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- Dombrink-Kurtzman, M.A.; Gomez-Flores, R.; Weber, R.J.
- Immunopharmacology 2000 v.49 no.3 pp. 401
- mycotoxicosis; immune response; macrophage activation; spleen; T-lymphocytes; cell proliferation; rats; animal disease models; Gibberella fujikuroi; Fusarium proliferatum; animal pathogenic fungi; fumonisin B1; mycotoxins; food contamination; feed contamination; dose response; interferons; nitric oxide; signal transduction; interleukin-2; human health; animal health; interferon-gamma
- ... Fumonisins represent a family of toxic, structurally related metabolites produced by fungi that are found in corn worldwide. We investigated the effects of the mycotoxin, fumonisin B1, on rat splenic macrophage and lymphocyte functions. Pretreatment (24 h) of resident macrophages with fumonisin B1 (1, 10, and 100 μg/ml) significantly (p<0.01) stimulated nitric oxide production (0.48, 2.60, and 4.4 ...