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- Woo, Ju Rang; Kim, Soon-Jong; Kim, Keon Young; Jang, Hyonchol; Shoelson, Steven E.; Park, SangYoun
- International journal of biological macromolecules 2017 v.103 pp. 965-971
- GTPase-activating proteins; catalytic activity; dimerization; glucose; glucose transporters; insulin; phosphorylation; plasma membrane; prediction; thermal stability
- ... TBC1D4 (also known as AS160) is a Rab·GTPase-activating protein (RabGAP) which functions in insulin signaling. TBC1D4 is critical for translocation of glucose transporter 4 (GLUT4), from an inactive, intracellular, vesicle-bound site to the plasma membrane, where it promotes glucose entry into cells. The TBC1D4 protein is structurally subdivided into two N-terminal phosphotyrosine-binding (PTB) do ...
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