PubAg

Main content area

You searched for: Subject "coagulation" Remove constraint Subject: "coagulation" Journal International journal of biological macromolecules Remove constraint Journal: International journal of biological macromolecules Subject humans Remove constraint Subject: humans
Start Over

Search

17  Search Results

1 - 17 of 17
Number of results to display per page

Search Results

1. Characterisation and the effects of bilirubin binding to human fibrinogen

Author:
Gligorijević, Nikola; Minić, Simeon; Robajac, Dragana; Nikolić, Milan; Ćirković Veličković, Tanja; Nedić, Olgica
Source:
International journal of biological macromolecules 2019 v.128 pp. 74-79
ISSN:
0141-8130
Subject:
blood coagulation; coagulation,   etc   ; absorption; antioxidant activity; antioxidants; bilirubin; binding sites; fibrin; fibrinogen; hemostasis; humans; oxidation; thermal stability;     Show all 13 Subjects
Abstract:
... Fibrinogen, a protein involved in blood coagulation, is very susceptible to oxidation. Oxidation alters its function and usually makes it more thrombogenic. Bilirubin, an end-product of the haem degradation in vertebrates, is known for its antioxidant properties. The present paper describes interaction between fibrinogen and bilirubin, and the influence of bilirubin on the formation of fibrin and ...
DOI:
10.1016/j.ijbiomac.2019.01.124

2. Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin

Author:
Wei, Ling-Hua; Chen, Tian-Ran; Fang, Hong-Bo; Jin, Qiang; Zhang, Shui-Jun; Hou, Jie; Yu, Yang; Dou, Tong-Yi; Cao, Yun-Feng; Guo, Wen-Zhi; Ge, Guang-Bo
Source:
International journal of biological macromolecules 2019 v.134 pp. 622-630
ISSN:
0141-8130
Subject:
blood coagulation,   etc   ; Hypericum perforatum; acetates; fibrinogen; flavones; humans; hydrolysis; hypericin; inhibitory concentration 50; proteolysis; therapeutics; thrombin;     Show all 12 Subjects
Abstract:
... Thrombin, a multifunctional serine protease responsible for the proteolytic hydrolysis of soluble fibrinogen, plays a pivotal role in the blood coagulation cascade. Currently, thrombin inhibitor therapy has been recognized as an effective therapeutic strategy for the prevention and treatment of thrombotic diseases. In this study, the inhibitory effects of natural constituents in St. John's Wort ag ...
DOI:
10.1016/j.ijbiomac.2019.04.181

3. Secondary hemostasis studies of crude venom and isolated proteins from the snake Crotalus durissus terrificus

Author:
Sousa, Ivancia D.L.; Barbosa, Ayrton R.; Salvador, Guilherme H.M.; Frihling, Breno E.F.; Santa-Rita, Paula H.; Soares, Andreimar M.; Pessôa, Hilzeth L.F.; Marchi-Salvador, Daniela P.
Source:
International journal of biological macromolecules 2019 v.131 pp. 127-133
ISSN:
0141-8130
Subject:
coagulation,   etc   ; Crotalus durissus terrificus; anticoagulant activity; anticoagulants; coagulants; enzyme inhibition; fibrin; fibrinogen; hemostasis; humans; plasminogen activator; snake venoms; snakes;     Show all 13 Subjects
Abstract:
... Among the activities triggered by Crotalus durissus terrificus snake venom, coagulation is intriguing and contradictory since the venom contains both coagulant and anticoagulant precursor proteins. This work describes the in vitro effects of crude venom and purified proteins from snake Crotalus durissus terrificus as they affect coagulation factors of clotting pathways. Coagulant and/or anticoagul ...
DOI:
10.1016/j.ijbiomac.2019.03.059

