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You searched for: Author "Li, Deshan" Remove constraint Author: "Li, Deshan" Journal International journal of biological macromolecules Remove constraint Journal: International journal of biological macromolecules Subject diabetes Remove constraint Subject: diabetes Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. An efficient large-scale refolding technique for recovering biologically active recombinant human FGF-21 from inclusion bodies

Author:
Li, Deshan,   et al.   ; Ye, Xianlong; Yu, Dan; Wu, Yunzhou; Han, Jun; Li, Shujie; Wu, Qiang; Qi, Jianying;     Show all 8 Authors
Source:
International journal of biological macromolecules 2019 v.135 pp. 362-372
ISSN:
0141-8130
Subject:
Escherichia coli; affinity chromatography; bacteria; diabetes; disulfide bonds; drugs; fermentation; fibroblast growth factors; glucose; glycemic effect; glycolipids; human cell lines; humans; inclusion bodies; mice; microfiltration; molecular weight; obesity; proteins
Abstract:
... Fibroblast growth factor 21 (FGF-21) is an important regulator in glycolipid metabolism that is a promising drug candidate for treatment of diabetes and obesity. However, the productivity of recombinant hFGF-21 (rhFGF-21) in Escherichia coli (E. coli) is relatively low, which limits its clinical application. To meet the clinical demand and control the production cost, rhFGF-21 proteins were expres ...
DOI:
10.1016/j.ijbiomac.2019.05.167