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- Fu, Songbin, et al. Show all 13 Authors
- Journal of Proteome Research 2015 v.14 no.6 pp. 2480-2491
- adhesion; adjuvants; biomarkers; correlation; drug resistance; drug therapy; drugs; human cell lines; humans; lung neoplasms; messenger RNA; mitosis; paclitaxel; patients; precipitin tests; proteome; proteomics; reverse transcriptase polymerase chain reaction; tissues; ubiquitin
- ... Paclitaxel (PTX) is a widely used chemotherapeutic drug effective against numerous cancers. To elucidate cellular pathways targeted by PTX and identify novel mechanisms of PTX resistance, we used a SILAC based quantitative proteomic approach to evaluate global changes of cellular protein abundance in HeLa cells. We identified 347 proteins involved in a number of biological processes including spin ...