4. Cryogel composites based on hyaluronic acid and halloysite nanotubes as scaffold for tissue engineering

Author:
Suner, Selin S.; Demirci, Sahin; Yetiskin, Berkant; Fakhrullin, Rawil; Naumenko, Ekaterina; Okay, Oguz; Ayyala, Ramesh S.; Sahiner, Nurettin
Source:
International journal of biological macromolecules 2019 v.130 pp. 627-635
ISSN:
0141-8130
Subject:
blood coagulation,   etc   ; blood; colorectal neoplasms; cryogels; growing media; halloysite; hemolysis; humans; hyaluronic acid; mesenchymal stromal cells; modulus of elasticity; nanotubes; neoplasm cells; rats; tissue engineering; uterine cervical neoplasms;     Show all 16 Subjects
Abstract:
... We present here preparation of mechanically strong and biocompatible cryogel composites based on hyaluronic acid (HA) and halloysite nanotubes (HNTs) of various compositions, and their applications as scaffold for different cell growing media. Uniaxial compression tests reveal that the incorporation of HNTs into HA cryogels leads to a ~2.5-fold increase in their Young moduli, e.g., from 38 ± 1 to ...
DOI:
10.1016/j.ijbiomac.2019.03.025

5. Polymeric nanoengineered HBsAg DNA vaccine designed in combination with β‑glucan

Author:
Soares, Edna; Cordeiro, Rosemeyre; Faneca, Henrique; Borges, Olga
Source:
International journal of biological macromolecules 2019 v.122 pp. 930-939
ISSN:
0141-8130
Subject:
coagulation,   etc   ; DNA; adjuvants; beta-glucans; blood; cell lines; gene expression; hemolysis; hepatitis B antigens; humans; immune response; luciferase; mice; nanotechnology; recombinant vaccines; seroconversion; storage conditions; transfection; vaccination;     Show all 19 Subjects
Abstract:
... Antigen-specific immune responses following DNA vaccination are hard to achieve, owing to the difficulty to mediate efficient gene delivery. This study proposed the use of PDMAEMA:PβAE/DNA polyplexes (Pol) as the vehicle of a pDNA vaccine encoding the hepatitis B surface antigen (HBsAg), with these Pol designed in combination with a soluble (Glu) or a particulate (GPs) form of β‑glucan. β‑Glucans ...
DOI:
10.1016/j.ijbiomac.2018.11.024

6. Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film for wound healing application

Author:
Picone, Pasquale; Sabatino, Maria Antonietta; Ajovalasit, Alessia; Giacomazza, Daniela; Dispenza, Clelia; Di Carlo, Marta
Source:
International journal of biological macromolecules 2019 v.121 pp. 784-795
ISSN:
0141-8130
Subject:
coagulation,   etc   ; Escherichia coli; adhesion; ampicillin; antibacterial properties; bacteria; biocompatibility; biomarkers; cell viability; crosslinking; erythrocytes; fibrinogen; films (materials); humans; hydrogels; mitochondria; mononuclear leukocytes; oxidative stress; staining; thrombin; tissue repair;     Show all 21 Subjects
Abstract:
... Crosslinked xyloglucan-poly(vinyl alcohol) based hydrogel films are interesting materials for wound healing applications. This work focuses on the hydrolytic degradation and consequent morphological modification of a XG-PVA film and on its interaction with cells, blood, bacteria. Biocompatibility of the film was assessed in vitro by investigating different aspects, such as cell viability, oxidativ ...
DOI:
10.1016/j.ijbiomac.2018.10.078

