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You searched for: Journal name International journal of biological macromolecules Remove constraint Journal name: International journal of biological macromolecules Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.209 Remove constraint Source: 2022 v.209
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1. Abortive ligation intermediate blocks seamless repair of double-stranded breaks

Author:
Xuegang Li; Jiacheng Jin; Wenxuan Xu; Mingdao Wang; Liangwei Liu
Source:
International journal of biological macromolecules 2022 v.209 pp. 1498-1503
ISSN:
0141-8130
Subject:
DNA repair; fluorescence; fluorescent dyes; genome; ligases; molecular biology; plasmids; synthetic biology
Abstract:
... Because indel results in frame-shift mutations, seamless repair of double-stranded break (DSB)s plays a pivotal role in synthetic biology, molecular biology, and genome integrity. However, DSB repair is not well documented. T4 DNA ligase (T4lig) served to ligate intra-molecularly a zero bp break-apart DSB linear plasmid DNA pET22b(28a)-xylanase. An ATP T4lig ligation reaction joined one single-str ...
DOI:
10.1016/j.ijbiomac.2022.04.098

2. Ameliorative effect of pioglitazone on glucose induced glycation of α-crystallin: Management of complications associated with diabetic retinopathy

Author:
Zengjin Ren; Jing Song
Source:
International journal of biological macromolecules 2022 v.209 pp. 107-116
ISSN:
0141-8130
Subject:
cataract; crosslinking; crystallins; diabetic retinopathy; drugs; glucose; glycation; lysine; mechanism of action
Abstract:
... The glycation and aggregation of lens proteins significantly contribute to the onset of diabetic cataracts as well as the retinopathy. The glycation exerts numerous alterations in the tertiary structural of proteins. Moreover, the covalent crosslinking of lens crystallins also contribute to the cataract formation. In this article, the effect of pioglitazone on glucose induced glycation and aggrega ...
DOI:
10.1016/j.ijbiomac.2022.03.202

3. Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota

Author:
Qing Hu; Changyu Wu; Juntong Yu; Jianming Luo; Xichun Peng
Source:
International journal of biological macromolecules 2022 v.209 pp. 153-161
ISSN:
0141-8130
Subject:
Angelica sinensis; Lactobacillus; diet; gene expression; intestinal microorganisms; intestines; osteoblasts; osteoclasts; polysaccharides; rheumatoid arthritis; tight junctions; transcriptome
Abstract:
... Rheumatoid arthritis (RA) is an autoimmune disease with a high incidence. Recent studies have demonstrated that diet can contribute to the development and progression of RA. Indeed, non-starch polysaccharides (NSPs) were known to be related to the improvement of RA. In this study, the collagen-induced rats were administrated with Angelica sinensis polysaccharide (ASP) at 200 mg/kg (L), 400 mg/kg ( ...
DOI:
10.1016/j.ijbiomac.2022.03.090

4. Anti-calcification potential of collagen based biological patch crosslinked by epoxidized polysaccharide

Author:
Xin Zheng; Yining Chen; Nianhua Dan; Zhengjun Li; Weihua Dan
Source:
International journal of biological macromolecules 2022 v.209 pp. 1695-1702
ISSN:
0141-8130
Subject:
ammonium salts; biocompatibility; biocompatible materials; biopolymers; calcification; chitosan; collagen; collagenase; crosslinking; fibroblasts; humans; quaternary ammonium compounds; swine
Abstract:
... Biological patch is a kind of tissue substitute material derived from natural polymer materials for the repair of human soft tissue defects. The serious calcification of biological patch after implantation is one of the reasons for the decline and failure of patch. In previous studies, we synthesized a new biomaterial crosslinker epoxidized chitosan quaternary ammonium salt (EHTCC) and used it for ...
DOI:
10.1016/j.ijbiomac.2022.04.117

