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International journal of biological macromolecules
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- Author:
- Uyanga Dashdorj; Mark Kenneth Reyes; Afeesh Rajan Unnithan; Arjun Prasad Tiwari; Batgerel Tumurbaatar; Chan Hee Park; Cheol Sang Kim
- Source:
- International journal of biological macromolecules 2015 v.80 pp. 1-7
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray photoelectron spectroscopy; antibacterial properties; cell viability; fibroblasts; nanocomposites; nanofibers; nanoparticles; scanning electron microscopy; silver; tissue repair; transmission electron microscopy; zein
- Abstract:
- ... Wound dressing is a very important factor in the process of wound healing as proper wound care can accelerate the recovery of the wound. In this study, zein nanofibrous mats with fiber diameters around 350–500nm were prepared by electrospinning and silver (Ag) nanoparticles around 20nm were concurrently synthesized in situ into the mats. The electrospun nanofibers were characterized by Field Emiss ...
- DOI:
- 10.1016/j.ijbiomac.2015.06.026
- https://doi.org/10.1016/j.ijbiomac.2015.06.026
- Author:
- Zhongzheng Zhou; Dong Yan; Xiaojie Cheng; Ming Kong; Ya Liu; Chao Feng; Xiguang Chen
- Source:
- International journal of biological macromolecules 2016 v.89 pp. 471-476
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Gram-negative bacteria; Gram-positive bacteria; Staphylococcus aureus; absorption; animals; antibacterial properties; biocompatible materials; chitosan; cytotoxicity; fibroblasts; tissue repair
- Abstract:
- ... In the present work, N,N,N-trimethyl chitosan (TMC) fibers were synthesized successfully and the resulting quaternized materials were characterized by FTIR. The designed TMC fibers with different degree of quaternization achieved high water absorption capability. In antibacterial activity study, TMC fibers showed high antibacterial activity than chitosan fibers against the gram-negative bacteria E ...
- DOI:
- 10.1016/j.ijbiomac.2016.02.036
- https://doi.org/10.1016/j.ijbiomac.2016.02.036
- Author:
- Laura Elizabeth Valencia-Gómez; Santos Adriana Martel-Estrada; Claudia Vargas-Requena; José Luis Rivera-Armenta; Noe Alba-Baena; Claudia Rodríguez-González; Imelda Olivas-Armendáriz
- Source:
- International journal of biological macromolecules 2016 v.93 pp. 1217-1225
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Micrococcus luteus; Mimosa tenuiflora; antibacterial properties; aqueous solutions; bark; biocomposites; chitosan; cytotoxicity; drying; functional properties; glass; scanning electron microscopy; temperature; thermal stability; tissue repair; wettability
- Abstract:
- ... Bio-composites films were prepared by casting and drying of aqueous solutions containing different weight ratios of chitosan and bark of Mimosa tenuiflora. The physico-chemical and functional properties of the films were characterized by scanning electron microscopy, dynamical mechanical analysis, wettability, cytotoxicity and in vitro antibacterial activities. The morphology studies confirmed tha ...
- DOI:
- 10.1016/j.ijbiomac.2016.09.083
- https://doi.org/10.1016/j.ijbiomac.2016.09.083
- Author:
- Soraya Ghayempour; Majid Montazer; Mahnaz Mahmoudi Rad
- Source:
- International journal of biological macromolecules 2016 v.93 pp. 344-349
- ISSN:
- 0141-8130
- Subject:
- Aloe vera; Escherichia coli; Fourier transform infrared spectroscopy; adverse effects; aluminum; anti-infective properties; cell viability; crosslinking; cytotoxicity; encapsulation; energy-dispersive X-ray analysis; fibroblasts; gum tragacanth; humans; ions; microbial activity; nanocapsules; scanning electron microscopy; tissue repair
- Abstract:
- ... Application of natural materials in wound healing is an interest topic due to effective treatment with no side effects. In this paper, Aloe Vera extract was encapsulated into Tragacanth Gum through a sonochemical microemulsion process to prepare a wound healing product. FESEM/EDX and FT-IR proved the successfully formation of the nanocapsules with spherical shape by cross-linking aluminum ions wit ...
