; proanthocyanidins; sequence analysis; stress response; tobacco
Abstract:
... Flavonoids and lignin consist of a large number of secondarymetabolites which are derived from the phenylpropanoid pathway, and they act as a significant role in plant growth, development, and stress response. However, few reports have documented that how different subbranches of phenylpropanoid metablolic pathway mutually interact. In Arabidopsis, AtCPC (AtCAPRICE) is known to play a negative rol ...
DOI:
10.1016/j.gene.2021.146017

12. Identification of hub genes associated with EMT-induced chemoresistance in breast cancer using integrated bioinformatics analysis

Author:
Bhavjot Kaur; Yahya Mukhlis; Jagadish Natesh; Dhanamjai Penta; Syed Musthapa Meeran
Source:
Gene 2022 v.809 pp. 146016
ISSN:
0378-1119
Subject:
bioinformatics; breast neoplasms; data collection; dimerization; drug therapy; drugs; gene expression regulation; genes; metastasis; patients; protein-protein interactions; proteoglycans; relapse
Abstract:
... Chemoresistance is one of the major challenges in the treatment of breast cancer. Recent evidence suggests that epithelial-to-mesenchymal transition (EMT) plays a critical role in not only metastasis but also in chemoresistance, hence causing tumor relapse. This study aimed to identify the hub genes associated with EMT and chemoresistance in breast cancer affecting patient/clinical survival. Commo ...
DOI:
10.1016/j.gene.2021.146016

13. Intragenic codon usage in proteobacteria: Translational selection, IS expansion and genomic shrinkage

Author:
Anders Fuglsang
Source:
Gene 2022 v.809 pp. 146015
ISSN:
0378-1119
Subject:
Bordetella pertussis; Buchnera aphidicola; Escherichia coli; Rickettsia prowazekii; codon usage; correspondence analysis; genomics; shrinkage
Abstract:
... This manuscript presents a method to systematically study intragenic variations in codon usage using correspondence analysis and the effective number of codons. The method is applied to >1100 proteobacteria. Codon usage biases (measured as inertia) increases with genome size, the same is true for the percentage of inertia explained by the first axis. It is shown that there is often a relaxed or mo ...
DOI:
10.1016/j.gene.2021.146015

14. METTL14 gene polymorphisms influence hepatoblastoma predisposition in Chinese children: Evidences from a seven-center case-control study

Author:
Huitong Chen; Zhen Chen; Mi Wang; Jiao Zhang; Yong Li; Li Li; Suhong Li; Jiwen Cheng; Xianqiang Wang; Huimin Xia; Zhonghua Yang; Jing He
Source:
Gene 2022 v.809 pp. 146050
ISSN:
0378-1119
Subject:
carcinogenesis; case-control studies; etiology; genes; genotype; genotyping; methyltransferases; quantitative traits; risk
Abstract:
... Hepatoblastoma as the most prevalent hepatic malignancy in children, its etiology remains unclear. N⁶-Methyladenosine (m⁶A) modification which can modify various physiological processes, plays a critical role in tumorigenesis. Methyltransferase-like 14 (METTL14), an important component of the m⁶A methyltransferase complex, remains elusive during hepatoblastoma occurrence and development. We explor ...
DOI:
10.1016/j.gene.2021.146050

15. Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

Author:
A. Bazina Martinović; A. Merkler; I. Ćelić; K. Starčević; M. Šimić; I. Karmelić; Z. Poljaković; D. Kalinić; J. Sertić
Source:
Gene 2022 v.809 pp. 146029
ISSN:
0378-1119
Subject:
C-reactive protein; blood serum; body mass index; genes; genotype; high density lipoprotein cholesterol; hypertension; protein content; stroke; therapeutics
Abstract:
... The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS).A total of 114 patients with IS and 135 healthy controls were included.After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, b ...
DOI:
10.1016/j.gene.2021.146029

16. Multilocus evaluation of genetic predictors of multiple sclerosis

Author:
Yanina Timasheva; Timur R. Nasibullin; Ilsiyar A. Tuktarova; Vera V. Erdman; Timur R. Galiullin; Oksana V. Zaplakhova; Klara Z. Bakhtiiarova
Source:
Gene 2022 v.809 pp. 146008
ISSN:
0378-1119
Subject:
Russia; ancestry; genes; genetic models; linkage disequilibrium; meta-analysis; regression analysis; risk; sclerosis
Abstract:
... Genome-wide association studies identified numerous susceptibility loci for multiple sclerosis in populations of European ancestry, but the associations are not always reproducible in other populations due to admixture and different linkage disequilibrium patterns obscuring true association signals.Our aim was to identify genetic predictors of multiple sclerosis in three ethnically homogenous popu ...
DOI:
10.1016/j.gene.2021.146008