7. Hemostasis and anti-necrotic activity of wound-healing dressing containing chitosan nanoparticles

Author:
Biranje, Santosh S.; Madiwale, Pallavi V.; Patankar, Kaustubh C.; Chhabra, Rohan; Dandekar-Jain, Prajakta; Adivarekar, Ravindra V.
Source:
International journal of biological macromolecules 2019 v.121 pp. 936-946
ISSN:
0141-8130
Subject:
blood coagulation,   etc   ; biodegradability; biodegradation; blood; chitosan; enzyme-linked immunosorbent assay; fibroblasts; freeze drying; gelation; hemostasis; humans; nanoparticles; porosity; surface area; thrombin; tissue repair;     Show all 16 Subjects
Abstract:
... Necrotic tissues are the dead tissues present in the wounded areas, which need to be removed for rapid wound healing. Various biopolymer-based dressings have been exploited to heal infected wounds, but with limited success. In a quest to develop an effective and economic wound dressing, a biodegradable dressing containing chitosan nanoparticles has been successfully developed. Chitosan nanoparticl ...
DOI:
10.1016/j.ijbiomac.2018.10.125

8. Effect of chitosan and coagulation factors on the wound repair phenotype of bioengineered blood clots

Author:
Hoemann, Caroline D.; Marchand, Catherine; Rivard, Georges-Etienne; El-Gabalawy, Hani; Poubelle, Patrice E.
Source:
International journal of biological macromolecules 2017
ISSN:
0141-8130
Subject:
blood coagulation; coagulation,   etc   ; blood serum; chemoattractants; chitosan; humans; interleukin-12; interleukin-6; interleukin-8; lipopolysaccharides; neutrophils; phenotype; platelet-derived growth factor; rabbits; thrombin; tissue engineering;     Show all 16 Subjects
Abstract:
... Controlling the blood clot phenotype in a surgically prepared wound is an evolving concept in scaffold-guided tissue engineering. Here, we investigated the effect of added chitosan (80% or 95% Degree of Deacetylation, DDA) or coagulation factors (recombinant human Factor VIIa, Tissue Factor, thrombin) on inflammatory factors released by blood clots. We tested the hypothesis that 80% DDA chitosan s ...
DOI:
10.1016/j.ijbiomac.2017.04.114

9. Perspectives on progressive strategies and recent trends in the production of recombinant human factor VIII

Author:
Mannully, S.T.; L.N., Ramya; Pulicherla, K.K.
Source:
International journal of biological macromolecules 2018 v.119 pp. 496-504
ISSN:
0141-8130
Subject:
blood coagulation,   etc   ; Chinese hamsters; animal ovaries; bioprocessing; blood; cell lines; factor VIII; freeze drying; glycoproteins; glycosylation; hemophilia; humans; patients; product safety; therapeutics;     Show all 15 Subjects
Abstract:
... Factor VIII (fVIII), a glycoprotein cofactor, plays a crucial role in the intrinsic blood coagulation pathway. As one of the most essential blood clotting factors known today, fVIII is the largest and most complex commercialized therapeutic protein used in the treatment of hemophilia A, an X-linked recessive disorder. Two lyophilized fVIII concentrates (viz., plasma fractionated and recombinant) a ...
DOI:
10.1016/j.ijbiomac.2018.07.164

10. Thrombin-like enzymes from snake venom: Structural characterization and mechanism of action

Author:
Ullah, Anwar; Masood, Rehana; Ali, Ijaz; Ullah, Kifayat; Ali, Hamid; Akbar, Haji; Betzel, Christian
Source:
International journal of biological macromolecules 2018 v.114 pp. 788-811
ISSN:
0141-8130
Subject:
coagulation,   etc   ; active sites; coagulants; crystal structure; databases; fibrinolysis; heart failure; humans; mechanism of action; nervous system diseases; platelet aggregation; sequence analysis; snake venoms; stroke; substrate specificity; suramin; therapeutics; thrombosis; trypsin;     Show all 19 Subjects
Abstract:
... Snake venom thrombin-like enzymes (SVTLEs) constitute the major portion (10–24%) of snake venom and these are the second most abundant enzymes present in the crude venom. During envenomation, these enzymes had shown prominently the various pathological effects, such as disturbance in hemostatic system, fibrinogenolysis, fibrinolysis, platelet aggregation, thrombosis, neurologic disorders, activati ...
DOI:
10.1016/j.ijbiomac.2018.03.164

