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- Chen, Fan; Yan, Qinying; Yu, Yang; Wu, Mei X.
- Journal of Controlled Release 2017 v.255 pp. 36-44
- BCG vaccine; adverse effects; ambient temperature; caves; cell-mediated immunity; dermis; freeze drying; hyaluronic acid; inflammation; live vaccines; melting; powders; skin irritation; storage time; strength (mechanics); tuberculosis; vaccination; viability
- ... Live attenuated Bacille Calmette–Guerin (BCG) bacillus is the only licensed vaccine for tuberculosis prevention worldwide to date. It must be delivered intradermally to be effective, which causes severe skin inflammation and sometimes, permanent scars. To minimize the side effects, we developed a novel microneedle array (MNA) that could deliver live attenuated freeze-dried BCG powder into the epid ...
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