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You searched for: Journal name International journal of biological macromolecules Remove constraint Journal name: International journal of biological macromolecules Publication year rev 7979-2021 Remove constraint Publication year rev: 7979-2021 Source 2021 v.167 Remove constraint Source: 2021 v.167
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1. 3-D macro/microporous-nanofibrous bacterial cellulose scaffolds seeded with BMP-2 preconditioned mesenchymal stem cells exhibit remarkable potential for bone tissue engineering

Author:
Swati Dubey; Rutusmita Mishra; Partha Roy; R.P. Singh
Source:
International journal of biological macromolecules 2021 v.167 pp. 934-946
ISSN:
0141-8130
Subject:
bone formation; bones; cell adhesion; cellulose; cost effectiveness; mice; mineralization; secretion; therapeutics; topography
Abstract:
... Bone repair using BMP-2 is a promising therapeutic approach in clinical practices, however, high dosages required to be effective pose issues of cost and safety. The present study explores the potential of low dose BMP-2 treatment via tissue engineering approach, which amalgamates 3-D macro/microporous-nanofibrous bacterial cellulose (mNBC) scaffolds and low dose BMP-2 primed murine mesenchymal st ...
DOI:
10.1016/j.ijbiomac.2020.11.049

2. Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: A review

Author:
Yongxia Wang; Hua Zhang
Source:
International journal of biological macromolecules 2021 v.167 pp. 528-538
ISSN:
0141-8130
Subject:
Flammulina velutipes; liver; mushrooms; polysaccharides; research and development
Abstract:
... With the further research in recent years, Flammulina velutipes (F. velutipes), an edible mushroom, has great application value in many fields. As one of the main bioactive components in F. velutipes, polysaccharide has a series of functions such as anti-oxidation, immune regulation, anti-inflammation, liver protection, anti-tumor, anti-hyperlipidemia and so on. In this paper, the current progress ...
DOI:
10.1016/j.ijbiomac.2020.11.208

3. Alginate-magnetic short nanofibers 3D composite hydrogel enhances the encapsulated human olfactory mucosa stem cells bioactivity for potential nerve regeneration application

Author:
Sarah Karimi; Zohreh Bagher; Najmeh Najmoddin; Sara Simorgh; Mohamad Pezeshki-Modaress
Source:
International journal of biological macromolecules 2021 v.167 pp. 796-806
ISSN:
0141-8130
Subject:
alginates; bioactive properties; cell viability; encapsulation; extracellular matrix; gelatin; humans; hydrogels; iron oxides; magnetism; mucosa; nanocomposites; nanofibers; nerve regeneration; nerve tissue; neural crest; neurons; sonication; storage modulus
Abstract:
... The design of 3D hydrogel constructs to elicit highly controlled cell response is a major field of interest in developing tissue engineering. The bioactivity of encapsulated cells inside pure alginate hydrogel is limited by its relatively inertness. Combining short nanofibers within a hydrogel serves as a promising method to develop a cell friendly environment mimicking the extracellular matrix. I ...
DOI:
10.1016/j.ijbiomac.2020.11.199

4. Anti-acetylcholinesterase and toxicity against Artemia salina of chitosan microparticles loaded with essential oils of Cymbopogon flexuosus, Pelargonium x ssp and Copaifera officinalis

Author:
Laysa Rocha Lima; Fabia Karine Andrade; Daniela Ribeiro Alves; Selene Maia de Morais; Rodrigo Silveira Vieira
Source:
International journal of biological macromolecules 2021 v.167 pp. 1361-1370
ISSN:
0141-8130
Subject:
Alzheimer disease; Artemia salina; Copaifera; Cymbopogon flexuosus; Geranium; Pelargonium; acetylcholinesterase; chitosan; inhibitory concentration 50; microencapsulation; oils; pH; therapeutics; thermal stability; toxicity; zeta potential
Abstract:
... Essential oils (EOs) are bioactive compounds with therapeutic potential for use as alternatives or as support to conventional treatments. However, EOs present limitations, such as sensibility to environmental factors, which can be overcome through microencapsulation. The objective of this study was to produce, by spray drying, chitosan microparticles (CMs) loaded with EO of Lemongrass (Cymbopogon ...
DOI:
10.1016/j.ijbiomac.2020.11.090

