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International journal of biological macromolecules
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- Author:
- Ramalingam Shenbhagaraman; Loganathan K. Jagadish; Kishorekumar Premalatha; Venkatesan Kaviyarasan
- Source:
- International journal of biological macromolecules 2012 v.50 no.4 pp. 957-964
- ISSN:
- 0141-8130
- Subject:
- Pleurotus eryngii; angiogenesis; biomass; glucans; glucose; models; mushrooms; mycelium; pH; prediction; response surface methodology; temperature; yeast extract
- Abstract:
- ... Pleurotus eryngii, an edible mushroom with therapeutic potential was optimized using response surface methodology of four-factor Box–Behnken design for maximum mycelial biomass and extracellular glucan (EPS) production. The model predicts to gain a maximal mycelial biomass and extracellular polysaccharide at 39.4g/l; 36.04g/l of glucose, 8.27g/l; 7.51g/l of yeast extract, pH 6.99; 7.07 and tempera ...
- DOI:
- 10.1016/j.ijbiomac.2012.02.008
- https://doi.org/10.1016/j.ijbiomac.2012.02.008
- Author:
- Kalimuthu Senthilkumar; Panchanathan Manivasagan; Jayachandran Venkatesan; Se-Kwon Kim
- Source:
- International journal of biological macromolecules 2013 v.60 no. pp. 366-374
- ISSN:
- 0141-8130
- Subject:
- macroalgae; DNA damage; cell growth; cytotoxicity; Phaeophyceae; fucoidan; metastasis; antineoplastic agents; neoplasm cells; biomedical research; medicinal properties; angiogenesis; apoptosis
- Abstract:
- ... Seaweeds, being abundant sources of bioactive components have much interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. The sulfated polysaccharides are routinely used in biomedical research and have known biological activities. Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed has various biol ...
- DOI:
- 10.1016/j.ijbiomac.2013.06.030
- https://doi.org/10.1016/j.ijbiomac.2013.06.030
- Author:
- Xinlin Wei; Wei Chen; Fang Mao; Yuanfeng Wang
- Source:
- International journal of biological macromolecules 2013 v.54 no. pp. 71-75
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; bone formation; bone marrow; cartilage; chitooligosaccharides; growth factors; hematopoietic stem cells; hyperplasia; mice; polysaccharides; secretion
- Abstract:
- ... Chitooligosaccharides (COSs) is a kind of polysaccharide scaffolds used to enhance cartilage repair during treatments involving bone marrow stimulation, angiogenesis and osteogenesis increase in vivo. Capabilities of COSs in promoting the proliferation and differentiation of hematopoietic stem cells/hematopoietic progenitor cells were mainly explored in the paper. The results showed that a high co ...
- DOI:
- 10.1016/j.ijbiomac.2012.10.022
- https://doi.org/10.1016/j.ijbiomac.2012.10.022
- Author:
- David Collares Achê; Mário Sérgio R. Gomes; Dayane Lorena Naves de Souza; Makswell Almeida Silva; Maria Inês Homsi Brandeburgo; Kelly Aparecida Geraldo Yoneyama; Renata Santos Rodrigues; Márcia Helena Borges; Daiana Silva Lopes; Veridiana de Melo Rodrigues
- Source:
- International journal of biological macromolecules 2015 v.72 pp. 445-453
- ISSN:
- 0141-8130
- Subject:
- Bothrops; EDTA (chelating agent); angiogenesis; beta-mercaptoethanol; cattle; cell adhesion; cell viability; chromatography; creatine kinase; endothelial cells; fibrinogen; functional properties; hemorrhage; isoelectric point; mice; molecular weight; muscles; proteolysis; snakes; venoms
- Abstract:
- ... In the present work, we demonstrate some biochemical and functional properties of a new PI snake venom metalloproteinase (SVMP) isolated from Bothrops pauloensis snake venom (BpMP-II), in addition we evaluated its capacity to inhibit endothelial cell adhesion and in vitro angiogenesis. BpMP-II was purified after a combination of three chromatography steps and showed molecular mass of 23,000Da dete ...
- DOI:
- 10.1016/j.ijbiomac.2014.08.050
- https://doi.org/10.1016/j.ijbiomac.2014.08.050
- Author:
- Afeesh Rajan Unnithan; Arathyram Ramachandra Kurup Sasikala; Priya Murugesan; Malarvizhi Gurusamy; Dongmei Wu; Chan Hee Park; Cheol Sang Kim
- Source:
- International journal of biological macromolecules 2015 v.77 pp. 1-8
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; anti-inflammatory activity; biocomposites; cell growth; dextran; elderly; estradiol; health services; nanofibers; polymers; postmenopause; tissue repair
- Abstract:
- ... Post-menopausal wound care management is a substantial burden on health services, since there are an increased number of elderly populations linked with age-related delayed wound healing. The controlled estrogen replacement can accelerate healing of acute cutaneous wounds, linked to its potent anti-inflammatory activity. The electrospinning technique can be used to introduce the desired therapeuti ...
- DOI:
- 10.1016/j.ijbiomac.2015.02.044
- https://doi.org/10.1016/j.ijbiomac.2015.02.044
- Author:
- Caroline R. Delma; Somasundaram T. Somasundaram; Guru Prasad Srinivasan; Md Khursheed; Murali D. Bashyam; Natarajan Aravindan
- Source:
- International journal of biological macromolecules 2015 v.74 pp. 447-457
- ISSN:
- 0141-8130
- Subject:
- Turbinaria conoides; angiogenesis; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cell proliferation; free radicals; fucoidan; gelatin; metalloproteinases; metastasis; neoplasm cells; pancreatic neoplasms; therapeutics
- Abstract:
- ... The presence of occult metastases at the time of diagnosis together with the lack of effective chemotherapies pose a dire need for designing new and targeted therapeutics for pancreatic cancer. Fucoidans from brown algae can be regarded as potential candidates in view of their antioxidant, anti-cancer and anti-angiogenic potential. Herein, we investigated the antioxidant and anti-cancer effects of ...
- DOI:
- 10.1016/j.ijbiomac.2014.12.031
- https://doi.org/10.1016/j.ijbiomac.2014.12.031
- Author:
- Cong Li; Xia Wu; Honghai Zhang; Gengxia Yang; Meijun Hao; Shoupeng Sheng; Yu Sun; Jiang Long; Caixia Hu; Xicai Sun; Li Li; Jiasheng Zheng
- Source:
- International journal of biological macromolecules 2015 v.75 pp. 115-120
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; fungi; hepatoma; immunohistochemistry; mechanism of action; metastasis; mice; polysaccharides; proliferating cell nuclear antigen; protein synthesis; signal transduction; tissues; toxicity; vascular endothelial growth factors
- Abstract:
- ... Hepatocellular carcinoma (HCC) is a highly metastatic cancer. Huaier polysaccharide (TP-1) is a naturally occurring bioactive macromolecule, found in Huaier fungus and has been shown to exert in vitro antitumor and antimetastasis for HCC, but no study has addressed in vivo efficacy and mechanisms of action. Presently, we found that TP-1 at doses of 0.5, 1 and 2mg/kg significantly inhibited tumor g ...
- DOI:
- 10.1016/j.ijbiomac.2015.01.016
- https://doi.org/10.1016/j.ijbiomac.2015.01.016
8. LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells
- Author:
- Xiaojuan He; Qingfeng Huang; Xiaojun Qiu; Xianchen Liu; Guan Sun; Jun Guo; Zongmei Ding; Lixiang Yang; Na Ban; Tao Tao; Dongling Wang
- Source:
- International journal of biological macromolecules 2015 v.72 pp. 1081-1089
- ISSN:
- 0141-8130
- Subject:
- Western blotting; angiogenesis; cell cycle; cell growth; cell proliferation; cell viability; flow cytometry; humans; hydrolysis; immunohistochemistry; leucine; leucyl aminopeptidase; patients; prognosis; reverse transcriptase polymerase chain reaction; small interfering RNA; tissue repair; tissues; transfection
- Abstract:
- ... Leucine aminopeptidase 3 (LAP3), belonging to the M1 family, has been proved to catalyze the hydrolysis of leucine residues. Leucine aminopeptidases are involved in many pathological disorders and regulate cell proliferation, invasion and/or angiogenesis of tumor. Recent study showed that LAP3 is highly expressed in several malignant and affects tumor angiogenesis. We aimed at investigating the cl ...
- DOI:
- 10.1016/j.ijbiomac.2014.10.021
- https://doi.org/10.1016/j.ijbiomac.2014.10.021
- Author:
- Hazem Ben-Mabrouk; Raoudha Zouari-Kessentini; Fadoua Montassar; Zeineb Abdelkefi- Koubaa; Erij Messaadi; Xavier Guillonneau; Mohamed ElAyeb; Najet Srairi-Abid; José Luis; Olivier Micheau; Naziha Marrakchi
- Source:
- International journal of biological macromolecules 2016 v.86 pp. 670-680
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; apoptosis; caspases; chicks; chorioallantoic membrane; endothelial cells; humans; models; neoplasms; venoms; viability; Tunisia
- Abstract:
- ... Angiogenesis constitutes a fundamental step in tumor progression. Thus, targeting tumour angiogenesis has been identified to be promising in cancer treatment.In this work, CC5 and CC8, two highly homologous disintegrins isolated from the venom Cerastes cerastes viper from the south of Tunisia, were assessed for their anti-angiogenic effect by testing their ability to interfere with viability, adhe ...
- DOI:
- 10.1016/j.ijbiomac.2016.02.008
- https://doi.org/10.1016/j.ijbiomac.2016.02.008
- Author:
- Mythili Tummalapalli; Morgane Berthet; Bernard Verrier; B.L. Deopura; M.S. Alam; Bhuvanesh Gupta
- Source:
- International journal of biological macromolecules 2016 v.82 pp. 104-113
- ISSN:
- 0141-8130
- Subject:
- Aloe vera; angiogenesis; animal disease models; anti-infective properties; anti-inflammatory activity; apoptosis; biocomposites; collagen; cotton fabric; curcumin; drugs; fibroblasts; finishes; gelatin; histology; leaching; mice; nonwoven fabrics; pectins; plant extracts; tissue repair; viability; wound treatment
- Abstract:
- ... Aloe vera and curcumin loaded oxidized pectin–gelatin (OP-Gel) matrices were used as antimicrobial finishes on nonwoven cotton fabrics to produce composite wound care devices. The drug release characteristics of the biocomposite dressings indicated that curcumin is released through a biphasic mechanism – erosion of the polymeric matrix, followed by diffusion, while aloe vera is released upon leach ...
- DOI:
- 10.1016/j.ijbiomac.2015.10.087
- https://doi.org/10.1016/j.ijbiomac.2015.10.087
- Author:
- Mahadevappa Hemshekhar; Ram M. Thushara; Siddaiah Chandranayaka; Larry S. Sherman; Kempaiah Kemparaju; Kesturu S. Girish
- Source:
- International journal of biological macromolecules 2016 v.86 pp. 917-928
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatible materials; carcinogenesis; extracellular matrix; glucuronic acid; homeostasis; hyaluronic acid; hydrocolloids; hydrophilicity; hypersensitivity; inflammation; medicinal properties; medicine; multiple drug resistance; solubility; tissue engineering; tissue repair; tissues; viscoelasticity
- Abstract:
- ... Hyaluronic acid (HA), is a glycosaminoglycan comprised of repeating disaccharide units of N-acetyl-d-glucosamine and d-glucuronic acid. HA is synthesized by hyaluronan synthases and reaches sizes in excess of 2MDa. It plays numerous roles in normal tissues but also has been implicated in inflammatory processes, multiple drug resistance, angiogenesis, tumorigenesis, water homeostasis, and altered v ...
- DOI:
- 10.1016/j.ijbiomac.2016.02.032
- https://doi.org/10.1016/j.ijbiomac.2016.02.032
- Author:
- Tarun Agarwal; Rajan Narayan; Somnath Maji; Shubhanath Behera; Senthilguru Kulanthaivel; Tapas Kumar Maiti; Indranil Banerjee; Kunal Pal; Supratim Giri
- Source:
- International journal of biological macromolecules 2016 v.93 pp. 1499-1506
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; adhesion; ampicillin; angiogenesis; bovine serum albumin; chitosan; collagen; collagenase; drugs; fibroblasts; freeze drying; gelatin; mice; porosity; scanning electron microscopy; tissue engineering; tissue repair; vascular endothelial growth factors; water holding capacity; water uptake
- Abstract:
- ... The present study delineates the preparation, characterization and application of gelatin-carboxymethyl chitosan scaffolds for dermal tissue engineering. The effect of carboxymethyl chitosan and gelatin ratio was evaluated for variations in their physico-chemical-biological characteristics and drug release kinetics. The scaffolds were prepared by freeze drying method and characterized by SEM and F ...
