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- Author:
- Zhang, Huo; Zhu, Mingxia; Shan, Xia; Zhou, Xin; Wang, Tongshan; Zhang, Jinying; Tao, Jinsong; Cheng, Wenfang; Chen, Gang; Li, Jian; Liu, Ping; Wang, Qiang; Zhu, Wei
- Source:
- Gene 2019 v.687 pp. 246-254
- ISSN:
- 0378-1119
- Subject:
- biomarkers; colorectal neoplasms; exosomes; gene expression regulation; microRNA; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; screening; tissues
- Abstract:
- ... Colorectal cancer (CRC) has been one of the most commonly diagnosed cancers in global. The differential expression profiles of microRNAs (miRNAs) in CRC plasma of patients have the potential to serve as a diagnostic biomarker. We conducted a four-stage study to identify the potential plasma miRNAs for CRC detection. In the initial screening phase, Exiqon panel (miRCURY-Ready-to-Use-PCR-Human-panel ...
- DOI:
- 10.1016/j.gene.2018.11.055
-
https://dx.doi.org/10.1016/j.gene.2018.11.055
- Author:
- Pawłowicz, Izabela; Masajada, Katarzyna
- Source:
- Gene 2019 v.687 pp. 166-172
- ISSN:
- 0378-1119
- Subject:
- abiotic stress; aquaporins; carbon dioxide; leaves; mesophyll; permeability; photosynthesis; plant organs; roots; solutes; stress tolerance
- Abstract:
- ... Plant aquaporins constitute a large family of proteins involved in facilitating the transport of water and small neutral molecules across biological membranes. In higher plants they are divided into several sub-families, depending on membrane-type localization and permeability to specific solutes. They are abundantly expressed in the majority of plant organs and tissues, and play a function in pri ...
- DOI:
- 10.1016/j.gene.2018.11.031
-
https://dx.doi.org/10.1016/j.gene.2018.11.031
- Author:
- Qiu, Pingfeng; Wang, Licheng; Ni, Jianming; Zhang, Yunlong
- Source:
- Gene 2019 v.687 pp. 23-29
- ISSN:
- 0378-1119
- Subject:
- Chinese people; alleles; blood serum; enzyme-linked immunosorbent assay; genetic variation; genotype; loci; mutants; nucleoproteins; patients; risk factors; sepsis (infection); single nucleotide polymorphism; survival rate
- Abstract:
- ... High mobility group box 1 protein (HMGB1) is an important late inflammatory mediator in the body. In recent years, studies have found that it plays an important pathogenic role in various diseases such as sepsis. However, it is unclear whether the genetic variation of the HMGB1 gene is related to the susceptibility to sepsis. This study investigated the relationship between susceptibility and outc ...
- DOI:
- 10.1016/j.gene.2018.11.027
-
https://dx.doi.org/10.1016/j.gene.2018.11.027
- Author:
- Ghaedi, Hamid; Mozaffari, Mohammad Amin Nazer; Salehi, Zaker; Ghasemi, Hassan; Zadian, Seyed Sajjad; Alipoor, Sadegh; Hadianpour, Shiva; Alipoor, Behnam
- Source:
- Gene 2019 v.687 pp. 135-142
- ISSN:
- 0378-1119
- Subject:
- case-control studies; microRNA; non-coding RNA; pathogenesis; patients; quantitative polymerase chain reaction; stomach neoplasms
- Abstract:
- ... The recent researches indicate that differential non-coding RNAs expression signatures could be associated with the pathogenesis of gastric cancer (GC). However, there are few studies focused on lncRNA-miRNAs co-expression profiling in GC patients. Therefore, in the present study the expression of H19 and MEG3 and their related miRNAs including miR-148a-3p, miR-181a-5p, miR-675-5p and miR-141-3p w ...