- DOI:
- 10.1016/j.ijbiomac.2016.08.076
- https://doi.org/10.1016/j.ijbiomac.2016.08.076
5. Healing of skin wounds with a chitosan–gelatin sponge loaded with tannins and platelet-rich plasma
- Author:
- Bitao Lu; Tianyou Wang; Zhiquan Li; Fangying Dai; Lingmei Lv; Fengling Tang; Kun Yu; Jiawei Liu; Guangqian Lan
- Source:
- International journal of biological macromolecules 2016 v.82 pp. 884-891
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; absorption; animal experimentation; antibacterial properties; ascorbic acid; chitosan; crosslinking; cytotoxicity; freeze drying; gelatin; infrared spectroscopy; mechanical properties; scanning electron microscopy; tannins; thermal stability; thermogravimetry; tissue repair; water holding capacity
- Abstract:
- ... A chitosan–gelatin sponge (CSGT) was prepared using a chitosan/ascorbic acid solution blend containing gelatin, followed by crosslinking with tannin acid and freeze-drying, thereby combining the chitosan sponge and gelatin sponge. The structure of the CSGT was observed by scanning electron microscopy and was shown to have uniform and abundant pores measuring about 145–240μm in size. We also charac ...
- DOI:
- 10.1016/j.ijbiomac.2015.11.009
- https://doi.org/10.1016/j.ijbiomac.2015.11.009
- Author:
- A.S. Montaser; A.M. Abdel-Mohsen; M.A. Ramadan; A.A. Sleem; N.M. Sahffie; J. Jancar; A. Hebeish
- Source:
- International journal of biological macromolecules 2016 v.92 pp. 739-747
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; animal disease models; anti-inflammatory agents; antibacterial properties; diabetes; energy-dispersive X-ray analysis; light scattering; nanocomposites; nanoparticles; nanosilver; nicotinamide; nonwoven fabrics; particle size; rats; scanning electron microscopes; scanning electron microscopy; silver; sodium alginate; spectroscopy; tissue repair; transmission electron microscopes; transmission electron microscopy
- Abstract:
- ... Silver/Alginate/Nicotinamide nanoparticles composite (Ag/ALG/Nic) was prepared and used for the first time to fabricate wound dressing material. Sodium alginate (ALG) was used as reducing and stabilizing agents for preparation of silver nanoparticles (Ag-NPs). Effect of concentrations of alginate (ALG) on the particle size of silver were studied and confirmed by different techniques like UV/vis sp ...
- DOI:
- 10.1016/j.ijbiomac.2016.07.050
- https://doi.org/10.1016/j.ijbiomac.2016.07.050
- Author:
- Yuvaraja Gutha; Janak L. Pathak; Weijiang Zhang; Yaping Zhang; Xu Jiao
- Source:
- International journal of biological macromolecules 2017 v.103 pp. 234-241
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray diffraction; alcohols; antibacterial properties; antibiotics; bacterial infections; biocompatibility; chitosan; cost effectiveness; mice; polyvinyl alcohol; scanning electron microscopy; tissue repair; transmission electron microscopy; zinc oxide
- Abstract:
- ... Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SE ...
- DOI:
- 10.1016/j.ijbiomac.2017.05.020
- https://doi.org/10.1016/j.ijbiomac.2017.05.020
- Author:
- Seda Güneş; Funda Tıhmınlıoğlu
- Source:
- International journal of biological macromolecules 2017 v.102 pp. 933-943
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Hypericum perforatum; Staphylococcus aureus; antibacterial properties; chitosan; cytotoxicity; films (materials); growth retardation; hydrophobicity; lipid content; microorganisms; permeability; plant fats and oils; solvents; tensile strength; tissue repair; water vapor
- Abstract:
- ... Recent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John’s Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan fil ...
- DOI:
- 10.1016/j.ijbiomac.2017.04.080
- https://doi.org/10.1016/j.ijbiomac.2017.04.080
- Author:
- Surabhi Singh; Amlan Gupta; Deepika Sharma; Bhuvanesh Gupta
- Source:
- International journal of biological macromolecules 2018 v.113 pp. 227-239
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Santalum; Staphylococcus aureus; albino; antibacterial properties; bacterial adhesion; biocomposites; chitosan; clove oil; collagen; dextran; disk diffusion antimicrobial test; drugs; encapsulation; fibroblasts; glycerol; histology; males; mechanical properties; mice; nanocomposites; solvents; tissue repair
- Abstract:
- ... Dextran based bionanocomposite membranes encapsulating clove oil (CO) and sandalwood oil (SO) that are capable of preventing infection due to their inherent virtue of antibacterial activity and modifying the wound healing cascade for accelerated scar free healing, were developed. A facile solvent casting technique was used to fabricate dextran/nanosoy/glycerol/chitosan (DNG/Ch) nanocomposite membr ...