- DOI:
- 10.1016/j.ijbiomac.2016.04.028
- https://doi.org/10.1016/j.ijbiomac.2016.04.028
- Author:
- Thawatchai Phaechamud; Pongsathorn Issarayungyuen; Wiwat Pichayakorn
- Source:
- International journal of biological macromolecules 2016 v.85 pp. 634-644
- ISSN:
- 0141-8130
- Subject:
- Gibbs free energy; Pseudomonas aeruginosa; Staphylococcus aureus; angiogenesis; anti-infective properties; chicks; citrates; drugs; gentamicin; glycerol; hydrophilicity; mechanical properties; oxygen; permeability; rubber; sorption; sulfates; therapeutics; topography; water vapor; xanthan gum
- Abstract:
- ... Antimicrobial wound dressings have been developed for effectiveness of wound therapy. In this study, gentamicin sulfate was loaded into modified porous natural rubber films. The hydrophilic porous structure in natural rubber films was formed when the polar liquid such as glycerin or triethyl citrate and hydrophilic xanthan gum were blended. Film properties including morphology, drug release, water ...
- DOI:
- 10.1016/j.ijbiomac.2016.01.040
- https://doi.org/10.1016/j.ijbiomac.2016.01.040
- Author:
- Asim Azhar; Mohammad Sazzad Khan; Akila Swaminathan; Asma Naseem; Suvro Chatterjee; Mohamad Aman Jairajpuri
- Source:
- International journal of biological macromolecules 2016 v.82 pp. 541-550
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; anticoagulant activity; blood coagulation; cell movement; chelation; chorioallantoic membrane; coagulation; drugs; endothelial cells; heparin; polymers; proteinases; proteins; therapeutics; tissue repair
- Abstract:
- ... Endogenous proteins that promote vascular endothelial cell based inhibition of angiogenesis are an attractive option for antitumor therapy. Inactive cleaved and latent conformations of antithrombin (AT) are antiangiogenic, but not its native form which is an inhibitor of proteases involved in blood coagulation. Unlike native, the cleaved and latent conformations are reactive center loop inserted c ...
- DOI:
- 10.1016/j.ijbiomac.2015.10.013
- https://doi.org/10.1016/j.ijbiomac.2015.10.013
- Author:
- J.Y. Park; M.S. Shin; S.N. Kim; H.Y. Kim; K.H. Kim; K.S. Shin; K.S. Kang
- Source:
- International journal of biological macromolecules 2016 v.85 pp. 522-529
- ISSN:
- 0141-8130
- Subject:
- Citrus; angiogenesis; breast neoplasms; cell movement; endothelial cells; gel chromatography; gelatinase B; human health; humans; ingredients; metastasis; neoplasm cells; polysaccharides; umbilical veins; wastes
- Abstract:
- ... Although the peel of the hallabong (Citrus sphaerocarpa) fruit is rich in polysaccharides, which are valuable dietary ingredients for human health, it is normally wasted. The present study aimed to utilize the peel waste and identify properties it may have against breast cancer metastasis. Hallabong peel extract containing crude polysaccharides was fractionated by gel permeation chromatography to ...
- DOI:
- 10.1016/j.ijbiomac.2016.01.015
- https://doi.org/10.1016/j.ijbiomac.2016.01.015
- Author:
- Letícia Eulalio Castanheira; Daiana Silva Lopes; Sarah Natalie Cirilo Gimenes; Simone Ramos Deconte; Bruno Antônio Ferreira; Patricia Terra Alves; Luiz Ricardo Goulart Filho; Tatiana Carla Tomiosso; Renata Santos Rodrigues; Kelly Aparecida Geraldo Yoneyama; Fernanda de Assis Araújo; Veridiana de Melo Rodrigues
- Source:
- International journal of biological macromolecules 2017 v.102 pp. 153-161
- ISSN:
- 0141-8130
- Subject:
- Bothrops; angiogenesis; collagen; cytokines; cytotoxicity; endothelial cells; extracellular matrix; galactose; hemoglobin; inflammation; lectins; mice; models; myeloperoxidase; secretion; snakes; venoms
- Abstract:
- ... The present work reports the effects of a C-type lectin (BpLec) isolated from Bothrops pauloensis snake venom upon in vitro and in vivo angiogenesis models. Initially, we noted that BpLec was not cytotoxic to endothelial cells (tEnd) in doses up to 40μg/mL, but lower doses (2.5μg/mL, 5μg/mL, 10μg/mL and 20μg/mL) reduced tEnd cells adhesion to some extracellular matrix proteins and inhibited the in ...
- DOI:
- 10.1016/j.ijbiomac.2017.04.012
- https://doi.org/10.1016/j.ijbiomac.2017.04.012
- Author:
- Hassan Rasouli; Sharham Parvaneh; Azadeh Mahnam; Mohsen Rastegari-Pouyani; Zohreh Hoseinkhani; Kamran Mansouri
- Source:
- International journal of biological macromolecules 2017 v.96 pp. 118-128
- ISSN:
- 0141-8130
- Subject:
- Cucumis melo; angiogenesis; cell proliferation; dose response; endothelial cells; inhibitory concentration 50; integrins; mechanism of action; melons; molecular models; molecular weight; probability; secretion; seeds; traditional medicine; trypsin inhibitors; vascular endothelial growth factor receptor-1; vascular endothelial growth factors
- Abstract:
- ... Melons have a good source of protease inhibitors. Its fruit and seeds have been used as a traditional medicine. However, its effects on angiogenesis and mechanism of its action remain elusive.Herein trypsin inhibitor from aqueous extract of C. melo seeds (TICMS) was purified. Its effects on different steps of angiogenesis were evaluated. Also, we examined its effects on migration and angiogenesis ...
- DOI:
- 10.1016/j.ijbiomac.2016.12.027
- https://doi.org/10.1016/j.ijbiomac.2016.12.027
- Author:
- Sivakamasundari Pichu; Jayalalitha Sathiyamoorthy; Selvaraj Vimalraj; Vijay Viswanathan; Suvro Chatterjee
- Source:
- International journal of biological macromolecules 2017 pp. -
- ISSN:
- 0141-8130
- Subject:
- alleles; angiogenesis; cell proliferation; diabetic foot; exons; genetic polymorphism; genotype; metastasis; noninsulin-dependent diabetes mellitus; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Lysyl oxidase (LOX) is an extra-cellular matrix-modifying enzyme that has been linked to cell proliferation, metastasis, angiogenesis and wound healing. This study was designed to examine the association of LOX gene polymorphism G473A, G>A, (rs1800449) located in exon 1 of the LOX gene in diabetic subjects with and without diabetic foot ulcers (DFU) and its impact of expression on DFU. Genotypic a ...
- DOI:
- 10.1016/j.ijbiomac.2017.05.050
- https://doi.org/10.1016/j.ijbiomac.2017.05.050
- Author:
- Denise de Oliveira Guimarães; Daiana Silva Lopes; Fernanda Van Petten Vasconcelos Azevedo; Sarah Natalie Cirilo Gimenes; Makswell Almeida Silva; David Collares Achê; Mário Sérgio Rocha Gomes; Lara Vecchi; Luiz Ricardo Goulart; Kelly Aparecida Geraldo Yoneyama; Renata Santos Rodrigues; Veridiana de Melo Rodrigues
- Source:
- International journal of biological macromolecules 2017 v.97 pp. 770-777
- ISSN:
- 0141-8130
- Subject:
- Bothrops; adhesion; angiogenesis; antineoplastic activity; apoptosis; breast neoplasms; carcinoma; cell movement; cell viability; cytotoxicity; dose response; endothelial cells; humans; metalloproteinases; mortality; neoplasm cells; snakes; venoms; women
- Abstract:
- ... Breast cancer is a highly malignant carcinoma and remains the second leading cause of mortality among women. The antitumor effects of metalloproteinases and disintegrins from snake venom on various types of cancer cells have been investigated. In this study, we evaluated the antitumor and antiangiogenic effects on MDA-MB-231 human breast cancer cells and endothelial cells induced by Bothropoidin, ...
- DOI:
- 10.1016/j.ijbiomac.2017.01.064
- https://doi.org/10.1016/j.ijbiomac.2017.01.064
- Author:
- Yuhua Li; Lei Fan; Tianle Tang; Yuan Tang; Ming Xie; Xiaocong Zeng; Yang Sun; Qibing Mei
- Source:
- International journal of biological macromolecules 2017 v.103 pp. 1217-1223
- ISSN:
- 0141-8130
- Subject:
- Western blotting; angiogenesis; animal models; anti-inflammatory activity; apples; binding proteins; carcinogenesis; cell proliferation; coculture; colitis; colorectal neoplasms; enzyme-linked immunosorbent assay; inflammation; intestines; mice; polysaccharides; protective effect; staining
- Abstract:
- ... Chronic intestinal inflammation enhances cell proliferation, angiogenesis, and migration, then promotes the development of colorectal cancer (CRC). Many ingredients of apples have been proven to have anti-inflammatory properties, and show benefits for colitis treatment. In our previous studies, we found modified apple polysaccharide (MAP) could prevent colitis associated colorectal carcinogenesis ...
- DOI:
- 10.1016/j.ijbiomac.2017.05.172
- https://doi.org/10.1016/j.ijbiomac.2017.05.172
- Author:
- Sheeja Varghese; Manu M. Joseph; Aravind S.R.; Unnikrishnan B.S.; T.T Sreelekha
- Source:
- International journal of biological macromolecules 2017 v.103 pp. 1000-1010
- ISSN:
- 0141-8130
- Subject:
- Punica granatum; angiogenesis; antioxidants; chickens; chicks; embryo (animal); fruit peels; galactomannans; humans; mechanism of action; metastasis; mice; models; neoplasm cells; neoplasms; survival rate; vascular endothelial growth factors; vincristine
- Abstract:
- ... Galactomannan (PSP001) isolated from the fruit rind of Punica granatum was demonstrated as an excellent antioxidant, immunomodulatory and anticancer agent both in vitro and in vivo models. Since the most lethal and debilitating attribute of cancer cells is their ability to evolve to a state of malignancy, with key features like increased angiogenesis, invasion, migration, colony formation, and met ...
- DOI:
- 10.1016/j.ijbiomac.2017.05.137
- https://doi.org/10.1016/j.ijbiomac.2017.05.137
- Author:
- Minghui Ou; Xuezhi Sun; Jiancheng Liang; Fei Liu; Liqin Wang; Xiaomin Wu; Jie Tu
- Source:
- International journal of biological macromolecules 2017 v.94 pp. 451-458
- ISSN:
- 0141-8130
- Subject:
- Sargassum thunbergii; angiogenesis; calcium chloride; cell movement; chromatography; endothelial cells; enzyme activity; fucose; galactose; gene expression; glucuronic acid; lung neoplasms; messenger RNA; molecular weight; polysaccharides; protein synthesis; signal transduction; toxicity; transcription (genetics); vascular endothelial growth factor A; xylose
- Abstract:
- ... A water-soluble polysaccharide (STPC2) was isolated from the boiling-water extract of Sargassum thunbergii, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300 column. It was found that STPC2, with a molecular weight of 57kD, was composed of fucose, xylose, galactose and glucuronic acid, in a ratio of 8.1: 3.8: 2.1: 1.0. Additionally, we found that STPC2 signif ...
- DOI:
- 10.1016/j.ijbiomac.2016.10.046
- https://doi.org/10.1016/j.ijbiomac.2016.10.046
- Author:
- Shuangshuang Li; Li Li; Chengrui Guo; Huanhuan Qin; Xixun Yu
- Source:
- International journal of biological macromolecules 2017 pp. -
- ISSN:
- 0141-8130
- Subject:
- absorption; angiogenesis; antibacterial properties; fibroins; mechanical properties; protein secretion; silk; sodium alginate; strontium; tissue repair; vascular endothelial growth factors; water vapor
- Abstract:
- ... Effectively stimulating angiogenesis is great challenge in wound care management. It’s necessary to develop a new wound dressing with angiogenic capacity. Therefore, strontium loaded SF/SA blend films were prepared as a potential wound dressing material, and their physicochemical and bioactive properties were evaluated. The strontium loaded SF/SA blend films (especially the strontium loaded SF/SA ...
- DOI:
- 10.1016/j.ijbiomac.2017.07.020
- https://doi.org/10.1016/j.ijbiomac.2017.07.020
- Author:
- Hua Yao; Ping Cui; Dan Xu; Yunduo Liu; Qinghua Tian; Fubin Zhang
- Source:
- International journal of biological macromolecules 2017 pp. -
- ISSN:
- 0141-8130
- Subject:
- Polygala tenuifolia; angiogenesis; antineoplastic activity; apoptosis; blood serum; chemoprevention; gas chromatography-mass spectrometry; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; patients; polysaccharides; roots; vascular endothelial growth factors
- Abstract:
- ... PTP, one polysaccharide extracted from the roots of Polygala tenuifolia, has displayed anti-cancer activity in several types of ovarian cancer cells. This study aims to elucidate the structure of PTP and investigate its anticancer effects against SKOV3 xenograft tumor growth in BALB/c mice, as well as the underlying mechanisms involved. GC-MS and NMR data indicate that PTP has a backbone composed ...
