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You searched for: Journal name Gene Remove constraint Journal name: Gene Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.751 Remove constraint Source: 2020 v.751
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1. Analysis of compositional properties and codon usage bias of mitochondrial CYB gene in anura, urodela and gymnophiona

Author:
Parvin A Barbhuiya; Arif Uddin; Supriyo Chakraborty
Source:
Gene 2020 v.751 pp. 144762
ISSN:
0378-1119
Subject:
Anura; Gymnophiona; amphibians; bias; codon usage; correlation; electron transport chain; mitochondria; mutation; natural selection; nucleobases; pressure; regression analysis
Abstract:
... We delineated the pattern of synonymous codon usage bias (CUB) and its determinants in mitochondrial CYB gene of respiratory chain across different amphibian groups namely orders anura, urodela and gymnophiona. We observed that CUB was low in CYB gene of amphibia. The gymnophionans had comparatively high bias followed by urodeles and anurans. The codons namely TCA, CCA, CAA, CGA, TGA, AAA and ACA ...
DOI:
10.1016/j.gene.2020.144762

2. Exosomes derived from miRNA-210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF-κB pathway

Author:
Lei He; Yuyong Chen; Zekai Ke; Mao Pang; Bu Yang; Feng Feng; Zizhao Wu; Chang Liu; Bin Liu; Xiaozuo Zheng; Tao Wu; Tao Shu
Source:
Gene 2020 v.751 pp. 144764
ISSN:
0378-1119
Subject:
apoptosis; bone marrow; chondrocytes; cytokines; exosomes; genes; lipopolysaccharides; mesenchymal stromal cells; tumor necrosis factor receptors
Abstract:
... Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (Exos) have anti-inflammatory and anti-apoptotic functions. miRNA-210 has also been confirmed to play a role in inhibiting proinflammatory cytokines. Herein, we aimed to explore the effects of Exos derived from miRNA-210-overexpressing BMSCs (BMSCs-210-Exos) and the mechanisms by which they provide protection to chondrocytes from lipopoly ...
DOI:
10.1016/j.gene.2020.144764

3. Population genetic diversity of mud crab (Scylla paramamosain) from southeast coastal regions of China based on mitochondrial COI gene sequence

Author:
Wei Wang; Chunyan Ma; Wei Chen; Zhongwen Jin; Ming Zhao; Fengying Zhang; Zhiqiang Liu; Lingbo Ma
Source:
Gene 2020 v.751 pp. 144763
ISSN:
0378-1119
Subject:
Scylla paramamosain; coasts; crabs; cytochrome-c oxidase; genes; genetic background; genetic distance; genetic variation; haplotypes; mitochondria; nucleotide sequences; population structure; progeny; variance; China
Abstract:
... Mud crab (Scylla paramamosain) is a native and economically important species in East Asia. In order to provide a comprehensive genetic background for the resource protection and management in this species, the genetic diversity and population structure of S. paramamosain were analyzed based on mitochondrial cytochrome oxidase subunit I (COI) gene sequence. Totally, 599 individuals were sampled fr ...
DOI:
10.1016/j.gene.2020.144763

4. UvHrip1, an effector secreted by Ustilaginoidea virens, suppresses basal defense and promotes disease development in Arabidopsis thaliana

Author:
Shuai Li; Shibo Xiang; Yingling Wang; Jianming Zhou; Yingfan Hai; Xunwen Peng; Yan Wang; Songhong Wei
Source:
Gene 2020 v.751 pp. 144776
ISSN:
0378-1119
Subject:
Arabidopsis thaliana; Burkholderia glumae; Nicotiana benthamiana; Pseudomonas syringae pv. tomato; Ustilaginoidea virens; cell death; disease progression; fungi; genes; genetic engineering; innate immunity; mutants; pathogens; rice; rice false smut; secretion; virulence
Abstract:
... Rice false smut (RFS), caused by Ustilaginoidea virens, is one of the most detrimental rice fungal diseases and pose a severe threat to rice production and quality. Effectors in U. virens often act as a set of essential virulence factors that play crucial roles in the interaction between host and the pathogen. Thus, the functions of each effector in U. virens need to be further explored. Here, a c ...
DOI:
10.1016/j.gene.2020.144776

5. Zebrafish ubiquitin-specific peptidase 5 (USP5) activates interferon resistance to the virus by increase the expression of RIG-I

Author:
Jian Yao; Chen Li; Lin Shi; Yuanan Lu; Xueqin Liu
Source:
Gene 2020 v.751 pp. 144761
ISSN:
0378-1119
Subject:
Danio rerio; amino acid sequences; cytoplasm; genes; interferons; sequence analysis; ubiquitin; viruses
Abstract:
... The ubiquitin specific peptidase (USP) family is involved in many life processes, of which antiviral is also an important basic function. One of the more important ways is to activate interferon. In this study, we reported the antiviral function of the ubiquitin specific peptidase 5(USP5) gene in zebrafish. Evolutionary and comparative protein sequence analysis of the USP5 was performed. The local ...
DOI:
10.1016/j.gene.2020.144761