5. Antimicrobial effects of thymol-loaded phytoglycogen/zein nanocomplexes against foodborne pathogens on fresh produce

Author:
Jingyi Xue; Yaguang Luo; Beifang Li; Xinhao Wang; Zhenlei Xiao; Yangchao Luo
Source:
International journal of biological macromolecules 2022 v.209 pp. 1188-1196
ISSN:
0141-8130
Subject:
Escherichia coli; Listeria monocytogenes; Salmonella Enteritidis; antimicrobial properties; atomic force microscopy; biofilm; cantaloupes; cytolysis; disinfectants; disinfection; encapsulation; fresh produce; lettuce; particle size; thymol; zein
Abstract:
... In this study, thymol-loaded hydrophobically modified phytoglycogen/zein nanocomplexes with a particle size around 100 nm were developed for improving microbial safety of fresh produce. The antimicrobial activities, including the determination of minimum inhibitory and bactericidal concentration, growth kinetic curves, and inhibition zone of the nanocomplexes against foodborne pathogens (Listeria ...
DOI:
10.1016/j.ijbiomac.2022.04.101
CHORUS:
10.1016/j.ijbiomac.2022.04.101

6. Antitumor mechanisms of an exopolysaccharide from Lactobacillus fermentum on HT-29 cells and HT-29 tumor-bearing mice

Author:
Fei Li; Xu Jiao; Jing Zhao; Xiaojun Liao; Yunlu Wei; Quanhong Li
Source:
International journal of biological macromolecules 2022 v.209 pp. 552-562
ISSN:
0141-8130
Subject:
Lactobacillus fermentum; apoptosis; colorectal neoplasms; dietary supplements; exopolysaccharides; fermented milk; membrane potential; mitochondria; mitochondrial membrane; xenotransplantation
Abstract:
... We have obtained an exopolysaccharide (YL-11 EPS) produced by Lactobacillus fermentum YL-11 isolated from fermented milk and confirmed that it can effectively inhibit colon cancer HT-29 cells proliferation in vitro. The aim of this study is to study anti-colon cancer effect in vivo and its possible mechanisms. Animal assays indicated YL-11 EPS treatment significantly suppressed the growth of HT-29 ...
DOI:
10.1016/j.ijbiomac.2022.04.023

7. Arabinogalactan derived from Larix gmelinii (Rupr.) Kuzen. Alleviates cisplatin-induced acute intestinal injury in vitro and in vivo through IRE1α/JNK axis mediated apoptotic signaling pathways

Author:
Jun-jie Zhang; Shuang Wang; Xu-fei Gao; Yun-yi Hou; Jun-nan Hu; Jing-tian Zhang; Jin-gang Hou; Zi Wang; Xia Li; Wei Li
Source:
International journal of biological macromolecules 2022 v.209 pp. 871-884
ISSN:
0141-8130
Subject:
Larix gmelinii; antioxidant activity; antioxidants; apoptosis; arabinogalactans; arabinose; cisplatin; drug therapy; endoplasmic reticulum stress; galactose; histopathology; intestines; molecular weight; oxidative stress; protective effect; protein synthesis; toxicity
Abstract:
... Many dietary polysaccharides have been shown to protect against various harmful external stimuli by protecting the integrity of the intestinal barrier. Arabinogalactan (AG) is a high molecular weight polysaccharide composed of arabinose and galactose, which has good immunomodulatory, antioxidant and intestinal conditioning activities. Gastrointestinal injury caused by cisplatin (CP) is an inevitab ...
DOI:
10.1016/j.ijbiomac.2022.04.068

8. Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing

Author:
Haofeng Hu; Fulin Luo; Qian Zhang; Ming Xu; Xin Chen; Zhihao Liu; Haodong Xu; Lei Wang; Fei Ye; Kui Zhang; Bin Chen; Song Zheng; Jia Jin
Source:
International journal of biological macromolecules 2022 v.209 pp. 1731-1744
ISSN:
0141-8130
Subject:
alginates; amputation; antibacterial properties; berberine; biocompatibility; biocompatible materials; biocomposites; calcium; cytotoxicity; hemolysis; rats; wound treatment
Abstract:
... In wound treatment, severe bleeding and infection are always primary challenges. Therefore, it is highly desired to develop novel dressing with both hemostatic and antibacterial capability. Herein, a series of biocomposite hemostatic films (BHFs) based alginate/chitosan/collagen-berberine have been prepared and well characterized for further biofunctional study. We have demonstrated that the hemos ...
DOI:
10.1016/j.ijbiomac.2022.04.132

