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- Li, Jing-ru; Walker, Simon; Nie, Jing-bao; Zhang, Xin-qing
- Journal of Zhejiang University 2019 v.20 no.1 pp. 32-38
- Human immunodeficiency virus; bioethics; biomedical research; gene editing; germ cells; governance; guidelines; humans; infants; professional ethics; China
- ... The rapid developments of science and technology in China over recent decades, particularly in biomedical research, have brought forward serious challenges regarding ethical governance. Recently, Jian-kui HE, a Chinese scientist, claimed to have “created” the first gene-edited babies, designed to be naturally immune to the human immunodeficiency virus (HIV). The news immediately triggered widespre ...
- Quah, Yixian; Mohd Ismail, Nor Ismaliza; Ooi, Jillian Lean Sim; Affendi, Yang Amri; Abd Manan, Fazilah; Teh, Lai-Kuan; Wong, Fai-Chu; Chai, Tsun-Thai
- Journal of Zhejiang University 2019 v.20 no.1 pp. 59-70
- Sarcophyton; chymotrypsin; corals; cytotoxicity; fluorouracil; gel chromatography; human cell lines; humans; hydrolysates; median effective concentration; oligopeptides; papain; purification methods; reversed-phase high performance liquid chromatography; solid phase extraction; subtilisin; trypsin; ultrafiltration; uterine cervical neoplasms
- ... Globally, peptide-based anticancer therapies have drawn much attention. Marine organisms are a reservoir of anticancer peptides that await discovery. In this study, we aimed to identify cytotoxic oligopeptides from Sarcophyton glaucum. Peptides were purified from among the S. glaucum hydrolysates produced by alcalase, chymotrypsin, papain, and trypsin, guided by a methylthiazolyldiphenyl-tetrazoli ...