- DOI:
- 10.1016/j.ijbiomac.2018.02.097
- https://doi.org/10.1016/j.ijbiomac.2018.02.097
- Author:
- Rashid Ahmed; Muhammad Tariq; Imran Ali; Rehana Asghar; P. Noorunnisa Khanam; Robin Augustine; Anwarul Hasan
- Source:
- International journal of biological macromolecules 2018 v.120 pp. 385-393
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray diffraction; amputation; antibacterial properties; antioxidant activity; antioxidants; chitosan; diabetes; health care costs; nanofibers; patients; polyvinyl alcohol; rabbits; scanning electron microscopy; tissue repair; zinc oxide
- Abstract:
- ... Non-healing wound is a serious complication of diabetes, associated with extremely slow wound closure, and a high rate of infection, resulting in amputation or losses of limbs, high health care cost and poor quality of patient's life. In the present study, we hypothesized that nanofiber mats composed of a combination of chitosan, polyvinyl alcohol (PVA) and Zinc oxide (ZnO) could be an effective o ...
- DOI:
- 10.1016/j.ijbiomac.2018.08.057
- https://doi.org/10.1016/j.ijbiomac.2018.08.057
- Author:
- Mojtaba Ghanbari Mehrabani; Ramin Karimian; Bahareh Mehramouz; Mahdi Rahimi; Hossein Samadi Kafil
- Source:
- International journal of biological macromolecules 2018 v.114 pp. 961-971
- ISSN:
- 0141-8130
- Subject:
- 4',6-diamidino-2-phenylindole; Candida albicans; Escherichia coli; Staphylococcus aureus; antimicrobial properties; bacterial infections; biocompatibility; biodegradability; blood coagulation; cell viability; chitin; disease control; fibroins; freeze drying; mechanical properties; nanocomposites; nanosilver; porosity; silk; staining; tissue repair; toxicity testing; water uptake
- Abstract:
- ... One of the most serious challenge in wound care is difficulty of the infection control in wound healing process. Wound dressings with antimicrobial effects are useful to minimize the bacterial infections of wounds. In this study a biocompatible and biodegradable silk fibroin/chitin nanocomposite scaffolds with various content of silver nanoparticles (0.001, 0.01, and 0.1%) were fabricated via free ...
- DOI:
- 10.1016/j.ijbiomac.2018.03.128
- https://doi.org/10.1016/j.ijbiomac.2018.03.128
- Author:
- Surabhi Singh; Amlan Gupta; Bhuvanesh Gupta
- Source:
- International journal of biological macromolecules 2018 v.120 pp. 1581-1590
- ISSN:
- 0141-8130
- Subject:
- Aloe vera; Escherichia coli; Staphylococcus aureus; aesthetics; antibacterial properties; bacterial adhesion; biocompatibility; biodegradability; chitosan; collagen; cost effectiveness; crosslinking; cytotoxicity; dextran; drugs; glycerol; histology; manuka honey; mice; models; nanocomposites; solvents; tissue repair
- Abstract:
- ... Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This work was a challenge to fabricate herbal dressing that promotes healing, which at the same time is biocompatible, non-toxic, biodegradable, and cost effective in terms of the simplicity of application in complex chronic wound situations. With this aim, ...
