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- Du, Guan-Hua, et al. Show all 7 Authors
- Journal of Asian natural products research 2017 v.19 no.6 pp. 630-643
- Western blotting; actinomycin D; apoptosis; cell viability; cisplatin; cytotoxicity; enzyme-linked immunosorbent assay; fluorescent antibody technique; membrane potential; mice; mitochondrial membrane; molecular models; neoplasm cells; neoplasms; proteins; staining; synergism; therapeutics
- ... The aim of this study is to investigate the synergism of low dose of actinomycin D (LDActD) to the cytotoxicity of cisplatin (CDDP) on KB cells. The role of P53 reactivation by LDActD in the synergism and its mechanism were further studied. Cell viability was determined by MTT assay. Apoptosis was determined by AnnexinV-FITC/PI staining. Mitochondrial membrane potential (MMP) was detected by JC-1 ...