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- Cho, Sung-Joon; Kim, Sang-Bum; Cho, Hyun-Jong; Chong, Saeho; Chung, Suk-Jae; Kang, Il-Mo; Lee, JangikIke; Yoon, In-Soo; Kim, Dae-Duk
- Journal of agricultural and food chemistry 2016 v.64 no.27 pp. 5598-5606
- rats, etc ; animal models; blood chemistry; cytochrome P-450; diet; drugs; enzymes; fatty liver; fibrosis; hepatoma; liver; messenger RNA; patients; pharmacokinetics; Show all 14 Subjects
- ... Nonalcoholic fatty liver disease (NAFLD) refers to hepatic pathologies, including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, that may progress to hepatocellular carcinoma. These liver disease states may affect the activity and expression levels of drug-metabolizing enzymes, potentially resulting in an alteration in the pharmacokinetics, therapeutic effi ...
- Tan, Eddie T. T.; Al Jassim, Rafat; Cawdell-Smith, A. Judy; Ossedryver, Selina M.; D’Arcy, Bruce R.; Fletcher, Mary T.
- Journal of agricultural and food chemistry 2016 v.64 no.34 pp. 6622-6629
- rats, etc ; Chloris gayana; Indigofera linnaei; Indigofera spicata; barley; biopsy; blood; body weight; camels; cattle; chaff; diet; dietary exposure; dogs; excretion; food safety; grass hay; half life; heart; histopathology; kidneys; liquid chromatography; liver; liver diseases; muscles; necropsy; pancreas; poisoning; sheep; tandem mass spectrometry; tissues; Australia; Show all 32 Subjects
- ... Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies have documented a susceptibility to this hepatotoxin in different species of animals, including cattle, sheep, dogs, and rats, which are associated with mild to severe liver disease after prolonged ingestion. However ...