5. Arabinogalactan in banana: Chemical characterization and pharmaceutical effects

Author:
Wei Guo; Guohua Rao; Xu Wen
Source:
International journal of biological macromolecules 2021 v.167 pp. 1059-1065
ISSN:
0141-8130
Subject:
arabinogalactans; bananas; dose response; molecular weight; spectroscopy
Abstract:
... It is generally recognized that banana has diverse health benefits. However, most of the molecules responsible for the health benefits remain unknown. In this work, an important polysaccharide was extracted from banana and purified. The molecular weight was determined to be 526.2 kDa. It was identified by chemical and spectroscopic methods as arabinogalactan with β-D-(1→6)-galactan as backbone. Th ...
DOI:
10.1016/j.ijbiomac.2020.11.060

6. Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1

Author:
Xin Zong; Xiao Xiao; Lixia Kai; Yuanzhi Cheng; Jie Fu; Wei Xu; Yizhen Wang; Ke Zhao; Mingliang Jin
Source:
International journal of biological macromolecules 2021 v.167 pp. 76-84
ISSN:
0141-8130
Subject:
dextran sulfate; inflammation; physiological transport; tight junctions
Abstract:
... Many dietary polysaccharides have been shown to protect the intestinal barrier integrity against several noxious stimuli. Previously, we have isolated a polysaccharide RAMPtp from Atractylodis macrocephalae Koidz, and analyzed its structure. However, the effects of RAMPtp on intestinal barrier function have not been investigated. Here, we evaluated the protective effects of RAMPtp on Dextran sulfa ...
DOI:
10.1016/j.ijbiomac.2020.11.144

7. Bacterial triacylglycerol lipase is a potential cholesterol esterase: Identification of a key determinant for sterol-binding specificity

Author:
Yoshiaki Yasutake; Kenji Konishi; Shuji Muramatsu; Keitaro Yoshida; Sachiyo Aburatani; Shin-ichi Sakasegawa; Tomohiro Tamura
Source:
International journal of biological macromolecules 2021 v.167 pp. 578-586
ISSN:
0141-8130
Subject:
Burkholderia cepacia; Burkholderia stabilis; Burkholderia ubonensis; X-radiation; active sites; blood serum; cholesterol; site-directed mutagenesis; sterol esterase; triacylglycerol lipase; triacylglycerols
Abstract:
... Cholesterol esterase (Che) from Burkholderia stabilis (BsChe) is a homolog of well-characterized and industrially relevant bacterial triacylglycerol lipases (Lips). BsChe is a rare bacterial Lip enzyme that exhibits practical Che activity and is currently used in clinical applications to determine total serum cholesterol levels. To investigate the sterol specificity of BsChe, we determined the X-r ...
DOI:
10.1016/j.ijbiomac.2020.11.184

8. Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model

Author:
Alvaro Ferreira-Lazarte; Javier Fernández; Pablo Gallego-Lobillo; Claudio J. Villar; Felipe Lombó; F. Javier Moreno; Mar Villamiel
Source:
International journal of biological macromolecules 2021 v.167 pp. 1349-1360
ISSN:
0141-8130
Subject:
Bifidobacterium; Citrus; Enterobacteriaceae; Lactobacillaceae; Rattus norvegicus; acetates; azoxymethane; blood glucose; body weight; carcinogenesis; cecum; colorectal neoplasms; death; dextran; dysbiosis; lactic acid; metabolism; metagenomics; models; pH; pectins; rats; sodium sulfate; triacylglycerols; viscosity; water holding capacity
Abstract:
... Large intestine cancer is one of the most relevant chronic diseases taking place at present. Despite therapies have evolved very positively, this pathology is still under deep investigation. One of the recent approaches is the prevention by natural compounds such as pectin. In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus n ...
DOI:
10.1016/j.ijbiomac.2020.11.089

