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You searched for: Journal name Genetica Remove constraint Journal name: Genetica Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.150 no.1 Remove constraint Source: 2022 v.150 no.1
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1. A comparative study of microsatellites among crocodiles and development of genomic resources for the critically endangered Indian gharial

Author:
Sahil Mahfooz; Pallavi Singh; Yusuf Akhter
Source:
Genetica 2022 v.150 no.1 pp. 67-75
ISSN:
0016-6707
Subject:
Alligator mississippiensis; Crocodylus porosus; Gavialis gangeticus; comparative study; metagenomics; microsatellite repeats; species identification; transcriptomics
Abstract:
... Next-generation sequencing has allowed us to explore new methods, where comparative and population genomics can be used simultaneously. Keeping this in mind, we surveyed and analyzed the frequency and distribution of microsatellites in the Indian gharial (Gavialis gangeticus) and compared it with American alligator (Alligator mississippiensis) and saltwater crocodile (Crocodylus porosus) to enrich ...
DOI:
10.1007/s10709-021-00148-0

2. Comprehensive analysis of the LncRNAs, MiRNAs, and MRNAs acting within the competing endogenous RNA network of LGG

Author:
Yiming Ding; Hanjie Liu; Chuanbao Zhang; Zhaoshi Bao; Shuqing Yu
Source:
Genetica 2022 v.150 no.1 pp. 41-50
ISSN:
0016-6707
Subject:
gene ontology; glioma; messenger RNA; microRNA; non-coding RNA; pathogenesis
Abstract:
... Messenger RNA (mRNA) and long noncoding RNA (lncRNA) targets interact via competitive microRNA (miRNA) binding. However, the roles of cancer-specific lncRNAs in the competing endogenous RNA (ceRNA) networks of low-grade glioma (LGG) remain unclear. This study obtained RNA sequencing data for normal solid tissue and LGG primary tumour tissue from The Cancer Genome Atlas database. We used a computat ...
DOI:
10.1007/s10709-021-00145-3

3. Applications of CRISPR/Cas9 technology for modification of the plant genome

Author:
Sohini Deb; Amrita Choudhury; Banridor Kharbyngar; Rama Rao Satyawada
Source:
Genetica 2022 v.150 no.1 pp. 1-12
ISSN:
0016-6707
Subject:
CRISPR-Cas systems; CRISPR-associated endonuclease 9; DNA; adaptive immunity; biosafety; genes
Abstract:
... The CRISPR/Cas (Clustered regularly interspaced short palindromic repeats/ CRISPR associated protein 9) system was discovered in bacteria and archea as an acquired immune response to protect the cells from infection. This technology has now evolved to become an efficient genome editing tool, and is replacing older gene editing technologies. This technique uses programmable sgRNAs to guide the Cas9 ...
DOI:
10.1007/s10709-021-00146-2

4. De novo assembly, transcriptome characterization and marker discovery in Indian major carp, Labeo rohita through pyrosequencing

Author:
L. Sahoo; S. P. Das; A. Bit; S. Patnaik; M. Mohanty; G. Das; P. Das
Source:
Genetica 2022 v.150 no.1 pp. 59-66
ISSN:
0016-6707
Subject:
Labeo rohita; allelic imbalance; body weight; carp; consumer preferences; databases; genetic improvement; genomics; high-throughput nucleotide sequencing; liver; microsatellite repeats; muscles; transcription factors; transcriptome; India
Abstract:
... Labeo rohita, one of the Indian major carps, is the most popular culture species in Indian subcontinent due to its consumer preference and delicacy. A selective breeding program for harvest body weight has resulted in an average genetic gain of 17% per generation. Transcriptome resource for this species is scanty. Here, we have characterized the liver and muscle transcriptomes of rohu using Roche ...
DOI:
10.1007/s10709-021-00141-7

5. Genome-wide mining of potentially-hypervariable microsatellites and validation of markers in Momordica charantia L.

Author:
Lavale Shivaji Ajinath; Deepu Mathew
Source:
Genetica 2022 v.150 no.1 pp. 77-85
ISSN:
0016-6707
Subject:
Momordica charantia; cultivars; microsatellite repeats; phylogeny
Abstract:
... Relatively large number of bitter melon microsatellite markers have been reported; however, only few resulted in successful PCR amplification and a small fraction shown polymorphisms. This limited chance of recovering polymorphic markers makes the primer screening a cost-demanding process. To test the hypothesis that microsatellites with longer motifs as well as shorter motifs repeated substantial ...
DOI:
10.1007/s10709-021-00142-6

6. Pathogen resistance in Sphagneticola trilobata (Singapore daisy): molecular associations and differentially expressed genes in response to disease from a widespread fungus

Author:
Shan-Shan Qi; Bharani Manoharan; Vignesh Dhandapani; Sridharan Jegadeesan; Susan Rutherford; Justin S. H. Wan; Ping Huang; Zhi-Cong Dai; Dao-Lin Du
Source:
Genetica 2022 v.150 no.1 pp. 13-26
ISSN:
0016-6707
Subject:
RNA; Sphagneticola trilobata; Thanatephorus cucumeris; biodiversity; disease resistance; fungi; gene expression regulation; indigenous species; invasive species; noxious weeds; pathogens; stress response; transcriptome; unigenes
Abstract:
... Understanding the molecular associations underlying pathogen resistance in invasive plant species is likely to provide useful insights into the effective control of alien plants, thereby facilitating the conservation of native biodiversity. In the current study, we investigated pathogen resistance in an invasive clonal plant, Sphagneticola trilobata, at the molecular level. Sphagneticola trilobata ...
DOI:
10.1007/s10709-021-00147-1

7. Predominant monomorphism of the RIT2 and GPM6B exceptionally long GA blocks in human and enriched divergent alleles in the disease compartment

Author:
S. Khamse; M. Arabfard; M. Salesi; E. Behmard; Z. Jafarian; H. Afshar; M. Khazaei; M. Ohadi
Source:
Genetica 2022 v.150 no.1 pp. 27-40
ISSN:
0016-6707
Subject:
alleles; databases; females; gene expression; genotype; humans; natural selection; phenotype; sclerosis
Abstract:
... Across human protein-coding genes, the human neuron-specific genes, RIT2 and GPM6B, contain the two longest GA short tandem repeats (STRs) of 11 and 9-repeats, respectively, the length ranges of which are functional, and result in gene expression alteration. Here we sequenced the RIT2 and GPM6B STRs in 600 human subjects, consisting of late-onset neurocognitive disorder (n = 200), multiple scleros ...
DOI:
10.1007/s10709-021-00143-5

8. The statistical power of genome-wide association studies for threshold traits with different frequencies of causal variants

Author:
Hassan Khanzadeh; Navid Ghavi Hossein-Zadeh; Shahrokh Ghovvati
Source:
Genetica 2022 v.150 no.1 pp. 51-57
ISSN:
0016-6707
Subject:
heritability; statistical models; variance
Abstract:
... This study aimed to investigate the effects of incidence rate, heritability, and polygenic variance on the statistical power of genome-wide association studies (GWAS) for threshold traits. Different incidence rates of threshold trait (1, 3, 5, 10, 25, 40, 50, 60, 75 and 90%), heritability (10 and 25%), and polygenic variance ratio (0 and 25%) were simulated separately for common (MAF ≥ 0.05), low- ...
DOI:
10.1007/s10709-021-00140-8