11. Wet electrospun alginate/gelatin hydrogel nanofibers for 3D cell culture

Author:
Majidi, Sara Seidelin; Adamsen, Peter Slemming; Hanif, Muhammad; Zhang, Zhongyang; Wang, Zhiming; Chen, Menglin
Source:
International journal of biological macromolecules 2018
ISSN:
0141-8130
Subject:
coagulation,   etc   ; alginates; biocompatible materials; biofabrication; cardiomyocytes; cell adhesion; cell culture; cell growth; cell movement; crosslinking; cytotoxicity; electrolytes; ethanol; gelatin; humans; hydrogels; ionic strength; nanofibers; polyethylene glycol; porous media; stem cells; surface tension; surfactants; tissue repair; viscoelasticity;     Show all 25 Subjects
Abstract:
... Convergence of biological and biofabrication approaches is necessary to progress new biomaterials promoting three dimensional (3D) cell growth and maturation towards tissue regeneration and integration. Here, we have developed a novel approach to fabricate 3D macroporous, alginate/gelatin hydrogel nanofibers (Alg/GelF-MA) which provide superior cell adhesion, motility, proliferation and maturation ...
DOI:
10.1016/j.ijbiomac.2018.07.005

12. The susceptibility of plasma coagulation factor XI to nitration and peroxynitrite action

Author:
Ponczek, Michaſ Bſażej
Source:
International journal of biological macromolecules 2016 v.91 pp. 589-597
ISSN:
0141-8130
Subject:
blood coagulation; coagulation,   etc   ; Western blotting; bioinformatics; blood plasma; computer simulation; humans; inflammation; nitric oxide; oxidative stress; precipitin tests; protective effect; thrombin; tyrosine;     Show all 14 Subjects
Abstract:
... Coagulation factor XI is present in blood plasma as the zymogen, like other serine proteases of hemostatic system, but as the only coagulation factor forms 140⿿160kDa homodimers. Its activation is induced by thrombin, and a positive feedback increases the generation of the extra thrombin. Experimental and clinical observations confirm protective roles of factor XI deficiencies in certain types of ...
DOI:
10.1016/j.ijbiomac.2016.05.076

13. Purification and characterization of Cc-Lec, C-type lactose-binding lectin: A platelet aggregation and blood-clotting inhibitor from Cerastes cerastes venom

Author:
Samah, Saoud; Fatah, Chérifi; Jean-Marc, Berjeaud; Safia, Kellou-Taîri; Fatima, Laraba-Djebari
Source:
International journal of biological macromolecules 2017 v.102 pp. 336-350
ISSN:
0141-8130
Subject:
coagulation,   etc   ; adenosine diphosphate; affinity chromatography; amino acids; arachidonic acid; calcium; crosslinking; disulfide bonds; erythrocytes; fibrinogen; hemagglutination; humans; lectins; mass spectrometry; mice; platelet aggregation; polyacrylamide gel electrophoresis; polypeptides; receptors; therapeutics; thrombosis; venoms;     Show all 22 Subjects
Abstract:
... In this study, we reported for the first time the biochemical and structural characterization of Cc-Lec, a C-type lectin purified from Cerastes cerastes venom by affinity chromatography. This lectin was homogeneous by SDS-PAGE, and was shown to be a 34 271.59Da polypeptide by Electrospray mass spectrometry MS-ES-TOF. Its identified sequence of 160 amino acids corresponding to one subunit, revealed ...
DOI:
10.1016/j.ijbiomac.2017.04.018