9. Beta-tricalcium phosphate enhanced mechanical and biological properties of 3D-printed polyhydroxyalkanoates scaffold for bone tissue engineering

Author:
Xiangling Ye; Yongqiang Zhang; Tao Liu; Zehua Chen; Weijian Chen; Zugui Wu; Yi Wang; Junyi Li; Congcong Li; Tao Jiang; Ying Zhang; Huai Wu; Xuemeng Xu
Source:
International journal of biological macromolecules 2022 v.209 pp. 1553-1561
ISSN:
0141-8130
Subject:
adhesion; bioactive properties; biocompatibility; bones; compression strength; hardness; phosphates; polyhydroxyalkanoates
Abstract:
... Polyhydroxyalkanoates (PHA) is a naturally degradable polyester with good biocompatibility. However, several disadvantages including poor bioactivity and mechanical properties limit the biomedical application of PHA. To circumvent these drawbacks, PHA needs to be blended with other materials to improve performance. Beta-tricalcium phosphate (β-TCP) has emerged as one of the most promising bone rep ...
DOI:
10.1016/j.ijbiomac.2022.04.056

10. Bioactive and multifunctional keratin-pullulan based hydrogel membranes facilitate re-epithelization in diabetic model

Author:
Touba Khaliq; Muhammad Sohail; Syed Ahmed Shah; Arshad Mahmood; Mubeen Kousar; Nazish Jabeen
Source:
International journal of biological macromolecules 2022 v.209 pp. 1826-1836
ISSN:
0141-8130
Subject:
angiogenesis; biocompatibility; cefotaxime; collagen; hydrogels; hydrophilicity; keratin; models; oxygen; permeability; tensile strength; therapeutics; vapors
Abstract:
... Hydrogel membrane dressings with multifunctional tunable properties encompassing biocompatibility, anti-bacterial, oxygen permeability, and adequate mechanical strength are highly preferred for wound healing. The present study aimed to develop biopolymer-based hydrogel membranes for the controlled release of therapeutic agent at the wound site. Toward this end we developed Cefotaxime sodium (CTX) ...
DOI:
10.1016/j.ijbiomac.2022.04.156

11. Boosting physical-mechanical properties of adipic acid/chitosan films by DMTMM cross-linking

Author:
Roberto Sole; Chiara Buranello; Alessandro Di Michele; Valentina Beghetto
Source:
International journal of biological macromolecules 2022 v.209 pp. 2009-2019
ISSN:
0141-8130
Subject:
adipic acid; biodegradability; chitosan; cross-linking reagents; crosslinking; glycerol; permeability; plasticizers; tensile strength; thermogravimetry; water content; water vapor
Abstract:
... In this paper we present a novel strategy to easily prepare biodegradable chitosan derived films as new packaging systems. Combination of chitosan, adipic acid and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM) allowed to obtain high-performing cross-linked films. Biobased glycerol was employed as plasticizer. An in-depth study was performed on ten different samples in ...
DOI:
10.1016/j.ijbiomac.2022.04.181

12. Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings

Author:
Chengpeng Li; Xiaoyan Luo; Lefan Li; Ying Cai; Xinhuang Kang; Puwang Li
Source:
International journal of biological macromolecules 2022 v.209 pp. 344-355
ISSN:
0141-8130
Subject:
Escherichia coli; Staphylococcus aureus; alcohols; antibiotics; chitosan; citral; emulsions; fibroblasts; hemolysis; hydrophilicity; mice; nanofibers; odors; oils; permeability; solubility; storage quality; volatilization
Abstract:
... As a natural antibacterial agent with pleasant fragrance, citral possesses low aqueous solubility. To improve citral loading in hydrophilic nanofiber, Pickering emulsion electrospinning strategy was proposed for anti-infection dressing development. The in-situ aggerated β-cyclodextrin-citral inclusion complex particles (βCPs) were used as emulsion stabilizers, while citral and carboxymethyl chitos ...
DOI:
10.1016/j.ijbiomac.2022.04.025