- DOI:
- 10.1016/j.ijbiomac.2017.09.043
- https://doi.org/10.1016/j.ijbiomac.2017.09.043
25. Anti-angiogenic activity and mechanism of a chemically sulfated natural glucan from Phellinus ribis
- Author:
- Yuhong Liu; Jiazhen Xu; Aizhen Zong; Jihui Wang; Yuguo Liu; Wei Jia; Juan Jin; Guangling Yan; Yongqing Zhang
- Source:
- International journal of biological macromolecules 2018 v.107 pp. 2475-2483
- ISSN:
- 0141-8130
- Subject:
- Phellinus; Western blotting; angiogenesis; antagonists; chickens; chorioallantoic membrane; endothelial cells; gene expression; glucans; mechanism of action; messenger RNA; mitogen-activated protein kinase; non-specific serine/threonine protein kinase; phosphorylation; protein synthesis; signal transduction; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
- Abstract:
- ... A sulfated polysaccharide named PRP-S16 was obtained by sulfation of a glucan from Phellinus ribis using the chlorosulfonic acid method. PRP-S16 could significantly block the formation of new vessels in chicken chorioallantoic membrane (CAM). It could also inhibit the proliferation, migration, and tube formation and significantly reduced the mRNA expression of vascular endothelial growth factor (V ...
- DOI:
- 10.1016/j.ijbiomac.2017.10.134
- https://doi.org/10.1016/j.ijbiomac.2017.10.134
- Author:
- Mihaela D. Leonida; Sabrina Belbekhouche; Alice Benzecry; Manasa Peddineni; Andrea Suria; Benjamin Carbonnier
- Source:
- International journal of biological macromolecules 2018 v.120 pp. 1335-1343
- ISSN:
- 0141-8130
- Subject:
- Candida; Fourier transform infrared spectroscopy; Gram-positive bacteria; angiogenesis; antagonists; antibacterial properties; antibiotics; antioxidants; beers; bioavailability; biopolymers; bitterness; chitosan; encapsulation; food preservatives; gelation; hops; hormone replacement therapy; lupulone; nanocomposites; nanoparticles; sodium tripolyphosphate; synergism; titration; zeta potential
- Abstract:
- ... Hops and the components extracted from them are well known antibacterial agents used in beers and as food preservatives, in formulations for topical applications on their own or together with other antimicrobial agents, in hormone replacement therapy, as antioxidants, tumor development antagonists, and angiogenesis inhibitors. Their shortcomings: very low bioavailability, bitter taste, and suscept ...
- DOI:
- 10.1016/j.ijbiomac.2018.09.003
- https://doi.org/10.1016/j.ijbiomac.2018.09.003
- Author:
- Mohammad Hasanzadeh; Nasrin Razmi; Ahad Mokhtarzadeh; Nasrin Shadjou; Soltanali Mahboob
- Source:
- International journal of biological macromolecules 2018 v.108 pp. 69-80
- ISSN:
- 0141-8130
- Subject:
- alpha-cyclodextrin; angiogenesis; aptasensors; biomarkers; breast neoplasms; electrochemistry; electrodes; energy-dispersive X-ray analysis; gold; humans; metastasis; nanogold; nanoparticles; nucleotide aptamers; pH; phosphates; platelet-derived growth factor; scanning electron microscopes; scanning electron microscopy; surface area
- Abstract:
- ... Platelet-derived growth factor (PDGF), a protein biomarker, is directly involved in many cell transformation processes, such as tumor growth and progression. Elevation platelet-derived growth factor (PDGF-BB) concentration in plasma could indicate the accelerating growth of metastatic breast tumors and angiogenesis. The development of an apta-assay for detection of PDGF-BB in is presented in this ...
- DOI:
- 10.1016/j.ijbiomac.2017.11.149
- https://doi.org/10.1016/j.ijbiomac.2017.11.149
- Author:
- Hongfang Zhang; Junjie Chen; Ying Cen
- Source:
- International journal of biological macromolecules 2018 v.112 pp. 862-867
- ISSN:
- 0141-8130
- Subject:
- Sanguisorba officinalis; angiogenesis; burning; collagen; histopathology; hydroxyproline; interleukin-1beta; mice; models; oral administration; plant products; polysaccharides; roots; tissues; vascular endothelial growth factors; China
- Abstract:
- ... Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200mg/kg) significantly stimulated wound contraction and reduced epithelializa ...
- DOI:
- 10.1016/j.ijbiomac.2018.01.214
- https://doi.org/10.1016/j.ijbiomac.2018.01.214
- Author:
- Lubna Shahzadi; Aqif Anwar Chaudhry; Abdur Raheem Aleem; Muhammad Hamza Malik; Kashif Ijaz; Hafsah Akhtar; Farah Alvi; Ather Farooq Khan; Ihtesham Ur Rehman; Muhammad Yar
- Source:
- International journal of biological macromolecules 2018 v.120 pp. 721-728
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; angiogenesis; blood vessels; chicks; chitosan; chorioallantoic membrane; crosslinking; gelation; hydrogels; hydrogen peroxide; lysozyme; nanoparticles; phosphates; physicochemical properties; potassium; scanning electron microscopy; surface area; zinc oxide
- Abstract:
- ... Nanoparticles are well recognized for their biological applications including tissue-regeneration due to large surface area and chemical properties. In this study, K-doped zinc oxide (ZnO) nanoparticles containing porous hydrogels were synthesized via freeze gelation. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). The chemical structural analysis of the synt ...
- DOI:
- 10.1016/j.ijbiomac.2018.08.103
- https://doi.org/10.1016/j.ijbiomac.2018.08.103
- Author:
- Haitian Fu; Chao Deng; Liping Teng; Zhi Cai; Jinghua Chen; Guozhong Lu
- Source:
- International journal of biological macromolecules 2018 v.107 pp. 2492-2500
- ISSN:
- 0141-8130
- Subject:
- CXCR4 receptor; Escherichia coli; angiogenesis; bone marrow; carcinogenesis; cell cycle; chemokine CXCL12; heparan sulfate; hypoxia; mitogen-activated protein kinase; proteoglycans; rats; secretion; stem cells; sulfates; viability
- Abstract:
- ... In tumorigenesis, CXCL12 level increases sharply because of tumor tissue hypoxia. As CXCR4 cells, endothelial progenitor cells (EPCs) are mobilized to tumor bed through the CXCL12/CXCR4 axis and are involved in tumor angiogenesis. In this process, either glycosaminoglycan (GAG) or heparan sulfate (HS) carried by membrane proteoglycans is implicated. Exogenous soluble HS mimetics can act as a compe ...
- DOI:
- 10.1016/j.ijbiomac.2017.10.132
- https://doi.org/10.1016/j.ijbiomac.2017.10.132
- Author:
- Zefu Yang; Jianping Wan; Wei Pan; Jun Zou
- Source:
- International journal of biological macromolecules 2018 v.113 pp. 179-185
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; apoptosis; blood serum; cardiomyocytes; cell proliferation; endothelial cells; endothelial nitric oxide synthase; gene expression; messenger RNA; myocardial infarction; protective effect; protein synthesis; rats; vascular endothelial growth factors
- Abstract:
- ... The present study was aimed to investigate the vascular endothelial growth factor expression pattern in acute myocardial infarction induced rats. Serum level of vascular endothelial growth factor and its mRNA expression in myocardium were determined. Protein expression of vascular endothelial growth factor and endothelial nitric oxide synthase were measured. Serum level of vascular endothelial gro ...
- DOI:
- 10.1016/j.ijbiomac.2018.02.111
- https://doi.org/10.1016/j.ijbiomac.2018.02.111
- Author:
- Bruno Antonio Ferreira; Simone Ramos Deconte; Francyelle Borges Rosa de Moura; Tatiana Carla Tomiosso; Patrícia Bianca Clissa; Silvia Passos Andrade; Fernanda de Assis Araújo
- Source:
- International journal of biological macromolecules 2018 v.119 pp. 1179-1187
- ISSN:
- 0141-8130
- Subject:
- Bothrops jararaca; angiogenesis; beta-N-acetylhexosaminidase; blood vessels; chemokine CCL2; chemokine CXCL1; collagen; enzyme activity; extracellular matrix; inflammation; metalloproteinases; mice; models; myeloperoxidase; snake venoms; transforming growth factor beta 1; tumor necrosis factor-alpha; vascular endothelial growth factors
- Abstract:
- ... Jararhagin, a metalloprotease from Bothrops jararaca snake venom, is a toxin containing the metalloproteinase, disintegrin-like and cysteine-rich domains; it causes acute inflammation and damage to vascular tissue. However, the actions of these domains on key components of chronic inflammation have not been determined. Our aim was to investigate the effects of jararhagin (Jar), jararhagin-C (Jar-C ...
- DOI:
- 10.1016/j.ijbiomac.2018.08.051
- https://doi.org/10.1016/j.ijbiomac.2018.08.051
- Author:
- Pankaj Garg; Shambhavi Pandey; Seonwoo Hoon; Kyoung-Je Jang; Myung Chul Lee; Yun-Hoon Choung; Pill-Hoon Choung; Jong Hoon Chung
- Source:
- International journal of biological macromolecules 2018 v.120 pp. 2215-2224
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; animal models; apoptosis; caspase-9; endocytosis; interphase; mice; mitogen-activated protein kinase; neoplasms; polymers; prostaglandin synthase; proto-oncogenes; small interfering RNA; therapeutics; transcription factors
- Abstract:
- ... c-Jun N-terminal kinase 2 (JNK2) is primarily responsible for the oncogenic transformation of the transcription factor c-Jun. Expression of the proto-oncogene c-Jun progresses the cell cycle from G1 to S phase, but when its expression becomes awry it leads to uncontrolled proliferation and angiogenesis. Delivering a JNK2 siRNA (siJNK2) in tumor tissue was anticipated to reverse the condition with ...
- DOI:
- 10.1016/j.ijbiomac.2018.07.019
- https://doi.org/10.1016/j.ijbiomac.2018.07.019
- Author:
- Jing-Jy Cheng; Chi-Hsein Chao; Mei-Kuang Lu
- Source:
- International journal of biological macromolecules 2018 v.113 pp. 1198-1205
- ISSN:
- 0141-8130
- Subject:
- Antrodia; Taiwanofungus camphoratus; angiogenesis; anti-inflammatory activity; chromatography; endothelial cells; fermentation; galactose; glucose; in vitro studies; inflammation; inhibitory concentration 50; interleukin-1beta; interleukin-6; macrophages; manganese; molecular weight; polysaccharides; potassium sulfate; tumor necrosis factor-alpha
- Abstract:
- ... Sulfated polysaccharides (SPSs) were isolated from 0.5mM potassium-sulfate fed Antrodia cinnamomea. We investigated the chemical properties and bio-activities of the five different fractions (SPS-K1, SPS-K2, SPS-K3, SPS-K4, and SPS-K5) with molecular weights ranging from 0.51 to 523.48kDa. SPS-K3 was consisted mainly of glucose, galactose and sulfate in a molar ratio of 15:1:30 with Mn value of 6. ...
- DOI:
- 10.1016/j.ijbiomac.2018.03.056
- https://doi.org/10.1016/j.ijbiomac.2018.03.056
- Author:
- Abshar Hasan; Gyan Waibhaw; Varun Saxena; Lalit M. Pandey
- Source:
- International journal of biological macromolecules 2018 v.111 pp. 923-934
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; X-ray diffraction; angiogenesis; antimicrobial properties; biomineralization; bones; carboxylation; carboxymethylcellulose; chitosan; crystal structure; drugs; freeze drying; nanocomposites; nanocrystals; nanosilver; osteomyelitis; porosity; scanning electron microscopy; strength (mechanics); swelling (materials); tissue engineering
- Abstract:
- ... In the present work, we aimed to synthesize highly efficient nano-composite polymeric scaffolds with controllable pore size and mechanical strength. We prepared nanocomposite (CCNWs-AgNPs) of silver nanoparticles (AgNPs) decorated on carboxylated CNWs (CCNWs) which serves dual functions of providing mechanical strength and antimicrobial activity. Scaffolds containing chitosan (CS) and carboxymethy ...
- DOI:
- 10.1016/j.ijbiomac.2018.01.089
- https://doi.org/10.1016/j.ijbiomac.2018.01.089
- Author:
- Najeh Krayem; Zaineb Abdelkefi-Koubaa; Naziha Marrakchi; Youssef Gargouri; José Luis
- Source:
- International journal of biological macromolecules 2018 v.116 pp. 305-315
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Scorpiones; adhesion; angiogenesis; catalytic activity; chicks; chorioallantoic membrane; dissociation; dose response; endothelial cells; humans; integrins; phospholipase A2; phospholipases; scorpion venoms; synthesis
- Abstract:
- ... We recently purified an heterodimeric phospholipase A₂ named Sm-PLGV from the venom glands of scorpion Scorpio maurus containing a Long chain, a penta-peptide insertion, which is cut out during the maturation, followed by a short chain. Three recombinant forms of Sm-PLGV were produced in Escherichia coli: rPLA₂(+5) containing the full-length sequence including the penta-peptide insert, rPLA₂(−5) a ...
