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- He, Lin, et al. Show all 7 Authors
- Gene 2014 v.536 pp. 9-17
- Drosophila; Eriocheir sinensis; amino acids; antibodies; cell cycle; genes; mammals; messenger RNA; nucleotides; open reading frames; proteolysis; quantitative polymerase chain reaction; regulatory proteins; spermatocytes; spermatogenesis; spermatogonia; spermatozoa; testes; ubiquitin-protein ligase
- ... The Cullin-RING finger ligases (CRLs) are involved in the ubiquitin-mediated degradation of cell cycle regulators and play an important role in gametogenesis. Cullin 4 (CUL4) is a conserved core component of a new class of ubiquitin E3 ligase, and participates in the proteolysis of several regulatory proteins through the ubiquitin–proteasome pathway. The mammals encode two paralogs of CUL4, CUL4A ...