- DOI:
- 10.1016/j.gene.2018.11.034
-
https://dx.doi.org/10.1016/j.gene.2018.11.034
- Author:
- Rojas, Andrea; Mardones, Rodrigo; Pritzker, Kenneth; van Wijnen, Andre J.; Galindo, Mario A.; Las Heras, Facundo
- Source:
- Gene 2019 v.687 pp. 228-237
- ISSN:
- 0378-1119
- Subject:
- alkaline phosphatase; bone marrow; cartilage; cell culture; chondrocytes; collagen; genes; glycosaminoglycans; growth plate; humans; hypertrophy; mesenchymal stromal cells; muscles; phenotype; sequence analysis; stem cells; tissue engineering
- Abstract:
- ... The in vitro process of chondrogenic differentiation of mesenchymal stem cells (MSCs) induces a pre-apoptotic hypertrophic phenotype, guided by the active status of the WNT/β‑catenin pathway. To achieve a stable chondrocyte phenotype for cartilage tissue engineering, it is necessary to gain a better understanding of specific genes that regulate the cartilage tissue phenotype. RNA sequencing (RNA-s ...
- DOI:
- 10.1016/j.gene.2018.11.037
-
https://dx.doi.org/10.1016/j.gene.2018.11.037
- Author:
- Wei, Ling; Li, Xiaoyan; Li, Minghui; Tang, Yaohao; Wei, Jing; Wang, Deshou
- Source:
- Gene 2019 v.687 pp. 109-115
- ISSN:
- 0378-1119
- Subject:
- Oreochromis niloticus; chromatin; gel electrophoresis; genes; luciferase; males; mammals; precipitin tests; regulatory sequences; sexual development; site-directed mutagenesis; testes; transcription (genetics); transcription factors; translation (genetics)
- Abstract:
- ... The Nile tilapia Sox9b gene is characterized as a homolog of the mammalian Sox9 gene, which exhibits testis-biased expression and is involved in testis development. However, the transcriptional regulation of the Sox9b gene is poorly understood. In this study, we demonstrated that the male sex differentiation gene doublesex and mab-3 related transcription factor 1 (Dmrt1) was predominantly expresse ...
- DOI:
- 10.1016/j.gene.2018.11.016
-
https://dx.doi.org/10.1016/j.gene.2018.11.016
- Author:
- Karakus, Nevin; Yigit, Serbulent; Duygu, Fazilet; Barut, Sener; Rustemoglu, Aydin; Basol, Nursah
- Source:
- Gene 2019 v.687 pp. 188-192
- ISSN:
- 0378-1119
- Subject:
- Crimean-Congo hemorrhagic fever; alleles; disease severity; fever; genotype; high density lipoprotein; mortality; oxidative stress; patients; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; viruses
- Abstract:
- ... Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever caused by Crimean Congo hemorrhagic fever virus (CCHFV). Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-binding protein which defense the body against oxidative stress. To investigate the role of the PON1 gene in CCHF, we screened the genotypes of two single nucleotide polymorphisms (Q192R [rs662] and L55M [rs8545 ...
- DOI:
- 10.1016/j.gene.2018.11.059
-
https://dx.doi.org/10.1016/j.gene.2018.11.059
- Author:
- Orangi, Elham; Motovali-Bashi, Majid
- Source:
- Gene 2019 v.687 pp. 272-279
- ISSN:
- 0378-1119
- Subject:
- analysis of variance; biomarkers; breast neoplasms; data analysis; microRNA; patients; reverse transcriptase polymerase chain reaction; t-test; tissues; women; women's health
- Abstract:
- ... MicroRNAs are involved in diverse biological processes and their dysregulation is a common event in various diseases including breast cancer. Breast cancer is a major threat to women's health. This study was designed to examine the expression levels of miR-9 and miR-34a in breast tumor tissue samples and plasma of breast cancer patients, compare their expression pattern between tissue samples and ...
