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- Singh, Surya Prakash; Sharma, Mrinalini; Gupta, Pradeep Kumar
- International journal of biological macromolecules 2015 v.74 pp. 162-170
- curcumin, etc ; colorectal neoplasms; cytotoxicity; endocytosis; fluorescence; humans; hyaluronic acid; hyaluronoglucosaminidase; nanoparticles; neoplasm cells; silica; zeta potential; Show all 12 Subjects
- ... We report results of our investigations on the cytotoxic efficacy of Organically modified silica nanoparticle (SiNp)-curcumin complex conjugated with hyaluronic acid (HA) (HA-SiNp-cur) and HA free SiNp-cur complex in human colon carcinoma (colo-205) cells. Curcumin was loaded in SiNp and resulting complexes were conjugated with HA, which has a strong affinity for cancer cells expressing CD44. Afte ...
- Ying, Ming; Huang, Fengwen; Ye, Haidong; Xu, Hong; Shen, Liangliang; Huan, Tianwen; Huang, Shitong; Xie, Jiangfeng; Tian, Shengli; Hu, Zhangli; He, Zhendan; Lu, Jun; Zhou, Kai
- International journal of biological macromolecules 2015 v.79 pp. 201-208
- curcumin, etc ; absorbance; binding sites; circular dichroism spectroscopy; energy transfer; fluorescence; hydrogen bonding; hydrophobicity; molecular models; pH; pepsin; stomach; temperature; thermodynamics; tryptophan; tyrosine; ultraviolet-visible spectroscopy; Show all 17 Subjects
- ... The interaction between curcumin and pepsin was investigated by fluorescence, synchronous fluorescence, UV–vis absorption, circular dichroism (CD), and molecular docking. Under physiological pH value in stomach, the fluorescence of pepsin can be quenched effectively by curcumin via a combined quenching process. Binding constant (Ka) and binding site number (n) of curcumin to pepsin were obtained. ...