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- Stenglein, Mark D., et al. Show all 11 Authors
- Journal of Molecular Biology 2014 v.426 pp. 1452-1468
- Arenaviridae; Corallus; Ebolavirus; Marburg virus; acidification; cell membranes; crystal structure; denaturation; etiology; genome; glycoproteins; pH; viruses
- ... Fusion of the viral and host cell membranes is a necessary first step for infection by enveloped viruses and is mediated by the envelope glycoprotein. The transmembrane subunits from the structurally defined “class I” glycoproteins adopt an α-helical “trimer-of-hairpins” conformation during the fusion pathway. Here, we present our studies on the envelope glycoprotein transmembrane subunit, GP2, of ...
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