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- Li, Deshan, et al. Show all 8 Authors
- International journal of biological macromolecules 2019 v.135 pp. 362-372
- Escherichia coli; affinity chromatography; bacteria; diabetes; disulfide bonds; drugs; fermentation; fibroblast growth factors; glucose; glycemic effect; glycolipids; human cell lines; humans; inclusion bodies; mice; microfiltration; molecular weight; obesity; proteins
- ... Fibroblast growth factor 21 (FGF-21) is an important regulator in glycolipid metabolism that is a promising drug candidate for treatment of diabetes and obesity. However, the productivity of recombinant hFGF-21 (rhFGF-21) in Escherichia coli (E. coli) is relatively low, which limits its clinical application. To meet the clinical demand and control the production cost, rhFGF-21 proteins were expres ...