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You searched for: Journal name Journal of Asian natural products research Remove constraint Journal name: Journal of Asian natural products research Publication year rev 7984-2016 Remove constraint Publication year rev: 7984-2016 Source 2016 v.18 no.11 Remove constraint Source: 2016 v.18 no.11
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1. 12b-hydroxy-des-D-garcigerin A enhances glucose metabolism in insulin-resistant HepG2 cells via the IRS-1/PI3-K/Akt cell signaling pathway

Author:
Yu Chen; Sha Wang; Shi-Ting Tian; Xin Hu; Jing Xu; Guang-Zhong Yang; Chao-Yuan Wang
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1091-1100
ISSN:
1477-2213
Subject:
AMP-activated protein kinase; glucose; glucose oxidase; hexokinase; human cell lines; insulin; insulin receptors; insulin resistance; metabolism; models; peroxidase; phosphatidylinositol 3-kinase; phosphorylation; pyruvate kinase; serine; signal transducing adaptor proteins; signal transduction; threonine
Abstract:
... HepG2 cells were induced with a high concentration of insulin to establish an insulin-resistant cell model (HepG2/IR). The effect of 12b-hydroxy-des-D-garcigerin A (DGA) on the glucose consumption (GC) of HepG2/IR cells was analyzed with the glucose oxidase/peroxidase assay. The results showed that DGA significantly stimulated GC by enhancing the activity of hexokinase (HK) and pyruvate kinase (PK ...
DOI:
10.1080/10286020.2016.1193489

2. 5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

Author:
Xin-Xin Zhao; Juan-Juan Chang; Qi-Lin Wang; Rong Lu; Ling-Jun Li; Xiao Sun; Wei-Dong Xie; Xia Li
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1079-1090
ISSN:
1477-2213
Subject:
4',6-diamidino-2-phenylindole; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; cyclins; cytochrome c; cytotoxicity; flavonoids; flow cytometry; hepatoma; humans; mitochondria; neoplasm cells; phosphorylation; staining; structure-activity relationships
Abstract:
... 5,6-Dihydroxy-3,7,4′-trimethoxyflavonol (AH5), 5,6,3′-trihydroxy-3,7,4′-trimethoxyflavonol (AH22), artemetin, and oroxylin A are four flavonoids with the same 2-phenyl-chromone skeleton isolated from the Chinese herb Aster himalaicus . The aim of this study was to evaluate the structure–activity relationship of these four analogs and the mediation of AH5 cytotoxicity via G2/M arrest and apoptosis ...
DOI:
10.1080/10286020.2016.1191473

3. Four new taraxastane-type triterpenoic acids from Cirsium setosum

Author:
Na Luan; Wen-Di Wei; Ali Wang; Xiu-Li Wu; Yan Qi; Jin-Jie Li; Jian-Quan Zheng; Xiao-Ya Shang
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1015-1023
ISSN:
1477-2213
Subject:
Cirsium arvense; acids; animal ovaries; cytotoxicity; humans; inhibitory concentration 50; mass spectrometry; nuclear magnetic resonance spectroscopy; ovarian neoplasms; triterpenoids
Abstract:
... Four new taraxastane-type triterpenoids acids 3 β ,22 α -dihydroxy-20-taraxasten-30-oic acid (1), 3 β -hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22 α -hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ( ...
DOI:
10.1080/10286020.2016.1217519

4. New conjugates of mycophenolic acid and their antiproliferative activity

Author:
Michał Prejs; Grzegorz Cholewinski; Agnieszka Siebert; Piotr Trzonkowski; Krystyna Dzierzbicka
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1057-1062
ISSN:
1477-2213
Subject:
anticarcinogenic activity; antineoplastic agents; chemical reactions; mononuclear leukocytes; neoplasm cells
Abstract:
... The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N ⁶-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can ...
DOI:
10.1080/10286020.2016.1184653

5. Two new xyloketals from the endophytic fungus Endomelanconiopsis endophytica derived from medicinal plant Ficus hirta

Author:
Zhang-Hua Sun; Fa-Liang Liang; Yu-Chan Chen; Hong-Xin Liu; Hao-Hua Li; Wei-Min Zhang
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1036-1041
ISSN:
1477-2213
Subject:
Ficus; cytotoxicity; endophytes; fungi; medicinal plants; neoplasm cells; spectroscopy; traditional medicine
Abstract:
... Chemical examination of the liquid culture of Endomelanconiopsis endophytica A326 isolated from the Chinese folk medicine Ficus hirta resulted in the isolation of two new xyloketals named xyloketals K and L (1 – 2) and three known analogs (3 – 5) including a new natural product (5). Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for ...
DOI:
10.1080/10286020.2016.1188084

6. The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine and their cytotoxicity against three human cancer cell lines

