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- Du, Guan-Hua, et al. Show all 9 Authors
- Journal of Asian natural products research 2019 v.21 no.11 pp. 1052-1067
- active ingredients; active sites; biological assessment; drugs; enzyme inhibitors; epoxidation reactions; honokiol; influenza; polyphenols; sialidase; structure-activity relationships; viruses
- ... Honokiol, a natural polyphenol, which was reported to have satisfactory influenza neuraminidase (NA) inhibitory activity, was structurally modified. Twenty-three compounds were synthesized and the ortho-effects in the epoxidation and hydrolyzation reactions were studied. The derivatives were evaluated for NA inhibitory activity and the benzoylhydrazone derivatives showed much better anti-NA activi ...