14. Gelatin blending and sonication of chitosan nanofiber mats produce synergistic effects on hemostatic functions

Author:
Gu, Bon Kang; Park, Sang Jun; Kim, Min Sup; Lee, Yong Jin; Kim, Jong-Il; Kim, Chun-Ho
Source:
International journal of biological macromolecules 2016 v.82 pp. 89-96
ISSN:
0141-8130
Subject:
blood coagulation,   etc   ; DNA; blood; cell movement; cell viability; chitosan; fibroblasts; gelatin; humans; hydrophilicity; mechanical properties; nanofibers; porosity; rabbits; scanning electron microscopy; synergism; wettability;     Show all 17 Subjects
Abstract:
... To improve the hemostatic function of chitosan nanofiber mats, we studied the synergetic effects of gelatin blending and porosity control. Gelatin-blended-chitosan (Chi-Gel) nanofiber mats were evaluated with respect to surface morphology, mechanical properties and wettability, and functionally tested in a blood clotting study. The blood clotting efficiency of Chi-Gel nanofiber mats using rabbit w ...
DOI:
10.1016/j.ijbiomac.2015.10.009

15. Aronia melanocarpa as a protector against nitration of fibrinogen

Author:
Bijak, Michał; Saluk, Joanna; Antosik, Adam; Ponczek, Michał B.; Żbikowska, Halina M.; Borowiecka, Marta; Nowak, Paweł
Source:
International journal of biological macromolecules 2013 v.55 pp. 264-268
ISSN:
0141-8130
Subject:
blood coagulation; coagulation,   etc   ; Aronia melanocarpa; antioxidant activity; fibrin; fibrinogen; fruits; glycoproteins; herbs; humans; molecular weight; polymerization; protective effect; protein aggregates; screening; small fruits; vegetables;     Show all 17 Subjects
Abstract:
... Fibrinogen (Fg) also known as coagulation factor I represents about 4% of the total human plasma proteins. The main function of Fg is its involvement in last phase of blood coagulation cascade, when thrombin-induced conversion of dissolved plasma fibrinogen into an insoluble fibrin clot occurs. The reaction of fibrinogen with peroxynitrite causes both structural modifications and changes of the bi ...
DOI:
10.1016/j.ijbiomac.2013.01.019

16. Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro

Author:
Kolodziejczyk-Czepas, Joanna; Talar, Beata; Nowak, Pawel; Olas, Beata; Wachowicz, Barbara
Source:
International journal of biological macromolecules 2012 v.50 no.3 pp. 754-758
ISSN:
0141-8130
Subject:
coagulation,   etc   ; fibrinogen; fibrinolysis; homocysteine; humans; hydrolysis; plasmin; plasminogen; proteolysis; thrombosis; u-plasminogen activator;     Show all 11 Subjects
Abstract:
... Mechanisms of homocysteine (Hcy) contribution to thrombosis are complex and only partly recognized. The available data suggest that the prothrombotic activity of homocysteine may be not only a result of the changes in coagulation process and endothelial dysfunction, but also the dysfunction of fibrinolysis. The aim of the present work was to assess the effects of homocysteine (10–100μMmM) and its ...
DOI:
10.1016/j.ijbiomac.2011.12.002

17. Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

Author:
Arunraj, T.R.; Sanoj Rejinold, N.; Ashwin Kumar, N.; Jayakumar, R.
Source:
International journal of biological macromolecules 2013 v.62 pp. 35-43
ISSN:
0141-8130
Subject:
coagulation,   etc   ; Fourier transform infrared spectroscopy; blood; cytotoxicity; dose response; doxorubicin; epithelial cells; fluorescence microscopy; humans; hydrophilicity; lung neoplasms; neoplasm cells; pH; scanning electron microscopy;     Show all 14 Subjects
Abstract:
... In this work, we developed a pH responsive chitin-poly(caprolactone) composite nanogels (chitin-PCL CNGs) system for non-small cell lung cancer (NSCLC). A hydrophilic drug, doxorubicin (Dox) was loaded in Chitin-PCL CNGs (Dox-chitin-PCL CNGs). Both control and drug loaded systems were analyzed by DLS, SEM, FTIR and TG/DTA. The size ranges of the control composite nanogels and their drug loaded cou ...
DOI:
10.1016/j.ijbiomac.2013.08.013