- DOI:
- 10.1016/j.ijbiomac.2018.04.141
- https://doi.org/10.1016/j.ijbiomac.2018.04.141
- Author:
- Dandan Duan; Hongyan Wang; Rong Zhou; Qi Jiang; Rong Xiao
- Source:
- International journal of biological macromolecules 2018 v.107 pp. 2102-2112
- ISSN:
- 0141-8130
- Subject:
- Lethenteron camtschaticum; adhesion; angiogenesis; apoptosis; caspase-3; chorioallantoic membrane; cytoskeleton; cytotoxicity; dose response; inhibitory concentration 50; models
- Abstract:
- ... Previous studies have shown that cysteine-rich buccal gland protein (CRBGP) from buccal glands of Lampetra japonica could suppress angiogenesis in chick chorioallantoic membrane models. As CRBGP is composed of a pathogenesis-related group 1 (PR-1) domain and a cysteine-rich domain (CRD), which domain accounts for the effects of CRBGP on anti-angiogenesis? In the present study, recombinant PR-1 and ...
- DOI:
- 10.1016/j.ijbiomac.2017.10.079
- https://doi.org/10.1016/j.ijbiomac.2017.10.079
- Author:
- Aidong Zhu; Lifen Chu; Qiuju Ma; Yu Li
- Source:
- International journal of biological macromolecules 2018 pp. -
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; endothelial cells; endothelial nitric oxide synthase; gene expression regulation; gene overexpression; mitogen-activated protein kinase; neoplasms; non-coding RNA; protein content; signal transduction; vascular endothelial growth factors
- Abstract:
- ... This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
- DOI:
- 10.1016/j.ijbiomac.2018.08.091
- https://doi.org/10.1016/j.ijbiomac.2018.08.091
- Author:
- Martiniano Bello; Lucia Saldaña-Rivero; José Correa-Basurto; Benjamín García; Victor Armando Sánchez-Espinosa
- Source:
- International journal of biological macromolecules 2018 v.111 pp. 569-586
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; binding capacity; dimerization; epigallocatechin gallate; gene expression; ligands; molecular dynamics; neoplasms; phosphorylation; screening; signal transduction; synthetic products
- Abstract:
- ... Activation of EGFR starts by ligand binding at the extracellular domain which results in homo and heterodimerization, leading to phosphorylation, activation of downstream signaling pathways which upregulate expression of genes, proliferation and angiogenesis. Abnormalities in the expression of EGFR play a critical role in the development of different types of cancer. HER2 is the preferred heterodi ...
- DOI:
- 10.1016/j.ijbiomac.2017.12.162
- https://doi.org/10.1016/j.ijbiomac.2017.12.162
- Author:
- Lishuang Zhou; Lulin Huang; Han Yue; Kan Ding
- Source:
- International journal of biological macromolecules 2018 v.108 pp. 47-55
- ISSN:
- 0141-8130
- Subject:
- Lycium barbarum; acid hydrolysis; angiogenesis; arabinose; cytotoxicity; endothelial cells; fruits; galactose; glucuronic acid; growth and development; humans; methylation; molecular weight; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; polysaccharides; rhamnose; therapeutics
- Abstract:
- ... Angiogenesis plays a crucial role in tumor growth and development. Blocking angiogenesis of tumor cells has become one of the most promising approaches in cancer therapy. Here, an acidic polysaccharide designated LBP1B-S-2 with an average molecular weight of 80.00kDa, was extracted and purified from dried mature fruits of Lycium barbarum L. by DEAE Sepharose™ Fast Flow and Sephacryl S-300 HR colum ...
- DOI:
- 10.1016/j.ijbiomac.2017.11.111
- https://doi.org/10.1016/j.ijbiomac.2017.11.111
- Author:
- Maram Morjen; Houcemeddine Othman; Zaineb Abdelkafi-Koubaa; Erij Messadi; Jed Jebali; Mohamed El Ayeb; Najet Srairi Abid; José Luis; Naziha Marrakchi
- Source:
- International journal of biological macromolecules 2018 v.117 pp. 790-799
- ISSN:
- 0141-8130
- Subject:
- adhesion; angiogenesis; antineoplastic activity; bioinformatics; biotechnology; carcinogenesis; cardioprotective effect; chicks; chorioallantoic membrane; collagen; hypertension; integrins; models; neoplasms; new drugs; phosphorylation; rats; snake venoms
- Abstract:
- ... Through the recent development of knowledge in biotechnology and bioinformatics, snake venoms are widely used to develop new drugs to treat diseases such as hypertension and cancer. We have previously reported that Lebetin 2 isolated from Macrovipera lebetina transmediterranea venom displays a potent anti-platelet activity and exerts a cardioprotective effect in ischemia-reperfusion (IR) injury mo ...
- DOI:
- 10.1016/j.ijbiomac.2018.05.230
- https://doi.org/10.1016/j.ijbiomac.2018.05.230
- Author:
- Ning Xu; Lili Wang; Junjie Guan; Chao Tang; Ning He; Wei Zhang; Shiping Fu
- Source:
- International journal of biological macromolecules 2018 v.117 pp. 102-107
- ISSN:
- 0141-8130
- Subject:
- Curcuma zedoaria; adverse effects; angiogenesis; animal disease models; chitosan; collagen; diabetes; exosomes; hydrogels; rats; rhizomes; silk; therapeutics; tissue repair
- Abstract:
- ... One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments ...
- DOI:
- 10.1016/j.ijbiomac.2018.05.066
- https://doi.org/10.1016/j.ijbiomac.2018.05.066
- Author:
- Fanhui Kong; Conghui Fan; Yulian Yang; Bae Hoon Lee; Kun Wei
- Source:
- International journal of biological macromolecules 2019 v.138 pp. 933-949
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; antibacterial properties; antioxidants; biocompatibility; collagen; fibroblasts; foods; garlic; honey; hydrogels; hydroxymethylfurfural; in vitro studies; inflammation; mechanical properties; mortality; nanosilver; neoplasms; polyvinyl alcohol; skin (animal); sodium alginate; tissue repair
- Abstract:
- ... Treating large acute or chronic wounds remains a challenging task because of a lack of effective methods to accelerate wound healing. Though growth factor-based wound products are found to be effective, they are costly and are potentially associated with increased cancer mortality. Effective, safe, and affordable strategies to tackle large or chronic wounds need to further be designed and develope ...
- DOI:
- 10.1016/j.ijbiomac.2019.07.152
- https://doi.org/10.1016/j.ijbiomac.2019.07.152
- Author:
- Xianzhen Yin; Yiting Li; Congling Yang; Jie Weng; Jianxin Wang; Jie Zhou; Bo Feng
- Source:
- International journal of biological macromolecules 2019 v.132 pp. 495-505
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatible materials; calcium chloride; cell-mediated immunity; chitosan; coatings; crosslinking; drugs; electrolytes; gene expression regulation; interleukin-4; macrophages; messenger RNA; nanotubes; phenotype; protein content; protein secretion; sodium alginate; tissue engineering; tissue repair; titanium; titanium dioxide
- Abstract:
- ... Macrophage phenotype conversion is crucial for improving post-traumatic angiogenesis and tissue repair. Biomaterials with the ability of skewing macrophage phenotype have attracted widespread attention in the field of tissue engineering. The aim of this study was to transform macrophage phenotype by a three-step process; anodizing, drug loading and coating with polyelectrolyte multilayer (PEM) fil ...
- DOI:
- 10.1016/j.ijbiomac.2019.03.184
- https://doi.org/10.1016/j.ijbiomac.2019.03.184
- Author:
- Xianzhen Yin; Yiting Li; Congling Yang; Jie Weng; Jianxin Wang; Jie Zhou; Bo Feng
- Source:
- International journal of biological macromolecules 2019 v.133 pp. 503-513
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatible materials; calcium chloride; cell-mediated immunity; chitosan; coatings; crosslinking; drugs; electrolytes; gene expression; gene expression regulation; interleukin-4; macrophages; messenger RNA; nanotubes; phenotype; protein content; protein secretion; sodium alginate; tissue engineering; tissue repair; titanium; titanium dioxide
- Abstract:
- ... Macrophage phenotype conversion is crucial for improving post-traumatic angiogenesis and tissue repair. Biomaterials with the ability of skewing macrophage phenotype have attracted widespread attention in the field of tissue engineering. The aim of this study was to transform macrophage phenotype by a three-step process; anodizing, drug loading and coating with polyelectrolyte multilayer (PEM) fil ...
- DOI:
- 10.1016/j.ijbiomac.2019.04.028
- https://doi.org/10.1016/j.ijbiomac.2019.04.028
- Author:
- Luis Fernando Gonçalves Rabelo; Bruno Antonio Ferreira; Simone Ramos Deconte; Tatiana Carla Tomiosso; Patty Karina dos Santos; Silvia Passos Andrade; Heloisa Sobreiro Selistre de Araújo; Fernanda de Assis Araújo
- Source:
- International journal of biological macromolecules 2019 v.140 pp. 653-660
- ISSN:
- 0141-8130
- Subject:
- Bothrops; adhesion; angiogenesis; chemokine CCL2; collagen; hemoglobin; inflammation; integrins; mast cells; mice; transforming growth factor beta 1; tumor necrosis factor-alpha; vascular endothelial growth factors; venoms
- Abstract:
- ... Alternagin-C (ALT-C), a disintegrin-like protein obtained from the venom of Bothrops alternatus, is able to modulate cellular behaviors such as adhesion, migration and proliferation, as well as the production of various growth factors via α2β1 integrin, important processes during inflammation, angiogenesis and fibrogenesis, which although appear as distinct events, act concomitantly in several chr ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.171
- https://doi.org/10.1016/j.ijbiomac.2019.08.171
- Author:
- Abdur Raheem Aleem; Lubna Shahzadi; Saimoon Tehseen; Farah Alvi; Aqif Anwar Chaudhry; Ihtesham ur Rehman; Muhammad Yar
- Source:
- International journal of biological macromolecules 2019 v.140 pp. 401-406
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; alanine; angiogenesis; arginine; biocompatibility; biodegradation; blood vessels; cell proliferation; chitosan; chorioallantoic membrane; collagen; endothelial cells; freeze drying; hydrogels; phenylalanine; polymers; qualitative analysis; tissue engineering; tissue repair
- Abstract:
- ... Chitosan/collagen-based hydrogels were studied for their promising role in skin tissue engineering applications due to their unique biocompatibility and biodegradation properties. Amino acids are not only the mean of protein building units but also support endothelial cells proliferation and trigger angiogenesis during wound healing. The purpose of this study was to prepare amino acid based pro-an ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.095
- https://doi.org/10.1016/j.ijbiomac.2019.08.095
- Author:
- Eliécer Jiménez–Charris; Daiana Silva Lopes; Sarah Natalie Cirilo Gimenes; Samuel Cota Teixeira; Leonel Montealegre–Sánchez; Luis Solano–Redondo; Leonardo Fierro–Pérez; Veridiana de Melo Rodrigues Ávila
- Source:
- International journal of biological macromolecules 2019 v.122 pp. 1053-1061
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; antineoplastic activity; apoptosis; breast neoplasms; breasts; cell cycle checkpoints; cell movement; cytotoxicity; dose response; epithelial cells; flow cytometry; genes; human cell lines; human umbilical vein endothelial cells; humans; integrins; interphase; pro-apoptotic proteins; prototypes; snake venoms; uterine cervical neoplasms
- Abstract:
- ... This work shows for the first time the antitumoral and angiostatic potential effects of Pllans–II, an acidic monomeric Asp49–PLA2 from Porthidium lansbergii lansbergii snake venom on HeLa cells. Pllans–II exhibited a predominant dose–dependent cytotoxicity on cervical carcinoma HeLa cells more than human breast cancer MCF7 and MDA–MB–231 cells. Interestingly, Pllans–II showed negligible effect in ...
- DOI:
- 10.1016/j.ijbiomac.2018.09.053
- https://doi.org/10.1016/j.ijbiomac.2018.09.053
- Author:
- Zefeng Lin; Tingting Wu; Wanshun Wang; Binglin Li; Ming Wang; Lingling Chen; Hong Xia; Tao Zhang
- Source:
- International journal of biological macromolecules 2019 v.140 pp. 330-342
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; alginates; angiogenesis; antibiotic resistance; antibiotics; antimicrobial peptides; antimicrobial properties; biodegradability; collagen; drugs; fibroblasts; hyaluronic acid; mechanical properties; methicillin-resistant Staphylococcus aureus; porosity; silver; tissue repair
- Abstract:
- ... The increase in severe infections caused by antibiotic drug resistance and the decrease in the number of new antibacterial drugs approved for use in the last few decades are driving the need for the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) are a potential new class of antimicrobial drugs that are expected to solve the problem of global antibiotic drug resistance. ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.087
- https://doi.org/10.1016/j.ijbiomac.2019.08.087
50. Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB)
- Author:
- T.G. Volova; A.A. Shumilova; E.D. Nikolaeva; A.K. Kirichenko; E.I. Shishatskaya
- Source:
- International journal of biological macromolecules 2019 v.131 pp. 230-240
- ISSN:
- 0141-8130
- Subject:
- acids; angiogenesis; biocompatible materials; biodegradability; cellulose; collagen; composite polymers; drugs; fibroblasts; histology; in vitro studies; inflammation; keratin; laboratory animals; mechanical properties; mesenchymal stromal cells; models; tissue repair
- Abstract:
- ... Hybrid wound dressings have been constructed using two biomaterials: bacterial cellulose (BC) and copolymer of 3-hydroxybutyric and 4-hydroxybutyric acids [P(3HB/4HB)] – a biodegradable polymer of microbial origin. Some of the experimental membranes were loaded with drugs promoting wound healing and epidermal cells differentiated from multipotent adipose-derived mesenchymal stem cells. A study has ...