9. Bioinformatics analysis of correlation between protein function and intrinsic disorder

Author:
Goran Vinterhalter; Jovana J. Kovačević; Vladimir N. Uversky; Gordana M. Pavlović-Lažetić
Source:
International journal of biological macromolecules 2021 v.167 pp. 446-456
ISSN:
0141-8130
Subject:
bioinformatics; data collection; gene ontology; proteome
Abstract:
... The correlation of molecular function and protein intrinsic disorder is an important aspect of understanding the relationship between function, sequence and structure. This research was inspired by statistical correlation evaluation method described by Xie et al. (J Proteome Res 6 (2007) 1882–1898, reference study), where the authors analyzed the relationship between structure and function of prot ...
DOI:
10.1016/j.ijbiomac.2020.11.211

10. Bispecific monoclonal antibodies for targeted immunotherapy of solid tumors: Recent advances and clinical trials

Author:
Seyed Samad Hosseini; Saeed Khalili; Behzad Baradaran; Negar Bidar; Mohammad-Ali Shahbazi; Jafar Mosafer; Mahmoud Hashemzaei; Ahad Mokhtarzadeh; Michael R. Hamblin
Source:
International journal of biological macromolecules 2021 v.167 pp. 1030-1047
ISSN:
0141-8130
Subject:
apoptosis; cancer therapy; disease prevention; epitopes; immune response; immunotherapy; leukemia; lymphoma; mechanism of action
Abstract:
... Bispecific antibodie (BsAbs) combine two or more epitope-recognizing sequences into a single protein molecule. The first therapeutic applications of BsAbs were focused on cancer therapy. However, these antibodies have grown to cover a wider disease spectrum, including imaging, diagnosis, prophylaxis, and therapy of inflammatory and autoimmune diseases. BsAbs can be categorized into IgG-like format ...
DOI:
10.1016/j.ijbiomac.2020.11.058

11. Carboxymethyl cellulose nanocomposite beads as super-efficient catalyst for the reduction of organic and inorganic pollutants

Author:
Nujud Maslamani; Sher Bahadar Khan; Ekram Y. Danish; Esraa M. Bakhsh; Shaik M. Zakeeruddin; Abdullah M. Asiri
Source:
International journal of biological macromolecules 2021 v.167 pp. 101-116
ISSN:
0141-8130
Subject:
aminophenols; carboxymethylcellulose; catalysts; catalytic activity; eosin; nanocomposites; p-nitrophenol; polymers; potassium; smart materials; sodium borohydride; sustainable technology
Abstract:
... Carboxymethyl cellulose/copper oxide-nickel oxide (CMC/CuO-NiO) nanocomposite beads were prepared by facile, simple and environmentally friendly method. Initially, CuO-NiO was prepared and applied for the catalytic reduction of 4-nitrophenol (4-NP). The results showed that CuO-NiO demonstrate high catalytic activity toward the reduction of 4-NP to 4-aminophenol (4-AP) with a rate constant of 2.97  ...
DOI:
10.1016/j.ijbiomac.2020.11.074

12. Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease

Author:
Shangwen Zhang; Li Kang; Sheng Hu; Jie Hu; Yanping Fu; Yan Hu; Xinzhou Yang
Source:
International journal of biological macromolecules 2021 v.167 pp. 1598-1612
ISSN:
0141-8130
Subject:
X-ray diffraction; anti-inflammatory agents; bioavailability; chitosan; colitis; colon; curcumin; drug delivery systems; eosin; gelatin; histopathology; hyaluronic acid; hydrogels; infrared spectroscopy; interleukin-6; macrophages; microparticles; myeloperoxidase; necrosis; neoplasms; oral administration; pharmacodynamics; pharmacokinetics
Abstract:
... A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment. Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment. Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC ...
DOI:
10.1016/j.ijbiomac.2020.11.117

13. Cataract-causing mutations L45P and Y46D promote γC-crystallin aggregation by disturbing hydrogen bonds network in the second Greek key motif

