Jump to Main Content
- Williams, Kelly P., et al. Show all 7 Authors
- Infection and immunity 2010 v.78 no.5 pp. 1809-1823
- Agrobacterium radiobacter; Rickettsia; bioinformatics; coevolution; genes; genomics; hosts; nucleotide sequences; phylogeny; plasmids; proteins; researchers; secretion; vaccine development
- ... With an obligate intracellular lifestyle, Alphaproteobacteria of the order Rickettsiales have inextricably coevolved with their various eukaryotic hosts, resulting in small, reductive genomes and strict dependency on host resources. Unsurprisingly, large portions of Rickettsiales genomes encode proteins involved in transport and secretion. One particular transporter that has garnered recent attent ...
- PubMed Central:
- Williams, Kelly P., et al. Show all 12 Authors
- Infection and immunity 2009 v.77 no.2 pp. 642-656
- Coxiella burnetii; DNA; Q fever; bacterial proteins; endocarditis; evolution; genetic variation; genomics; horizontal gene transfer; human diseases; humans; laboratory animals; niches; pathogens; phenotype; pseudogenes; rodents; transposons; virulence
- ... Genetically distinct isolates of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in vitro infectivity/cytopathology and pathogenicity for laboratory animals. Moreover, correlations between C. burnetii genomic groups and human disease presentation (acute versus chronic) have been described, suggesting that isolates have distinct virulence characteristics. ...