- DOI:
- 10.1016/j.ijbiomac.2019.03.068
- https://doi.org/10.1016/j.ijbiomac.2019.03.068
- Author:
- Hui-Ying Hu; Chen-Huan Yu; Huan-Huan Zhang; Song-Zhao Zhang; Wen-Ying Yu; Yang Yang; Qin Chen
- Source:
- International journal of biological macromolecules 2019 v.132 pp. 470-477
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biomarkers; blood serum; colorectal neoplasms; exosomes; metastasis; mice; microRNA; models; neoplasm cells; patients; protein synthesis; transfection; vascular endothelial growth factors
- Abstract:
- ... Circulating exosomal microRNAs (exomiR) have been demonstrated to be novel diagnostic biomarkers for various cancers. In this study, we found that circulating exomiR-1229 levels were significantly increased in the serum exosomes of patients with colorectal cancer (CRC) and significantly associated with tumor size, lymphatic metastasis, TNM stage and poor survival. Treatment with siRNA-Drosha, siRN ...
- DOI:
- 10.1016/j.ijbiomac.2019.03.221
- https://doi.org/10.1016/j.ijbiomac.2019.03.221
- Author:
- Duraipandy Natarajan; Manikantan Syamala Kiran
- Source:
- International journal of biological macromolecules 2019 v.124 pp. 1002-1015
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; angiogenesis; beta catenin; cadherins; cell proliferation; collagen; in vivo studies; juglone; nanosilver; pathophysiology; proteinases; proteolysis; thermal properties; vascular endothelial growth factor receptor-2; vascular endothelial growth factors; wound treatment
- Abstract:
- ... The effective wound management strategies depends on identification and manipulation of the molecular defects in the pathophysiology of wound. Poor vascularization, protease susceptibility and microbial invasion at wound site affect the early wound closure. Hence, an efficient wound dressing material needs to promote angiogenesis, control proteolytic activity and microbial attack. The present stud ...
- DOI:
- 10.1016/j.ijbiomac.2018.11.221
- https://doi.org/10.1016/j.ijbiomac.2018.11.221
- Author:
- Felipe Domingos de Sousa; Pedrinha Diógenes Vasconselos; Ayrles Fernanda Brandão da Silva; Erika Freitas Mota; Adriana da Rocha Tomé; Francisco Rogênio da Silva Mendes; Anida Maria Moraes Gomes; David J. Abraham; Xu Shiwen; James S. Owen; Marcos Roberto Lourenzoni; Adriana Rolim Campos; Renato de Azevedo Moreira; Ana Cristina de Oliveira Monteiro-Moreira
- Source:
- International journal of biological macromolecules 2019 v.121 pp. 429-442
- ISSN:
- 0141-8130
- Subject:
- Caesalpinia pulcherrima; Toll-like receptor 4; angiogenesis; artificial skin; breadfruits; carbohydrate binding; cytotoxicity; fibroblasts; galactomannans; galactose; hybrids; hydrogels; immunomodulators; infrared spectroscopy; interleukin-6; keratinocytes; lectins; permeability; porosity; secretion; seeds; tissue repair; viscosity; water vapor
- Abstract:
- ... Plant lectins are carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions. Here, we have extracted, purified and part-characterized the bioactivity of Jacalin, Frutalin, DAL and PNA, before evaluating their potential for wound healing in cultured human skin fibroblasts. Only Frutalin stimulated fibroblast mi ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.050
- https://doi.org/10.1016/j.ijbiomac.2018.10.050
54. Injectable angiogenic and osteogenic carrageenan nanocomposite hydrogel for bone tissue engineering
- Author:
- Ramanathan Yegappan; Vignesh Selvaprithiviraj; Sivashanmugam Amirthalingam; Annapoorna Mohandas; Nathaniel S. Hwang; R. Jayakumar
- Source:
- International journal of biological macromolecules 2019 v.122 pp. 320-328
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; adsorption; alkaline phosphatase; angiogenesis; biocompatible materials; bone formation; bones; carrageenan; cell movement; drugs; energy-dispersive X-ray analysis; enzyme activity; human umbilical vein endothelial cells; hydrogels; mesenchymal stromal cells; nanocomposites; nanoparticles; rats; scanning electron microscopy; tissue engineering; transmission electron microscopy
- Abstract:
- ... Functional biomaterials that couple angiogenesis and osteogenesis processes are vital for bone tissue engineering and bone remodeling. Herein we developed an injectable carrageenan nanocomposite hydrogel incorporated with whitlockite nanoparticles and an angiogenic drug, dimethyloxallylglycine. Synthesized whitlockite nanoparticles and nanocomposite hydrogels were characterized using SEM, TEM, EDS ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.182
- https://doi.org/10.1016/j.ijbiomac.2018.10.182
- Author:
- Jun Yi; Zhi-Feng Gao
- Source:
- International journal of biological macromolecules 2019 v.130 pp. 1-9
- ISSN:
- 0141-8130
- Subject:
- CXCR4 receptor; Western blotting; angiogenesis; apoptosis; cell proliferation; chemokines; endothelial cells; glucose; humans; inflammation; luciferase; microRNA; mitogen-activated protein kinase; non-specific serine/threonine protein kinase; phosphorylation; quantitative polymerase chain reaction; rapamycin; reporter genes; reverse transcriptase polymerase chain reaction; small interfering RNA
- Abstract:
- ... High glucose (HG) has the potential to cause vascular endothelial cell injury, while microRNAs (miRNAs) play a key role in treating endothelial cell injury. CXC chemokine receptor-4 (CXCR4) is reported to be expressed in vascular endothelial cells. Hence, this study investigated role of miR-9-5p in the angiogenesis and apoptosis of HG-induced human umbilical vascular endothelial cells (HUVECs) inj ...
- DOI:
- 10.1016/j.ijbiomac.2019.02.003
- https://doi.org/10.1016/j.ijbiomac.2019.02.003
- Author:
- Selvaraj Vimalraj; Sekaran Saravanan; Dhanasekaran Anuradha; Suvro Chatterjee
- Source:
- International journal of biological macromolecules 2019 v.123 pp. 1229-1240
- ISSN:
- 0141-8130
- Subject:
- Danio rerio; angiogenesis; biomedical research; gene editing; genome; giant cells; models; neoplasms; sprouting; therapeutics
- Abstract:
- ... Angiogenesis is a distinct process which follows sprouting angiogenesis (SA) and intussusceptive angiogenesis (IA) forming the basis for various physiological and pathological scenarios. Angiogenesis is a double edged sword exerting both desirable and discernible effects owing to the referred microenvironment. Therapeutic interventions to promote angiogenesis in regenerative medicine is essential ...
- DOI:
- 10.1016/j.ijbiomac.2018.11.164
- https://doi.org/10.1016/j.ijbiomac.2018.11.164
- Author:
- Tamires Krupp; Bruna Daniele dos Santos; Loyane Almeida Gama; Josmary Rodrigues Silva; Wagner Welber Arrais-Silva; Nara Cristina de Souza; Madileine Francely Américo; Paula Cristina de Souza Souto
- Source:
- International journal of biological macromolecules 2019 v.131 pp. 980-988
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biopsy; burning; collagen; epithelium; hydrophilicity; laboratory animals; liquids; males; models; propolis; rats; rubber; silver; sulfadiazine; temperature; tissue repair; wettability
- Abstract:
- ... Our aim was to evaluate effects of natural rubber membrane (NR) associated with aqueous propolis extract (P) on the wound healing in rats burn model. The membranes were characterized for wettability and pore presence after the membrane preparation by casting the liquid solution in Petri dishes, at different temperatures (27 and 60 °C). Male Wistar rats were divided into treatment groups (n = 5 per ...
- DOI:
- 10.1016/j.ijbiomac.2019.03.147
- https://doi.org/10.1016/j.ijbiomac.2019.03.147
- Author:
- Alap Ali Zahid; Rashid Ahmed; Syed Raza ur Rehman; Robin Augustine; Muhammad Tariq; Anwarul Hasan
- Source:
- International journal of biological macromolecules 2019 v.136 pp. 901-910
- ISSN:
- 0141-8130
- Subject:
- amputation; angiogenesis; cell proliferation; chick embryos; chickens; chitosan; hydrogels; models; nitric oxide; nitric oxide synthase; patients; polyvinyl alcohol
- Abstract:
- ... The lack of angiogenic activity is one of the serious complications of chronic wounds associated with delayed wound closure, chronic ulceration, and subsequent limb amputation. Multiple lines of evidence suggest that nitric oxide (NO) produced endogenously by nitric oxide synthase pathway plays a significant role in angiogenic activity and accelerates wounds closure. In this work, chitosan (CS), p ...
- DOI:
- 10.1016/j.ijbiomac.2019.06.136
- https://doi.org/10.1016/j.ijbiomac.2019.06.136
- Author:
- Manman Li; Mei Han; Yusheng Sun; Yingying Hua; Guifang Chen; Liefeng Zhang
- Source:
- International journal of biological macromolecules 2019 v.122 pp. 1120-1127
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; Staphylococcus aureus; angiogenesis; antibacterial properties; chitosan; collagen; cytotoxicity; differential scanning calorimetry; gels; granulation tissue; histopathology; mice; physicochemical properties; scanning electron microscopy; therapeutics; tissue repair
- Abstract:
- ... In this study, the collagen/chitosan gel composite supplemented with a cell-penetrating peptide (CPP) (Oligoarginine, R8) was prepared. Then, the physicochemical properties of the new collagen/chitosan/CPPs gel obtained were analyzed and the related characteristics were evaluated by scanning electron microscopy (SEM), fourier transform infrared (FTIR), differential scanning calorimetry (DSC), diff ...
- DOI:
- 10.1016/j.ijbiomac.2018.09.061
- https://doi.org/10.1016/j.ijbiomac.2018.09.061
- Author:
- Isra H. Ali; Islam A. Khalil; Ibrahim M. El-Sherbiny
- Source:
- International journal of biological macromolecules 2019 v.136 pp. 154-164
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; angiogenesis; animal models; biocompatibility; biodegradability; biopolymers; bone density; bone fractures; cell adhesion; cell proliferation; cytotoxicity; differential scanning calorimetry; fibroblasts; histopathology; mice; nanofibers; orthopedics; permeability; phenytoin; polylactic acid; porosity; solvents; tissue repair; water vapor
- Abstract:
- ... Autologous and synthetic bone grafts showed some limitations during their usage in bone tissue regeneration. This is attributed to several drawbacks such as difficulty of finding a donor in addition to the autoimmune rejection. This study aims to fabricate a well-designed biocompatible double-layered structure of highly porous poly(lactic acid)-based electrospun nanofibers (NFs) as scaffolds for b ...
- DOI:
- 10.1016/j.ijbiomac.2019.06.048
- https://doi.org/10.1016/j.ijbiomac.2019.06.048
- Author:
- Shengxue Hu; Xianqun Cai; Xin Qu; Bangrui Yu; Chenyan Yan; Jianmin Yang; Feng Li; Yunquan Zheng; Xianai Shi
- Source:
- International journal of biological macromolecules 2019 v.123 pp. 1320-1330
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; antimicrobial properties; chemical bonding; chitosan; ciprofloxacin; collagen; diabetic foot; fibroblasts; gentamicin; in vivo studies; mechanical properties; polymers; silver; skin (animal); sulfates; tissue repair; water binding capacity; water vapor
- Abstract:
- ... Wound dressings with long-term antimicrobial activity are highly desired for treatment of chronic wound infections. Herein, the sustained antimicrobial wound dressings were developed by using antibiotic agents, ciprofloxacin HCL (CIP) and gentamicin sulfate (GS), covalent bonding to natural polymer matrix composites, carboxymethyl chitosan (CMC) and collagen (COL). By amide bond formation between ...
- DOI:
- 10.1016/j.ijbiomac.2018.09.122
- https://doi.org/10.1016/j.ijbiomac.2018.09.122
- Author:
- Goeun Choe; Junggeon Park; Hyerim Jo; Yong Sook Kim; Youngkeun Ahn; Jae Young Lee
- Source:
- International journal of biological macromolecules 2019 v.123 pp. 512-520
- ISSN:
- 0141-8130
- Subject:
- alginates; angiogenesis; biomimetics; cardiomyocytes; cell transplantation; coculture; growth factors; humans; hydrogen peroxide; mesenchymal stromal cells; microencapsulation; myocardial infarction; oxidative stress; stem cells
- Abstract:
- ... Stem cell therapy has been recognized as a promising approach for myocardium regeneration post myocardial infarction (MI); however, it unfortunately often remains a challenge because of poor survival of transplanted cells and a lack of clear understanding of their interactions with host cells. High oxidative stress at heart tissues post MI is considered one of the important factors damaging transp ...