- DOI:
- 10.1016/j.ijbiomac.2018.09.124
- https://doi.org/10.1016/j.ijbiomac.2018.09.124
- Author:
- Pasquale Picone; Maria Antonietta Sabatino; Alessia Ajovalasit; Daniela Giacomazza; Clelia Dispenza; Marta Di Carlo
- Source:
- International journal of biological macromolecules 2019 v.121 pp. 784-795
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; adhesion; ampicillin; antibacterial properties; bacteria; biocompatibility; biomarkers; cell viability; coagulation; crosslinking; erythrocytes; fibrinogen; films (materials); humans; hydrogels; mitochondria; mononuclear leukocytes; oxidative stress; staining; thrombin; tissue repair
- Abstract:
- ... Crosslinked xyloglucan-poly(vinyl alcohol) based hydrogel films are interesting materials for wound healing applications. This work focuses on the hydrolytic degradation and consequent morphological modification of a XG-PVA film and on its interaction with cells, blood, bacteria. Biocompatibility of the film was assessed in vitro by investigating different aspects, such as cell viability, oxidativ ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.078
- https://doi.org/10.1016/j.ijbiomac.2018.10.078
- Author:
- Zefeng Lin; Tingting Wu; Wanshun Wang; Binglin Li; Ming Wang; Lingling Chen; Hong Xia; Tao Zhang
- Source:
- International journal of biological macromolecules 2019 v.140 pp. 330-342
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; alginates; angiogenesis; antibiotic resistance; antibiotics; antimicrobial peptides; antimicrobial properties; biodegradability; collagen; drugs; fibroblasts; hyaluronic acid; mechanical properties; methicillin-resistant Staphylococcus aureus; porosity; silver; tissue repair
- Abstract:
- ... The increase in severe infections caused by antibiotic drug resistance and the decrease in the number of new antibacterial drugs approved for use in the last few decades are driving the need for the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) are a potential new class of antimicrobial drugs that are expected to solve the problem of global antibiotic drug resistance. ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.087
- https://doi.org/10.1016/j.ijbiomac.2019.08.087
- Author:
- Da-Yong Shin; Kwang-Hee Cheon; Eun-Ho Song; Yun-Jeong Seong; Ji-Ung Park; Hyoun-Ee Kim; Seol-Ha Jeong
- Source:
- International journal of biological macromolecules 2019 v.123 pp. 866-877
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; alginates; antibacterial properties; bacterial growth; calcium; cell proliferation; extracellular matrix; fibroblasts; fluorides; fluorine; gelation; hydrogels; ions; models; nanocomposites; tissue repair
- Abstract:
- ... The creation of a moist environment and promotion of cell proliferation and migration together with antibacterial property are critical to the wound-healing process. Alginate (Alg) is an excellent candidate for injectable wound dressing materials because it can form a gel in a mild environment. Taking advantage of its gelation property, an injectable nano composite hydrogel containing nano-sized ( ...
- DOI:
- 10.1016/j.ijbiomac.2018.11.108
- https://doi.org/10.1016/j.ijbiomac.2018.11.108
- Author:
- Asghar Eskandarinia; Amirhosein Kefayat; Mosayeb Gharakhloo; Maria Agheb; Darioush Khodabakhshi; Mehdi Khorshidi; Vafa Sheikhmoradi; Mohammad Rafienia; Hossein Salehi
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 467-476
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; animal models; antibacterial properties; biocompatibility; collagen; dermis; fibroblasts; histopathology; in vivo studies; nanofibers; propolis; reflectance spectroscopy; scanning electron microscopy; thermogravimetry; tissue repair; water uptake
- Abstract:
- ... A biocompatible and antibacterial scaffold with efficient wound healing activity can be an appropriate option for wound dressing application. In this study, polyurethane-hyaluronic acid (PU-HA) nanofibrous wound dressing was fabricated and then enriched with three different concentrations of ethanolic extract of propolis (EEP). The obtained samples were characterized by attenuated total reflectanc ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.255
- https://doi.org/10.1016/j.ijbiomac.2020.01.255
- Author:
- Haiyan Liu; Yang Hu; Yongjun Zhu; Xiuping Wu; Xin Zhou; Haobo Pan; Shu Chen; Pengfei Tian
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 224-234
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; ammonium salts; antibacterial properties; biocompatibility; biosynthesis; cellulose; chitin; chlorides; free radicals; moieties; polymerization; polymers; quaternary ammonium compounds; tissue repair; water holding capacity
- Abstract:
- ... Bacterial cellulose (BC) is a biosynthesized carbohydrate polymer with excellent biocompatibility and water holding capability. However, it lacks an inherent antibacterial activity that has limited its in-depth biomedical applications. This study investigated a novel strategy of adopting a simultaneous process to chemically anchor a quaternary ammonium salt (R-N(CH₃)⁺) with a special vinyl group ( ...
- DOI:
- 10.1016/j.ijbiomac.2019.12.052
- https://doi.org/10.1016/j.ijbiomac.2019.12.052
- Author:
- Marjan Ghorbani; Parinaz Nezhad-Mokhtari; Soghra Ramazani
- Source:
- International journal of biological macromolecules 2020 v.153 pp. 921-930
- ISSN:
- 0141-8130
- Subject:
- Aloe vera; Escherichia coli; Staphylococcus aureus; bacteria; cell adhesion; cell culture; collagen; contact angle; fibroblasts; hydrophilicity; lactones; mechanical properties; nanofibers; thermal stability; tissue engineering; tissue repair; zein; zinc oxide
- Abstract:
- ... Recently, the use of nanofibers (NFs) for tissue engineering has been more developed. For this purpose, we fabricated the NFs (Zein/Polycaprolactone/Collagen) (Zein/PCL/Collagen) incorporated by zinc oxide NPs (ZnO NPs) and Aloe-vera (NFs/ZnO/Alv) using the electrospinning method. Prepared NFs were studied for their morphological, mechanical, thermal stability, and hydrophilic properties. Among th ...
