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- Choi, Jeong-Hyeon, et al. Show all 7 Authors
- Genome biology 2014 v.15 no.6 pp. 3288
- chromatin; gene expression; genes; genomic islands; humans; loci; methylation; models; neoplasm cells; neoplasms; transcription (genetics)
- ... BACKGROUND: The TET family of dioxygenases catalyze conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), but their involvement in establishing normal 5mC patterns during mammalian development and their contributions to aberrant control of 5mC during cellular transformation remain largely unknown. We depleted TET1, TET2, and TET3 in a pluripotent embryonic carcinoma cell model an ...
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