6. A novel lncRNA, lnc403, involved in bovine skeletal muscle myogenesis by mediating KRAS/Myf6

Author:
Xiaojuan Zhang; Mingming Chen; Xinfeng Liu; Linlin Zhang; Xiangbin Ding; Yiwen Guo; Xin Li; Hong Guo
Source:
Gene 2020 v.751 pp. 144706
ISSN:
0378-1119
Subject:
bioinformatics; breathing; cattle; cell differentiation; cell proliferation; genes; mass spectrometry; metabolism; models; muscle development; myoblasts; myotubes; plasticity; posture; satellites; skeletal muscle; transcription factors
Abstract:
... Skeletal muscle, the most abundant and plasticity tissue in mammals, is essential for various functions such as movement, breathing, maintaining posture and metabolism. Myogenesis is a complex and precise process, which is regulated by the sequential expression of multiple transcription factors, and accumulating evidence have confirmed that multiple lncRNAs are involved in muscle development as th ...
DOI:
10.1016/j.gene.2020.144706

7. Genetic determinants of fracture non-union: A systematic review from the literature

Author:
Ting Yan; Jin Li; Xindie Zhou; Zhicheng Yang; Yi Zhang; Junjie Zhang; Nanwei Xu; Yong Huang; Haoyu Yang
Source:
Gene 2020 v.751 pp. 144766
ISSN:
0378-1119
Subject:
bioinformatics; bone fractures; fibroblast growth factor receptor 1; genes; inflammation; systematic review
Abstract:
... Approximately 10–15% of fracture patients suffer impaired healing, which is either delayed or even results in non-union. We performed a Systematic Review, aiming to examine the types and frequency of specific genetic abnormalities in patients experiencing bone fracture and to ascertain whether a genetic association exists regarding the tendency for some patients to suffer fracture non-union or pos ...
DOI:
10.1016/j.gene.2020.144766

8. Involvement of Leptinotarsa hormone receptor 38 in the larval-pupal transition

Author:
Chen-Hui Shen; Qing-Yu Xu; Li-Li Mu; Kai-Yun Fu; Wen-Chao Guo; Guo-Qing Li
Source:
Gene 2020 v.751 pp. 144779
ISSN:
0378-1119
Subject:
Leptinotarsa decemlineata; RNA interference; biosynthesis; chitin; death; dietary supplements; dose response; ecdysteroidogenesis; ecdysterone; genes; hormone receptors; insects; instars; larvae; liquids; mortality; prepupae; pupation
Abstract:
... In insects, nuclear receptors (NRs) including EcR (NR1H1), USP (NR2B4), E75 (NR1D3), HR3 (NR1F), HR4 (NR6) and FTZ-F1 (NR5A3) mediate the 20-hydroxyecdysone (20E) signaling cascade to play a critical role during larval metamorphosis. In this present paper, we focused on hormone receptor 38 (HR38) in Leptinotarsa decemlineata, the only insect homolog of the NR4A subclass. RNA interference (RNAi) of ...
DOI:
10.1016/j.gene.2020.144779

9. Study the association of transmembrane serine protease 6 gene polymorphisms with iron deficiency status in Saudi Arabia

Author:
Osama Al-Amer; Yousef Hawasawi; Atif Abdulwahab A. Oyouni; Mohammed Alshehri; Abdulrahman Alasmari; Othman Alzahrani; Saad Ali S. Aljohani
Source:
Gene 2020 v.751 pp. 144767
ISSN:
0378-1119
Subject:
blood sampling; college students; females; genes; genetic polymorphism; genotype; genotyping; iron; men; polymorphism; pregnant women; preschool children; serine proteinases; Saudi Arabia
Abstract:
... Intheclinical setting, iron deficiencyanaemia(IDA) represents a majorglobalhealthconcern. This health condition is reported in 30% of non-pregnant women, 42% of pregnant women (aged 15–50 years), 12.7% of men (15 years or older) and in 47% of preschool children (aged 0 to 5 years). Several genetic polymorphisms associated with iron status havebeen identified by using genome-wide association studie ...
DOI:
10.1016/j.gene.2020.144767

10. Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway

Author:
Xiaoliu Liu; Chuchan Zhou; Yongjian Li; Yurong Deng; Wensheng Lu; Juan Li
Source:
Gene 2020 v.751 pp. 144726
ISSN:
0378-1119
Subject:
Western blotting; apoptosis; assays; biomarkers; cell proliferation; cell viability; circular RNA; genes; lymphocytic leukemia; neoplasm cells; therapeutics
Abstract:
... Acute lymphoblastic leukemia (ALL) is a common hematologic malignancy. Circular RNAs (circRNAs) have been reported as an important factor in regulating cellular process expressed in all hematopoietic compartment. But the molecular mechanism of circRNAs in ALL remain unclear. In this study, we observed circ-0000745 upregulated in leukemia cells (Kasumi-1 and KG-1). Upregulated the expression of cir ...
DOI:
10.1016/j.gene.2020.144726