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- Venancio, Thiago M.; Wilson, R. Alan; Verjovski-Almeida, Sergio; DeMarco, Ricardo
- International journal for parasitology 2010 v.40 no.6 pp. 743-749
- Schistosoma japonicum; Schistosoma mansoni; blood flukes; evolution; genome; humans; models; people; retrotransposons; schistosomiasis; terminal repeat sequences; transposition (genetics); transposons; Africa; Asia
- ... The genus Schistosoma is composed of blood flukes that infect vertebrates, from which three species are major causative agents of human schistosomiasis, a tropical disease that affects more than 200 million people. Current models of the recent evolution of Schistosoma indicate multiple events of migration and speciation from an Asian ancestral species. Transposable elements are important drivers o ...
- Wu, Jun-Fang; Holmes, Elaine; Xue, Jian; Xiao, Shu-Hua; Singer, Burton H.; Tang, Hui-Ru; Utzinger, Jürg; Wang, Yu-Lan
- International journal for parasitology 2010 v.40 no.6 pp. 695-703
- Necator americanus; Schistosoma japonicum; amino acids; animal models; blood serum; cercariae; citrates; digestive system; glucose; hamsters; hookworms; humans; metabolites; metabolomics; mixed infection; multivariate analysis; nuclear magnetic resonance spectroscopy; parasitoses; succinic acid; tricarboxylic acid cycle; urine; South America
- ... Co-infection with hookworm and schistosomes is a common phenomenon in sub-Saharan Africa, as well as in parts of South America and southeast Asia. As a first step towards understanding the metabolic response of a hookworm-schistosome co-infection in humans, we investigated the metabolic consequences of co-infection in an animal model, using a nuclear magnetic resonance (NMR)-based metabolic profil ...