Author:
Chenxi Fu; Jingjie Xu; Zhekun Jia; Ke Yao; Xiangjun Chen
Source:
International journal of biological macromolecules 2021 v.167 pp. 470-478
ISSN:
0141-8130
Subject:
blindness; cataract; children; denaturation; hydrogen; hydrophobicity; molecular dynamics; mutants; oxidative stress; pH; pathogenesis; protein solubility; spectroscopy; ultraviolet radiation
Abstract:
... Congenital cataracts caused by genetic disorders are the primary cause of child blindness across the globe. In this work, we investigated the underlying molecular mechanism of two mutations, L45P and Y46D of γC-crystallin in two Chinese families causing nuclear congenital cataracts. Spectroscopic experiments were performed to determine structural differences between the wild-type (WT) and the L45P ...
DOI:
10.1016/j.ijbiomac.2020.11.158

14. Characterization and potential application of an α-amylase (BmAmy1) selected during silkworm domestication

Author:
Hao Yan; Qingsong Liu; Feng Wen; Bingchuan Bai; Yuchan Wen; Wenwen Chen; Wei Lu; Ying Lin; Qingyou Xia; Genhong Wang
Source:
International journal of biological macromolecules 2021 v.167 pp. 1102-1112
ISSN:
0141-8130
Subject:
Bombyx mandarina; Bombyx mori; alpha-amylase; ancestry; artificial selection; bioluminescence assay; domestication; females; males; mulberries; pH; silkworms; transposons
Abstract:
... Efficient resource utilization plays a central role in the high productivity of domesticated plants and animals. Whether artificial selection acts on digestive enzymes in the domesticated silkworm (Bombyx mori), which is larger than its wild ancestor, Bombyx mandarina (B. mandarina), remains unknown. In this study, we present the characteristics of a novel alpha-amylase, BmAmy1, in B. mori. The ac ...
DOI:
10.1016/j.ijbiomac.2020.11.064

15. Characterization of complexes formed between debranched starch and fatty acids having different carbon chain lengths

Author:
Hao Lu; Zhen Yang; Mengting Yu; Na Ji; Lei Dai; Xuyan Dong; Liu Xiong; Qingjie Sun
Source:
International journal of biological macromolecules 2021 v.167 pp. 595-604
ISSN:
0141-8130
Subject:
carbon; crystal structure; decanoic acid; dodecanoic acid; hexanoic acid; myristic acid; octanoic acid; palmitic acid; starch; stearic acid
Abstract:
... Recently, amylose–lipid complexes have attracted widespread attention because of their various applications. However, DBS complexed with fatty acids of different carbon chain length are rarely studied. This study aimed to probe the complexation of DBS with saturated fatty acids having different carbon chain lengths (C6–C18). The results revealed that DBS was able to form V-type complexes with all ...
DOI:
10.1016/j.ijbiomac.2020.11.198

16. Chitosan capping of CuO nanoparticles: Facile chemical preparation, biological analysis, and applications in dentistry

Author:
Rabia Javed; Farwa Rais; Muhammad Kaleem; Bushra Jamil; Muhammad Arslan Ahmad; Tianhao Yu; Saba Waqar Qureshi; Qiang Ao
Source:
International journal of biological macromolecules 2021 v.167 pp. 1452-1467
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; Lactobacillus; Streptococcus mutans; X-ray diffraction; antioxidants; chitosan; coprecipitation; crystallites; cytotoxicity; dentistry; drugs; energy-dispersive X-ray analysis; glycemic effect; health services; nanobiotechnology; solubility; sorption; teeth; transmission electron microscopy
Abstract:
... This investigation is vital contribution to the healthcare system utilizing techniques of nanobiotechnology. It interestingly applies chitosan capped CuO nanoparticles in the field of medicine and restorative dentistry. The CuO nanoparticles and CuO-Chitosan nanoparticles are prepared by co-precipitation, and their characterization is performed using X-ray diffraction (XRD), Fourier transform infr ...
DOI:
10.1016/j.ijbiomac.2020.11.099

17. Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment

Author:
Nida Nehal; Bushra Nabi; Saleha Rehman; Ankita Pathak; Ashif Iqubal; Saif Ahmad Khan; M. Shahar Yar; Suhel Parvez; Sanjula Baboota; Javed Ali
Source:
International journal of biological macromolecules 2021 v.167 pp. 605-619
ISSN:
0141-8130
Subject:
Parkinson disease; arginine; chitosan; computer simulation; drugs; histopathology; hydrogen bonding; immunohistochemistry; nanoemulsions; oils; pH stability; permeability; pharmacokinetics; thymoquinone; toxicity; transmittance; zeta potential
Abstract:
... The research presented aims at developing Ropinirole hydrochloride (RHCl) nanoemulsion (NE) with nigella oil for Parkinson's disease (PD). In silico study was done to explore interactions of ropinirole and thymoquinone at receptor site (TNF-α and NFK-β). Ropinirole and Thymoquinone forms a hydrogen bond with residue Arginine 201 and residue Arginine 253 with a bond length of 1.89 Å and 2.30 Å at t ...
DOI:
10.1016/j.ijbiomac.2020.11.207

18. Chitosan-capped ternary metal selenide nanocatalysts for efficient degradation of Congo red dye in sunlight irradiation

Author:
Yong Yang; Nisar Ali; Adnan Khan; Saraf Khan; Sana Khan; Hammad Khan; Shi Xiaoqi; Waqar Ahmad; Salah Uddin; Nauman Ali; Muhammad Bilal
Source:
International journal of biological macromolecules 2021 v.167 pp. 169-181
ISSN:
0141-8130
Subject:
Congo red; aquatic organisms; carcinogenicity; chitosan; crystal structure; crystallites; industrial wastewater; iron; irradiation; microparticles; mutagens; nanocatalysts; nanocomposites; nickel; pH; particle size; photocatalysis; photocatalysts; photolysis; public health; selenides; selenium
Abstract:
... Wastewater emerging from the industries containing organic pollutants is a severe threat to humans' health and aquatic life. Therefore, the degradation of highly poisonous organic dye pollutants is necessary to ensure public health and environmental protection. To tackle this problem, visible-light-driven ternary metal selenide nanocomposites were synthesized successfully by the solvothermal metho ...
DOI:
10.1016/j.ijbiomac.2020.11.167

19. Cholesterol-lowering drugs the simvastatin and atorvastatin change the protease activity of pepsin: An experimental and computational study

Author:
Mohsen Shahlaei; Paria Zamani; Negin Farhadian; Fatemeh Balaei; Mohabbat Ansari; Sajad Moradi
Source:
International journal of biological macromolecules 2021 v.167 pp. 1414-1423
ISSN:
0141-8130
Subject:
active sites; atorvastatin; catalytic activity; enzyme activity; fluorescence; hydrophobicity; pepsin; simvastatin; thermodynamics; van der Waals forces
Abstract:
... In this study, the effect of long-term use drugs of cholesterol-lowering atorvastatin and simvastatin on the activity and molecular structure of pepsin as important gastric enzyme was investigated by various experimental and computational methods. Based on the results obtained from fluorescence experiments, both drugs can bond to pepsin and quench the fluorescence intensity of protein through the ...
DOI:
10.1016/j.ijbiomac.2020.11.095

20. Classifying the superfamily of small heat shock proteins by using g-gap dipeptide compositions

Author:
Pengmian Feng; Weiwei Liu; Cong Huang; Zhaohui Tang
Source:
International journal of biological macromolecules 2021 v.167 pp. 1575-1578
ISSN:
0141-8130
Subject:
dipeptides; heat shock proteins; heat stress; humans
Abstract:
... Small heat shock protein (sHSP) is a superfamily of molecular chaperone and is found from archaea to human. Recent researches have demonstrated that sHSPs participate in a series of biological processes and are even closely associated with serious diseases. Since sHSP is a very large superfamily and members from different superfamilies exhibit distinct functions, accurate classification of the sub ...
DOI:
10.1016/j.ijbiomac.2020.11.111