13. Carboxymethyl chitosan-based multifunctional hydrogels incorporated with photothermal therapy against drug-resistant bacterial wound infection

Author:
Peng Jiang; Lijie Huang; Junjie Wang; Qiulei Li; Haibo Mu
Source:
International journal of biological macromolecules 2022 v.209 pp. 452-463
ISSN:
0141-8130
Subject:
adhesion; adsorption; chitosan; crosslinking; drug resistance; energy; heat; hemostasis; hydrogels; light; methicillin-resistant Staphylococcus aureus; photothermotherapy; polyacrylic acid; toxins; wound treatment
Abstract:
... Wound infection especially that induced by drug resistant bacteria has been considered an increasing medical crisis. Herein a biocompatible wound dressing is conveniently constructed by incorporating (Sr₀.₆Bi₀.₃₀₅)₂Bi₂O₇ (denoted as SBO) with excellent photothermal performance into a facile antibacterial hydrogel (gel) obtained from multiple physical crosslinks among Ag⁺, carboxymethyl chitosan an ...
DOI:
10.1016/j.ijbiomac.2022.04.026

14. Cellulose, clay and sodium alginate composites for the removal of methylene blue dye: Experimental and DFT studies

Author:
Abida Kausar; Shafiq Ur Rehman; Farwa Khalid; Adrián Bonilla-Petriciolet; Didilia Ileana Mendoza-Castillo; Haq Nawaz Bhatti; Sobhy M. Ibrahim; Munawar Iqbal
Source:
International journal of biological macromolecules 2022 v.209 pp. 576-585
ISSN:
0141-8130
Subject:
adsorbents; adsorption; cellulose; clay; density functional theory; heat production; methylene blue; models; pH; pollution; pulp and paper mills; remediation; sodium alginate; temperature; wastewater
Abstract:
... Cellulose/clay/sodium alginate composites were prepared and employed for the removal of methylene blue (MB) dye. Cellulose was extracted from a paper mill waste and used for composite preparation with sodium alginate (Na-Alg) and clay. MB dye removal was analyzed at different operating conditions (pH, initial concentration, temperature, composite dose). The dye was adsorbed up to 90% for an equili ...
DOI:
10.1016/j.ijbiomac.2022.04.044

15. Characterization of a cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis and its potential role in protection from oxidative damage and wound healing

Author:
Deena Nath Gupta; Ruchi Rani; Amol D. Kokane; Dilip Kumar Ghosh; Shailly Tomar; Ashwani Kumar Sharma
Source:
International journal of biological macromolecules 2022 v.209 pp. 1088-1099
ISSN:
0141-8130
Subject:
Citrus sinensis; cell proliferation; circular dichroism spectroscopy; fluorescence; hydrogen peroxide; oxidation; peroxidase; peroxiredoxin; plasmids; thermal stability
Abstract:
... In present work, the recombinant cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis (CsPrx) was purified and characterized. The peroxidase activity was examined with different substrates using DTT, a non-physiological electron donor. The conformational studies, in oxidized and reduced states, were performed using circular dichroism (CD) and fluorescence measurement. The CD analysis showed higher ...
DOI:
10.1016/j.ijbiomac.2022.04.086

16. Characterization of a thermostable, protease-tolerant inhibitor of α-glycosidase from carrot: A potential oral additive for treatment of diabetes

Author:
Yang Hao; Tao Guo; Jinqi Ren; Yaxin Wang; Lei Wang; Yawei Shi; Wei Feng
Source:
International journal of biological macromolecules 2022 v.209 pp. 1271-1279
ISSN:
0141-8130
Subject:
Daucus; carrots; chymotrypsin; crystal structure; dietary supplements; glucose; hyperglycemia; lactic acid; molecular weight; mutation; noninsulin-dependent diabetes mellitus; peptides; thermal stability; trypsin
Abstract:
... Inhibiting α-glucosidase activity is important in controlling postprandial hyperglycemia and, thus, helping to manage type-2 diabetes mellitus (T2DM). In the present study, we purified a hypothetical protein of carrots called DCHP (Daucus Carrot hypoglycemic peptide), and their inhibitory effects on α-glucosidase, as well as related mechanisms, were investigated. The recombinant DCHP protein with ...
DOI:
10.1016/j.ijbiomac.2022.04.110