- DOI:
- 10.1016/j.gene.2018.11.036
-
https://dx.doi.org/10.1016/j.gene.2018.11.036
- Author:
- Zhao, Lei; Cao, Huan; Chi, Weiwei; Meng, Wenxia; Cui, Weina; Guo, Wei; Wang, Baoshan
- Source:
- Gene 2019 v.687 pp. 47-55
- ISSN:
- 0378-1119
- Subject:
- bioinformatics; carcinogenicity; cell proliferation; data collection; gene expression; gene expression regulation; genes; in vitro studies; landscapes; larynx; lymph nodes; messenger RNA; metastasis; non-coding RNA; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; screening; squamous cell carcinoma
- Abstract:
- ... In order to explore the differentially expressed long non-coding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC), the GSE84957 lncRNA expression profile was included in the present study through data mining in the National Center for Biotechnology Information/Gene Expression Omnibus (NCBI/GEO). Then, the differentially expressed genes (DEGs) of LSCC (1646 lncRNAs and 2713 mRNAs, fold ch ...
- DOI:
- 10.1016/j.gene.2018.11.020
-
https://dx.doi.org/10.1016/j.gene.2018.11.020
- Author:
- Zhao, Xinqian; He, Jing; Xie, Guoyan; Xu, Song; Xie, Jun; Chen, Youyuan; Wu, Hui
- Source:
- Gene 2019 v.687 pp. 16-22
- ISSN:
- 0378-1119
- Subject:
- adults; alleles; biomarkers; children; genetic variation; genotyping; heterozygosity; homozygosity; interleukin-10; interleukin-18; interleukin-6; lungs; pathogenesis; patients; regression analysis; restriction fragment length polymorphism; risk; tumor necrosis factors
- Abstract:
- ... Acute lung injury (ALI) is a serious clinical syndrome that can cause respiratory failure and threaten the life of the patients. A biomarker that can predict the syndrome can contribute to a better clinical management of the patients. In adults, genetic polymorphisms in inflammatory-response genes have been shown to be a promising biomarker. However, the pathogenesis of ALI in adult is known to be ...
- DOI:
- 10.1016/j.gene.2018.11.009
-
https://dx.doi.org/10.1016/j.gene.2018.11.009
- Author:
- Zou, Zhi; Zhu, Jiali; Zhang, Xicai
- Source:
- Gene 2019 v.687 pp. 298-307
- ISSN:
- 0378-1119
- Subject:
- Manihot esculenta; cassava; chromosomes; genes; phylogeny; staple crops; tissues; transcription (genetics); transcription factors
- Abstract:
- ... Dof proteins comprise a plant-specific transcription factor family involved in regulation of many plant processes. Despite their diverse roles, little information is available in cassava (Manihot esculenta, Euphorbiaceae), the sixth major staple crop in the world. This study presents the first genome-wide identification of Dof family genes in cassava, resulting in 45 family members that are uneven ...
- DOI:
- 10.1016/j.gene.2018.11.053
-
https://dx.doi.org/10.1016/j.gene.2018.11.053
- Author:
- Koca, Serhat; Tümer, Leyla; Okur, İlyas; Erten, Yasemin; Bakkaloğlu, Sevcan; Biberoğlu, Gürsel; Kasapkara, Çiğdem; Küçükçongar, Aynur; Dalgıç, Buket; Oktar, Suna Özhan; Öner, Yusuf; Atalay, Tuba; Cemri, Mustafa; Çiftçi, Bahattin; Topçu, Burcu; Hasanoğlu, Alev; Ezgü, Fatih
- Source:
- Gene 2019 v.687 pp. 280-288
- ISSN:
- 0378-1119
- Subject:
- Fabry disease; alpha-galactosidase; antibodies; celiac disease; cholesterol; disease course; females; fever; heterozygosity; homocysteine; image analysis; immunoglobulin M; lipoproteins; males; patients; phenotype; prothrombin; risk factors; signs and symptoms (animals and humans); Turkey (country)
- Abstract:
- ... Fabry disease results from deficiency of the lysosomal enzyme alpha-galactosidase A.The families of 11 index cases were screened by enzyme and molecular assays. Further clinical and laboratory investigations were carried out in all cases.Including 33 new patients, a total of 28 females (Age 25,82 ± 12,1 Range 8–46) and 16 males (Age 24,56 ± 15,04 Range 2–48) were investigated. Ten different diseas ...