- DOI:
- 10.1016/j.ijbiomac.2018.11.115
- https://doi.org/10.1016/j.ijbiomac.2018.11.115
63. Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy
- Author:
- Enhui Zhang; Ronge Xing; Song Liu; Kecheng Li; Yukun Qin; Huahua Yu; Pengcheng Li
- Source:
- International journal of biological macromolecules 2019 v.126 pp. 662-672
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; antineoplastic activity; chitosan; coculture; cytotoxicity; drug delivery systems; drugs; fluorescence; human umbilical vein endothelial cells; ligands; mice; microscopy; nanoparticles; neoplasm cells; pH; peptides; stomach neoplasms; texture
- Abstract:
- ... A gastric cancer angiogenesis marker peptide, GX1, is promising to be a desirable ligand for anti-angiogenesis targeted drug of gastric cancer treatment. In this study, GX1 was utilized to fabricate a multifunctional vascular targeting docetaxel (DCT)-loaded nanoparticle with N-deoxycholic acid glycol chitosan (DGC) as the carrier and GX1-PEG-deoxycholic acid (GPD) conjugate as the targeting ligan ...
- DOI:
- 10.1016/j.ijbiomac.2018.12.262
- https://doi.org/10.1016/j.ijbiomac.2018.12.262
- Author:
- Ni Qin; Shiyin Lu; Ning Chen; Chunxia Chen; Qiuqiao Xie; Xiaojie Wei; Fangxing Ye; Junhui He; Yuchun Li; Lixiu Chen; Luhui Jiang; Xiaoqi Lu; Yuchan Yuan; Jian Li; Yang Jiao; Renbin Huang
- Source:
- International journal of biological macromolecules 2019 v.121 pp. 971-980
- ISSN:
- 0141-8130
- Subject:
- Western blotting; metastasis; neoplasm cells; lungs; polysaccharides; oral administration; Millettia; immunohistochemistry; enzyme-linked immunosorbent assay; vascular endothelial growth factors; apoptosis; animal tissues; caspase-3; models; mice; in vitro studies; antioxidant activity; cell proliferation; quantitative polymerase chain reaction; viability; flow cytometry; angiogenesis; breast neoplasms
- Abstract:
- ... Yulangsan polysaccharide (YLSPS) is derived from the root of Millettia pulchra (Benth.) Kurz var. Recent studies have postulated YLSPS as a regimen for cancer treatment. However, the underlying mechanism anti-breast cancer is still poorly unknown. The aim of this study was to examine the suppressive and apoptosis effect of YLSPS on the growth of breast cancer cell 4T1 and its possible underlying m ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.082
- https://doi.org/10.1016/j.ijbiomac.2018.10.082
- Author:
- Yang Liu; Xia Liu; Minghui Wu; Peihong Ji; Huilin Lv; Linhong Deng
- Source:
- International journal of biological macromolecules 2019 v.121 pp. 233-238
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; collagen; cornea; corneal diseases; epithelium; freeze drying; mechanical properties; nutrient solutions; permeability; rabbits; sodium chloride; tryptophan; water uptake
- Abstract:
- ... Corneal disease is a major cause of blindness and keratoplasty is an effective treatment method. A freeze-dried collagen film (FD-Col) with micro-rough surface structure for corneal epithelial repair was reported in our previous studies. In this research, we conducted a more comprehensive study on the FD-Col film. Besides with excellent mechanical property and optical transparency, the FD-Col film ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.026
- https://doi.org/10.1016/j.ijbiomac.2018.10.026
- Author:
- Jie Ding; Wei Jia; Yangang Cui; Juan Jin; Yongqing Zhang; Lingchuan Xu; Yuhong Liu
- Source:
- International journal of biological macromolecules 2020 v.154 pp. 72-81
- ISSN:
- 0141-8130
- Subject:
- Phellinus; Western blotting; adverse effects; angiogenesis; animal disease models; blood serum; endothelial cells; enzyme-linked immunosorbent assay; hypoxia-inducible factor 1; immunohistochemistry; lung neoplasms; messenger RNA; mice; non-specific serine/threonine protein kinase; polysaccharides; protein synthesis; quantitative polymerase chain reaction; signal transduction; therapeutics; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
- Abstract:
- ... Previous studies have demonstrated that the sulfated polysaccharide named PRP-S16 could inhibit the proliferation, migration, and tube formation of endothelial cells in vitro. Here, its anti-angiogenic effect and mechanism in vivo were investigated by Lewis lung carcinoma (LLC) mice model. PRP-S16 significantly reduced the microvessel density (MVD) of tumor, exhibiting a high tumor growth inhibito ...
- DOI:
- 10.1016/j.ijbiomac.2020.03.068
- https://doi.org/10.1016/j.ijbiomac.2020.03.068
- Author:
- Madeeha Khalil; Uzair Hashmi; Ramish Riaz; Shah Rukh Abbas
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 483-491
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; animal models; chitosan; cornea; encapsulation; epithelium; high performance liquid chromatography; nanocarriers; permeability; topical application; triamcinolone
- Abstract:
- ... Drug delivery to the posterior eye is limited by epithelial and mucosal barriers limiting the topical administration of drugs leading to invasive modes of repeated long-term painful administration of drugs. Several constructs of liposomes have been prepared to counter this challenge yet are often limited by size and surface charge resulting in poor encapsulation efficiency, low retention time, and ...
- DOI:
- 10.1016/j.ijbiomac.2019.10.256
- https://doi.org/10.1016/j.ijbiomac.2019.10.256
- Author:
- Hoda Elkhenany; M. Abd Elkodous; Nehal I. Ghoneim; Toka A. Ahmed; Sara M. Ahmed; Ihab K. Mohamed; Nagwa El-Badri
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 763-774
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; apoptosis; biosafety; cell movement; cell proliferation; ferric oxide; nanoparticles; protective effect; stem cells; transfection; viability
- Abstract:
- ... However, labelling of stem cells using nanoparticles (NPs) for tracking purpose has been intensively investigated, the biosafety of these materials needs more clarification. Herein, different forms of iron oxide Fe₂O₃, Fe₃O₄, and CoₓNi₁₋ₓ Fe₂O₄ NPs either uncoated or starch-coated (ST-coated) were prepared. We successfully labelled adipose-derived stem cells (ASCs) using these NPs with the aid of ...
- DOI:
- 10.1016/j.ijbiomac.2019.10.031
- https://doi.org/10.1016/j.ijbiomac.2019.10.031
- Author:
- K.S. Venkataprasanna; J. Prakash; S. Vignesh; G. Bharath; Manigandan Venkatesan; Fawzi Banat; S. Sahabudeen; Saravanan Ramachandran; G. Devanand Venkatasubbu
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 744-762
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; Raman spectroscopy; X-ray diffraction; angiogenesis; antimicrobial properties; bacteria; biocompatibility; biodegradability; cell proliferation; cell viability; chitosan; cupric oxide; evaporation; extracellular matrix; graphene oxide; immune system; nanocomposites; polyvinyl alcohol; proteins; sol-gel processing; tissue repair; transmission electron microscopy
- Abstract:
- ... Wound healing is a common issue in our day to day life. Our immune system repairs the damaged tissue by itself and its a time-consuming process. The GO/CuO nanocomposite (NC) was synthesized through the sol-gel method. XRD, FT-IR, Raman, and TEM analysis were used to analysis the physico-chemical properties of the sample. The GO/CuO patches were prepared using chitosan (Cs)/poly vinyl alcohol (PVA ...
- DOI:
- 10.1016/j.ijbiomac.2019.10.029
- https://doi.org/10.1016/j.ijbiomac.2019.10.029
- Author:
- Wen-Jing Hsu; Mei-Hsiang Lin; Tai-Chih Kuo; Chih-Ming Chou; Fwu-Long Mi; Chia-Hsiung Cheng; Cheng-Wei Lin
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 600-608
- ISSN:
- 0141-8130
- Subject:
- Danio rerio; Saccharina japonica; adhesion; angiogenesis; antineoplastic activity; breast neoplasms; endothelial cells; fucoidan; genetically modified organisms; humans; mitogen-activated protein kinase; models; neoplasm cells; phosphatidylinositol 3-kinase; transcription factor NF-kappa B
- Abstract:
- ... Fucoidan is a fucose-rich polysaccharide that has gained attention for its various anticancer properties. However, the effect and underlying mechanism of fucoidan on triple-negative breast cancer (TNBC) are still unknown. Herein, we investigated the anticancer potential of fucoidan from Laminaria japonica. We found that fucoidan showed modest antiproliferative activity against TNBC cells, while it ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.256
- https://doi.org/10.1016/j.ijbiomac.2020.01.256
- Author:
- Takayuki Takei; Ryosuke Yoshihara; So Danjo; Yoshiki Fukuhara; Courtney Evans; Rio Tomimatsu; Yoshihiro Ohzuno; Masahiro Yoshida
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 140-147
- ISSN:
- 0141-8130
- Subject:
- adsorption; angiogenesis; crosslinking; cytotoxicity; dimethyl sulfoxide; drugs; fibroblast growth factor 2; fluorescein; freeze drying; gelatin; hydrogels; hydrophilicity; hydrophobic bonding; hydrophobicity; in vitro studies; models; therapeutics
- Abstract:
- ... Gelatin molecules have been chemically crosslinked using potentially cytotoxic reagents to prepare stable hydrogels. Hydrophobic interaction is a means of forming physical crosslinks that is a good candidate for enhancing the stability of gelatin hydrogels without using cytotoxic chemicals. In this study, we proposed a new method to fabricate hydrogels from hydrophobically-modified gelatin (HMG) w ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.227
- https://doi.org/10.1016/j.ijbiomac.2020.01.227
- Author:
- Lais C.G.F. Palhares; Jefferson S. Barbosa; Kátia C. Scortecci; Hugo A.O. Rocha; Adriana S. Brito; Suely F. Chavante
- Source:
- International journal of biological macromolecules 2020 v.162 pp. 1153-1165
- ISSN:
- 0141-8130
- Subject:
- Litopenaeus vannamei; angiogenesis; cancer therapy; cell cycle; cell death; cell movement; chondroitin sulfate; cytotoxicity; melanin; melanoma; oncogenes; shrimp; thrombin
- Abstract:
- ... Thrombin triggers cellular responses that are crucial for development and progression of cancer, such as proliferation, migration, oncogene expression and angiogenesis. Thus, biomolecules capable of inhibiting this protease have become targets in cancer research. The present work describes the in vitro antitumor properties of a chondroitin sulfate with anti-thrombin activity, isolated from the Lit ...
- DOI:
- 10.1016/j.ijbiomac.2020.06.100
- https://doi.org/10.1016/j.ijbiomac.2020.06.100
- Author:
- Jovana Petrović; Jasmina Glamočlija; Tatjana Ilić-Tomić; Marina Soković; Dragana Robajac; Olgica Nedić; Aleksandar Pavić
- Source:
- International journal of biological macromolecules 2020 v.148 pp. 129-139
- ISSN:
- 0141-8130
- Subject:
- Danio rerio; Laetiporus sulphureus; adjuvants; angiogenesis; animal models; antineoplastic activity; cancer therapy; carcinogenesis; cisplatin; colorectal neoplasms; cytotoxicity; drug therapy; ethanol; fibroblasts; human diseases; inflammation; lectins; lungs; melanoma; metastasis; mice; neutropenia; sulfur; tissue repair; traditional medicine
- Abstract:
- ... In spite of extensive usage of Laetiporus sulphureus (sulphur polypore) in traditional European and Asian ethno-medicine for centuries, its anticancer therapeutic potential and toxicity profile remained explored in animal models. Herein, using zebrafish (Danio rerio), as a preclinical animal model, we demonstrated that L. sulphureus lectin (LSL) and ethanol extract (LSE) are non-toxic at high dose ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.033
- https://doi.org/10.1016/j.ijbiomac.2020.01.033
- Author:
- Xinyue Guo; Shaojie Ding; Tiantian Li; Jianzhang Wang; Qin Yu; Libo Zhu; Xinxin Xu; Gen Zou; Yangying Peng; Xinmei Zhang
- Source:
- International journal of biological macromolecules 2020 v.148 pp. 226-237
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; endothelial cells; ganglia; macrophages; mitogen-activated protein kinase; nerve tissue; neurites; neutralizing antibodies; phosphorylation; rats; receptors
- Abstract:
- ... Netrin-1 is an extracellular guidance cue of neuronal navigation, mediated through interaction with its main receptors, and is known to be crucial in the development of multiple chronic inflammatory diseases. However, the expression pattern and mechanism of netrin-1 in endometriosis are currently undefined. Here we report that netrin-1 expression peaked in peritoneal macrophages found in endometri ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.130
- https://doi.org/10.1016/j.ijbiomac.2020.01.130
- Author:
- Faez Iqbal Khan; Preeti Gupta; Sonam Roy; Naved Azum; Khalid A. Alamry; Abdullah M. Asiri; Dakun Lai; Md. Imtaiyaz Hassan
- Source:
- International journal of biological macromolecules 2020 v.161 pp. 1496-1505
- ISSN:
- 0141-8130
- Subject:
- Gibbs free energy; angiogenesis; apoptosis; cell proliferation; circular dichroism spectroscopy; denaturation; drug development; fluorescence; fluorescence emission spectroscopy; humans; molecular dynamics; pH; sphingosine; urea
- Abstract:
- ... Sphingosine kinase 1 (SphK1) plays a significant role in various cellular processes, including cell proliferation, apoptosis, and angiogenesis. SphK1 is considered as an attractive target for drug development owing to its connection with several diseases, including cancer. In the current work, the urea-induced unfolding of SphK1 was performed at pH 8.0 and 25 °C using CD and fluorescence spectrosc ...