- DOI:
- 10.1016/j.ijbiomac.2020.03.036
- https://doi.org/10.1016/j.ijbiomac.2020.03.036
- Author:
- Xuewei Cheng; Qin Wei; Yingao Ma; Rui Shi; Tongtong Chen; Yingbo Wang; Chuang Ma; Yong Lu
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 958-967
- ISSN:
- 0141-8130
- Subject:
- Candida albicans; Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; antibacterial properties; bacteria; bone diseases; bones; calcium; endothelial cells; fluorescence; gelatin; mesenchymal stromal cells; nanosilver; osteoblasts; phosphorus; polylactic acid; prostheses; silver; staining; tissue repair
- Abstract:
- ... Bone implant materials have been widely used in bone therapy. However, bone infections caused by bacteria can damage the healing and repairing ability of bone tissue, which remains a major problem to be solved in clinical bone regeneration with implants. In this study, silver nanoparticles (Ag-NPs) were uniformly distributed on the inner of Polylactic acid and Gelatin composite fibers (PLLA and Ge ...
- DOI:
- 10.1016/j.ijbiomac.2019.09.156
- https://doi.org/10.1016/j.ijbiomac.2019.09.156
- Author:
- Jikang Zhang; Junliang Ge; Yurui Xu; Jianmei Chen; Anwei Zhou; Lei Sun; Ya Gao; Yu Zhang; Tingting Gu; Xinghai Ning
- Source:
- International journal of biological macromolecules 2020 v.164 pp. 4466-4474
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; antibacterial properties; antibiotic resistance; bacteriophages; fibroblast growth factor 1; gelatin; hyaluronic acid; hydrogels; modulus of elasticity; oxidation; sodium alginate; tissue repair
- Abstract:
- ... Wound healing is a complex process involved in repairing tissue damage and preventing infection. However, there is a lack of appropriate treatment solutions that can simultaneously promote tissue repair and protect againstbacteria, especially antibiotic-resistant bacteria. In this study, we have developed an injectable hydrogel encapsulating acidic fibroblast growth factor (aFGF) and bacteriophage ...
- DOI:
- 10.1016/j.ijbiomac.2020.08.247
- https://doi.org/10.1016/j.ijbiomac.2020.08.247
- Author:
- Adriana Gilarska; Joanna Lewandowska-Łańcucka; Katarzyna Guzdek-Zając; Anna Karewicz; Wojciech Horak; Radosław Lach; Kinga Wójcik; Maria Nowakowska
- Source:
- International journal of biological macromolecules 2020 v.155 pp. 938-950
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; adhesion; antibacterial properties; bones; cell culture; chemical bonding; chitosan; collagen; crosslinking; hyaluronic acid; hydrogels; in vitro studies; lysine; mechanical properties; porosity; storage modulus; tissue engineering; tissue repair; wettability
- Abstract:
- ... Novel, biocompatible, multifunctional, injectable genipin crosslinked collagen/chitosan/lysine-modified hyaluronic acid based hydrogels (ColChHAₘₒd) were prepared in a facile, one-step procedure. The novelty of the current approach lies in the functionalization of hyaluronic acid (HA) with primary amine groups by lysine attachment, and its further use as a component of the injectable sol. The obta ...