17. Neuronatin gene expression levels affect foetal growth and development by regulating glucose transport in porcine placenta

Author:
Pingping Xing; Linjun Hong; Guanhao Yan; Baohua Tan; Jiaxin Qiao; Shanshan Wang; Zicong Li; Jie Yang; Enqin Zheng; Gengyuan Cai; Zhenfang Wu; Ting Gu
Source:
Gene 2022 v.809 pp. 146051
ISSN:
0378-1119
Subject:
calcium; fetus; genes; glucose; glucose transporters; growth and development; pregnancy; trophoblast
Abstract:
... Imprinted genes play important regulatory roles in the growth and development of placentas and foetuses during pregnancy. In a previous study, we found that the imprinted gene Neuronatin (NNAT) is involved in foetal development; NNAT expression was significantly lower in the placentas of piglets that died neonatally compared to the placentas of surviving piglets. However, the function and mechanis ...
DOI:
10.1016/j.gene.2021.146051

18. Peptidoglycan recognition protein-S1 (PGRP-S1) from Diaphania pyloalis (Walker) is involved in the agglutination and prophenoloxidase activation pathway

Author:
Dongxu Shen; Xianghan Mei; Jiyun Guo; Meijin Tong; Dingguo Xia; Zhiyong Qiu; Qiaoling Zhao
Source:
Gene 2022 v.809 pp. 146004
ISSN:
0378-1119
Subject:
Bacillus subtilis; Escherichia coli; Glyphodes pyloalis; Micrococcus luteus; Staphylococcus aureus; agglutination; amidase; amino acids; cell walls; fat body; genes; head; innate immunity; monophenol monooxygenase; pathogens; peptidoglycans; prophenoloxidase; secretion; signal peptide; zinc
Abstract:
... Recognition of invading foreign exogenous pathogen is the first step to initiate the innate immune response of insects, which accomplished by the pattern recognition receptors (PRRs). Peptidoglycan recognition proteins (PGRPs) serve as an important type of PRRs, which activate immune response by detecting peptidoglycan of microbial cell wall. In this study, we have cloned the full-length cDNA of P ...
DOI:
10.1016/j.gene.2021.146004

19. Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced

Author:
Izabela Rudzińska; Marta Płonka; Alicja Armatowska; Tomasz W. Turowski; Magdalena Boguta
Source:
Gene 2022 v.809 pp. 146034
ISSN:
0378-1119
Subject:
DNA-directed RNA polymerase; Saccharomyces cerevisiae; cyclins; fractionation; genes; genome-wide association study; metabolism; microscopy; transcription factors; yeasts
Abstract:
... We previously reported the function of Rbs1 protein in RNA polymerase III complex assembly via interactions with both, proteins and mRNAs. Rbs1 is a poly(A)-binding protein. The R3H domain in Rbs1 is required for mRNA interactions. The present study utilized the results of a genome-wide analysis of RNA binding by Rbs1 to show a direct interaction between Rbs1 with the 5′-untranslated region (5′-UT ...
DOI:
10.1016/j.gene.2021.146034

20. STAT1 and CXCL10 involve in M1 macrophage polarization that may affect osteolysis and bone remodeling in extrapulmonary tuberculosis

Author:
Tuo Liang; Jiarui Chen; GuoYong Xu; Zide Zhang; Jiang Xue; Haopeng Zeng; Jie Jiang; Tianyou Chen; Zhaojie Qin; Hao Li; Zhen Ye; Yunfeng Nie; Chong Liu; Xinli Zhan
Source:
Gene 2022 v.809 pp. 146040
ISSN:
0378-1119
Subject:
biomarkers; bone resorption; data collection; databases; flow cytometry; gene expression regulation; genes; macrophages; pathogenesis; therapeutics; tuberculosis
Abstract:
... This study was aimed to reveal the molecular mechanism of bone destruction due to macrophage polarization leading to during extrapulmonary tuberculosis (EPTB) infection.The dataset GSE83456 was downloaded from the GEO database, and the xCell tool was used to obtain the 64 types of immune cells. The flow cytometry was performed to identified the differences between M1 and M2 macrophages between EPT ...
DOI:
10.1016/j.gene.2021.146040