17. Characterization of virus-like particles assembled by co-expression of BmCPV capsid shell protein and large protrusion protein

Author:
Feifei Ren; Jiming Yan; Dimitrios Kontogiannatos; Xiong Wang; Jingyang Li; Luc Swevers; Jingchen Sun
Source:
International journal of biological macromolecules 2022 v.209 pp. 1656-1664
ISSN:
0141-8130
Subject:
Bombyx mori cytoplasmic polyhedrosis virus; capsid; coat proteins; cryo-electron microscopy; genes; innate immunity; midgut; models; silkworms; transcription (genetics); viruses
Abstract:
... Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) is a typical single-layer capsid dsRNA virus belonging to the Reoviridae family of the Cypovirus genus. Previous studies have shown that the BmCPV major capsid shell protein (CSP) has the ability to self-assemble into virus-like particles (VLPs), and cryo-electron microscopy of the BmCPV virions has revealed a tight mutual binding region between C ...
DOI:
10.1016/j.ijbiomac.2022.04.097

18. Chitosan-modified biochar: Preparation, modifications, mechanisms and applications

Author:
Nan Gao; Wenzhen Du; Manyue Zhang; Guixia Ling; Peng Zhang
Source:
International journal of biological macromolecules 2022 v.209 pp. 31-49
ISSN:
0141-8130
Subject:
adsorbents; adsorption; biochar; chitosan; decontamination; heavy metals; perfluorocarbons; polymers; remediation; sewage; soil; wastewater
Abstract:
... The chitosan-modified biochar composite, as a carbohydrate polymer, has received increasing attention and becomes a research hotspot. It is a promising impurity adsorption material, which has potential application value in the agricultural environment fields such as soil improvement and sewage purification. The composite can combine the advantages of biochar with chitosan, and the resulting compos ...
DOI:
10.1016/j.ijbiomac.2022.04.006

19. Chitosan-salicylide Schiff base with aggregation-induced emission property and its multiple applications

Author:
Lifeng Xu; Qingye Meng; Zhenqian Zhang; Shuangling Zhong; Yan Gao; Xuejun Cui
Source:
International journal of biological macromolecules 2022 v.209 pp. 1124-1132
ISSN:
0141-8130
Subject:
Escherichia coli; aqueous solutions; bioimaging; biosensors; chitosan; hydroxybenzaldehyde; schiff bases
Abstract:
... Aggregation-induced emission (AIE) active compounds are fascinated due to their unique properties of limiting intramolecular rotation, and they have been developed in the biomedical fields. In this work, AIE material based on the Schiff base compound of chitosan (Cs) and salicylaldehyde (SA) was designed and synthesized. Cs-SA emits weak light in dilute aqueous solution, and emits bright light in ...
DOI:
10.1016/j.ijbiomac.2022.04.126

20. Chitosan‑sodium alginate-collagen/gelatin three-dimensional edible scaffolds for building a structured model for cell cultured meat

Author:
Linzi Li; Lin Chen; Xiaohong Chen; Yan Chen; Shijie Ding; Xiaojing Fan; Yaping Liu; Xinglian Xu; Guanghong Zhou; Beiwei Zhu; Niamat Ullah; Xianchao Feng
Source:
International journal of biological macromolecules 2022 v.209 pp. 668-679
ISSN:
0141-8130
Subject:
adhesion; biocompatibility; chewiness; chitosan; cytoskeleton; extracellular matrix; fluorescent antibody technique; freeze drying; models; pork; skeletal muscle; sodium alginate; swine; texture
Abstract:
... Cell cultured meat (CCM) production is an innovative technology that does not depend on livestock farming practices to produce meat. The construction of structured CCM requires a three-dimensional (3D) scaffold to mimic the extracellular matrix to provide mechanical support for the cells. Furthermore, the 3D scaffolds should be edible and have good biocompatibility and tissue-like texture. Here, w ...
DOI:
10.1016/j.ijbiomac.2022.04.052