- DOI:
- 10.1016/j.ijbiomac.2020.07.280
- https://doi.org/10.1016/j.ijbiomac.2020.07.280
- Author:
- Pallavi Shyam Kaparekar; Srinivetha Pathmanapan; Suresh Kumar Anandasadagopan
- Source:
- International journal of biological macromolecules 2020 v.165 pp. 930-947
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; X-ray diffraction; angiogenesis; biodegradation; cell movement; chitosan; collagen; collagenase; colorimetry; crosslinking; crystal structure; drugs; electron microscopy; encapsulation; fibroblasts; gallic acid; gelation; hexosamines; nanocomposites; polymers; porosity; thermal stability; thermogravimetry; tissue repair; zeta potential
- Abstract:
- ... The present study explores the curative efficacy of collagen-fibrin scaffold with Gallic acid loaded Chitosan nanoparticles (GA-CSNPs) in wound healing. GA-CSNPs were synthesized by ionotropic gelation and the incorporation of GA was confirmed with Fourier Transform Infra-Red Spectroscopy (FTIR). Change in the crystal structure of GA was confirmed by X-ray Powder Diffraction (X-PRD) and Differenti ...
- DOI:
- 10.1016/j.ijbiomac.2020.09.212
- https://doi.org/10.1016/j.ijbiomac.2020.09.212
- Author:
- Eliana Rezende Adami; Claudia Rita Corso; Natalia Mulinari Turin-Oliveira; Claudia Martins Galindo; Leticia Milani; Maria Carolina Stipp; Liziane Cristine Malaquias da Silva; Georgia Erdmann do Nascimento; Pedro Felipe Pereira Chaves; Andressa Chequin; Marihá Mariott; Luisa Mota da Silva; Giseli Klassen; Edneia A.S. Ramos; Lucimara M.C. Cordeiro; Alexandra Acco
- Source:
- International journal of biological macromolecules 2020 v.158 pp. 1071-1081
- ISSN:
- 0141-8130
- Subject:
- Capsicum annuum; angiogenesis; cell viability; drug therapy; females; gene expression; human cell lines; inflammation; interleukin-10; interleukin-4; interleukin-6; laboratory animals; mammary neoplasms (animal); methotrexate; mice; necrosis; neoplasm cells; polysaccharides; sweet peppers; toxicity; tumor necrosis factor-alpha
- Abstract:
- ... This study investigated the antineoplastic effects and toxicity of long-term treatment with polysaccharides from sweet green pepper (Capsicum annuum [CAP]), and concomitant treatment with CAP + methotrexate (MTX) on mammary tumor cells in vivo and in vitro. Ehrlich tumor cells were subcutaneously inoculated in female Swiss mice. The long-term treatment (31 days) with CAP (100 mg kg⁻¹, p.o.) reduce ...
- DOI:
- 10.1016/j.ijbiomac.2020.05.001
- https://doi.org/10.1016/j.ijbiomac.2020.05.001
- Author:
- Minghui Sun; Qianjin Xie; Xiaqiang Cai; Zenghui Liu; Ying Wang; Xu Dong; Yan Xu
- Source:
- International journal of biological macromolecules 2020 v.148 pp. 777-784
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; animal disease models; ascorbic acid; chitosan; collagen; crosslinking; diabetes; epigallocatechin gallate; gelatin; mice; nanoparticles; patients; streptozotocin; tissue repair; transmission electron microscopes; transmission electron microscopy
- Abstract:
- ... The wounds of diabetic patients are difficult to heal, which could lead to a limb amputation or even death. The experiment aims to develop a new type of nanoparticles that could accelerate wound healing. Epigallocatechin gallate, ascorbic acid, gelatin and chitosan nanoparticles (EV NPS) were prepared by ion cross-linking method, and their properties were studied. The optimal formula ratio of EV N ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.198
- https://doi.org/10.1016/j.ijbiomac.2020.01.198
- Author:
- Xiaolian Feng; Xiaofang Zhang; Shiqi Li; Yunquan Zheng; Xianai Shi; Feng Li; Shaobin Guo; Jianmin Yang
- Source:
- International journal of biological macromolecules 2020 v.164 pp. 626-637
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; angiogenesis; animal models; antimicrobial peptides; bacitracin; biocompatibility; cell growth; collagen; crosslinking; hydrogels; immunogenicity; marine fish; necrosis; oxidation; polymyxin B; risk; scales (integument); schiff bases; sodium alginate; sulfates
- Abstract:
- ... Acute full-thickness wounds require a more extended healing period, thus increasing the risk of infection. Severe infection frequently resulted in wound ulceration, necrosis, and even life-threatening complications. Here, a hybrid hydrogel comprising aminated collagen (AC), oxidized sodium alginate (OSA), and antimicrobial peptides (polymyxin B sulfate and bacitracin) was developed to enhance full ...
- DOI:
- 10.1016/j.ijbiomac.2020.07.058
- https://doi.org/10.1016/j.ijbiomac.2020.07.058
- Author:
- Baocheng Hao; Xinjian Wang; Xueqing Ma; Yongming Jin; Wenguang Fan; Cidan Laba; Cuomu Wujin; Yonggang Wang; Jianping Liang
- Source:
- International journal of biological macromolecules 2020 v.156 pp. 906-917
- ISSN:
- 0141-8130
- Subject:
- Glycyrrhiza uralensis; angiogenesis; collagen; fibroblasts; granulation tissue; hydroxyproline; microvessels; models; phosphorylation; polysaccharides; protein content; rats
- Abstract:
- ... The extraction process of Glycyrrhiza soluble polysaccharide (GP) was optimized by RSM, a rat trauma model was established via longitudinal incision on the back skin. The effects of GP combined with microcapsule collagen on the repair of rat injury model were discussed at different levels, Based on the content of hydroxyproline at the whole animal level, the proliferation of granulation tissue sta ...
- DOI:
- 10.1016/j.ijbiomac.2020.03.121
- https://doi.org/10.1016/j.ijbiomac.2020.03.121
- Author:
- Bao Hou; Mengting Qi; Jiangnan Sun; Min Ai; Xinyu Ma; Weiwei Cai; Yuetao Zhou; Lulu Ni; Jing Hu; Fei Xu; Liying Qiu
- Source:
- International journal of biological macromolecules 2020 v.165 pp. 3169-3179
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; animal models; biocompatibility; cytotoxicity; encapsulation; hydrogels; particle size distribution; toxicity testing; transmission electron microscopy
- Abstract:
- ... Wound healing is a complex, dynamic and difficult process. Much effort and attempt has been made to accelerate this process. The purpose of this study is to prepare nanoparticles loaded with vaccarin (VAC-NPS)hydrogel and evaluate its effect on promoting wound healing. In the present study, the physicochemical properties of VAC-NPS were characterized. Transmission electron microscopy (TEM) was use ...
- DOI:
- 10.1016/j.ijbiomac.2020.10.182
- https://doi.org/10.1016/j.ijbiomac.2020.10.182
- Author:
- Ali Masjedi; Armin Ahmadi; Fatemeh Atyabi; Shohreh Farhadi; Mahzad Irandoust; Yalda Khazaei-Poul; Mitra Ghasemi Chaleshtari; Mahdi Edalati Fathabad; Masoumeh Baghaei; Navideh Haghnavaz; Behzad Baradaran; Mohammad Hojjat-Farsangi; Ghasem Ghalamfarsa; Gholamabas Sabz; Sajad Hasanzadeh; Farhad Jadidi-Niaragh
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 487-500
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; chitosan; gene therapy; hyaluronic acid; immunosuppression; immunotherapy; interleukin-6; nanoparticles; neoplasm cells; neoplasm progression; neoplasms; physicochemical properties; signal transduction; small interfering RNA; toxicity; transactivators; transfection
- Abstract:
- ... The immunosuppressive nature of the tumor microenvironment is a critical problem that should be considered before the design of immunotherapies. Interleukin (IL)-6 and its related downstream molecules such as signal transducer and activator of transcription (STAT)3 play an important role in the cancer progression, which can be considered as potential therapeutic targets. In the present study, we g ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.273
- https://doi.org/10.1016/j.ijbiomac.2020.01.273
- Author:
- Richa Agrawal; Venuka Durani Goyal; Rahul Singh; Ashwani Kumar; Sahayog N. Jamdar; Amit Kumar; Ravindra D. Makde
- Source:
- International journal of biological macromolecules 2020 v.147 pp. 304-313
- ISSN:
- 0141-8130
- Subject:
- Deinococcus radiodurans; Escherichia coli; active sites; amino acids; angiogenesis; crystal structure; hydrophobicity; membrane alanyl aminopeptidase; metalloproteinases; neoplasms; peptides; substrate specificity
- Abstract:
- ... M1 metallopeptidases regulate many important biological processes such as angiogenesis, tumour growth, hormone regulation, and immune cell development. Knowledge of substrate specificity mechanism in this family is valuable. An M1 peptidase from Deinococcus radiodurans (M1dr) with preference for bulky hydrophobic residues at N-terminus of peptide substrates was recently reported. In contrast to Es ...
- DOI:
- 10.1016/j.ijbiomac.2019.12.239
- https://doi.org/10.1016/j.ijbiomac.2019.12.239
- Author:
- Honita Ramphul; Fanny Gimié; Jessica Andries; Dhanjay Jhurry; Archana Bhaw-Luximon
- Source:
- International journal of biological macromolecules 2020 v.157 pp. 296-310
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatibility; endothelial cells; fibroblasts; in vitro studies; inflammation; keratinocytes; laboratory animals; macrophages; rats; sugarcane; sugarcane bagasse; tissue repair; tumor necrosis factor-alpha
- Abstract:
- ... In a previous article, we reported on the physico-chemical properties of cellulose-based scaffolds derived from sugar-cane bagasse and their preliminary in vitro assessment. In view of skin tissue regeneration, we here present our findings of an extensive in vitro testing of these scaffolds using key cells involved in the wound healing cascade namely fibroblasts, keratinocytes, endothelial cells a ...
- DOI:
- 10.1016/j.ijbiomac.2020.04.176
- https://doi.org/10.1016/j.ijbiomac.2020.04.176
- Author:
- Rasha E. Elsayed; Tarek M. Madkour; Rasha A. Azzam
- Source:
- International journal of biological macromolecules 2020 v.164 pp. 1984-1999
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; bioactive properties; biodegradability; cell proliferation; cell viability; cellulose acetate; collagen; drugs; heterocyclic compounds; hydrogen; hydrophilicity; hydrophobicity; nanofibers; permeability; sorption; water vapor
- Abstract:
- ... To effectively allow for controlled release of a newly synthesized sulfonamide analog, biodegradable poly(lactic acid) nanofibrous dressing mats tailored-designed for maximum wound healing efficacy were developed. The heterocyclic analog, N-(3,4-diamino-7-(benzo [d]thiazol-2-yl)-6-oxo-1H-pyrazolo[4,3-c]pyridin-5(6H)-yl)benzenesulfonamide, has been specifically synthesized to possess superior antib ...
- DOI:
- 10.1016/j.ijbiomac.2020.07.316
- https://doi.org/10.1016/j.ijbiomac.2020.07.316
- Author:
- Lubna Shahzadi; Mustehsan Bashir; Saimoon Tehseen; Mubashra Zehra; Azra Mehmood; Aqif Anwar Chaudhry; Ihtesham ur Rehman; Muhammad Yar
- Source:
- International journal of biological macromolecules 2020 v.160 pp. 296-306
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; adsorption; angiogenesis; cell culture; chitosan; gelation; porosity; thyroxine
- Abstract:
- ... This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed by scanning electron microscopy (SEM) and chemical structures were investigated by Fourier transform ...
- DOI:
- 10.1016/j.ijbiomac.2020.05.127
- https://doi.org/10.1016/j.ijbiomac.2020.05.127
- Author:
- Muhammad Hamza Malik; Lubna Shahzadi; Razia Batool; Sher Zaman Safi; Abdul Samad Khan; Ather Farooq Khan; Aqif Anwar Chaudhry; Ihtesham Ur Rehman; Muhammad Yar
- Source:
- International journal of biological macromolecules 2020 v.145 pp. 1162-1170
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; absorption; angiogenesis; blood vessels; carboxymethylcellulose; chicks; chitosan; chorioallantoic membrane; cytotoxicity; hydrogels; hydroxyapatite; periodontitis; rolling; scanning electron microscopy; thyroxine; tissues
- Abstract:
- ... Angiogenesis is one of the most important processes in repair and regeneration of many tissues and organs. Blood vessel formation also play a major role in repair of dental tissue(s) after ailments like periodontitis. Here we report the preparation of chitosan/carboxymethyl cellulose/hydroxyapatite based hydrogels, loaded with variable concentrations of thyroxin i.e., 0.1 μg/ml, 0.5 μg/ml and 1 μg ...
