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- Fernandez-Chamorro, Javier, et al. Show all 4 Authors
- Genome biology 2019 v.20 no.1 pp. 141
- DNA damage; DNA-directed RNA polymerase; cell cycle; drugs; evolution; exons; humans; introns; neoplasms; spliceosomes
- ... BACKGROUND: The long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel exons. However, the permissibility of genes to this type of acquisition and its influence on the evolution of cell regulation is poorly understood. RESULTS: Here, we observe that human genes are highly permissive to the inclusion of novel exonic regi ...