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- Liu, Qian; Arseculeratne, Cristin; Liu, Zhugong; Whitmire, Jeannette; Grusby, Michael J.; Finkelman, Fred D.; Darling, Thomas N.; Cheever, Allen W.; Swearengen, James; Urban, Joseph F.; Gause, William C.
- Infection and immunity 2004 v.72 no.7 pp. 3706
- Demodex; ectoparasites; parasitoses; skin diseases; inflammation; mutants; transcription factors; lymphocyte antigens; CD4-positive T-lymphocytes; dermatitis; host-parasite relationships; nematode infections; Nippostrongylus brasiliensis; interleukin-4; immunoglobulin G; antibody formation; CD8-positive T-lymphocytes; mice
- ... A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28-/- BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was induced following infection with nematode parasites. Unexpectedly, when they were between 4 and 8 months old, ...
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