Author:
Kanok-on Rayanil; Cholthicha Prempree; Surachai Nimgirawath
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1042-1056
ISSN:
1477-2213
Subject:
alkaloids; anticarcinogenic activity; breast neoplasms; cytotoxicity; humans; inhibitory concentration 50; microwave treatment
Abstract:
... The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been achieved. The crucial step involved the formation of ring C by a microwave-assisted direct biaryl coupling to produce the aporphine skeleton in high yields. The synthetic alkaloids were evaluated for their cytotoxicity against three human cancer cell lines MCF7, KB and ...
DOI:
10.1080/10286020.2016.1177025

7. “Click” reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity

Author:
Ch. Pavan Kumar; A. Devi; P. Ashok Yadav; R. Rao Vadaparthi; G. Shankaraiah; P. Sowjanya; Nishant Jain; K. Suresh Babu
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1063-1078
ISSN:
1477-2213
Subject:
Saussurea costus; antineoplastic activity; cycloaddition reactions; cytotoxicity; flora; humans; medicinal plants; medicine; phytopharmaceuticals; spectroscopy
Abstract:
... As part of pharmacological–phytochemical integrated studies on medicinal plants from Indian flora, costunolide (1) and dehydrocostus lactone (2), were isolated as major phytochemicals from Saussurea lappa , a plant traditionally used in different Asian systems of medicine. A series of 1,4-disubstituted-1,2,3-triazoles conjugates were synthesized through diastereo selective Michael addition followe ...
DOI:
10.1080/10286020.2016.1193012

8. Chemical constituents from the fruiting bodies of Amauroderma subresinosum

Author:
Qiao Wang; Yu-Guang Wang; Qing-Yun Ma; Sheng-Zhuo Huang; Fan-Dong Kong; Li-Man Zhou; Hao-Fu Dai; You-Xing Zhao
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1030-1035
ISSN:
1477-2213
Subject:
Amauroderma; acetylcholinesterase; bioassays; chemical composition; fruiting bodies; nuclear magnetic resonance spectroscopy
Abstract:
... The chemical investigation on the fruiting bodies of Amauroderma subresinosum led to the isolation of 10 compounds including 2 new ones named amaurosubresin (1) and erythro (23,24)-5α,6α-epoxyergosta-8-ene-7-one-3β,23-diol (2). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of two ne ...
DOI:
10.1080/10286020.2016.1183650

9. Cycloartane triterpenes from Beesia calthaefolia and their anticomplement structure–activity relationship study

Author:
Li-Hua Mu; Jin-Yuan Zhao; Jing Zhang; Ping Liu
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1101-1107
ISSN:
1477-2213
Subject:
chemical analysis; saponins; spectroscopy; structure-activity relationships; triterpenoids
Abstract:
... Fifteen cycloartane triterpenes were isolated from Beesia calthaefolia and among them one was new cycloartane triterpenoid. The structure of new compound was determined by the application of spectroscopic analyses and chemical methods. The fifteen compounds were evaluated for their anticomplement activity by classic pathway. The structure–activity relationship analysis indicated that the configura ...
DOI:
10.1080/10286020.2016.1174698

10. Perangustols A and B, a pair of new azaphilone epimers from a marine sediment-derived fungus Cladosporium perangustm FS62

Author:
Zhen Fan; Zhang-Hua Sun; Hong-Xin Liu; Yu-Chan Chen; Hao-Hua Li; Wei-Min Zhang
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1024-1029
ISSN:
1477-2213
Subject:
Cladosporium; cytotoxicity; fungi; metabolites; neoplasm cells; spectroscopy
Abstract:
... A pair of new azaphilone epimers, perangustols A-B (1 – 2), and two new natural products (3 – 4), together with two known metabolites (5 – 6) were isolated from the culture of the marine sediment-derived fungus Cladosporium perangustum FS62. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The isolated compounds (1 – 6) were evaluated for their c ...
DOI:
10.1080/10286020.2016.1181623

11. Rhobupcyanoside B, A new cyanoside from Rhodiola bupleuroides

Author:
Hong Wang; Li Dong; Jing-Qiu Ge; Li-Na Deng; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen
Source:
Journal of Asian natural products research 2016 v.18 no.11 pp. 1108-1114
ISSN:
1477-2213
Subject:
Rhodiola; acarbose; alpha-glucosidase; ethanol; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; rhizomes; roots; spectral analysis
Abstract:
... One new cyanoside, rhobupcyanoside B (1), together with 7 known ones, was isolated from the 70% ethanol extract of the roots and rhizomes of Rhodiola bupleuroides . Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compound 1 was evaluated for its inhibitory activity against α-glucosidase with IC ₅₀ value of 278.28 ± 0.55 μM by comparing with the positive cont ...
DOI:
10.1080/10286020.2016.1188806