- DOI:
- 10.1016/j.ijbiomac.2019.11.052
- https://doi.org/10.1016/j.ijbiomac.2019.11.052
- Author:
- Hamid Reza Bakhsheshi-Rad; Ahmad Fauzi Ismail; Madzlan Aziz; Mohsen Akbari; Zhina Hadisi; Mahdi Omidi; Xiongbiao Chen
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 513-521
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; chitosan; collagen; fibroblasts; hydrophilicity; nanofibers; polyvinyl alcohol; sericin; silk; strength (mechanics); tetracycline; tissue repair
- Abstract:
- ... Skin and soft tissue infections are major concerns with respect to wound repair. Recently, anti-bacterial wound dressings have been emerging as promising candidates to reduce infection, thus accelerating the wound healing process. This paper presents our work to develop and characterize poly(vinyl alcohol) (PVA)/chitosan (CS)/silk sericin (SS)/tetracycline (TCN) porous nanofibers, with diameters v ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.139
- https://doi.org/10.1016/j.ijbiomac.2020.01.139
- Author:
- Jing Cao; Pan Wang; Yannan Liu; Chenhui Zhu; Daidi Fan
- Source:
- International journal of biological macromolecules 2020 v.155 pp. 625-635
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; artificial skin; cell growth; chitosan; collagen; crosslinking; extracellular matrix; fermentation; gelatin; humans; hydrogels; mechanical properties; nutrients; porosity; raw materials; tissue engineering; tissue repair
- Abstract:
- ... Skin defects caused by various reasons are currently common clinical problems. At present, hydrogels have been proposed as tissue-engineered skin scaffolds to regenerate the tissues of the defect. We used human-like collagen (HLC), which was isolated and purified after high-density fermentation of recombinant E. coli BL21 The gel uses HLC and carboxymethylated chitosan (CCS) as raw materials and c ...
- DOI:
- 10.1016/j.ijbiomac.2020.03.236
- https://doi.org/10.1016/j.ijbiomac.2020.03.236
- Author:
- Xingqiao Peng; Li Zhu; Jiayun Guo; Zhenglong Sun; Mingming Zhao; Xiaobei Zhan
- Source:
- International journal of biological macromolecules 2020 v.147 pp. 734-740
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Pseudomonas aeruginosa; anti-inflammatory activity; anti-inflammatory agents; aqueous solutions; biocompatibility; chemical bonding; cytotoxicity; gellan gum; micelles; neurons; nitric oxide; polymyxin B; tissue repair
- Abstract:
- ... Polymyxins, as strong antibiotics with high liposaccharide deactivation abilities, are rarely used as neuronal anti-inflammatory agent because of their high cytotoxicity. In this study, polymyxin B (PMB) was conjugated with deacylated gellan gum for the sustained release of PMB to reduce its cytotoxicity at high concentration without affecting the antibacterial and liposaccharide binding activitie ...
- DOI:
- 10.1016/j.ijbiomac.2019.12.200
- https://doi.org/10.1016/j.ijbiomac.2019.12.200
- Author:
- Sevinc Ilkar Erdagi; Fahanwi Asabuwa Ngwabebhoh; Ufuk Yildiz
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 651-663
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; antibacterial properties; bacteria; cell viability; cellulose; crosslinking; drugs; gelatin; gelation; humans; hydrogels; mechanical properties; swelling (materials); thermal properties; tissue repair
- Abstract:
- ... The present study focuses on the synthesis and evaluation of neomycin-loaded hydrogels as potential substrate for wound healing application. Herein, genipin crosslinked gelatin interpenetrated diosgenin-modified nanocellulose (DGN-NC) hydrogels were synthesized. The hydrogels' chemical structures as well as surface morphology, mechanical property, and thermal behavior were characterized. Swelling ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.279
- https://doi.org/10.1016/j.ijbiomac.2020.01.279
- Author:
- Siyu Wang; Fei Yan; Ping Ren; Yi Li; Qiong Wu; Xuedong Fang; Fangfang Chen; Ce Wang
- Source:
- International journal of biological macromolecules 2020 v.158 pp. 9-17
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; animals; antibacterial properties; bacterial infections; biocompatibility; cell adhesion; chitosan; coordination polymers; inflammation; mechanical properties; mixing; nanofibers; physical properties; polyvinyl alcohol; therapeutics; tissue repair; toxicity testing; water uptake; water vapor
- Abstract:
- ... Developing wound dressing that inhibits bacterial infection for treating complex wound healing processes has been a research hotspot. Here, we report the fabrication of Cu-MOFs (HKUST-1) incorporated electrospun chitosan/polyvinyl alcohol (HKUST-1/chitosan/PVA) fibers through the blending electrospinning for wound therapy. HKUST-1/chitosan/PVA fibers displayed satisfying physical properties, such ...