- DOI:
- 10.1016/j.gene.2018.11.054
-
https://dx.doi.org/10.1016/j.gene.2018.11.054
- Author:
- Li, Ruth Zhen; Hou, Jing; Wei, Yaxun; Luo, Xiaotian; Ye, Yali; Zhang, Yi
- Source:
- Gene 2019 v.687 pp. 125-134
- ISSN:
- 0378-1119
- Subject:
- RNA-binding proteins; alternative splicing; apoptosis; cell movement; cell proliferation; females; gene expression; genes; messenger RNA; pregnancy; sequence analysis; signal transduction; transcription (genetics); transcriptome; tumor necrosis factors
- Abstract:
- ... RNA binding proteins (RBPs) are key players of genome regulation. Here we report the transcriptome study of HnRNP D-Like protein, which belongs to the hnRNP family. We used RNA-seq to analyze the global transcript level and alternative splicing on hnRNPDL shRNA-treated cells and control. Sh-hnRNPDL extensively increased in the expression of genes involved in female pregnancy, cell apoptosis, cell ...
- DOI:
- 10.1016/j.gene.2018.11.026
-
https://dx.doi.org/10.1016/j.gene.2018.11.026
- Author:
- Jo, Ara; Lee, Hee-Eun; Kim, Heui-Soo
- Source:
- Gene 2019 v.687 pp. 238-245
- ISSN:
- 0378-1119
- Subject:
- Retroviridae; binding sites; bioinformatics; databases; genome; horses; messenger RNA; microRNA; phylogeny; quantitative polymerase chain reaction; terminal repeat sequences; tissues
- Abstract:
- ... Horses (Equus caballus) have been domesticated and bred to enhance speed, strength, and agility. Members of the Equus caballus Endogenous Retrovirus (EqERV) family affect several of these abilities in horses. EqERV elements have been integrated in the horse genome during evolution and generate repeat elements such as long terminal repeats (LTRs). LTR sequences are involved in retrovirus replicatio ...
- DOI:
- 10.1016/j.gene.2018.11.043
-
https://dx.doi.org/10.1016/j.gene.2018.11.043
- Author:
- Wu, Jixiang; He, Keshuai; Zhang, Yajun; Song, Jixiang; Shi, Zhan; Chen, Weiwei; Shao, Yongfeng
- Source:
- Gene 2019 v.687 pp. 193-199
- ISSN:
- 0378-1119
- Subject:
- adenocarcinoma; carcinogenesis; chromatin; databases; gene expression; gene expression regulation; genomic islands; in vitro studies; lung neoplasms; lungs; messenger RNA; methylation; neoplasm cells; patients; tissues; transcription (genetics); tumor suppressor genes
- Abstract:
- ... The SWI/SNF complex is a multimeric chromatin remodeling complex that has vital roles in regulating gene expression and cancer development. However, to date few studies have deeply explored the mechanism of SMARCA2 inactivation. We applied multi-omics analysis to explore the mechanism of SMARCA2 inactivation in The Cancer Genome Atlas (TCGA) database and performed the dCas9-DNMT3a system to evalua ...
- DOI:
- 10.1016/j.gene.2018.11.032
-
https://dx.doi.org/10.1016/j.gene.2018.11.032
- Author:
- Kunceviciene, Edita; Liutkeviciene, Rasa; Budiene, Brigita; Sriubiene, Margarita; Smalinskiene, Alina
- Source:
- Gene 2019 v.687 pp. 151-155
- ISSN:
- 0378-1119
- Subject:
- 3' untranslated regions; DNA; alleles; blood cells; blood sampling; genotype; genotyping; homeotic genes; myopia; odds ratio; patients; quantitative polymerase chain reaction; risk; single nucleotide polymorphism
- Abstract:
- ... This study aimed to find associations between miR-328 expression in whole blood, polymorphism at 3′UTR of the PAX6 gene (paired box homeotic gene 6) and myopia.We evaluated 451 individuals (142 individuals with low, 49 with moderate and 13 with high-degree myopia, and 247 healthy individuals). DNA and RNA were extracted from peripheral blood samples. Expression of miR-328 was assessed and genotypi ...
