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Genes & genomics
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7978-2022
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2022 v.44 no.3
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- Author:
- Karolina Czajka; Melanie Mehes-Smith; Kabwe Nkongolo
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 279-297
- ISSN:
- 1976-9571
- Subject:
- DNA hypermethylation; DNA hypomethylation; abiotic stress; bisulfites; epigenetics; genomics; high performance liquid chromatography; histone code; histones; plant response
- Abstract:
- ... BACKGROUND: A review of research shows that methylation in plants is more complex and sophisticated than in microorganisms and animals. Overall, studies on the effects of abiotic stress on epigenetic modifications in plants are still scarce and limited to few species. Epigenetic regulation of plant responses to environmental stresses has not been elucidated. This study summarizes key effects of ab ...
- DOI:
- 10.1007/s13258-021-01191-z
- https://doi.org/10.1007/s13258-021-01191-z
- Author:
- Sunglan Chung; Chian Kwon; Jae-Hoon Lee
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 267-278
- ISSN:
- 1976-9571
- Subject:
- DNA; DNA methylation; abiotic stress; acetylation; chromatin; cold; drought; epigenetics; genomics; heat; histones
- Abstract:
- ... BACKGROUND: Although plants may be regularly exposed to various abiotic stresses, including drought, salt, cold, heat, heavy metals, and UV-B throughout their lives, it is not possible to actively escape from such stresses due to the immobile nature of plants. To overcome adverse environmental stresses, plants have developed adaptive systems that allow appropriate responses to diverse environmenta ...
- DOI:
- 10.1007/s13258-021-01163-3
- https://doi.org/10.1007/s13258-021-01163-3
- Author:
- Haitong Fang; Zhuojuan Luo; Chengqi Lin
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 379-387
- ISSN:
- 1976-9571
- Subject:
- DNA methylation; blastocyst; chromatin; epigenetics; epigenome; gastrulation; gene expression; genomics; histone code; mice; transcription (genetics); transcription factors
- Abstract:
- ... BACKGROUND: Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and ...
- DOI:
- 10.1007/s13258-021-01213-w
- https://doi.org/10.1007/s13258-021-01213-w
- Author:
- Weixuan Cong; Ning Li; Jinbin Wang; Ying Kang; Yiling Miao; Chunming Xu; Ziqi Wang; Tongtong Liu; Lei Gong; Bao Liu; Xiufang Ou
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 299-306
- ISSN:
- 1976-9571
- Subject:
- DNA methylation; DNA methyltransferase; bisulfites; epigenetics; evolution; gene ontology; genes; genomics; heterozygosity; mercury; mutants; rice
- Abstract:
- ... BACKGROUND: Albeit a relatively stable epigenetic modification, DNA methylation in plants can be repatterned and play important roles in response to biotic and abiotic stresses. However, whether DNA methylation dynamics may contribute to cope with mercury (Hg) stress in plants remains to be fully investigated. OBJECTIVE: To probe the potential roles of DNA methylation dynamics in coping with Hg st ...
- DOI:
- 10.1007/s13258-021-01192-y
- https://doi.org/10.1007/s13258-021-01192-y
- Author:
- Jung-Shin Lee; Nam-Soo Kim
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 247-249
- ISSN:
- 1976-9571
- Subject:
- epigenetics; genomics; intergenic DNA; molecular biology; phenotype
- Abstract:
- ... For much of the twentieth century, it was accepted that genes dictate phenotypes. Nevertheless, genetics in combination with molecular biology and genomics has facilitated the explanation of some peculiar molecular phenomena. Most eukaryotic genomes are crammed with noncoding DNA, which was previously hypothesized to be selfish DNA, with only a small fraction of sequences encoding proteins. We now ...
- DOI:
- 10.1007/s13258-022-01225-0
- https://doi.org/10.1007/s13258-022-01225-0
- Author:
- Yuhong Huang; Yang Liu; Chang Liu; James A. Birchler; Fangpu Han
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 251-257
- ISSN:
- 1976-9571
- Subject:
- chromatin; corn; disease resistance; epigenetics; epigenome; genomics; growth and development; multiomics; rice; wheat
- Abstract:
- ... BACKGROUND: The advent of high-throughput epigenome mapping techniques has ushered in a new era of multiomics with powerful tools now available to map and record genomic output at different levels. Integrating the different components of the epigenome from these multiomics measures allows investigations of cis-regulatory elements on a genome-scale. Mapping of chromatin state, chromatin accessibili ...
- DOI:
- 10.1007/s13258-021-01187-9
- https://doi.org/10.1007/s13258-021-01187-9
- Author:
- Takuma Unno; Hisashi Takatsuka; Yuto Ohnishi; Masahiro Ito; Yukihiko Kubota
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 343-357
- ISSN:
- 1976-9571
- Subject:
- Caenorhabditis elegans; eggs; embryogenesis; embryonic mortality; epigenetics; gene expression; gene targeting; genomics; histone deacetylase; mutants; transcriptome; transcriptomics; variance; viability
- Abstract:
- ... BACKGROUND: Caenorhabditis elegans encodes three class I histone deacetylases (HDACs), HDA-1, HDA-2, and HDA-3. Although HDA-1 is known to be involved in embryogenesis, the regulatory roles of HDA-2 and HDA-3 in embryonic development remain unexplored. OBJECTIVE: To elucidate the functional roles of the three class I HDACs in C. elegans embryonic development. METHODS: The roles of Class I HDACs, H ...