- DOI:
- 10.1016/j.ijbiomac.2020.04.116
- https://doi.org/10.1016/j.ijbiomac.2020.04.116
- Author:
- Jesús A. Claudio-Rizo; Irving A. González-Lara; Tirso E. Flores-Guía; Lucía F. Cano-Salazar; Denis A. Cabrera-Munguía; Juan J. Becerra-Rodríguez
- Source:
- International journal of biological macromolecules 2020 v.156 pp. 27-39
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; biocompatibility; biocompatible materials; collagen; crosslinking; fibroblasts; hydrogels; metabolism; monocytes; polyacrylic acid; polymerization; polyurethanes; proteolysis; thermal stability; tissue repair
- Abstract:
- ... Currently, the control of the properties of collagen based hydrogels represents a promising area of research to develop novel materials for biomedical applications. The crosslinking of the collagen with trifunctional polyurethane (PU) allows a hybrid matrix to be formed by improving the coupling with exogenous polymeric chains to generate innovative semi-interpenetrated network (semi-IPN) hydrogel ...
- DOI:
- 10.1016/j.ijbiomac.2020.04.005
- https://doi.org/10.1016/j.ijbiomac.2020.04.005
- Author:
- Mohd Hasmizam Razali; Nur Arifah Ismail; Khairul Anuar Mat Amin
- Source:
- International journal of biological macromolecules 2020 v.153 pp. 1117-1135
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus; X-ray diffraction; animal models; antibacterial properties; atomic force microscopy; biocompatibility; excision; fibroblasts; gellan gum; hydrophilicity; in vivo studies; laboratory animals; mice; nanocomposites; nanotubes; rats; scanning electron microscopy; synergism; tensile strength; thermogravimetry; tissue repair; titanium dioxide; transmission electron microscopy
- Abstract:
- ... The synthesized titanium dioxide nanotubes (TiO₂-NTs) were emerged as wound healing enhancer as well as exhibited significant wound healing activity on Sprague Dawley rats. In our present study, the blends of GG and TiO₂-NTs bio-nanocomposite film was characterised by fourier transform infrared (FTIR), x-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis, atomic ...
- DOI:
- 10.1016/j.ijbiomac.2019.10.242
- https://doi.org/10.1016/j.ijbiomac.2019.10.242
- Author:
- Xiaoxue Wang; Jingjie Qi; Wenjie Zhang; Yajie Pu; Rong Yang; Penghui Wang; Shuai Liu; Xiaoyan Tan; Bo Chi
- Source:
- International journal of biological macromolecules 2021 v.187 pp. 91-104
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; carboxymethylcellulose; fibroblasts; granulation tissue; hydrogels; inflammation; polymerization; reactive oxygen species; three-dimensional printing; tissue repair
- Abstract:
- ... Developing a wound dressing for the treatment of large and irregular-shaped wounds remains a great challenge. Herein we developed novel printable bionic hydrogels with antibacterial and antioxidant properties which could effectively overcome the challenge by inhibiting inflammation and accelerating wound healing. The CMC/PL (CP) hydrogels were customized with glycidyl methacrylate (GMA) modified c ...
- DOI:
- 10.1016/j.ijbiomac.2021.07.115
- https://doi.org/10.1016/j.ijbiomac.2021.07.115
- Author:
- Kefeng Liu; Lin Dai; Chenyu Li
- Source:
- International journal of biological macromolecules 2021 v.191 pp. 1249-1254
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; absorption; antibacterial properties; biocompatibility; blood; borates; extracellular matrix; hydrogels; hydrogen; lignocellulose; nanocomposites; nanofibers; nanosilver; pH; polyvinyl alcohol; sodium alginate; tissue repair
- Abstract:
- ... Hydrogel dressings with similar structural characteristics to the extracellular matrix and tunable physicochemical properties have become promising candidates for wound healing. However, the fabrication of an ideal hydrogel dressing with low-cost, good biocompatibility, excellent hemostatic capacity, potent and broad-spectrum antibacterial activity remains a huge challenge. Herein, a lignocellulos ...
- DOI:
- 10.1016/j.ijbiomac.2021.10.006
- https://doi.org/10.1016/j.ijbiomac.2021.10.006
- Author:
- Feifei Liu; Xuewei Cheng; Lu Xiao; Qiang Wang; Kun Yan; Zhi Su; Lei Wang; Chuang Ma; Yingbo Wang
- Source:
- International journal of biological macromolecules 2021 v.167 pp. 1338-1348
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; adhesion; antibacterial properties; bone transplantation; bones; chelation; chitosan; dopamine; electrochemistry; nanosilver; polylactic acid; prostheses; tissue repair
- Abstract:
- ... Bone infections caused by bacteria during bone graft implantations can impair the ability of bone tissue repair, which is currently a clinical problem. In this study, the electrospinning technique was used to prepare a polylactic acid (PLLA)/silver (Ag) composite fiber, in which the silver nanoparticles (Ag-NPs) were uniformly distributed on the inner surface of PLLA fibers; dopamine (DA) was self ...