- DOI:
- 10.1016/j.gene.2018.11.030
-
https://dx.doi.org/10.1016/j.gene.2018.11.030
- Author:
- Lee, Mihye; Nguyen, Thanh My Thi; Kim, Kiyoung
- Source:
- Gene 2019 v.687 pp. 64-72
- ISSN:
- 0378-1119
- Subject:
- Drosophila; RNA-binding proteins; adults; biogenesis; death; embryogenesis; gene overexpression; humans; intestines; larvae; messenger RNA; muscles; mutants; oogenesis; pathogenesis; pupae; stem cells; translation (genetics)
- Abstract:
- ... Lin-28 is a conserved RNA-binding protein that is involved in a wide range of developmental processes and pathogenesis. At the molecular level, Lin-28 blocks the maturation of let-7 and regulates translation of certain mRNA targets. In Drosophila, Lin-28 is reported to play a role in oogenesis, muscle formation, and the symmetric division of adult intestinal stem cells. In this study, we character ...
- DOI:
- 10.1016/j.gene.2018.11.017
-
https://dx.doi.org/10.1016/j.gene.2018.11.017
- Author:
- Dong, Ben-Sheng; Shi, Miao-Juan; Su, Shi-Bing; Zhang, Hui
- Source:
- Gene 2019 v.687 pp. 255-260
- ISSN:
- 0378-1119
- Subject:
- DNA; liver cirrhosis; messenger RNA; microRNA; non-coding RNA; pathological processes and conditions; prognosis; proteins; therapeutics
- Abstract:
- ... Mounting evidence has shown that long noncoding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) in distinct physiological and pathological states. The activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis (HF). LncRNAs have recently been revealed to be involved in HSC activation as ceRNAs. CeRNA analysis tremendously expands the fu ...
- DOI:
- 10.1016/j.gene.2018.11.063
-
https://dx.doi.org/10.1016/j.gene.2018.11.063
- Author:
- Doğan Şiğva, Zeynep Özlem; Balci Okcanoğlu, Tuğçe; Biray Avci, Çığır; Yilmaz Süslüer, Sunde; Kayabaşi, Çağla; Turna, Burak; Dodurga, Yavuz; Nazli, Oktay; Gündüz, Cumhur
- Source:
- Gene 2019 v.687 pp. 261-271
- ISSN:
- 0378-1119
- Subject:
- Alkanna; Phlomis; Rubia; Taxus brevifolia; active ingredients; anticarcinogenic activity; apoptosis; cell cycle checkpoints; cell lines; cyclins; drugs; gene expression; indigenous species; inhibitory concentration 50; neoplasm cells; paclitaxel; plant extracts; plants (botany); prostatic neoplasms; signal transduction; silymarin; synergism; Turkey (country)
- Abstract:
- ... Paclitaxel, which isolated from Taxus brevifolia, is recently started to be used against prostate cancer treatment and it is a very effective compound against cancer. In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tin ...
- DOI:
- 10.1016/j.gene.2018.11.049
-
https://dx.doi.org/10.1016/j.gene.2018.11.049
- Author:
- Sun, Yan; Liu, Jinxiang; Wang, Bo; Liu, Xiumei; Du, Xinxin; Liu, Yuxiang; Zhang, Quanqi
- Source:
- Gene 2019 v.687 pp. 56-63
- ISSN:
- 0378-1119
- Subject:
- Paralichthys olivaceus; animal ovaries; cell proliferation; complementary DNA; epithelial cells; epithelium; flounder; gastrulation; gene expression regulation; genes; gills; neoplasms; nucleotide sequences; oocytes; oogonia; phylogeny; spermatogonia; testes; transcription factors; zinc finger motif
- Abstract:
- ... Krüppel-like factor 4 (Klf4) is a zinc finger protein transcription factor of the KLF family and plays an important role in various important biological process, including cell proliferation, differentiation, embryonic development, and cancer formation. In this study, the full length Klf4 cDNA sequence of Japanese flounder (Paralichthys olivaceus) was analyzed. Phylogenetic, gene structure, and sy ...
- DOI:
- 10.1016/j.gene.2018.11.029
-
https://dx.doi.org/10.1016/j.gene.2018.11.029