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- Nagashima, Shigeo, et al. Show all 11 Authors
- Infection and immunity 2006 v.74 no.4 pp. 2423-2427
- Plasmodium chabaudi; immunity; interferon-gamma; interleukin-12; malaria; mice; osteopontin; parasites
- ... Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against ...
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