- DOI:
- 10.1016/j.ijbiomac.2020.11.088
- https://doi.org/10.1016/j.ijbiomac.2020.11.088
- Author:
- N.T. Thu Thao; H.M.S.M. Wijerathna; R. Saravana Kumar; Dongrack Choi; S.H.S. Dananjaya; A.P. Attanayake
- Source:
- International journal of biological macromolecules 2021 v.193 pp. 1823-1834
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Staphylococcus aureus; animal models; antimicrobial properties; biocompatibility; blood; chitosan; cytotoxicity; fibroblasts; gelation; humans; minimum inhibitory concentration; tissue repair
- Abstract:
- ... Development of novel wound dressing materials having the ability to prevent bacterial infections and capable of accelerating the tissue regeneration process is utmost important, since the wounds in patients can cause severe health issues. In the present work, we synthesized novel N-succinyl chitosan nanoparticles (N-SuC NPs) films and tested their antimicrobial, cytotoxicity, and in vitro and in v ...
- DOI:
- 10.1016/j.ijbiomac.2021.11.015
- https://doi.org/10.1016/j.ijbiomac.2021.11.015
- Author:
- Daniel A. Canales; Felipe Reyes; Marcela Saavedra; Laura Peponi; Adrián Leonés; Humberto Palza; Aldo R. Boccaccini; Alina Grünewald; Paula A. Zapata
- Source:
- International journal of biological macromolecules 2022 v.210 pp. 324-336
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; alkaline phosphatase; bioactive properties; bones; cell viability; glass; hydroxyapatite; magnesium oxide; modulus of elasticity; nanocomposites; phenotype; synergism; tissue repair
- Abstract:
- ... Electrospun fibers of poly (lactic acid) (PLA) containing 10 and 20 wt% of bioactive glass (n-BG) and magnesium oxide (n-MgO) nanoparticles of ca. 27 and 23 nm respectively, were prepared toward to application in bone tissue engineering. The addition of both nanoparticles into the PLA will produce a synergic effect increasing its bioactivity and antimicrobial behavior. Neat PLA scaffold and the co ...
- DOI:
- 10.1016/j.ijbiomac.2022.05.047
- https://doi.org/10.1016/j.ijbiomac.2022.05.047
- Author:
- Soumya Ranjan Jena; Ganeswar Dalei; Subhraseema Das; Jasmine Nayak; Manoranjan Pradhan; Luna Samanta
- Source:
- International journal of biological macromolecules 2022 v.207 pp. 493-506
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Western blotting; adhesion; adsorption; alginates; antibacterial properties; apoptosis; biocompatible materials; biomimetics; extracellular matrix; fibroblasts; genes; hydrogels; polyacrylamide gel electrophoresis; thermal stability; tissue repair; xanthan gum
- Abstract:
- ... Biomimetic hydrogels composed of natural polysaccharides have invariably blossomed as niche biomaterials in tissue engineering applications. The prospects of creating an extracellular matrix (ECM)-like milieu from such hydrogels has garnered considerable importance. In this study, we have fabricated bioscaffolds comprising dialdehyde alginate and xanthan gum and explored their potential use in tis ...
- DOI:
- 10.1016/j.ijbiomac.2022.03.024
- https://doi.org/10.1016/j.ijbiomac.2022.03.024
- Author:
- Jie Zhang; Liwei Hu; Qiang Zhang; Chuan Guo; Chenyi Wu; Yidong Shi; Rui Shu; Lin Tan
- Source:
- International journal of biological macromolecules 2022 v.209 pp. 2142-2150
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; absorption; antibacterial properties; bacterial infections; biocompatibility; blood coagulation; cytotoxicity; guanidines; hemolysis; liquids; models; permeability; skin irritation; sodium alginate; tissue repair; water vapor
- Abstract:
- ... The development of multifunctional wound dressings has always been considered as a promising strategy to promote blood coagulation, inhibit bacterial infection, and accelerate wound healing. Herein, an antibacterial and hemostatic dressing (SA-PHMG) was developed based on sodium alginate (SA) nonwoven and polyhexamethylene guanidine hydrochloride (PHMG) through a completely green industrial route, ...
- DOI:
- 10.1016/j.ijbiomac.2022.04.194
- https://doi.org/10.1016/j.ijbiomac.2022.04.194