- DOI:
- 10.1007/s13258-021-01195-9
- https://doi.org/10.1007/s13258-021-01195-9
8. Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype
- Author:
- Jeong-ki Kim; Yong-Gum Park; Beom Gyu Kim
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 389-394
- ISSN:
- 1976-9571
- Subject:
- Human immunodeficiency virus; Papillomaviridae; genomics; histopathology; medical facilities; sexually transmitted diseases; surgery
- Abstract:
- ... BACKGROUND: Anorectal condyloma is the representative venereal disease caused by human papilloma virus (HPV), which has more 180 subtypes. Although there are various known risk factors for recurrence, few studies have investigated the influence of HPV subtypes. OBJECTIVE: We aimed to investigate the correlation between the recurrence of anorectal condyloma and HPV subtypes. METHODS: We analyzed th ...
- DOI:
- 10.1007/s13258-022-01221-4
- https://doi.org/10.1007/s13258-022-01221-4
- Author:
- Taekyung Kim
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 317-325
- ISSN:
- 1976-9571
- Subject:
- DNA; epigenetics; genomics; heterochromatin; humans; kinetochores; meiosis; mitosis
- Abstract:
- ... BACKGROUND: The centromere is the special region on a chromosome, which serves as the site for assembly of kinetochore complex and is essential for maintaining genomic integrity. Neocentromeres are new centromeres that form on the non-centromeric regions of the chromosome when the natural centromere is disrupted or inactivated. Although neocentromeres lack the typical features found in centromeres ...
- DOI:
- 10.1007/s13258-021-01193-x
- https://doi.org/10.1007/s13258-021-01193-x
- Author:
- Hosub Shin; Woo Lee Choi; Joo Young Lim; Jin Hoe Huh
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 307-315
- ISSN:
- 1976-9571
- Subject:
- DNA methylation; cell differentiation; chromatin; crops; disease resistance; epigenetics; epigenome; gene expression; genes; genomics; histones; meiosis; mitosis; nucleotide sequences; phenotype; stress tolerance; therapeutics
- Abstract:
- ... BACKGROUND: Epigenetic modifications play important roles in diverse cellular processes such as X chromosome inactivation, cell differentiation, development and senescence. DNA methylation and histone modifications are major epigenetic modifications that regulate chromatin structure and gene expression without DNA sequence changes. Epigenetic alterations may induce phenotypic changes stable enough ...
- DOI:
- 10.1007/s13258-021-01199-5
- https://doi.org/10.1007/s13258-021-01199-5
- Author:
- Su Chan Park; Ji Min Lee
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 369-377
- ISSN:
- 1976-9571
- Subject:
- apoptosis; autophagy; carcinogenesis; cell growth; genomics; glucose; hepatoma; histones; homeostasis; lysine; methylation; methyltransferases; microRNA; models; neoplasm progression; point mutation; protein degradation; signal transduction; starvation; therapeutics; thyroid hormone receptors; transcription (genetics); triiodothyronine; ubiquitination
- Abstract:
- ... BACKGROUND: Post-translational modification (PTM) of proteins controls various cellular functions of transcriptional regulators and participates in diverse signal transduction pathways in cancer. The thyroid hormone (triiodothyronine, T3) plays a critical role in metabolic homeostasis via its direct interaction with the thyroid hormone receptor beta (TRβ). TRβ is involved in physiological processe ...
- DOI:
- 10.1007/s13258-021-01196-8
- https://doi.org/10.1007/s13258-021-01196-8
- Author:
- Eun Yu Kim; Kyung Do Kim; Jungnam Cho
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 259-266
- ISSN:
- 1976-9571
- Subject:
- CRISPR-Cas systems; DNA methylation; artificial selection; epigenetics; epigenome; genes; genetic variation; genomics; tissue culture
- Abstract:
- ... BACKGROUND: The epigenetic mechanisms play critical roles in a vast diversity of biological processes of plants, including development and response to environmental challenges. Particularly, DNA methylation is a stable epigenetic signature that supplements the genetics-based view of complex life phenomena. In crop breeding, the decrease in genetic diversity due to artificial selection of conventio ...
- DOI:
- 10.1007/s13258-021-01189-7
- https://doi.org/10.1007/s13258-021-01189-7
- Author:
- Soojin Yeom; Junsoo Oh; Jung-Shin Lee
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 359-367
- ISSN:
- 1976-9571
- Subject:
- Saccharomyces cerevisiae; chromatin; chromatin immunoprecipitation; gene expression; genomics; landscapes; sequence analysis; telomeres; yeasts
- Abstract:
- ... BACKGROUND: In the budding yeast Saccharomyces cerevisiae, a silent chromatin structure is formed at three distinct loci, including telomeres, rDNA, and mating-type loci, which silence the expression of genes within their structures. Sir2 is the only common factor, regulating the three silent chromatin regions. S. cerevisiae has 32 telomeres, but studies on gene silencing in budding yeast have bee ...
- DOI:
- 10.1007/s13258-021-01203-y
- https://doi.org/10.1007/s13258-021-01203-y
- Author:
- Agnik Haldar; Ajay Kumar Singh
- Source:
- Genes & genomics 2022 v.44 no.3 pp. 327-342
- ISSN:
- 1976-9571
- Subject:
- genomics; hygiene; mouth neoplasms; non-coding RNA; prognosis; squamous cell carcinoma; tobacco; India
- Abstract:
- ... BACKGROUND: Oral cancer is considered one of the most prevalent cancers in India. This is mainly because India suffers from high usage of tobacco, which is one of the main causative agents of oral cancer, and lacks proper health and sexual hygiene in rural areas. DISCUSSION: Non-coding RNAs are reported to be involved in the various mechanism and causality of cancer. Numerous reports have identifi ...
- DOI:
- 10.1007/s13258-021-01194-w
- https://doi.org/10.1007/s13258-021-01194-w