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- Russo, Thomas A.; Luke, Nicole R.; Beanan, Janet M.; Olson, Ruth; Sauberan, Shauna L.; MacDonald, Ulrike; Schultz, L. Wayne; Umland, Timothy C.; Campagnari, Anthony A.
- Infection and immunity 2010 v.78 no.9 pp. 3993-4000
- rats, etc ; Acinetobacter baumannii; ascites; blood serum; drugs; essential genes; flow cytometry; humans; models; monoclonal antibodies; multiple drug resistance; mutants; outer membrane proteins; pathogenesis; pathogens; phenotype; polymerization; transposons; tyrosine; virulence; Show all 20 Subjects
- ... Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. baumannii strain AB307-0294 were screened to identify genes essential for growth in ...
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- Hamilton, Andrea; Popham, David L.; Carl, David J.; Lauth, Xavier; Nizet, Victor; Jones, Amanda L.
- Infection and immunity 2006 v.74 no.11 pp. 6179-6187
- rats, etc ; Streptococcus agalactiae; antimicrobial cationic peptides; complement; crosslinking; humans; innate immunity; models; mutants; neutrophils; pathogens; peptidoglycans; polymerization; virulence; Show all 14 Subjects
- ... Evasion of host immune defenses is critical for the progression of invasive infections caused by the leading neonatal pathogen, group B streptococcus (GBS). Upon characterizing the factors required for virulence in a neonatal rat sepsis model, we found that a surface-associated penicillin-binding protein (PBP1a), encoded by ponA, played an essential role in resistance of GBS to phagocytic clearanc ...
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