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- Chiang, Chung-Jen; Lin, Li-Jen; Wu, Chia-Pei; Chen, Chih-Jung; Chao, Yun-Peng
- Journal of agricultural and food chemistry 2018 v.66 no.36 pp. 9438-9445
- Escherichia coli; antineoplastic activity; antineoplastic agents; epidermal growth factor receptors; hydrophobicity; lipid bodies; lung neoplasms; neoplasm cells; oleosin; phospholipids; plant fats and oils; therapeutics
- ... Lung cancer is the most widespread disease and is frequently associated with a high level of epidermal growth factor receptor (EGFR). This study was thus conducted to provide a proof-of-concept approach for targeted therapy of lung cancer by development of nanoscale oil bodies (NOBs). This was carried out by fusion of anti-EGFR affibody (ZEGFR₂) with oleosin (Ole), a structure protein of plant see ...