- DOI:
- 10.1016/j.ijbiomac.2019.10.043
- https://doi.org/10.1016/j.ijbiomac.2019.10.043
- Author:
- Ting Wang; Qian Liao; Yihan Wu; Xiao Wang; Chaomei Fu; Funeng Geng; Yan Qu; Jinming Zhang
- Source:
- International journal of biological macromolecules 2020 v.164 pp. 3846-3857
- ISSN:
- 0141-8130
- Subject:
- Periplaneta americana; angiogenesis; carboxymethylcellulose; collagen; crosslinking; fibroblasts; hydrogels; macrophages; mechanical properties; rats; water holding capacity
- Abstract:
- ... In view of the long medicinal use history of Periplaneta americana for manifold ulcer or skin wounds treatment, the comprehensive utilization value of P. americana herbal residue was evaluated. In this study, we isolated a polysaccharide fraction from P. americana herbal residue with the potential wound healing effect, named as PAP faction, based on our previous study and provided the structural a ...
- DOI:
- 10.1016/j.ijbiomac.2020.08.156
- https://doi.org/10.1016/j.ijbiomac.2020.08.156
- Author:
- Sunisa Yoodee; Paleerath Peerapen; Sirikanya Plumworasawat; Visith Thongboonkerd
- Source:
- International journal of biological macromolecules 2021 v.180 pp. 1-13
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; angiopoietin-2; antibodies; cell proliferation; endothelial cells; humans; neoplasm progression; neutralization; secretion; tumor suppressor genes
- Abstract:
- ... AT-rich interactive domain 1A (ARID1A) is a novel tumor suppressor gene found in several human cells and its loss/defect is commonly observed in many cancers. However, its roles in angiogenesis, which is one of the hallmarks for tumor progression, remained unclear. Herein, we demonstrated the direct effects of ARID1A knockdown in human endothelial cells by lentivirus-based short-hairpin RNA (shRNA ...
- DOI:
- 10.1016/j.ijbiomac.2021.02.218
- https://doi.org/10.1016/j.ijbiomac.2021.02.218
- Author:
- Bing Liu; Qiang-Ming Li; Zhen-Zi Shang; Xue-Qiang Zha; Li-Hua Pan; Jian-Ping Luo
- Source:
- International journal of biological macromolecules 2021 v.192 pp. 590-599
- ISSN:
- 0141-8130
- Subject:
- Dendrobium catenatum; T-lymphocytes; angiogenesis; apoptosis; carcinoma; forestomach; immune response; mice; molecular weight; neoplasm cells; polysaccharides; stomach neoplasms
- Abstract:
- ... The present study aimed at assuring whether homogeneous cultivated Dendrobium huoshanense stem polysaccharide (cDHPS) could inhibit gastric cancer in vivo, and whether its anti-gastric cancer activity could be affected by its molecular weight and O-acetyl group. Three different fractions (cDHPS-I, cDHPS-II and cDHPS-III) with decreased molecular weights and one fraction (cDHPS-IV) without O-acetyl ...
- DOI:
- 10.1016/j.ijbiomac.2021.10.016
- https://doi.org/10.1016/j.ijbiomac.2021.10.016
- Author:
- Armin Mahmoud Salehi Khesht; Vahid Karpisheh; Parisa Sahami Gilan; Lyubov A. Melnikova; Angelina Olegovna Zekiy; Mahdis Mohammadi; Mohammad Hojjat-Farsangi; Naime Majidi Zolbanin; Ata Mahmoodpoor; Hadi Hassannia; Leili Aghebati-Maleki; Reza Jafari; Farhad Jadidi-Niaragh
- Source:
- International journal of biological macromolecules 2021 v.186 pp. 849-863
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; cell death; chitosan; cytotoxicity; death; doxorubicin; drug therapy; hyaluronic acid; lactic acid; metastasis; nanocarriers; neoplasm cells; neoplasms; peptides; transactivators
- Abstract:
- ... Chemotherapy drugs are still one of the first treatment options used in many cancers; however, problems such as cytotoxic side effects on normal cells after systemic administration and resistance to treatment have reduced the use of chemotherapeutics day by day. Targeted delivery of these drugs to the tumor site and sensitization of cancer cells to death induced by chemotherapy drugs are ways that ...
- DOI:
- 10.1016/j.ijbiomac.2021.07.034
- https://doi.org/10.1016/j.ijbiomac.2021.07.034
- Author:
- Krishnasamy naidu gopal Hariprabu; Muthusamy Sathya; Selvaraj Vimalraj
- Source:
- International journal of biological macromolecules 2021 v.192 pp. 913-930
- ISSN:
- 0141-8130
- Subject:
- CRISPR-Cas systems; adaptive immunity; angiogenesis; cancer therapy; carcinogenesis; drug therapy; gene editing; genome; molecular biology; neoplasms
- Abstract:
- ... Tumor angiogenesis is a critical target for cancer treatment and its inhibition has become a common anticancer approach following chemotherapy. However, due to the simultaneous activation of different compensatory molecular mechanisms that enhance tumor angiogenesis, clinically authorized anti-angiogenic medicines are ineffective. Additionally, medications used to treat cancer have an effect on no ...
- DOI:
- 10.1016/j.ijbiomac.2021.10.029
- https://doi.org/10.1016/j.ijbiomac.2021.10.029
- Author:
- Tong Lei; Jian Wang; Yanyan Liu; Peng Chen; Zhihui Zhang; Xiaoshuang Zhang; Xiao Wang; Quanhai Li; Hongwu Du
- Source:
- International journal of biological macromolecules 2021 v.178 pp. 229-239
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; calreticulin; dissociation; inflammation; protein content; proteomics; tooth pulp; two-dimensional gel electrophoresis
- Abstract:
- ... The construction of protein abundance profiles helps to interpret the clinical applications of stem cells. Dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) can be isolated from teeth and used as a highly convenient clinical potential material. Here, we aimed to explore commonalities and differences of DPSCs and GMSCs at the protein level. TMT-based quantitative proteomics ...
- DOI:
- 10.1016/j.ijbiomac.2021.02.126
- https://doi.org/10.1016/j.ijbiomac.2021.02.126
- Author:
- Murugan Prasathkumar; Subramaniam Sadhasivam
- Source:
- International journal of biological macromolecules 2021 v.186 pp. 656-685
- ISSN:
- 0141-8130
- Subject:
- alginates; amputation; andrographolide; angiogenesis; biocompatibility; biocompatible materials; biodegradability; biofilm; carrageenan; cartilage; cellulose; cellulose acetate; chitin; chitosan; curcumin; fibrin; gelatin; honey; hyaluronic acid; hydrogels; medicine; nanofibers; pullulan; quercetin; risk
- Abstract:
- ... Biomaterials are being extensively used in regenerative medicine including tissue engineering applications, as these enhance tissue development, repair, and help in the process of angiogenesis. Wound healing is a crucial biological process of regeneration of ruptured tissue after getting injury to the skin and other soft tissue in humans and animals. Besides, the accumulation of microbial biofilms ...
- DOI:
- 10.1016/j.ijbiomac.2021.07.067
- https://doi.org/10.1016/j.ijbiomac.2021.07.067
- Author:
- Linan Zhou; Ziteng Song; Shaojie Zhang; Yeling Li; Jing Xu; Yuanqiang Guo
- Source:
- International journal of biological macromolecules 2021 v.188 pp. 904-913
- ISSN:
- 0141-8130
- Subject:
- Citrus limon; Danio rerio; angiogenesis; antineoplastic activity; apoptosis; bioassays; bioavailability; cancer therapy; dispersibility; hepatoma; humans; liver; polysaccharides; polysorbates; selenium; water solubility
- Abstract:
- ... Selenium nanoparticles (SeNPs), a potential cancer therapeutic agent, have attracted widespread attention owing to their high bioavailability and remarkable anticancer activity. Nevertheless, the poor water solubility and dispersibility of SeNPs seriously limit their applications. In the present study, we synthesized stable and individual spherical selenium nanoparticles (CL90-Tw-SeNP2) with an av ...
- DOI:
- 10.1016/j.ijbiomac.2021.07.142
- https://doi.org/10.1016/j.ijbiomac.2021.07.142
- Author:
- Syed Ahmed Shah; Muhammad Sohail; Muhammad Usman Minhas; Shahzeb Khan; Zahid Hussain; Arshad Mahmood; Mubeen Kousar; Hnin Ei Thu; Mudassir Abbasi; Mehboob ur Rehman Kashif
- Source:
- International journal of biological macromolecules 2021 v.185 pp. 350-368
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatibility; biocompatible materials; cell proliferation; collagen; curcumin; drug delivery systems; fibroblasts; histology; hyaluronic acid; hydrogels; hydrophobicity; nuclear magnetic resonance spectroscopy; viability assays
- Abstract:
- ... Injectable hydrogel with multifunctional tunable properties comprising biocompatibility, anti-oxidative, anti-bacterial, and/or anti-infection are highly preferred to efficiently promote diabetic wound repair and its development remains a challenge. In this study, we report hyaluronic acid and Pullulan-based injectable hydrogel loaded with curcumin that could potentiate reepithelization, increase ...
- DOI:
- 10.1016/j.ijbiomac.2021.06.119
- https://doi.org/10.1016/j.ijbiomac.2021.06.119
- Author:
- Mou Zhou; Fang Lin; Wendan Li; Linying Shi; Yanhui Li; Guiqiu Shan
- Source:
- International journal of biological macromolecules 2021 v.166 pp. 1335-1351
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; antibacterial properties; biocompatible materials; chitosan; interleukin-6; nanosilver; sodium alginate; synergism; water vapor; wound treatment
- Abstract:
- ... Nowadays, treatment to the infected wounds caused by bacterial even multi-resistant bacterial strains and subsequently complete skin regeneration remain a critical clinical challenge. Herein, a novel multi-functional platform (Alg/1.0Ag@CMC-PAMAM/PRP) was prepared as wound dressings by mixing platelet rich plasma (PRP) with the sodium alginate (Alg) based dressing containing nano silver (Ag)-doped ...
- DOI:
- 10.1016/j.ijbiomac.2020.11.014
- https://doi.org/10.1016/j.ijbiomac.2020.11.014
- Author:
- Shahrzad Zirak Hassan Kiadeh; Azadeh Ghaee; Mehdi Farokhi; Jhamak Nourmohammadi; Addie Bahi; Frank K. Ko
- Source:
- International journal of biological macromolecules 2021 v.173 pp. 351-365
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; coordination polymers; copper; cytotoxicity; drug carriers; fibroblasts; folic acid; nanocomposites; nanofibers; pectins; strength (mechanics)
- Abstract:
- ... Pectin has been regarded as a drug carrier accelerating the healing process due to its bioactivities, abundance and lower cost of resources. However, a big challenge related to its practical application is its poor mechanical strength. In this study the modified Cu-based MOF containing Folic acid was synthesized and incorporated in the suitable pectin electrospun nanofibers which not only improved ...
- DOI:
- 10.1016/j.ijbiomac.2021.01.058
- https://doi.org/10.1016/j.ijbiomac.2021.01.058
- Author:
- Xiao-yu Wu; Yi-miao Zhu; Yang Qi; Wen-Wen Xu; Jing-Zhai
- Source:
- International journal of biological macromolecules 2021 v.193 pp. 2332-2342
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; cell proliferation; erythropoietin; extracellular matrix; inflammation; medicine; organ transplantation; programmed cell death
- Abstract:
- ... In recent years, tissue engineering has emerged as a promising approach to address limitations of organ transplantation. The ultimate goal of tissue engineering is to provide scaffolds that closely mimic the physicochemical and biological cues of native tissues' extracellular matrix. In this endeavor, new generation of scaffolds have been designed that utilize the incorporation of signaling molecu ...
- DOI:
- 10.1016/j.ijbiomac.2021.11.065
- https://doi.org/10.1016/j.ijbiomac.2021.11.065
- Author:
- Yu Fang; Lele Shi; Zhiwei Duan; Saeed Rohani
- Source:
- International journal of biological macromolecules 2021 v.189 pp. 554-566
- ISSN:
- 0141-8130
- Subject:
- angiogenesis; biocompatible materials; cell movement; cell proliferation; fetal development; humans; hyaluronic acid; hydrogels; longevity; molecular weight; stem cells; therapeutics
- Abstract:
- ... Stem cell-based therapies offer numerous potentials to repair damaged or defective organs. The therapeutic outcomes of human studies, however, fall far short from what is expected. Enhancing stem cells local density and longevity would possibly maximize their healing potential. One promising strategy is to administer stem cells via injectable hydrogels. However, stem cells differentiation process ...
- DOI:
- 10.1016/j.ijbiomac.2021.08.140
- https://doi.org/10.1016/j.ijbiomac.2021.08.140